{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:19:44Z","timestamp":1791386384380,"version":"4.3.3"},"reference-count":267,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Comput. Neurosci."],"abstract":"<jats:p>The neuroscientific field benefits from the conjoint evolution of experimental and computational techniques, allowing for the reconstruction and simulation of complex models of neurons and synapses. Chemical synapses are characterized by presynaptic vesicle cycling, neurotransmitter diffusion, and postsynaptic receptor activation, which eventually lead to postsynaptic currents and subsequent membrane potential changes. These mechanisms have been accurately modeled for different synapses and receptor types (AMPA, NMDA, and GABA) of the cerebellar cortical network, allowing simulation of their impact on computation. Of special relevance is short-term synaptic plasticity, which generates spatiotemporal filtering in local microcircuits and controls burst transmission and information flow through the network. Here, we present how data-driven computational models recapitulate the properties of neurotransmission at cerebellar synapses. The simulation of microcircuit models is starting to reveal how diverse synaptic mechanisms shape the spatiotemporal profiles of circuit activity and computation.<\/jats:p>","DOI":"10.3389\/fncom.2022.1006989","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:53:01Z","timestamp":1666932781000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation"],"prefix":"10.3389","volume":"16","author":[{"given":"Stefano","family":"Masoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina Francesca","family":"Rizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Tognolina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Prestori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egidio","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41586-019-1166-7","article-title":"Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics.","volume":"569","author":"Adam","year":"2019","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1109\/EMPDP.2019.8671560","article-title":"Arbor \u2014 A Morphologically-Detailed Neural Network Simulation Library for Contemporary High-Performance Computing Architectures","author":"Akar","year":"2019","journal-title":"2019 27th Euromicro International Conference on Parallel, Distributed and Network-Based Processing (PDP)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.1523\/JNEUROSCI.5204-05.2006","article-title":"Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons.","volume":"26","author":"Akemann","year":"2006","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5079","DOI":"10.1002\/hbm.22997","article-title":"Differential involvement of cortical and cerebellar areas using dominant and nondominant hands: An FMRI study.","volume":"36","author":"Alahmadi","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"B5","doi-asserted-by":"publisher","first-page":"E4798","DOI":"10.1073\/pnas.1310983110","article-title":"Estimating functional connectivity in an electrically coupled interneuron network.","volume":"110","author":"Alcami","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1152\/jn.00628.2014","article-title":"Cell type- and activity-dependent extracellular correlates of intracellular spiking.","volume":"114","author":"Anastassiou","year":"2015","journal-title":"J. Neurophysiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nn.2727","article-title":"Ephaptic coupling of cortical neurons.","volume":"14","author":"Anastassiou","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.conb.2014.02.008","article-title":"The role of neuronal activity and transmitter release on synapse formation.","volume":"27","author":"Andreae","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12311-010-0224-3","article-title":"Controlling Ca 2+-activated K + channels with models of Ca 2+ buffering in purkinje cells.","volume":"11","author":"Anwar","year":"2012","journal-title":"Cerebellum"},{"key":"B10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/syn.21898","article-title":"NMDA receptors amplify mossy fiber synaptic inputs at frequencies up to at least 750 Hz in cerebellar granule cells.","volume":"70","author":"Baade","year":"2016","journal-title":"Synapse"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63819","article-title":"Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse.","volume":"10","author":"Balmer","year":"2021","journal-title":"eLife"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44964","article-title":"Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers.","volume":"8","author":"Balmer","year":"2019","journal-title":"eLife"},{"key":"B13","doi-asserted-by":"publisher","first-page":"7969","DOI":"10.1523\/jneurosci.21-20-07969.2001","article-title":"An evaluation of synapse independence.","volume":"21","author":"Barbour","year":"2001","journal-title":"J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12040419","article-title":"Keeping the balance: GABAB receptors in the developing brain