{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:57:05Z","timestamp":1785898625245,"version":"3.56.0"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neural Circuits"],"abstract":"<jats:p>The orbitofrontal cortex (ORB) exhibits a complex structure and diverse functional roles, including emotion regulation, decision-making, and reward processing. Structurally, it comprises three distinct regions: the medial part (ORBm), the ventrolateral part (ORBvl), and the lateral part (ORBl), each with unique functional attributes, such as ORBm\u2019s involvement in reward processing, ORBvl\u2019s regulation of depression-like behavior, and ORBl\u2019s response to aversive stimuli. Dysregulation of the ORB has been implicated in various psychiatric disorders. However, the neurocircuitry underlying the functions and dysfunctions of the ORB remains poorly understood. This study employed recombinant adeno-associated viruses (rAAV) and rabies viruses with glycoprotein deletion (RV-\u0394G) to retrogradely trace monosynaptic inputs to three ORB subregions in male C57BL\/6J mice. Inputs were quantified across the whole brain using fluorescence imaging and statistical analysis. Results revealed distinct input patterns for each ORB subregion, with significant contributions from the isocortex and thalamus. The ORBm received prominent inputs from the prelimbic area, agranular insular area, and hippocampal field CA1, while the ORBvl received substantial intra-ORB inputs. The ORBl exhibited strong inputs from the somatomotor and somatosensory areas. Thalamic inputs, particularly from the mediodorsal nucleus and submedial nucleus of the thalamus, were widespread across all ORB subregions. These findings provide novel insights into the functional connectivity of ORB subregions and their roles in neural circuit mechanisms underlying behavior and psychiatric disorders.<\/jats:p>","DOI":"10.3389\/fncir.2025.1567036","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T12:03:10Z","timestamp":1743768190000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Anatomical mapping of whole-brain monosynaptic inputs to the orbitofrontal cortex"],"prefix":"10.3389","volume":"19","author":[{"given":"Mei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonghui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00429-018-1771-5","article-title":"The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter.","volume":"224","author":"Babalian","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"B2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41586-020-2704-z","article-title":"Value-guided remapping of sensory cortex by lateral orbitofrontal cortex.","volume":"585","author":"Banerjee","year":"2020","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.neuroscience.2021.02.017","article-title":"Organization of afferents along the anterior-posterior and medial-lateral axes of the rat orbitofrontal cortex.","volume":"460","author":"Barreiros","year":"2021","journal-title":"Neuroscience"},{"key":"B4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1001\/archpsyc.1987.01800150017003","article-title":"Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls.","volume":"44","author":"Baxter","year":"1987","journal-title":"Arch. Gen. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1001\/jamapsychiatry.2013.173","article-title":"Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder.","volume":"70","author":"Beucke","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00429-010-0264-y","article-title":"The insular cortex: A comparative perspective.","volume":"214","author":"Butti","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"B7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/(SICI)1096-9861(19960722)371:2<179::AID-CNE1<3.0.CO;2-#","article-title":"Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys.","volume":"371","author":"Carmichael","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jpsychires.2003.08.001","article-title":"Left anterior subregion of orbitofrontal cortex volume reduction and impaired organizational strategies in obsessive-compulsive disorder.","volume":"38","author":"Choi","year":"2004","journal-title":"J. Psychiatr. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1016\/j.neuron.2022.08.001","article-title":"A locus coeruleus-dorsal CA1 dopaminergic circuit modulates memory linking.","volume":"110","author":"Chowdhury","year":"2022","journal-title":"Neuron"},{"key":"B10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12868-021-00677-6","article-title":"Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats.","volume":"22","author":"Chu","year":"2021","journal-title":"BMC Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1152\/jn.1996.75.4.1673","article-title":"Hunger and satiety modify the responses of olfactory and visual neurons in the primate orbitofrontal cortex.","volume":"75","author":"Critchley","year":"1996","journal-title":"J. Neurophysiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1523\/JNEUROSCI.1703-19.2020","article-title":"Differential roles of mediodorsal nucleus of the thalamus and prefrontal cortex in decision-making and state representation in a cognitive control task measuring deficits in Schizophrenia.","volume":"40","author":"DeNicola","year":"2020","journal-title":"J. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"bhae476","DOI":"10.1093\/cercor\/bhae476","article-title":"Mediodorsal thalamus nucleus-medial prefrontal cortex circuitry regulates cost-benefit decision-making selections.","volume":"34","author":"Ding","year":"2024","journal-title":"Cereb. Cortex"},{"key":"B14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.parkreldis.2017.12.024","article-title":"Reward processing dysfunction in ventral striatum and orbitofrontal cortex in Parkinson\u2019s disease.","volume":"48","author":"du Plessis","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cercor\/1.1.1-a","article-title":"Distributed hierarchical processing in the primate cerebral cortex.","volume":"1","author":"Felleman","year":"1991","journal-title":"Cereb. Cortex"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e55585","DOI":"10.7554\/eLife.55585","article-title":"A whole-brain connectivity map of mouse insular cortex.","volume":"9","author":"Gehrlach","year":"2020","journal-title":"Elife"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/s41593-023-01409-1","article-title":"Orbitofrontal cortex control of striatum leads economic decision-making.","volume":"26","author":"Gore","year":"2023","journal-title":"Nat. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0304-3940(86)90054-6","article-title":"Projections to the midbrain from the medial versus lateral prefrontal cortices of the rat.","volume":"63","author":"Hardy","year":"1986","journal-title":"Neurosci. Lett."},{"key":"B19","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0304-3940(94)90346-8","article-title":"Anatomical data supporting the concept of prefrontal influences upon hypothalamo-medullary relays in the rat.","volume":"169","author":"Hardy","year":"1994","journal-title":"Neurosci. Lett."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1093\/cercor\/bhz144","article-title":"Dissociable and paradoxical roles of rat medial and lateral orbitofrontal cortex in visual serial reversal learning.","volume":"30","author":"Hervig","year":"2020","journal-title":"Cereb. Cortex"},{"key":"B21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/cne.20595","article-title":"Projections from orbitofrontal cortex to anterior piriform cortex in the rat suggest a role in olfactory information processing.","volume":"488","author":"Illig","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/cne.903130404","article-title":"Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin.","volume":"313","author":"Jay","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/cne.901540402","article-title":"Retrograde axonal transport and the demonstration of non-specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey.","volume":"154","author":"Jones","year":"1974","journal-title":"J. Comp. Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.schres.2012.11.015","article-title":"Orbitofrontal cortex abnormality and deficit schizophrenia.","volume":"143","author":"Kanahara","year":"2013","journal-title":"Schizophr. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/cne.902980104","article-title":"Amygdaloid projections to the frontal cortex and the striatum in the rat.","volume":"298","author":"Kita","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/cne.902630306","article-title":"Frontal projections to the region of the oculomotor complex in the rat: A retrograde and anterograde HRP study.","volume":"263","author":"Leichnetz","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"106699","DOI":"10.1016\/j.nbd.2024.106699","article-title":"A neural circuit from thalamic paraventricular nucleus via zona incerta to periaqueductal gray for the facilitation of neuropathic pain.","volume":"202","author":"Li","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e70218","DOI":"10.1002\/brb3.70218","article-title":"A neural circuit from paraventricular nucleus of the thalamus to the nucleus accumbens mediates inflammatory pain in mice.","volume":"15","author":"Liu","year":"2025","journal-title":"Brain Behav."},{"key":"B29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12264-020-00592-6","article-title":"Regulation of cued fear expression via corticotropin-releasing-factor neurons in the ventral anteromedial thalamic nucleus.","volume":"37","author":"Lv","year":"2021","journal-title":"Neurosci. Bull."},{"key":"B30","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1523\/JNEUROSCI.6620-10.2011","article-title":"Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat.","volume":"31","author":"Mar","year":"2011","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neures.2022.01.007","article-title":"Monosynaptic rabies virus tracing from projection-targeted single neurons.","volume":"178","author":"Masaki","year":"2022","journal-title":"Neurosci. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1131167","DOI":"10.3389\/fnana.2023.1131167","article-title":"Projections of the insular cortex to orbitofrontal and medial prefrontal cortex: A tracing study in the rat.","volume":"17","author":"Mathiasen","year":"2023","journal-title":"Front. Neuroanat."},{"key":"B33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0306-4522(95)00417-3","article-title":"Projections of the medial and lateral prefrontal cortices to the amygdala: A Phaseolus vulgaris leucoagglutinin study in the rat.","volume":"71","author":"McDonald","year":"1996","journal-title":"Neuroscience"},{"key":"B34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/B978-0-444-53860-4.00007-6","article-title":"The insular cortex: A review.","volume":"195","author":"Nieuwenhuys","year":"2012","journal-title":"Prog. Brain Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.euroneuro.2024.09.006","article-title":"Orbitofrontal cortex hypergyrification in hallucinating schizophrenia patients: Surface ratio as a promising brain biomarker.","volume":"89","author":"N\u00fa\u00f1ez","year":"2024","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/82959","article-title":"Abstract reward and punishment representations in the human orbitofrontal cortex.","volume":"4","author":"O\u2019Doherty","year":"2001","journal-title":"Nat. