{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:41:29Z","timestamp":1787802089799,"version":"build-2784847793"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neural Circuits"],"abstract":"<jats:p>\n                    Vasopressin (VP) plays a crucial role in social memory even at the level of the olfactory bulb (OB), where OB VP cells are activated during social interactions. However, it remains unclear how VP modulates olfactory processing to enable enhanced discrimination of very similar odors, e.g., rat body odors. Thus far, it has been shown that VP reduces firing rates in mitral cells (MCs) during odor presentation\n                    <jats:italic>in vivo<\/jats:italic>\n                    and decreases the amplitudes of olfactory nerve-evoked excitatory postsynaptic potentials (ON-evoked EPSPs) in external tufted cells\n                    <jats:italic>in vitro<\/jats:italic>\n                    . We performed whole-cell patch-clamp recordings and population Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging on acute rat OB slices. We recorded ON-evoked EPSPs as well as spontaneous inhibitory postsynaptic currents (IPSCs) from two types of projection neurons: middle tufted cells (mTCs) and MCs. VP bath application reduced the amplitudes of ON-evoked EPSPs and the frequencies of spontaneous IPSCs in mTCs but did not change those in MCs. Therefore, we analyzed ON-evoked EPSPs in inhibitory interneurons, i.e., periglomerular cells (PGCs) and granule cells (GCs), to search for the origin of increased inhibition in mTCs. However, VP did not increase the amplitudes of evoked EPSPs in either type of interneurons. We next performed two-photon population Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging in the glomerular layer and the superficial GC layer of responses to stronger ON stimulation than during patch-clamp experiments that should evoke action potentials in the measured cells. We observed that VP application increased ON-evoked Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx in juxtaglomerular cells and GC somata. Thus, our findings indicate inhibition by VP on projection neurons via strong ON input-mediated inhibitory interneuron activity. This neural modulation could improve representation of odors, hence, better discriminability of similar odors, e.g., conspecific body odors.\n                  <\/jats:p>","DOI":"10.3389\/fncir.2024.1448592","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T01:01:53Z","timestamp":1724893313000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Vasopressin differentially modulates the excitability of rat olfactory bulb neuron subtypes"],"prefix":"10.3389","volume":"18","author":[{"given":"Hajime","family":"Suyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Bianchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.neuron.2010.01.009","article-title":"Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice","volume":"65","author":"Abraham","year":"2010","journal-title":"Neuron"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"25808","DOI":"10.1038\/srep25808","article-title":"Increased olfactory bulb acetylcholine bi-directionally modulates glomerular odor sensitivity","volume":"6","author":"Bendahmane","year":"2016","journal-title":"Sci. Rep."},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1016\/B978-012532104-4\/50060-3","article-title":"58 - vasopressin receptors","volume-title":"Hormones, brain and behavior","author":"Birnbaumer","year":"2002"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00441-020-03365-9","article-title":"Extrinsic neuromodulation in the rodent olfactory bulb","volume":"383","author":"Brunert","year":"2021","journal-title":"Cell Tissue Res."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1523\/JNEUROSCI.4036-08.2009","article-title":"Bulbar acetylcholine enhances neural and perceptual odor discrimination","volume":"29","author":"Chaudhury","year":"2009","journal-title":"J. Neurosci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1073\/pnas.0608564104","article-title":"Relational representation in the olfactory system","volume":"104","author":"Cleland","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2202-7-7","article-title":"Non-topographical contrast enhancement in the olfactory bulb","volume":"7","author":"Cleland","year":"2006","journal-title":"BMC Neurosci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fnsyn.2014.00021","article-title":"Paying attention to smell: cholinergic signaling in the olfactory bulb","volume":"6","author":"D\u2019souza","year":"2014","journal-title":"Front. Synaptic Neurosci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0006-8993(88)90066-2","article-title":"Septal vasopressin modulates social memory in male-rats","volume":"457","author":"Dantzer","year":"1988","journal-title":"Brain Res."