and beyond.","volume":"12","author":"Bassetti","year":"2022","journal-title":"Brain Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/01973533.2011.614132","article-title":"Experiencing dehumanization: Cognitive and emotional effects of everyday dehumanization.","volume":"33","author":"Bastian","year":"2011","journal-title":"Basic Appl. Soc. Psychol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1152\/jn.00833.2018","article-title":"Synapse formation: From cellular and molecular mechanisms to neurodevelopmental and neurodegenerative disorders.","volume":"121","author":"Batool","year":"2019","journal-title":"J. Neurophysiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12311-014-0627-7","article-title":"Consensus paper: The role of the cerebellum in perceptual processes.","volume":"14","author":"Baumann","year":"2015","journal-title":"Cerebellum"},{"key":"B18","doi-asserted-by":"publisher","first-page":"36275","DOI":"10.1074\/jbc.M105240200","article-title":"Subunit arrangement of gamma-aminobutyric acid type A receptors.","volume":"276","author":"Baumann","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"46020","DOI":"10.1074\/jbc.M207663200","article-title":"Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement.","volume":"277","author":"Baumann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-neuro-062111-150339","article-title":"The physiology of the axon initial segment.","volume":"35","author":"Bender","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1142\/S0219635209002083","article-title":"A hierarchical modeling approach of hippocampus local circuit.","volume":"8","author":"Bennani","year":"2009","journal-title":"J. Integr. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2019.00003","article-title":"The original histological slides of camillo golgi and his discoveries on neuronal structure.","volume":"13","author":"Bentivoglio","year":"2019","journal-title":"Front. Neuroanat."},{"key":"B23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1113\/jphysiol.1990.sp018215","article-title":"A kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocampal neurones.","volume":"428","author":"Benveniste","year":"1990","journal-title":"J. Physiol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105275","article-title":"Increased responsiveness at the cerebellar input stage in the PRRT2 knockout model of paroxysmal kinesigenic dyskinesia.","volume":"152","author":"Binda","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/nn.3624","article-title":"Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceau.","volume":"17","author":"Blot","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.brainres.2004.07.088","article-title":"Potassium channel subunit Kv3.2 and the water channel aquaporin-4 are selectively localized to cerebellar pinceau.","volume":"1026","author":"Bobik","year":"2004","journal-title":"Brain Res."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2010.00027","article-title":"Model-founded explorations of the roles of molecular layer inhibition in regulating purkinje cell responses in cerebellar cortex: More trouble for the beam hypothesis.","volume":"4","author":"Bower","year":"2010","journal-title":"Front. Cell. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2015.00129","article-title":"The 40-year history of modeling active dendrites in cerebellar Purkinje cells: Emergence of the first single cell \u201ccommunity model\u201d.","volume":"9","author":"Bower","year":"2015","journal-title":"Front. Comput. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-1-59745-520-6_7","article-title":"Constructing realistic neural simulations with GENESIS.","volume":"401","author":"Bower","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.semcdb.2015.07.001","article-title":"How computational models can help unlock biological systems.","author":"Brodland","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-70","article-title":"Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia.","volume":"6","author":"Brown","year":"2012","journal-title":"BMC Syst. Biol."},{"key":"B32","article-title":"A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays.","author":"Buccino","year":"2022","journal-title":"bioRxiv."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007822","article-title":"Biophysically grounded mean-field models of neural populations under electrical stimulation.","volume":"16","author":"Cakan","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00079","article-title":"LEMS: A language for expressing complex biological models in concise and hierarchical form and its use in underpinning NeuroML 2.","volume":"8","author":"Cannon","year":"2014","journal-title":"Front. Neuroinform."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01360-y","article-title":"Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage.","volume":"3","author":"Casali","year":"2020","journal-title":"Commun. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.1523\/JNEUROSCI.20-16-05899.2000","article-title":"Developmental profile of the changing properties of NMDA receptors at cerebellar mossy fiber-granule cell synapses.","volume":"20","author":"Cathala","year":"2000","journal-title":"J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1152\/advan.00068.2017","article-title":"Reminiscing about Jan Evangelista Purkinje: A pioneer of modern experimental physiology.","volume":"41","author":"Cavero","year":"2017","journal-title":"Adv. Physiol. Educ."},{"key":"B38","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrn3886","article-title":"Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits.","volume":"16","author":"Cerminara","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"12430","DOI":"10.1523\/JNEUROSCI.4897-11.2013","article-title":"Granule cell ascending axon excitatory synapses onto Golgi cells implement a potent feedback circuit in the cerebellar granular layer.","volume":"33","author":"Cesana","year":"2013","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nn.3974.Synaptic","article-title":"Europe PMC funders group synaptic diversity enables temporal coding of coincident multi- sensory inputs in single neurons.","author":"Chabrol","year":"2015"},{"key":"B41","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/nature02442","article-title":"Integration of quanta in cerebellar granule cells during sensory processing.","volume":"428","author":"Chadderton","year":"2004","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2017.00013","article-title":"Parallel STEPS: Large scale stochastic spatial reaction-diffusion simulation with high performance computers.","volume":"11","author":"Chen","year":"2017","journal-title":"Front. Neuroinform."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-030-89439-9_1","article-title":"\u201cModeling neurons in 3D at the nanoscale.","volume":"1359","author":"Chen","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1162\/089976600300015295","article-title":"Dynamics of spiking neurons with electrical coupling.","volume":"12","author":"Chow","year":"2000","journal-title":"Neural Comput."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037031","article-title":"Roles of molecular layer interneurons in sensory information processing in mouse Cerebellar cortex Crus ii in vivo.","volume":"7","author":"Chu","year":"2012","journal-title":"PLoS One"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1126\/science.1359647","article-title":"The time course of glutamate in the synaptic cleft.","volume":"258","author":"Clements","year":"1992","journal-title":"Science"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape.","volume":"2","author":"Cline","year":"2007","journal-title":"Nat. Protoc."},{"key":"B48","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/s0959-4388(00)00215-4","article-title":"NMDA receptor subunits: Diversity, development and disease.","volume":"11","author":"Cull-Candy","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2552004re16","article-title":"Role of distinct NMDA receptor subtypes at central synapses.","volume":"2004","author":"Cull-Candy","year":"2004","journal-title":"Sci. STKE"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2571","article-title":"The cerebellum gets social.","volume":"363","author":"D\u2019Angelo","year":"2019","journal-title":"Science"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00176","article-title":"Modeling the cerebellar microcircuit: New strategies for a long-standing issue.","volume":"10","author":"D\u2019Angelo","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2012.00116","article-title":"Seeking a unified framework for cerebellar function and dysfunction: From circuit operations to cognition.","volume":"6","author":"D\u2019Angelo","year":"2012","journal-title":"Front. Neural Circuits"},{"key":"B53","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1113\/jphysiol.1995.sp020673","article-title":"Synaptic excitation of individual rat cerebellar granule cells in situ: Evidence for the role of NMDA receptors.","volume":"484","author":"D\u2019Angelo","year":"1995","journal-title":"J. Physiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1152\/jn.1998.80.2.493","article-title":"Ionic mechanism of electroresponsiveness in cerebellar granule cells implicates the action of a persistent sodium current.","volume":"80","author":"D\u2019Angelo","year":"1998","journal-title":"J. Neurophysiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tins.2008.09.007","article-title":"Timing and plasticity in the cerebellum: Focus on the granular layer.","volume":"32","author":"D\u2019Angelo","year":"2009","journal-title":"Trends Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/11494669_14","article-title":"Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum.","volume":"3512","author":"D\u2019Angelo","year":"2005","journal-title":"Lect. Notes Comput. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1523\/JNEUROSCI.21-03-00759.2001","article-title":"Theta-frequency bursting and resonance in cerebellar granule cells: Experimental evidence and modeling of a slow k+-dependent mechanism.","volume":"21","author":"D\u2019Angelo","year":"2001","journal-title":"J. Neurosci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1152\/jn.1999.81.1.277","article-title":"Evidence for NMDA and mGlu receptor-dependent long-term potentiation of mossy fiber-granule cell transmission in rat cerebellum.","volume":"81","author":"D\u2019Angelo","year":"1999","journal-title":"J. Neurophysiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/346467a0","article-title":"Dual-component NMDA receptor currents at a single central synapse.","volume":"346","author":"D\u2019Angelo","year":"1990","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0306-4522(93)90290-v","article-title":"Different proportions of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor currents at the mossy fibre-granule cell synapse of developing rat cerebellum.","volume":"53","author":"D\u2019Angelo","year":"1993","journal-title":"Neuroscience"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tins.2022.06.007","article-title":"Neurosciences The quest for multiscale brain modeling.","author":"D\u2019Angelo","year":"2022","journal-title":"Trends Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0169-328X(95)00021-J","article-title":"Distribution of AMPA-selective glutamate receptor subunits in the human hippocampus and cerebellum.","volume":"31","author":"Day","year":"1995","journal-title":"Mol. Brain Res."},{"key":"B63","article-title":"Scaffold modelling captures the structure-function-dynamics relationship in brain microcircuits.","author":"De Schepper","year":"2021","journal-title":"bioRxiv"},{"key":"B64","author":"De Schutter","year":"2001","journal-title":"Computational Neuroscience: Realistic Modeling for Experimentalists."},{"key":"B65","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/s0079-6123(00)24009-0","article-title":"The function of cerebellar Golgi cells revisited.","volume":"124","author":"De Schutter","year":"2000","journal-title":"Prog. Brain Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/s41593-020-00754-9","article-title":"Diversity and dynamism in the cerebellum.","volume":"24","author":"De Zeeuw","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1113\/jphysiol.2010.201574","article-title":"Evaluating the adaptive-filter model of the cerebellum.","volume":"589","author":"Dean","year":"2011","journal-title":"J. Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.tins.2016.09.006","article-title":"The cerebellar mossy fiber synapse as a model for high-frequency transmission in the mammalian CNS.","volume":"39","author":"Delvendahl","year":"2016","journal-title":"Trends Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.1113\/jphysiol.2009.177162","article-title":"Differential induction of bidirectional long-term changes in neurotransmitter release by frequency-coded patterns at the cerebellar input.","volume":"587","author":"D\u2019Errico","year":"2009","journal-title":"J. Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1152\/jn.1998.79.2.999","article-title":"Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells.","volume":"79","author":"Destexhe","year":"1998","journal-title":"J. Neurophysiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/BF00961734","article-title":"Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.","volume":"1","author":"Destexhe","year":"1994","journal-title":"J. Comput. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1523\/JNEUROSCI.5125-04.2005","article-title":"Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: Transmitter uptake gets faster during development.","volume":"25","author":"Diamond","year":"2005","journal-title":"J. Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/j.1469-7793.1998.845bj.x","article-title":"Submillisecond kinetics and low efficacy of parallel fibre-Golgi cell synaptic currents in the rat cerebellum.","volume":"510","author":"Dieudonn\u00e9","year":"1998","journal-title":"J. Physiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/s0896-6273(02)00787-0","article-title":"Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse.","volume":"35","author":"DiGregorio","year":"2002","journal-title":"Neuron"},{"key":"B75","doi-asserted-by":"publisher","first-page":"8344","DOI":"10.1523\/JNEUROSCI.2399-07.2007","article-title":"Desensitization properties of AMPA receptors at the cerebellar mossy fiber granule cell synapse.","volume":"27","author":"DiGregorio","year":"2007","journal-title":"J. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021928","article-title":"Local field potential modeling predicts dense activation in cerebellar granule cells clusters under LTP and LTD control.","volume":"6","author":"Diwakar","year":"2011","journal-title":"PLoS One"},{"key":"B77","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1152\/jn.90382.2008","article-title":"Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells.","volume":"101","author":"Diwakar","year":"2009","journal-title":"J. Neurophysiol."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/626378","article-title":"Simulations of Heart Function.","volume":"2015","author":"Dos Santos","year":"2015","journal-title":"Biomed Res. Int."