{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:54:51Z","timestamp":1791262491050,"version":"4.1.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Mutations in the glucocerebrosidase (\n                      <jats:italic>GBA1<\/jats:italic>\n                      ) gene are a major genetic risk factor for Parkinson's disease (PD) and result in dysfunctional glucocerebrosidase (GCase), the lysosomal enzyme responsible for cleaving glucosylceramide into glucose and ceramide. The pathogenic\n                      <jats:italic>L444P<\/jats:italic>\n                      variant disrupts the enzyme structure and activity, leading to lysosomal accumulation of glucosylceramide and ultimately impairing the clearance of monomeric \u03b1-synuclein (\u03b1-syn). Given the functional crosstalk among lysosomal homeostasis, the molecular circadian clock, and physical activity, we investigated whether GCase activity exhibits daily rhythmicity, and can be modulated by daily, fixed-time rotarod activity in healthy and\n                      <jats:italic>Gba1<\/jats:italic>\n                      -mutant mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      C57BL\/6J healthy controls and\n                      <jats:italic>Gba1<\/jats:italic>\n                      -mutant PD model mice were housed under a 12 h light\/dark cycle, and blood samples were collected at four Zeitgeber times (ZT2, ZT8, ZT14, and ZT20), with and without daily, fixed-time rotarod training. A fluorometric assay was performed on plasma samples to investigate the daily pattern of GCase activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results showed that rotarod performance was influenced by genotype-dependent vulnerabilities and by daily, fixed-time physical activity, with overall better performance during the dark-phase training. The fluorometric assay revealed that GCase activity shows a ZT-dependent daily pattern in healthy mice, whereas this pattern was disrupted in\n                      <jats:italic>Gba1<\/jats:italic>\n                      -mutant PD models and partially rescued by timed physical activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Overall, both the time of day and daily fixed-time physical activity influenced GCase regulation. Our findings reveal a functional interplay between daily biological timing and lysosomal enzyme regulation, suggesting that optimizing drug dosing and timing of administration may improve the efficacy of GCase-targeted treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fncel.2026.1924016","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:36Z","timestamp":1791260796000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Daily regulation of glucocerebrosidase activity and impact of fixed-time rotarod training in a mouse model of Gba1-associated Parkinson's disease"],"prefix":"10.3389","volume":"20","author":[{"given":"Chiara","family":"Bertasini","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Public Health, Section of Pharmacology, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Tavakolian Haghighi","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Section of Pharmacology, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giusy","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Paio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Artusi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Section of Pathology, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Schena","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, Section of Movement Sciences, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Venturelli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, Section of Movement Sciences, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Section of Pharmacology, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Paolone","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Section of Pharmacology, University of Verona","place":["Verona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fnagi.2020.00097","article-title":"Glucocerebrosidase defects as a major risk factor for Parkinson's disease","volume":"12","author":"Avenali","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-026-02418-4","article-title":"Aging is associated with behavioral alterations, lysosomal dysfunction, region-specific inflammation, and glutamatergic synaptic impairments in a Grn knockout mouse model of frontotemporal dementia","author":"Bertasini","year":"","journal-title":"Acta Neuropathol. Comm."},{"key":"B3","doi-asserted-by":"crossref","first-page":"115474","DOI":"10.1016\/j.expneurol.2025.115474","article-title":"Gene therapy device-based delivery of progranulin, prosaposin, and GDNF as a combined precision and neurorestorative therapy in the rat 6-OHDA model of parkinsonism","volume":"395","author":"Bertasini","year":"2026","journal-title":"Exp. Neurol."},{"key":"B4","first-page":"397","article-title":"Inferential statistical methods for estimating and comparing cosinor parameters","volume":"9","author":"Bingham","year":"1982","journal-title":"Chronobiologia"},{"key":"B5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/jnc.13517","article-title":"Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance","volume":"139","author":"Blanz","year":"2016","journal-title":"J. Neurochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.3390\/genes16121496","article-title":"Underlying mechanisms of GBA1 in Parkinson's disease and dementia with Lewy bodies: narrative review","volume":"16","author":"Bougea","year":"2025","journal-title":"Genes"},{"key":"B7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/9780470942390.mo110165","article-title":"Assessment of motor coordination and balance in mice using the rotarod, elevated bridge, and footprint tests","volume":"2","author":"Brooks","year":"2012","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.nlm.2004.01.001","article-title":"Short and long-term motor skill learning in an accelerated rotarod training paradigm","volume":"81","author":"Buitrago","year":"2004","journal-title":"Neurobiol. Learn. Mem."