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s0028-3932(02)00145-8","article-title":"Beauty in a smile: The role of medial orbitofrontal cortex in facial attractiveness.","volume":"41","author":"O\u2019Doherty","year":"2003","journal-title":"Neuropsychologia"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e80245","DOI":"10.1371\/journal.pone.0080245","article-title":"Rabies virus vector transgene expression level and cytotoxicity improvement induced by deletion of glycoprotein gene.","volume":"8","author":"Ohara","year":"2013","journal-title":"PLoS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/cercor\/10.3.206","article-title":"The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans.","volume":"10","author":"Ong\u00fcr","year":"2000","journal-title":"Cereb. Cortex"},{"key":"B40","doi-asserted-by":"publisher","first-page":"eabg4246","DOI":"10.1126\/sciadv.abg4246","article-title":"Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making.","volume":"7","author":"Oyama","year":"2021","journal-title":"Sci. Adv."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6487","DOI":"10.1038\/s41467-024-50505-8","article-title":"Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.","volume":"15","author":"Oyama","year":"2024","journal-title":"Nat. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature04676","article-title":"Neurons in the orbitofrontal cortex encode economic value.","volume":"441","author":"Padoa-Schioppa","year":"2006","journal-title":"Nature"},{"key":"B43","doi-asserted-by":"publisher","first-page":"R93509","DOI":"10.7554\/eLife.93509","article-title":"Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction.","volume":"12","author":"Peterson","year":"2024","journal-title":"Elife"},{"key":"B44","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1196\/annals.1401.008","article-title":"Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions.","volume":"1121","author":"Price","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s12264-018-0325-4","article-title":"The glutamatergic postrhinal cortex-ventrolateral orbitofrontal cortex pathway regulates spatial memory retrieval.","volume":"35","author":"Qi","year":"2019","journal-title":"Neurosci. Bull."},{"key":"B46","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nature15389","article-title":"Projections from neocortex mediate top-down control of memory retrieval.","volume":"526","author":"Rajasethupathy","year":"2015","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/nrn2719","article-title":"Evolution of the neocortex: A perspective from developmental biology.","volume":"10","author":"Rakic","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112114","article-title":"Nucleus reuniens mediates the extinction of contextual fear conditioning.","volume":"374","author":"Ramanathan","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/BF00227299","article-title":"Neuronal connections of orbital cortex in rats: Topography of cortical and thalamic afferents.","volume":"111","author":"Reep","year":"1996","journal-title":"Exp. Brain Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"11757","DOI":"10.1523\/JNEUROSCI.3432-05.2005","article-title":"Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala.","volume":"25","author":"Reynolds","year":"2005","journal-title":"J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neuropsychologia.2017.09.021","article-title":"The orbitofrontal cortex and emotion in health and disease, including depression.","volume":"128","author":"Rolls","year":"2019","journal-title":"Neuropsychologia"},{"key":"B52","doi-asserted-by":"publisher","first-page":"102334","DOI":"10.1016\/j.pneurobio.2022.102334","article-title":"The hippocampus, ventromedial prefrontal cortex, and episodic and semantic memory.","volume":"217","author":"Rolls","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s00429-023-02644-9","article-title":"Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala.","volume":"228","author":"Rolls","year":"2023","journal-title":"Brain Struct. Funct."},{"key":"B54","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/scan\/nsaa014","article-title":"Functional connectivity of the right inferior frontal gyrus and orbitofrontal cortex in depression.","volume":"15","author":"Rolls","year":"2020","journal-title":"Soc Cogn. Affect. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.bpsc.2017.10.004","article-title":"Effective connectivity in depression.","volume":"3","author":"Rolls","year":"2018","journal-title":"Biol. Psychiatry Cogn. Neurosci Neuroimaging"},{"key":"B56","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev.neuro.051508.135256","article-title":"Emotion, cognition, and mental state representation in amygdala and prefrontal cortex.","volume":"33","author":"Salzman","year":"2010","journal-title":"Annu. Rev. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neulet.2007.12.024","article-title":"The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex.","volume":"432","author":"Schilman","year":"2008","journal-title":"Neurosci. Lett."