{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:37:59Z","timestamp":1794073079252,"version":"4.8.0"},"reference-count":128,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA054826"],"award-info":[{"award-number":["R01DA054826"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21AG090171"],"award-info":[{"award-number":["R21AG090171"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R34DA061156"],"award-info":[{"award-number":["R34DA061156"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>\n                    Substance use disorders (\n                    <jats:bold>SUDs<\/jats:bold>\n                    ) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (\n                    <jats:bold>ROS<\/jats:bold>\n                    ) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused substances including alcohol, cocaine, methamphetamine (\n                    <jats:bold>METH)<\/jats:bold>\n                    nicotine, cannabis, and opioids have been shown to disrupt ferroptosis-relevant pathways, leading to microglial activation and neuronal injury. Inhibition of ferroptosis could mitigate these pathological changes in preclinical models. Here, we summarize current evidence demonstrating the effects of abused drugs on ferroptosis pathways. Collectively, these findings underscore the potential role of ferroptosis in the pathophysiology of SUDs. Targeting ferroptosis may represent a promising therapeutic strategy for alleviating drug-induced neurological damage and improving recovery outcomes such as cognitive and memory deficiency in individuals with addiction.\n                  <\/jats:p>","DOI":"10.3389\/fncel.2026.1899553","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:14:11Z","timestamp":1788412451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The effects of abused drugs on ferroptosis pathways: potential therapeutic targets for substance use disorders"],"prefix":"10.3389","volume":"20","author":[{"given":"Tamara","family":"Bouchard","sequence":"first","affiliation":[{"name":"Department of Biological and Translational Department, Macon and Joan Brock Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Biological and Translational Department, Macon and Joan Brock Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam Liyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of the University of Southern California","place":["Los Angeles, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biological and Translational Department, Macon and Joan Brock Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biological and Translational Department, Macon and Joan Brock Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Y.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Biological and Translational Department, Macon and Joan Brock Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]},{"name":"Center for Integrative Neuroscience and Inflammatory Diseases, Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biological and Translational Department, Macon and Joan Brock Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]},{"name":"Center for Integrative Neuroscience and Inflammatory Diseases, Eastern Virginia Medical School\/Virginia Health Sciences, Old Dominion University","place":["Norfolk, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0006-8993(98)01020-8","article-title":"Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum","volume":"813","author":"Acikgoz","year":"1998","journal-title":"Brain Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.bpsc.2018.11.006","article-title":"Elevated brain iron in cocaine use disorder as indexed by magnetic field correlation imaging","volume":"4","author":"Adisetiyo","year":"2019","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"B3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.bcmd.2016.07.006","article-title":"Inflammation-induced up-regulation of hepcidin and down-regulation of ferroportin transcription are dependent on macrophage polarization","volume":"61","author":"Agoro","year":"2016","journal-title":"Blood Cells Mol. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"853175","DOI":"10.1155\/2012\/853175","article-title":"Oxidative stress and inflammation: essential partners in alcoholic liver disease","volume":"2012","author":"Ambade","year":"2012","journal-title":"Int. J. Hepatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s42003-026-09728-2","article-title":"Single-nucleus RNA sequencing and functional studies of acute methamphetamine-induced cognitive impairment","volume":"9","author":"An","year":"2026","journal-title":"Commun. Biol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.neuro.2013.05.009","article-title":"Methamphetamine decreases levels of glutathione peroxidases 1 and 4 in SH-SY5Y neuronal cells: protective effects of selenium","volume":"37","author":"Barayuga","year":"2013","journal-title":"Neurotoxicology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/S0006-2952(98)00228-7","article-title":"Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain","volume":"56","author":"Bhagwat","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"9296","DOI":"10.26355\/eurrev_202310_33957","article-title":"Advancements in ferroptosis research and therapeutic strategies for alcoholic liver disease: a narrative review","volume":"27","author":"Bo","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.bbalip.2017.04.003","article-title":"Brain lipidomic changes after morphine, cocaine and amphetamine administration - DESI - MS imaging study","volume":"1862","author":"Bodzon-Kulakowska","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B10","doi-asserted-by":"publisher","first-page":"412","DOI":"10.2174\/1570162X14666160324125158","article-title":"Multiple faceted roles of cocaine in potentiation of HAND","volume":"14","author":"Cai","year":"2016","journal-title":"Curr. HIV Res."