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70179","article-title":"Effects of GBA1 variants in patients with Parkinson's disease and Levodopa\u2013Carbidopa intestinal gel: a nation-wide, multicenter, longitudinal, \u201cReal-World\u201d study. The EPIC study","author":"Cilia","year":"2025","journal-title":"Euro. J. Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.tins.2024.10.006","article-title":"The intertwined relationship between circadian dysfunction and Parkinson's disease","volume":"48","author":"Duret","year":"2025","journal-title":"Trends Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"a033993","DOI":"10.1101\/cshperspect.a033993","article-title":"The autophagy lysosomal pathway and neurodegeneration","volume":"12","author":"Finkbeiner","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1093\/brain\/awu291","article-title":"Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation","volume":"137","author":"Fishbein","year":"2014","journal-title":"Brain"},{"key":"B13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/laban1005-39","article-title":"A rapid, simple, and humane method for submandibular bleeding of mice using a lancet","volume":"34","author":"Golde","year":"2005","journal-title":"Lab Anim."},{"key":"B14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jneumeth.2017.05.014","article-title":"The 9 to 5 rodent\u2014Time for change? Scientific and animal welfare implications of circadian and light effects on laboratory mice and rats","volume":"300","author":"Hawkins","year":"2018","journal-title":"J. Neurosci. Methods"},{"key":"B15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1152\/japplphysiol.00608.2025","article-title":"Morning endurance training induces superior performance adaptations compared with afternoon training in mice","volume":"140","author":"Hesketh","year":"2026","journal-title":"J. Appl. Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/cns.13114","article-title":"Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway","volume":"25","author":"Huang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s12576-017-0586-0","article-title":"Neuroprotective effect of treadmill exercise possibly via regulation of lysosomal degradation molecules in mice with pharmacologically induced Parkinson's disease","volume":"68","author":"Hwang","year":"2018","journal-title":"J. Physiol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.20463\/jenb.2018.0001","article-title":"Association of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson's disease","volume":"22","author":"Jang","year":"2018","journal-title":"J. Exerc. Nutrition Biochem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1113\/JP279779","article-title":"Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock","volume":"598","author":"Kemler","year":"2020","journal-title":"J. Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"16522","DOI":"10.1523\/JNEUROSCI.2545-13.2013","article-title":"Modeling fall propensity in Parkinson's disease: Deficits in the attentional control of complex movements in rats with cortical-cholinergic and striatal-dopaminergic deafferentation","volume":"33","author":"Kucinski","year":"2013","journal-title":"J. Neurosc."},{"key":"B21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.expneurol.2011.08.003","article-title":"Circadian dysfunction in a mouse model of Parkinson's disease","volume":"232","author":"Kudo","year":"2011","journal-title":"Exp. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"a033613","DOI":"10.1101\/cshperspect.a033613","article-title":"Introduction to chronobiology","volume":"10","author":"Kuhlman","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1093\/brain\/awae380","article-title":"Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation","volume":"148","author":"Lado","year":"2025","journal-title":"Brain"},{"key":"B24","doi-asserted-by":"publisher","first-page":"10544","DOI":"10.1038\/s41598-022-14823-5","article-title":"Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson's disease mice","volume":"12","author":"Leem","year":"2022","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1021\/acschemneuro.5c00844","article-title":"Exercise as chronotherapy: regulating circadian rhythms to alleviate symptoms in Parkinson's disease","volume":"17","author":"Li","year":"2026","journal-title":"ACS Chem. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e095610","DOI":"10.1136\/bmjopen-2024-095610","article-title":"Global burden of Parkinson's disease from 1990 to 2021: a population-based study","volume":"15","author":"Li","year":"2025","journal-title":"BMJ Open"},{"key":"B27","doi-asserted-by":"publisher","first-page":"116967","DOI":"10.1016\/j.bcp.2025.116967","article-title":"Circadian clock controlled glycolipid metabolism and its relevance to disease management","volume":"238","author":"Lin","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5708","DOI":"10.1038\/s41467-025-60520-y","article-title":"Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"100094","DOI":"10.1016\/j.nbscr.2023.100094","article-title":"Circadian profile, daytime activity, and the Parkinson's phenotype: a motion sensor pilot study with neurobiological underpinnings","volume":"14","author":"Marano","year":"2023","journal-title":"Neurobiol. Sleep Circadian Rhythms"},{"key":"B30","doi-asserted-by":"publisher","first-page":"107271","DOI":"10.1016\/j.nbd.2026.107271","article-title":"Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's disease","volume":"219","author":"Marano","year":"2026","journal-title":"Neurobiol. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"eadh1403","DOI":"10.1126\/sciadv.adh1403","article-title":"Intensive exercise ameliorates motor and cognitive symptoms in experimental Parkinson's disease restoring striatal synaptic plasticity","volume":"9","author":"Marino","year":"2023","journal-title":"Sci. Adv."