{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:23:27Z","timestamp":1787289807693,"version":"build-2736575974"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peroxisomes are highly dynamic organelles that contribute to cellular homeostasis by coordinating lipid metabolism, reactive oxygen species handling, and adaptive responses to metabolic stress. Their plasticity is particularly relevant in the nervous system, where peroxisomes cooperate with mitochondria to maintain redox and metabolic balance in neuronal and glial cells. Peroxisome proliferator-activated receptor alpha (PPAR\u03b1), together with its coactivator PGC-1\u03b1, represents a major transcriptional regulator of peroxisomal and mitochondrial metabolic programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BV2 microglial cells were exposed to rotenone to investigate how mitochondrial oxidative stress influences the peroxisomal compartment. Mitochondrial and peroxisomal morphology, intracellular distribution, oxidative damage, and the expression of proteins involved in peroxisomal metabolism and PPAR\u03b1 signaling were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rotenone induced a stress-associated microglial phenotype characterized by cytoskeletal remodeling, mitochondrial network disruption, and oxidative damage. These alterations were accompanied by a coordinated reorganization of the peroxisomal compartment, including increased abundance of peroxisomal membrane markers, redistribution of peroxisomes toward the perinuclear region, and enhanced expression of enzymes associated with peroxisomal fatty acid oxidation. An increased spatial association between peroxisomes and mitochondria was also observed, suggesting that peroxisomal remodeling forms part of a broader inter-organelle adaptation to mitochondrial dysfunction. These changes occurred together with increased nuclear phosphorylated PPAR\u03b1 and enhanced PGC-1\u03b1 immunoreactivity, supporting the engagement of a PPAR\u03b1\u2013PGC-1\u03b1-related transcriptional response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Overall, our findings suggest that mitochondrial dysfunction in microglial cells activates a PPAR\u03b1-associated adaptive program that promotes peroxisomal remodeling and strengthens mitochondria\u2013peroxisome coordination. This response may represent an attempt to preserve lipid and redox homeostasis during cellular stress and identifies PPAR\u03b1-regulated peroxisomal pathways as potentially relevant components of microglial metabolic adaptation in neurodegenerative conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fncel.2026.1941513","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:23:42Z","timestamp":1787286222000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rotenone-induced oxidative stress triggers peroxisomal alterations in BV-2 microglial cells"],"prefix":"10.3389","volume":"20","author":[{"given":"Alessio","family":"Valenza","sequence":"first","affiliation":[{"name":"Department of Science, University Roma Tre","place":["Rome, Italy"]},{"name":"LIFE Institute for Research and Health Care\u2014Santa Lucia IRCCS","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Muzzi","sequence":"additional","affiliation":[{"name":"Department of Science, University Roma Tre","place":["Rome, Italy"]},{"name":"Department of Biosciences and Territory, University of Molise","place":["Pesche, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rendina","sequence":"additional","affiliation":[{"name":"Department of Science, University Roma Tre","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Montali","sequence":"additional","affiliation":[{"name":"Department of Science, University Roma Tre","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Pensabene","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise","place":["Pesche, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fracassi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, UTMB","place":["Galveston, TX, United States"]},{"name":"Moody Brain Health Institute, UTMB","place":["Galveston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Segatto","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise","place":["Pesche, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Science, University Roma Tre","place":["Rome, Italy"]},{"name":"LIFE Institute for Research and Health Care\u2014Santa Lucia IRCCS","place":["Rome, Italy"]},{"name":"Graduate School of Biomedical Sciences, UTMB","place":["Galveston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.freeradbiomed.2023.02.009","article-title":"Catalase: a critical node in the regulation of cell fate","volume":"199","author":"Baker","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"834411","DOI":"10.3389\/fphys.2022.834411","article-title":"Determinants of peroxisome membrane dynamics","volume":"13","author":"Carmichael","year":"2022","journal-title":"Front. Physiol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/tra.12549","article-title":"A role for mitochondrial rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes","volume":"19","author":"Castro","year":"2018","journal-title":"Traffic"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1007\/s11064-023-03907-x","article-title":"Mitochondrial complex I inhibition in dopaminergic neurons causes altered protein profile and protein oxidation: implications for Parkinson\u2019s disease","volume":"48","author":"Chithra","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1083\/jcb.201009132","article-title":"Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson\u2019s disease model","volume":"192","author":"Choi","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"100532","DOI":"10.1016\/j.cophys.2022.100532","article-title":"Mitochondria in neurodegeneration","volume":"26","author":"Chu","year":"2022","journal-title":"Curr. Opin. Physio."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"7017","DOI":"10.3390\/ijms24087017","article-title":"Bromodomain and extraterminal domain (BET) protein inhibition hinders glioblastoma progression by inducing autophagy-dependent differentiation","volume":"24","author":"Colardo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e70067","DOI":"10.1111\/apha.70067","article-title":"Branched-chain amino acids and Di-alanine supplementation attenuates muscle atrophy in a murine model of Cancer Cachexia","volume":"241","author":"Colardo","year":"2025","journal-title":"Acta Physiol. (Oxf.)