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040576","article-title":"Lipid metabolism. cold spring harb","author":"Chandel","year":"2021","journal-title":"Perspect. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4824","DOI":"10.1021\/acschemneuro.9b00539","article-title":"Liproxstatin-1 attenuates morphine tolerance through inhibiting spinal ferroptosis-like cell death","volume":"10","author":"Chen","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"biom16040526","DOI":"10.3390\/biom16040526","article-title":"Cocaine upregulates microglial lipid droplet formation through increasing lipid synthesis activity in vitro and in vivo","volume":"16","author":"Cheng","year":"2026","journal-title":"Biomolecules"},{"key":"B14","doi-asserted-by":"publisher","first-page":"NU18091392","DOI":"10.3390\/nu18091392","article-title":"Long-chain fatty acids as drivers of neuroinflammation in neurodegeneration: mechanistic links to lipid peroxidation, ferroptosis, and mitochondrial dysfunction","volume":"18","author":"Christodoulou","year":"2026","journal-title":"Nutrients"},{"key":"B15","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/HRP.0000000000000271","article-title":"Substance Use Disorders in Global Mental Health Delivery: Epidemiology, Treatment Gap, and Implementation of Evidence-Based Treatments","volume":"28","author":"Connery","year":"2020","journal-title":"Harv. Rev. Psychiatry"},{"key":"B16","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/S0028-3908(03)00041-8","article-title":"Nicotine protects rat brain mitochondria against experimental injuries","volume":"44","author":"Cormier","year":"2003","journal-title":"Neuropharmacology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.toxlet.2013.03.025","article-title":"Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria","volume":"219","author":"Cunha-Oliveira","year":"2013","journal-title":"Toxicol. Lett."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1016\/j.jfda.2013.09.038","article-title":"Family and social aspects of substance use disorders and treatment","volume":"21","author":"Daley","year":"2013","journal-title":"J. Food Drug Anal."},{"key":"B19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.lfs.2007.05.005","article-title":"Alcohol-induced oxidative stress","volume":"81","author":"Das","year":"2007","journal-title":"Life Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41398-025-03315-5","article-title":"Cocaine perturbs neurodevelopment and increases neuroinflammation in a prenatal cerebral organoid model","volume":"15","author":"Davis","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"ijms21103575","DOI":"10.3390\/ijms21103575","article-title":"Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes","volume":"21","author":"di Giacomo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00441-009-0777-y","article-title":"Alteration of blood-brain barrier function by methamphetamine and cocaine","volume":"336","author":"Dietrich","year":"2009","journal-title":"Cell Tissue Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/glia.23738","article-title":"Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS\/NF-kappaB-dependent signaling and glucose consumption","volume":"68","author":"Dos-Santos-Pereira","year":"2020","journal-title":"Glia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1040","DOI":"10.1038\/tp.2016.271","article-title":"Disrupted iron regulation in the brain and periphery in cocaine addiction","volume":"7","author":"Ersche","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neulet.2006.01.047","article-title":"Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement","volume":"399","author":"Esposito","year":"2006","journal-title":"Neurosci. Lett."},{"key":"B28","doi-asserted-by":"publisher","first-page":"154","DOI":"10.15585\/mmwr.mm7308a1","article-title":"Deaths from excessive alcohol use - United States, 2016-2021","volume":"73","author":"Esser","year":"2024","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/PL00005264","article-title":"Effects of nicotine on hydroxyl free radical formation in vitro and on MPTP-induced neurotoxicity in vivo","volume":"358","author":"Ferger","year":"1998","journal-title":"Naunyn Schmiedebergs. Arch. Pharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0197-0186(03)00009-3","article-title":"Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells","volume":"43","author":"Guan","year":"2003","journal-title":"Neurochem. Int."},{"key":"B32","doi-asserted-by":"publisher","first-page":"980340","DOI":"10.3389\/fphar.2022.980340","article-title":"Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neurobiolaging.2024.09.004","article-title":"Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood","volume":"144","author":"Gustavsson","year":"2024","journal-title":"Neurobiol. Aging"},{"key":"B34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1515\/nipt-2022-0013","article-title":"Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death","volume":"2","author":"Halcrow","year":"2023","journal-title":"NeuroImmune Pharm. Ther."