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0166-4328(90)90042-D","article-title":"Cerebral lateralization of olfactory-mediated affective processes in rats","volume":"40","author":"Dantzer","year":"1990","journal-title":"Behav. Brain Res."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1523\/JNEUROSCI.5317-08.2009","article-title":"External tufted cells drive the output of olfactory bulb glomeruli","volume":"29","author":"De Saint Jan","year":"2009","journal-title":"J. Neurosci."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01724-1","article-title":"A Gnrh neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice","author":"Decoster","year":"2024","journal-title":"Nature Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fnbeh.2012.00052","article-title":"Noradrenergic and cholinergic modulation of olfactory bulb sensory processing","volume":"6","author":"Devore","year":"2012","journal-title":"Front. Behav. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S0196-9781(98)00047-3","article-title":"The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats","volume":"19","author":"Dluzen","year":"1998","journal-title":"Peptides"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00441-020-03402-7","article-title":"Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors","volume":"383","author":"Egger","year":"2021","journal-title":"Cell Tissue Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"7551","DOI":"10.1523\/JNEUROSCI.23-20-07551.2003","article-title":"Mechanisms of lateral inhibition in the olfactory bulb: efficiency and modulation of spike-evoked calcium influx into granule cells","volume":"23","author":"Egger","year":"2003","journal-title":"J. Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1038\/nprot.2011.353","article-title":"Testing declarative memory in laboratory rats and mice using the nonconditioned social discrimination procedure","volume":"6","author":"Engelmann","year":"2011","journal-title":"Nat. Protoc."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/nn.3760","article-title":"Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb","volume":"17","author":"Fukunaga","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1152\/jn.2000.83.2.705","article-title":"Vasopressin increases Gabaergic inhibition of rat hypothalamic paraventricular nucleus neurons in vitro","volume":"83","author":"Hermes","year":"2000","journal-title":"J. Neurophysiol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"7970","DOI":"10.1523\/JNEUROSCI.0154-12.2012","article-title":"Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex","volume":"32","author":"Igarashi","year":"2012","journal-title":"J. Neurosci."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2020.561822","article-title":"Subpopulations of projection neurons in the olfactory bulb","volume":"14","author":"Imamura","year":"2020","journal-title":"Front. Neural Circuits"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0166-4328(97)83331-1","article-title":"Modulation of inhibition in a model of olfactory bulb reduces overlap in the neural representation of olfactory stimuli","volume":"84","author":"Linster","year":"1997","journal-title":"Behav. Brain Res."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1113\/JP275511","article-title":"Cholecystokinin selectively activates short axon cells to enhance inhibition of olfactory bulb output neurons","volume":"596","author":"Liu","year":"2018","journal-title":"J. Physiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1523\/ENEURO.0431-18.2019","article-title":"Vasopressin cells in the rodent olfactory bulb resemble non-bursting superficial tufted cells and are primarily inhibited upon olfactory nerve stimulation","volume":"6","author":"Lukas","year":"2019","journal-title":"eNeuro"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fncom.2012.00003","article-title":"Mitral cell spike synchrony modulated by dendrodendritic synapse location","volume":"6","author":"Mctavish","year":"2012","journal-title":"Front. Comput. Neurosci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fncir.2014.00098","article-title":"Neuronal organization of olfactory bulb circuits","volume":"8","author":"Nagayama","year":"2014","journal-title":"Front. Neural Circuits"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"8722","DOI":"10.1523\/JNEUROSCI.0527-11.2011","article-title":"Monosynaptic and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons","volume":"31","author":"Najac","year":"2011","journal-title":"J. Neurosci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.neuron.2016.03.033","article-title":"Oxytocin enhances social recognition by modulating cortical control of early olfactory processing","volume":"90","author":"Oettl","year":"2016","journal-title":"Neuron"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1152\/jn.00988.2015","article-title":"Granule