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41531-025-00917-0","article-title":"Rotenone induced acute miRNA alterations in extracellular vesicles produce mitochondrial dysfunction and cell death","volume":"11","author":"Currim","year":"2025","journal-title":"NPJ Parkinsons Dis."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"345","DOI":"10.2174\/1567205014666170505094549","article-title":"Targeting PPARalpha in Alzheimer\u2019s disease","volume":"15","author":"D\u2019Orio","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1007\/s12640-020-00323-9","article-title":"Peroxisomes of the brain: distribution, functions, and associated diseases","volume":"39","author":"Deb","year":"2021","journal-title":"Neurotox. Res."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.cell.2015.10.023","article-title":"Hypervulnerability to sound exposure through impaired adaptive proliferation of peroxisomes","volume":"163","author":"Delmaghani","year":"2015","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1126\/science.adn2804","article-title":"ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox","volume":"389","author":"DiGiovanni","year":"2025","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1002\/cne.25274","article-title":"Ultrastructural analysis of the morphological phenotypes of microglia associated with neuro-inflammatory cues","volume":"530","author":"Dyne","year":"2022","journal-title":"J. Comp. 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Sci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/diseases1010036","article-title":"The nervous system cytoskeleton under oxidative stress","volume":"1","author":"Gardiner","year":"2013","journal-title":"Diseases"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s10571-020-00790-w","article-title":"Silencing the cytoskeleton protein Iba1 (ionized calcium binding adapter protein 1) interferes with BV2 microglia functioning","volume":"40","author":"Gheorghe","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref9001","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00418-013-1133-6","article-title":"The biogenesis protein PEX14 is an optimal marker for the identification and localization of peroxisomes in different cell types, tissues, and species in morphological studies","volume":"140","author":"Grant","year":"2013","journal-title":"Histochem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-3-030-60204-8_4","article-title":"Peroxisome biogenesis disorders","volume":"1299","author":"Honsho","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1007\/s12035-022-03193-8","article-title":"Rotenone-induced model of Parkinson\u2019s disease: beyond mitochondrial complex I inhibition","volume":"60","author":"Ibarra-Guti\u00e9rrez","year":"2023","journal-title":"Mol. 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Neurosci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1002\/iub.1097","article-title":"Peroxisome proliferator-activated receptor-\u03b3 cofactors in neurodegeneration","volume":"64","author":"Katsouri","year":"2012","journal-title":"IUBMB Life"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"C881","DOI":"10.1152\/ajpcell.00104.2005","article-title":"Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency","volume":"289","author":"Koopman","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00401-011-0836-9","article-title":"Peroxisomal alterations in Alzheimer\u2019s disease","volume":"122","author":"Kou","year":"2011","journal-title":"Acta Neuropathol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00418-023-02259-5","article-title":"The peroxisome: an update on mysteries 3.0","volume":"161","author":"Kumar","year":"2024","journal-title":"Histochem. Cell Biol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"31521","DOI":"10.1074\/jbc.M103306200","article-title":"Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresson","volume":"276","author":"Lawrence","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.freeradbiomed.2024.09.008","article-title":"CD11b-NOX2 mutual regulation-mediated microglial exosome release contributes to rotenone-induced inflammation and neurotoxicity in BV2 microglia and primary cultures","volume":"224","author":"Li","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12974-022-02613-9","article-title":"Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer\u2019s disease","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41586-025-09517-7","article-title":"Peroxisomal metabolism of branched fatty acids regulates energy homeostasis","volume":"646","author":"Liu","year":"2025","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/0304-4165(78)90315-x","article-title":"Rotenone inhibition of tubulin self-assembly","volume":"543","author":"Marshall","year":"1978","journal-title":"Biochim. Biophys. Acta"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"16787","DOI":"10.3390\/ijms242316787","article-title":"Mitochondrial dysfunction in skeletal muscle of rotenone-induced rat model of Parkinson\u2019s disease: SC-Nanophytosomes as therapeutic approach","volume":"24","author":"Mendes","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.3390\/cells9102232","article-title":"ProNGF\/p75NTR axis drives fiber type specification by inducing the fast-glycolytic phenotype in mouse skeletal muscle cells","volume":"9","author":"Pallottini","year":"2020","journal-title":"Cells"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00418-017-1577-1","article-title":"The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilising activity","volume":"148","author":"Passmore","year":"2017","journal-title":"Histochem. Cell Biol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1103416","DOI":"10.3389\/fneur.2023.1103416","article-title":"Microglia activation in central nervous system disorders: a review of recent mechanistic investigations and development