},{"key":"B35","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.brainres.2004.08.043","article-title":"Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution","volume":"1027","author":"Hawkins","year":"2004","journal-title":"Brain Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/sj.bjp.0705146","article-title":"Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics","volume":"138","author":"Howard","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuro.2023.09.006","article-title":"Iron chelation prevents nigrostriatal neurodegeneration in a chronic methamphetamine mice model","volume":"99","author":"Hu","year":"2023","journal-title":"Neurotoxicology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00213-023-06485-6","article-title":"Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells","volume":"241","author":"Huang","year":"2024","journal-title":"Psychopharmacology"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11040761","article-title":"Metabolic pathway of natural antioxidants, antioxidant enzymes and ROS providence","author":"Huchzermeyer","year":"2022","journal-title":"Antioxidants"},{"key":"B40","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.cellbi.2007.08.026","article-title":"Effect of nicotine and polyaromtic hydrocarbons on cerebral endothelial cells","volume":"32","author":"Hutamekalin","year":"2008","journal-title":"Cell Biol. Int."},{"key":"B41","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s11481-023-10082-x","article-title":"The endolysosomal transporter DMT1 is required for morphine regulation of neuronal ferritin heavy chain","volume":"18","author":"Irollo","year":"2023","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1471-4159.2003.02327.x","article-title":"Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells","volume":"89","author":"Iuvone","year":"2004","journal-title":"J. Neurochem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"113795","DOI":"10.1016\/j.expneurol.2021.113795","article-title":"Neurotoxicity of methamphetamine: Main effects and mechanisms","volume":"344","author":"Jayanthi","year":"2021","journal-title":"Exp. Neurol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1749-6632.1998.tb08224.x","article-title":"Methamphetamine-induced changes in antioxidant enzymes and lipid peroxidation in copper\/zinc-superoxide dismutase transgenic mice","volume":"844","author":"Jayanthi","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.toxlet.2017.07.214","article-title":"Remodeling of brain lipidome in methamphetamine-sensitized mice","volume":"279","author":"Jiang","year":"2017","journal-title":"Toxicol. Lett."},{"key":"B46","doi-asserted-by":"publisher","first-page":"ijms22094642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of Reactive Oxygen Species (ROS) Revisited: outlining their role in biological macromolecules (dna, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2018.05.045","article-title":"Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: in vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure","volume":"682","author":"Kaisar","year":"2018","journal-title":"Neurosci. Lett."},{"key":"B48","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.bbadis.2005.03.013","article-title":"Inhibition of rat brain mitochondrial electron transport chain activity by dopamine oxidation products during extended in vitro incubation: implications for Parkinson's disease","volume":"1741","author":"Khan","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1641323","DOI":"10.3389\/fphys.2025.1641323","article-title":"Targeting ferroptosis for neuroprotection: potential therapeutic avenues in neurodegenerative and neuropsychiatric diseases","volume":"16","author":"Khan","year":"2025","journal-title":"Front. Physiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1089\/can.2019.0102","article-title":"Neuroprotective effect of cannabidiol against hydrogen peroxide in hippocampal neuron culture","volume":"6","author":"Kim","year":"2021","journal-title":"Cannabis Cannabinoid. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"157868","DOI":"10.1016\/j.phymed.2026.157868","article-title":"Ferroptosis under fire: cannabidiol mitigates iron-dependent injury in differentiated human neuroblastoma cells following oxygen-glucose deprivation","volume":"152","author":"Klimiuk","year":"2026","journal-title":"Phytomedicine"},{"key":"B52","doi-asserted-by":"publisher","first-page":"189S","DOI":"10.1097\/01.alc.0000189274.00479.62","article-title":"Iron accumulation in alcoholic liver diseases","volume":"29","author":"Kohgo","year":"2005","journal-title":"Alcohol Clin. Exp. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1111\/ejn.12628","article-title":"Methamphetamine self-administration results in persistent dopaminergic pathology: implications for Parkinson's disease risk and reward-seeking","volume":"40","author":"Kousik","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"8926","DOI":"10.3390\/ijms23168926","article-title":"Alterations of mitochondrial structure in methamphetamine toxicity","volume":"23","author":"Lenzi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.7150\/ijms.108518","article-title":"Cordycepin ameliorates morphine tolerance by inhibiting spinal cord ferroptosis and inflammation via targeting SIRT1","volume":"22","author":"Li","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s12640-023-00645-4","article-title":"NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11","volume":"41","author":"Lin","year":"2023","journal-title":"Neurotox. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0925-4439(99)00029-0","article-title":"In vitro and in vivo studies investigating possible antioxidant actions of nicotine: relevance to Parkinson's and Alzheimer's diseases","volume":"1454","author":"Linert","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"B58","doi-asserted-by":"publisher","first-page":"ph19040629","DOI":"10.3390\/ph19040629","article-title":"Ferroptosis in neuropsychiatric, neurodegenerative disorders: shared mechanisms and disease-specific signatures","volume":"19","author":"Liu","year":"2026","journal-title":"Pharmaceuticals"},{"key":"B59","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3389\/fncel.2015.00279","article-title":"Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum","volume":"9","author":"Lopez-Pedrajas","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41420-023-01608-6","article-title":"Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation","volume":"9","author":"Luo","year":"2023","journal-title":"Cell Death Discov."},{"key":"B61","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.lfs.2015.01.003","article-title":"The role of reactive oxygen species in morphine addiction of SH-SY5Y cells","volume":"124","author":"Ma","year":"2015","journal-title":"Life Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cbi.2015.11.030","article-title":"Nicotine alkaloids as antioxidant and potential protective agents against in vitro oxidative haemolysis","volume":"243","author":"Malczewska-Jaskola","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"B63","doi-asserted-by":"publisher","first-page":"ijms26157520","DOI":"10.3390\/ijms26157520","article-title":"Antioxidants and reactive oxygen species: shaping human health and disease outcomes","volume":"26","author":"Manful","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00210-013-0919-3","article-title":"Induction of mitochondrial permeability transition (MPT) pore opening and ROS formation as a mechanism for methamphetamine-induced mitochondrial toxicity","volume":"387","author":"Mashayekhi","year":"2014","journal-title":"Naunyn Schmiedebergs. Arch. Pharmacol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.conb.2013.01.024","article-title":"Neuroimmune signaling: a key component of alcohol abuse","volume":"23","author":"Mayfield","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1172\/JCI5584","article-title":"Alcohol-induced generation of lipid peroxidation products in humans","volume":"104","author":"Meagher","year":"1999","journal-title":"J. Clin. Invest."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1097\/WNR.0b013e3282f0d4f4","article-title":"Methamphetamine increases basal ganglia iron to levels observed in aging","volume":"18","author":"Melega","year":"2007","journal-title":"Neuroreport"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1111\/j.1471-4159.2004.02434.x","article-title":"Brain antioxidant systems in human methamphetamine users","volume":"89","author":"Mirecki","year":"2004","journal-title":"J. Neurochem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12640-018-9931-1","article-title":"Nicotine-induced neuroprotection in rotenone in vivo and in vitro models of parkinson's disease: evidences for the involvement of the labile iron pool level as the underlying mechanism","volume":"35","author":"Mouhape","year":"2019","journal-title":"Neurotox. Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/s41598-025-31097-9","article-title":"Dose- and tissue-dependent effects of cannabidiol on antioxidant status in developing chicken embryos","volume":"16","author":"Muchacka","year":"2025","journal-title":"Sci. Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","article-title":"A red carpet for iron metabolism","volume":"168","author":"Muckenthaler","year":"2017","journal-title":"Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1067\/mlc.2000.109097","article-title":"Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism","volume":"136","author":"Mutlu-Turkoglu","year":"2000","journal-title":"J. Lab. Clin. Med."},{"key":"B73","first-page":"616","article-title":"Study of Serum Malondialdehyde Level in Opioid and Methamphetamine Dependent Patients","volume":"55","author":"Najafi","year":"2017","journal-title":"Acta Med. Iran."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1523\/ENEURO.0237-19.2019","article-title":"Morphine-induced modulation of endolysosomal iron mediates upregulation of ferritin heavy chain in cortical neurons","volume":"6","author":"Nash","year":"2019","journal-title":"eNeuro"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"B76","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neuropharm.2016.03.018","article-title":"Peripheral ammonia and blood brain barrier structure and function after methamphetamine","volume":"107","author":"Northrop","year":"2016","journal-title":"Neuropharmacology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1749-6632.2002.tb04190.x","article-title":"Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells","volume":"965","author":"Oliveira","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11064-006-9217-5","article-title":"Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress","volume":"32","author":"Ozmen","year":"2007","journal-title":"Neurochem. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.lfs.2004.12.025","article-title":"Oxidative stress in heroin administered mice and natural antioxidants protection","volume":"77","author":"Pan","year":"2005","journal-title":"Life Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1089\/ars.2012.4671","article-title":"The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2","volume":"19","author":"Parada","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B81","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.alcohol.2004.07.009","article-title":"Perspectives on alcohol consumption: liver polyunsaturated fatty acids and essential fatty acid