{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:53:04Z","timestamp":1789487584361,"version":"build-2803163510"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>\n                    Maternal infection during pregnancy has emerged from epidemiological research as a key factor in the risk for neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and schizophrenia (SZ). Animal models provide translational tools to explore mechanisms linking maternal infection with altered offspring neurodevelopment. Maternal immune activation (MIA) models have been used to systematically explore the associations between specific maternal cytokines,\n                    <jats:italic>in vivo<\/jats:italic>\n                    measures of offspring brain, behavior and immune system development, and ultimately, to identify cellular and molecular changes that underly aberrant offspring neurodevelopment. Emerging evidence from rodent MIA models suggests that prenatal immune challenge induces NDD-relevant phenotypes not only in directly exposed individuals but also their descendants, suggesting that the public health consequences of MIA may be exponentially greater than previously understood. Epigenetic mechanisms have emerged as a critical, but understudied, area of research in the MIA field. Although epigenomic mechanisms could explain long-lived lifetime and intergenerational effects associated with maternal infection, there are limitations in translating epigenetic findings from preclinical rodent MIA models to humans. Here, we summarize the preclinical rodent studies investigating the effects of MIA on the offspring epigenome and highlight the translational potential of emerging data from non-rodent MIA models.\n                  <\/jats:p>","DOI":"10.3389\/fncel.2026.1941243","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:57:00Z","timestamp":1789484220000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring epigenetic modifications following maternal immune activation: a focus on cross-species translational potential"],"prefix":"10.3389","volume":"20","author":[{"given":"Felisa J.","family":"Carbajal","sequence":"first","affiliation":[{"name":"National Biomedical Research Institute, University of California Davis","place":["Davis, CA, United States"]},{"name":"Department of Psychology, University of California Davis","place":["Davis, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine M.","family":"LaSalle","sequence":"additional","affiliation":[{"name":"The MIND Institute, School of Medicine, University of California Davis","place":["Davis, CA, United States"]},{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis","place":["Davis, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa D.","family":"Bauman","sequence":"additional","affiliation":[{"name":"National Biomedical Research Institute, University of California Davis","place":["Davis, CA, United States"]},{"name":"The MIND Institute, School of Medicine, University of California Davis","place":["Davis, CA, United States"]},{"name":"Department of Physiology and Membrane Biology, School of Medicine, University of California Davis","place":["Davis, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"148329","DOI":"10.1016\/j.gene.2024.148329","article-title":"Epigenetic disruptions in the offspring hypothalamus in response to maternal infection","volume":"910","author":"Alsegehy","year":"2024","journal-title":"Gene"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41380-025-03403-4","article-title":"Prenatal maternal immune activation triggers lasting cell-specific transcriptomic dysregulation in the amygdala of primate offspring","volume":"31","author":"Ander","year":"2026","journal-title":"Mol. 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