efforts","volume":"14","author":"Qin","year":"2023","journal-title":"Front. Neurol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"116084","DOI":"10.1016\/j.taap.2022.116084","article-title":"Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia","volume":"447","author":"Ra\u010dkov\u00e1","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"317","DOI":"10.5114\/fn.2019.89857","article-title":"Rotenone: from modelling to implication in Parkinson\u2019s disease","volume":"57","author":"Radad","year":"2019","journal-title":"Folia Neuropathol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"136215","DOI":"10.1016\/j.jhazmat.2024.136215","article-title":"Rotenone exposure causes features of Parkinson\u2019s disease pathology linked with muscle atrophy in developing zebrafish embryo","volume":"480","author":"Ranasinghe","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"116280","DOI":"10.1016\/j.celrep.2025.116280","article-title":"Neurons and astrocytes have distinct organelle signatures and responses to stress","volume":"44","author":"Rhoads","year":"2025","journal-title":"Cell Rep."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/1452696","article-title":"PGC-1\u03b1, inflammation, and oxidative stress: an integrative view in metabolism","volume":"2020","author":"Rius-P\u00e9rez","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"119417","DOI":"10.1016\/j.bbamcr.2022.119417","article-title":"Rotenone induced neurodegeneration is mediated via cytoskeleton degradation and necroptosis","volume":"1870","author":"Roy","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"18129","DOI":"10.1038\/s41598-023-44807-y","article-title":"Disrupted brain mitochondrial morphology after in vivo hydrogen sulfide exposure","volume":"13","author":"Rumbeiha","year":"2023","journal-title":"Sci. Rep."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.bbamcr.2006.01.004","article-title":"Shared components of mitochondrial and peroxisomal division","volume":"1763","author":"Schrader","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref48","first-page":"24","article-title":"Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs","volume":"69","author":"Schrader","year":"1996","journal-title":"Eur. J. Cell Biol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.bbamcr.2015.09.024","article-title":"Proliferation and fission of peroxisomes\u2014an update","volume":"1863","author":"Schrader","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s10545-015-9819-7","article-title":"Peroxisome-mitochondria interplay and disease","volume":"38","author":"Schrader","year":"2015","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.bbamcr.2006.09.006","article-title":"Peroxisomes and oxidative stress","volume":"1763","author":"Schrader","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/jimd.12083","article-title":"Organelle interplay\u2014peroxisome interactions in health and disease","volume":"43","author":"Schrader","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/s41467-019-09253-3","article-title":"Coming together to define membrane contact sites","volume":"10","author":"Scorrano","year":"2019","journal-title":"Nat. Commun."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/s41467-018-03957-8","article-title":"Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact","volume":"9","author":"Shai","year":"2018","journal-title":"Nat. Commun."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e0162628","DOI":"10.1371\/journal.pone.0162628","article-title":"Activation of peroxisome proliferator-activated receptor alpha improves aged and UV-irradiated skin by catalase induction","volume":"11","author":"Shin","year":"2016","journal-title":"PLoS One"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2174\/09298673113209990181","article-title":"4-Hydroxynonenal in the pathogenesis and progression of human diseases","volume":"21","author":"Shoeb","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"8969","DOI":"10.3390\/ijms22168969","article-title":"Mechanisms mediating the regulation of peroxisomal fatty acid beta-oxidation by PPAR\u03b1","volume":"22","author":"Tahri-Joutey","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.neuron.2018.05.022","article-title":"ER lipid defects in neuropeptidergic neurons impair sleep patterns in Parkinson\u2019s disease","volume":"98","author":"Valadas","year":"2018","journal-title":"Neuron"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1895046","DOI":"10.3389\/fphar.2026.1895046","article-title":"Pharmacological modulation of p75 neurotrophin receptor in microglial cells improves resilience to rotenone cytotoxicity","volume":"17","author":"Valenza","year":"2026","journal-title":"Front. Pharmacol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cardiores.2005.01.026","article-title":"PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells","volume":"66","author":"Valle","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"4355","DOI":"10.1096\/fj.201801498R","article-title":"Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4","volume":"33","author":"Violante","year":"2019","journal-title":"FASEB J."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1152\/physrev.00051.2021","article-title":"The physiological functions of human peroxisomes","volume":"103","author":"Wanders","year":"2023","journal-title":"Physiol. Rev."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/978-981-13-2233-4_15","article-title":"Peroxisomes and their central role in metabolic interaction networks in humans","volume":"89","author":"Wanders","year":"2018","journal-title":"Subcell. Biochem."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e0209507","DOI":"10.1371\/journal.pone.0209507","article-title":"Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002","article-title":"Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease","volume":"22","author":"Wu","year":"2002","journal-title":"J. Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3892\/br.2020.1358","article-title":"Serum-deprivation leads to activation-like changes in primary microglia and BV-2 cells but not astrocytes","volume":"13","author":"Yao","year":"2020","journal-title":"Biomed. 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