metabolism","volume":"34","author":"Pawlosky","year":"2004","journal-title":"Alcohol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13365-023-01186-4","article-title":"Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice","volume":"30","author":"Rademeyer","year":"2024","journal-title":"J. Neurovirol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"ph13110328","DOI":"10.3390\/ph13110328","article-title":"Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells","volume":"13","author":"Raja","year":"2020","journal-title":"Pharmaceuticals"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1038\/jcbfm.2009.112","article-title":"Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells","volume":"29","author":"Ramirez","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B85","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1038\/s41598-022-08712-0","article-title":"Morphine-induced modulation of Nrf2-antioxidant response element signaling pathway in primary human brain microvascular endothelial cells","volume":"12","author":"Reymond","year":"2022","journal-title":"Sci. Rep."},{"key":"B86","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0376-8716(02)00022-4","article-title":"Decreased activity of brain phospholipid metabolic enzymes in human users of cocaine and methamphetamine","volume":"67","author":"Ross","year":"2002","journal-title":"Drug Alcohol Depend."},{"key":"B87","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1054\/plef.2002.0385","article-title":"Chronic cocaine administration reduces phospholipase A(2) activity in rat brain striatum","volume":"66","author":"Ross","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B88","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/0271678X15616978","article-title":"Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress","volume":"36","author":"Sajja","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B89","doi-asserted-by":"publisher","first-page":"104212","DOI":"10.1016\/j.ebiom.2022.104212","article-title":"Substance use and common contributors to morbidity: A genetics perspective","volume":"83","author":"Sanchez-Roige","year":"2022","journal-title":"EBioMedicine"},{"key":"B90","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11064-026-04751-5","article-title":"Targeting ferroptosis and necroptosis to treat stroke","volume":"51","author":"Sandra Monserrat","year":"2026","journal-title":"Neurochem. Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2147\/SAR.S337338","article-title":"Cocaine use disorder (cud): current clinical perspectives","volume":"13","author":"Schwartz","year":"2022","journal-title":"Subst. Abuse Rehabil."},{"key":"B92","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis","volume":"163","author":"Shadel","year":"2015","journal-title":"Cell"},{"key":"B93","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1007\/s11481-018-9787-4","article-title":"Methamphetamine induces apoptosis of microglia via the intrinsic mitochondrial-dependent pathway","volume":"13","author":"Sharikova","year":"2018","journal-title":"J. Neuroimm. Pharmacol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41398-018-0232-5","article-title":"Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload","volume":"8","author":"Silva","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"B95","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1007\/s12031-015-0545-2","article-title":"Cannabinoid-Induced Changes in the Activity of Electron Transport Chain Complexes of Brain Mitochondria","volume":"56","author":"Singh","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s43440-021-00283-7","article-title":"N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research","volume":"73","author":"Smaga","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s13365-015-0375-6","article-title":"Nicotine mediates expression of genes related to antioxidant capacity and oxidative stress response in HIV-1 transgenic rat brain","volume":"22","author":"Song","year":"2016","journal-title":"J. Neurovirol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0006-2952(02)01070-5","article-title":"Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease","volume":"64","author":"Soto-Otero","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B100","doi-asserted-by":"publisher","first-page":"4330","DOI":"10.1111\/bph.15185","article-title":"A systematic review of minor phytocannabinoids with promising neuroprotective potential","volume":"177","author":"Stone","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1023\/A:1021968526696","article-title":"Ethanol-induced cell death by lipid peroxidation in PC12 cells","volume":"22","author":"Sun","year":"1997","journal-title":"Neurochem. Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"e2508352123","DOI":"10.1073\/pnas.2508352123","article-title":"Pseudorabies virus triggers ferritinophagy-mediated ferroptosis and neuroinflammation in viral encephalitis","volume":"123","author":"Sun","year":"2026","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"B103","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.redox.2016.12.029","article-title":"Cannabidiol attenuates OGD\/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons","volume":"11","author":"Sun","year":"2017","journal-title":"Redox. Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/jnr.20850","article-title":"Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C\/IP3 pathway and modulate the cell activation toward a neuroprotective role","volume":"83","author":"Suzuki","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molimm.2026.04.009","article-title":"Wnt7a mediates the Wnt\/beta-catenin signaling pathway to influence ferroptosis in T lymphocytes of HIV-infected individuals","volume":"194","author":"Tao","year":"2026","journal-title":"Mol. Immunol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1152\/jn.1997.78.1.43","article-title":"Cannabinoids inhibit N- and P\/Q-type calcium channels in cultured rat hippocampal neurons","volume":"78","author":"Twitchell","year":"1997","journal-title":"J. Neurophysiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/nyas.13989","article-title":"The neurobiology of addiction","volume":"1451","author":"Uhl","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1590\/1516-4446-2012-0886","article-title":"Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain","volume":"35","author":"Valvassori","year":"2013","journal-title":"Braz. J. Psychiatry"},{"key":"B109","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/wps.21073","article-title":"Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention","volume":"22","author":"Volkow","year":"2023","journal-title":"World Psychiatr."},{"key":"B110","first-page":"1","article-title":"Brain ethanol metabolism and mitochondria","volume":"23","author":"Waddell","year":"2022","journal-title":"Curr. Top. Biochem. Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s43556-026-00416-5","article-title":"Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches","volume":"7","author":"Wang","year":"2026","journal-title":"Mol. Biomed"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1780573","DOI":"10.3389\/fnins.2026.1780573","article-title":"Ferroptosis in Parkinson's disease: a review of molecular mechanisms and emerging therapeutic strategies","volume":"20","author":"Wang","year":"2026","journal-title":"Front. Neurosci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"113374","DOI":"10.1016\/j.biopha.2022.113374","article-title":"An overview of ferroptosis in non-alcoholic fatty liver disease","volume":"153","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B114","doi-asserted-by":"publisher","first-page":"173535","DOI":"10.1016\/j.pbb.2023.173535","article-title":"Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens","volume":"224","author":"Wang","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040891","article-title":"The selenoprotein glutathione peroxidase 4: from molecular mechanisms to novel therapeutic opportunities","author":"Weaver","year":"2022","journal-title":"Biomedicines"},{"key":"B116","doi-asserted-by":"publisher","first-page":"ijms23105418","DOI":"10.3390\/ijms23105418","article-title":"Role of mitochondrial dynamics in cocaine's neurotoxicity","volume":"23","author":"Wen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70592","article-title":"Cannabidiol is a potential inhibitor of ferroptosis in human articular chondrocytes","author":"Wipplinger","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1111\/ejn.14130","article-title":"Targeting redox regulation to treat substance use disorder using N-acetylcysteine","volume":"50","author":"Womersley","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.taap.2012.05.010","article-title":"Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation","volume":"262","author":"Wu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"32405","DOI":"10.1074\/jbc.M504664200","article-title":"Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria","volume":"280","author":"Xie","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B121","doi-asserted-by":"publisher","first-page":"13828","DOI":"10.3390\/ijms232213828","article-title":"Alcohol exposure induces depressive and anxiety-like behaviors via activating ferroptosis in mice","volume":"23","author":"Xu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s11481-008-9121-7","article-title":"The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse","volume":"3","author":"Yamamoto","year":"2008","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1038\/s41401-021-00806-1","article-title":"Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice","volume":"43","author":"Yan","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"B124","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B125","doi-asserted-by":"publisher","first-page":"9145","DOI":"10.1038\/s41598-026-39849-x","article-title":"Ferrostatin 1 exerts multifaceted hepatic protection against alcoholic liver injury by inhibiting ferroptosis","volume":"16","author":"Yu","year":"2026","journal-title":"Sci. Rep."},{"key":"B126","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1177\/13872877261430002","article-title":"Regulated neuronal death in Alzheimer's disease: crosstalk and convergence of apoptosis, pyroptosis, senescence, and ferroptosis","volume":"111","author":"Zhang","year":"2026","journal-title":"J. Alzheimers. Dis."},{"key":"B127","doi-asserted-by":"publisher","first-page":"9671","DOI":"10.1021\/acs.jafc.1c03751","article-title":"Autophagy inhibition plays a protective role in ferroptosis induced by alcohol via the p62-Keap1-Nrf2 pathway","volume":"69","author":"Zhao","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"B128","doi-asserted-by":"publisher","first-page":"111728","DOI":"10.1016\/j.cellsig.2025.111728","article-title":"p38gamma modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia\/reperfusion by regulating the p53\/SLC7A11 signaling pathway","volume":"131","author":"Zhu","year":"2025","journal-title":"Cell. Signal."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2026.1899553\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:14:14Z","timestamp":1788412454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2026.1899553\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":128,"alternative-id":["10.3389\/fncel.2026.1899553"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2026.1899553","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"article-number":"1899553"}}