{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:00:43Z","timestamp":1785308443190,"version":"3.55.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neural Circuits"],"abstract":"<jats:p>\n                    Determining the organization of inputs to subtypes of striatal spiny projection neurons (SPNs) is essential to understand how the striatum integrates information to regulate motor control and decision making. Here, we employed monosynaptic rabies tracing in\n                    <jats:italic>Kremen1<\/jats:italic>\n                    <jats:sup>2A\u2013Cre<\/jats:sup>\n                    knock-in mice to map inputs to\n                    <jats:italic>Kremen1<\/jats:italic>\n                    -positive (\n                    <jats:italic>Kremen1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    ) SPNs, a subtype enriched in patch (striosome) compartments of the dorsal striatum. Starter cells were broadly distributed along the rostrocaudal axis of the dorsal striatum. Whole-brain analysis revealed that\n                    <jats:italic>Kremen1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    SPNs receive prominent inputs from motor, somatosensory, and prefrontal cortices, as well as from multiple thalamic nuclei. Additional inputs originated from the amygdala, basal ganglia, and midbrain regions, including dopaminergic populations. Quantitative analysis indicated a strong bias toward sensorimotor-related circuits. Together, these results provide a comprehensive whole-brain input map of\n                    <jats:italic>Kremen1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    SPNs and suggest that these neurons are positioned to integrate cortical, thalamic, and neuromodulatory signals within basal ganglia networks to regulate motor function.\n                  <\/jats:p>","DOI":"10.3389\/fncir.2026.1895042","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:04:01Z","timestamp":1785305041000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-brain input organization of Kremen1-positive striatal spiny projection neurons revealed by monosynaptic rabies tracing"],"prefix":"10.3389","volume":"20","author":[{"given":"Victor M. Martinez","family":"Smith","sequence":"first","affiliation":[{"name":"Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dong","sequence":"additional","affiliation":[{"name":"Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health","place":["Bethesda, MD, United States"]},{"name":"Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"Paletzki","sequence":"additional","affiliation":[{"name":"Section on Neuroanatomy, National Institute of Mental Health, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Chang","sequence":"additional","affiliation":[{"name":"Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lupeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Gerfen","sequence":"additional","affiliation":[{"name":"Section on Neuroanatomy, National Institute of Mental Health, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin","family":"Cai","sequence":"additional","affiliation":[{"name":"Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1021\/acschemneuro.6b00333","article-title":"The striosome and matrix compartments of the striatum: A path through the labyrinth from neurochemistry toward function.","volume":"8","author":"Brimblecombe","year":"2017","journal-title":"ACS Chem. 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