},{"key":"B32","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and \u03b1-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e2220551120","DOI":"10.1073\/pnas.2220551120","article-title":"Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes","volume":"120","author":"McKee","year":"2023","journal-title":"Proc. Nat. Acad. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0238075","DOI":"10.1371\/journal.pone.0238075","article-title":"L444P Gba1 mutation increases formation and spread of \u03b1-synuclein deposits in mice injected with mouse \u03b1-synuclein pre-formed fibrils","volume":"15","author":"Migdalska-Richards","year":"2020","journal-title":"PLoS ONE"},{"key":"B35","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.bbr.2011.05.030","article-title":"Reversed light-dark cycle and cage enrichment effects on ethanol-induced deficits in motor coordination assessed in inbred mouse strains with a compact battery of refined tests","volume":"224","author":"Munn","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e0293826","DOI":"10.1371\/journal.pone.0293826","article-title":"Physical exercise and its effects on people with Parkinson's disease: umbrella review","volume":"18","author":"Padilha","year":"2023","journal-title":"PLoS ONE"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3389\/fneur.2019.01143","article-title":"Exercise-induced neuroprotection and recovery of motor function in animal models of Parkinson's disease","volume":"10","author":"Palasz","year":"2019","journal-title":"Front. Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1002\/mds.26326","article-title":"Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity","volume":"30","author":"Paolone","year":"2015","journal-title":"Mov. Disord."},{"key":"B39","doi-asserted-by":"crossref","first-page":"12115","DOI":"10.1523\/JNEUROSCI.2271-12.2012","article-title":"Time to pay attention: attentional performance time-stamped prefrontal cholinergic activation, diurnality, and performance","volume":"32","author":"Paolone","year":"2012","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6615","DOI":"10.3390\/ijms25126615","article-title":"Deficiency of glucocerebrosidase activity beyond Gaucher disease: PSAP and LIMP-2 dysfunctions","volume":"25","author":"Pavan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.10.006","article-title":"\u201cCircadian regulation of cellular physiology,\u201d","author":"Peek","year":"2015","journal-title":"Methods in Enzymology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"8814028","DOI":"10.1155\/2020\/8814028","article-title":"Cytokine-, neurotrophin-, and motor rehabilitation-induced plasticity in Parkinson's disease","volume":"2020","author":"Policastro","year":"2020","journal-title":"Neural Plast."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e2020088","DOI":"10.23750\/abm.v91i3.9443","article-title":"Prevalence of Parkinson disease in Italy: a systematic review and meta-analysis","volume":"91","author":"Ricc\u00f2","year":"2020","journal-title":"Acta Bio Medica: Atenei Parmensis"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1002\/mds.27865","article-title":"Exercise increases caudate dopamine release and ventral striatal activation in Parkinson's disease","volume":"34","author":"Sacheli","year":"2019","journal-title":"Mov. Disord."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1534\/g3.119.400071","article-title":"The genome of C57BL\/6J \u201cEve\u201d, the mother of the laboratory mouse genome reference strain","volume":"9","author":"Sarsani","year":"2019","journal-title":"G3 (Bethesda)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ymgme.2017.11.001","article-title":"Glucocerebrosidase haploinsufficiency in A53T \u03b1-synuclein mice impacts disease onset and course","volume":"122","author":"Tayebi","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"B48","doi-asserted-by":"publisher","first-page":"891644","DOI":"10.3389\/fnagi.2022.891644","article-title":"Transcriptional profiling reveals brain region-specific gene networks regulated in exercise in a mouse model of Parkinson's disease","volume":"14","author":"Tong","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1002\/mds.30006","article-title":"Consensus guidance for genetic counseling in GBA1 variants: a focus on Parkinson's disease","volume":"39","author":"Vieira","year":"2024","journal-title":"Mov. Disord."},{"key":"B50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.crphar.2020.04.001","article-title":"Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain","volume":"1","author":"Wahlberg","year":"2020","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4803","DOI":"10.4103\/NRR.NRR-D-25-01082","article-title":"Interplay of GBA1 with lysosomal dysfunction and inflammation in Parkinson's disease","volume":"21","author":"Wang","year":"2025","journal-title":"Neural Regen. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41467-017-00462-2","article-title":"Misalignment with the external light environment drives metabolic and cardiac dysfunction","volume":"8","author":"West","year":"2017","journal-title":"Nat. Commun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1464595","DOI":"10.3389\/fncel.2024.1464595","article-title":"Circadian rhythm disruption: A potential trigger in Parkinson's disease pathogenesis","volume":"18","author":"Xu","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s41531-025-01009-9","article-title":"Circadian clock dysfunction in Parkinson's disease: Mechanisms, consequences, and therapeutic strategy","volume":"11","author":"Yal\u00e7in","year":"2025","journal-title":"npj Parkinson's Disease"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2026.1924016\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:37Z","timestamp":1791260797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2026.1924016\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":54,"alternative-id":["10.3389\/fncel.2026.1924016"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2026.1924016","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"article-number":"1924016"}}