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e133625","DOI":"10.1172\/jci.insight.133625","article-title":"Activation of ventrolateral orbital cortex improves mouse neuropathic pain-induced anxiodepression.","volume":"5","author":"Sheng","year":"2020","journal-title":"JCI Insight"},{"key":"B59","doi-asserted-by":"publisher","first-page":"17448069221094529","DOI":"10.1177\/17448069221094529","article-title":"Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice.","volume":"18","author":"Shi","year":"2022","journal-title":"Mol. Pain"},{"key":"B60","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13024-019-0308-6","article-title":"Differences in neurotropism and neurotoxicity among retrograde viral tracers.","volume":"14","author":"Sun","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"B61","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.pneurobio.2009.10.002","article-title":"The thalamic nucleus submedius and ventrolateral orbital cortex are involved in nociceptive modulation: A novel pain modulation pathway.","volume":"89","author":"Tang","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"107343","DOI":"10.1016\/j.nlm.2020.107343","article-title":"Nucleus reuniens of the thalamus controls fear memory reconsolidation.","volume":"177","author":"Troyner","year":"2021","journal-title":"Neurobiol. Learn. Mem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.neuron.2018.07.002","article-title":"Parcellating cerebral cortex: How invasive animal studies inform noninvasive mapmaking in humans.","volume":"99","author":"Van Essen","year":"2018","journal-title":"Neuron"},{"key":"B64","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/cne.25419","article-title":"Projections from the five divisions of the orbital cortex to the thalamus in the rat.","volume":"531","author":"Vertes","year":"2023","journal-title":"J. Comp. Neurol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.neuron.2020.04.027","article-title":"Incerta-thalamic circuit controls nocifensive behavior via cannabinoid type 1 receptors.","volume":"107","author":"Wang","year":"2020","journal-title":"Neuron"},{"key":"B66","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s12264-020-00616-1","article-title":"Divergent projection patterns revealed by reconstruction of individual neurons in orbitofrontal cortex.","volume":"37","author":"Wang","year":"2021","journal-title":"Neurosci. Bull."},{"key":"B67","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.cell.2020.04.007","article-title":"The allen mouse brain common coordinate framework: A 3D reference atlas.","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.neuron.2012.03.017","article-title":"Whole-brain mapping of direct inputs to midbrain dopamine neurons.","volume":"74","author":"Watabe-Uchida","year":"2012","journal-title":"Neuron"},{"key":"B69","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neubiorev.2011.05.003","article-title":"Thalamic mediodorsal nucleus and working memory.","volume":"36","author":"Watanabe","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B70","doi-asserted-by":"publisher","first-page":"ENEURO.0017","DOI":"10.1523\/ENEURO.0017-21.2021","article-title":"Effects of withdrawal from cocaine self-administration on rat orbitofrontal cortex parvalbumin neurons expressing cre recombinase: Sex-dependent changes in neuronal function and unaltered serotonin signaling.","volume":"8","author":"Wright","year":"2021","journal-title":"eNeuro"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1194299","DOI":"10.3389\/fnins.2023.1194299","article-title":"Possible rodent equivalent of the posterior cingulate cortex (area 23) interconnects with multimodal cortical and subcortical regions.","volume":"17","author":"Xiang","year":"2023","journal-title":"Front. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.brainresbull.2011.03.007","article-title":"Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antidepressant-like effect in the rat forced swim test.","volume":"85","author":"Xing","year":"2011","journal-title":"Brain Res. Bull."},{"key":"B73","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.clinph.2019.01.022","article-title":"Orbitofrontal dysfunction during the reward process in adults with ADHD: An fMRI study.","volume":"130","author":"Yang","year":"2019","journal-title":"Clin. Neurophysiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/bs.irn.2020.11.008","article-title":"Secondary motor cortex: Broadcasting and biasing animal\u2019s decisions through long-range circuits.","volume":"158","author":"Yang","year":"2021","journal-title":"Int. Rev. Neurobiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/cne.903240109","article-title":"The afferent and efferent connections of the nucleus submedius in the rat.","volume":"324","author":"Yoshida","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1523\/JNEUROSCI.21-10-03674.2001","article-title":"Susceptibility to kindling and neuronal connections of the anterior claustrum.","volume":"21","author":"Zhang","year":"2001","journal-title":"J. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1007\/s12264-024-01229-8","article-title":"Whole-brain mapping of inputs and outputs of specific orbitofrontal cortical neurons in mice.","volume":"40","author":"Zhang","year":"2024","journal-title":"Neurosci. Bull."},{"key":"B78","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.brainres.2017.05.020","article-title":"MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1).","volume":"1669","author":"Zhao","year":"2017","journal-title":"Brain Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.cell.2014.02.023","article-title":"Neural networks of the mouse neocortex.","volume":"156","author":"Zingg","year":"2014","journal-title":"Cell"}],"container-title":["Frontiers in Neural Circuits"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncir.2025.1567036\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T12:03:12Z","timestamp":1743768192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncir.2025.1567036\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":79,"alternative-id":["10.3389\/fncir.2025.1567036"],"URL":"https:\/\/doi.org\/10.3389\/fncir.2025.1567036","relation":{},"ISSN":["1662-5110"],"issn-type":[{"value":"1662-5110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]},"article-number":"1567036"}}