{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:02:39Z","timestamp":1792173759576,"version":"4.4.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neural Circuits"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adverse social experiences profoundly alter animal behavior, yet the processes underlying context-appropriate behavior selection based on prior social interactions remain poorly understood. Existing models capture statistical patterns but are not framed in mechanistic frameworks that explain individual variability and predict behavioral outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We address this gap by modeling social defeat in mice as a partially observable Markov decision process (POMDP), implementing a heterarchical agent architecture\u2014a structured network of interacting modules balancing exploration and exploitation. Our model successfully reconstructs observed behavioral motifs (e.g., investigation, hesitation, and flights), fits different mouse phenotypes (e.g., susceptible vs. resilient), and mechanistically captures the impact of social defeat as a parameter shift in the animal\u2019s internal generative model. Notably, characteristic behavioral motifs including investigation bouts, hesitation, and flight trajectories emerge from the model\u2019s inference dynamics, without any trajectory-level fitting. The model additionally reproduces effects of interventions like optogenetic stimulation, and generates testable predictions for future experiments. The model\u2019s modular architecture enables natural extension to other behavioral domains including foraging and multi-agent interactions, representing a foundational step toward interpretable models of mouse behavior. By capturing how adverse social experiences reshape decision-making at the computational level, this work offers potential clinical relevance for trauma and anxiety disorders in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fncir.2026.1812938","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:46:12Z","timestamp":1781243172000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Fleeing is believing: adaptive behavior under social threat as an inference process"],"prefix":"10.3389","volume":"20","author":[{"given":"Hridai S.","family":"Khurana","sequence":"first","affiliation":[{"name":"Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory","place":["Monterotondo, RM, Italy"]},{"name":"Department of Biotechnology, Indian Institute of Technology Madras","place":["Chennai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Mussetto","sequence":"additional","affiliation":[{"name":"Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory","place":["Monterotondo, RM, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiron","family":"Ferrarese","sequence":"additional","affiliation":[{"name":"Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory","place":["Monterotondo, RM, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius T.","family":"Gross","sequence":"additional","affiliation":[{"name":"Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory","place":["Monterotondo, RM, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory J.","family":"Bufacchi","sequence":"additional","affiliation":[{"name":"Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory","place":["Monterotondo, RM, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1907.10902","article-title":"Optuna: a next-generation hyperparameter optimization framework","author":"Akiba","year":"2019","journal-title":"arXiv"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"841085","DOI":"10.3389\/fnsys.2022.841085","article-title":"Neural circuits underlying social fear in rodents: an integrative computational model","volume":"16","author":"Alfieri","year":"2022","journal-title":"Front. 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