cell excitability regulates gamma and beta oscillations in a model of the olfactory bulb dendrodendritic microcircuit","volume":"116","author":"Osinski","year":"2016","journal-title":"J. Neurophysiol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1210\/endo.135.4.7925112","article-title":"Cellular localization of vasopressin V1a receptor messenger ribonucleic acid in adult male rat brain, pineal, and brain vasculature","volume":"135","author":"Ostrowski","year":"1994","journal-title":"Endocrinology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"9451","DOI":"10.1523\/JNEUROSCI.2376-04.2004","article-title":"Olfactory sex discrimination persists, whereas the preference for urinary odorants from estrous females disappears in male mice after vomeronasal organ removal","volume":"24","author":"Pankevich","year":"2004","journal-title":"J. Neurosci."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.neuropharm.2012.07.043","article-title":"Vasopressin facilitates Gabaergic transmission in rat hippocampus via activation of V1A receptors","volume":"63","author":"Ramanathan","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1152\/jn.91116.2008","article-title":"Two Gabaergic Intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals","volume":"101","author":"Shao","year":"2009","journal-title":"J. Neurophysiol."},{"key":"ref34","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780195159561.003.0005","article-title":"Olfactory bulb","volume-title":"The synaptic organization of the brain","author":"Shepherd","year":"2004"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1073\/pnas.94.6.2210","article-title":"Volatile signals of the major histocompatibility complex in male mouse urine","volume":"94","author":"Singer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e13382","DOI":"10.1111\/jne.13382","article-title":"The olfactory bulb: a neuroendocrine spotlight on feeding and metabolism","volume":"36","author":"Stark","year":"2024","journal-title":"J. Neuroendocrinol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"5737","DOI":"10.1523\/JNEUROSCI.3753-11.2012","article-title":"Nmda receptor-dependent synaptic activation of Trpc channels in olfactory bulb granule cells","volume":"32","author":"Stroh","year":"2012","journal-title":"J. Neurosci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e13626","DOI":"10.1111\/apha.13626","article-title":"Oxytocin modulates neural processing of mitral\/tufted cells in the olfactory bulb","author":"Sun","year":"2021","journal-title":"Acta Physiol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s42003-021-02129-7","article-title":"Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats","volume":"4","author":"Suyama","year":"2021","journal-title":"Commun. Biol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1515\/nf-2022-0004","article-title":"Mammalian social memory relies on neuromodulation in the olfactory bulb","volume":"28","author":"Suyama","year":"2022","journal-title":"e-Neuroforum"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/ejn.12476","article-title":"A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo","volume":"39","author":"Tada","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.1523\/JNEUROSCI.0303-18.2018","article-title":"Quantitative Association of Anatomical and Functional Classes of olfactory bulb neurons","volume":"38","author":"Tavakoli","year":"2018","journal-title":"J. Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nature08826","article-title":"An intrinsic vasopressin system in the olfactory bulb is involved in social recognition","volume":"464","author":"Tobin","year":"2010","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0143-4179(90)90116-G","article-title":"Two actions of vasopressin on neurons in the rat ventral hippocampus: a microiontophoretic study","volume":"16","author":"Urban","year":"1990","journal-title":"Neuropeptides"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/syn.890050305","article-title":"Vasopressin facilitates excitatory transmission in slices of the rat dorso-lateral septum","volume":"5","author":"Van Den Hooff","year":"1990","journal-title":"Synapse"}],"container-title":["Frontiers in Neural Circuits"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncir.2024.1448592\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T01:01:56Z","timestamp":1724893316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncir.2024.1448592\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":45,"alternative-id":["10.3389\/fncir.2024.1448592"],"URL":"https:\/\/doi.org\/10.3389\/fncir.2024.1448592","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.06.06.597738","asserted-by":"object"}]},"ISSN":["1662-5110"],"issn-type":[{"value":"1662-5110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"article-number":"1448592"}}