},{"key":"B79","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neuron.2008.11.028","article-title":"Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network.","volume":"61","author":"Dugu\u00e9","year":"2009","journal-title":"Neuron"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44494","article-title":"NetPyNE, a tool for data-driven multiscale modeling of brain circuits.","volume":"8","author":"Dura-Bernal","year":"2019","journal-title":"eLife"},{"key":"B81","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0301-0082(95)00010-S","article-title":"Use of voltage-sensitive dyes and optical recordings in the central nervous system.","volume":"46","author":"Ebner","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"B82","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00236869","article-title":"Intracellularly recorded responses of the cerebellar Purkinje cells.","volume":"1","author":"Eccles","year":"1966","journal-title":"Exp. Brain Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neunet.2012.09.006","article-title":"Bistability in purkinje neurons: Ups and downs in cerebellar research.","volume":"47","author":"Engbers","year":"2013","journal-title":"Neural Netw."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.11.012.2008","article-title":"PyNEST: A convenient interface to the NEST simulator.","volume":"2","author":"Eppler","year":"2008","journal-title":"Front. Neuroinform."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00289","article-title":"Enriched environment shortens the duration of action potentials in cerebellar granule cells.","volume":"13","author":"Eshra","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1080\/09687680210139839","article-title":"Gap junctions: Structure and function (Review).","volume":"19","author":"Evans","year":"2002","journal-title":"Mol. Membr. Biol."},{"key":"B87","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/368335a0","article-title":"NMDA-receptor channel diversity in the developing cerebellum.","volume":"368","author":"Farrant","year":"1994","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nrn1625","article-title":"Variations on an inhibitory theme: Phasic and tonic activation of GABA(A) receptors.","volume":"6","author":"Farrant","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.micpro.2016.05.015","article-title":"The Human brain project: Parallel technologies for biologically accurate simulation of granule cells.","volume":"47","author":"Florimbi","year":"2016","journal-title":"Microprocess. Microsyst."},{"key":"B90","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jpdc.2018.12.004","article-title":"Exploiting multi-core and many-core architectures for efficient simulation of biologically realistic models of Golgi cells.","volume":"126","author":"Florimbi","year":"2018","journal-title":"J. Parallel Distrib. Comput."},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2021.630795","article-title":"Granular layer simulator: design and Multi-GPU simulation of the cerebellar granular layer.","volume":"15","author":"Florimbi","year":"2021","journal-title":"Front. Comput. Neurosci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1113\/jphysiol.2006.110858","article-title":"Ionic mechanisms of autorhythmic firing in rat cerebellar Golgi cells.","volume":"574","author":"Forti","year":"2006","journal-title":"J. Physiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1016\/S0006-3495(02)75248-X","article-title":"A monte carlo model reveals independent signaling at central glutamatergic synapses.","volume":"83","author":"Franks","year":"2002","journal-title":"Biophys. J."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1109\/JPROC.2008.925458","article-title":"CellDesigner 3.5: A versatile modeling tool for biochemical networks.","volume":"96","author":"Funahashi","year":"2008","journal-title":"Proc. IEEE"},{"key":"B95","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1152\/jn.1994.72.2.999","article-title":"Synaptic integration in a model of cerebellar granule cells.","volume":"72","author":"Gabbiani","year":"1994","journal-title":"J. Neurophysiol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/cells11061047","article-title":"Non-linear frequency dependence of neurovascular coupling in the cerebellar cortex implies vasodilation-vasoconstriction competition.","volume":"11","author":"Gagliano","year":"2022","journal-title":"Cells"},{"key":"B97","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1113\/jphysiol.2010.189605","article-title":"Discovery and rediscoveries of Golgi cells.","volume":"588","author":"Galliano","year":"2010","journal-title":"J. Physiol."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00092","article-title":"The spatiotemporal organization of cerebellar network activity resolved by two-photon imaging of multiple single neurons.","volume":"8","author":"Gandolfi","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065716500209","article-title":"Oscillation-Driven Spike-Timing Dependent Plasticity Allows Multiple Overlapping Pattern Recognition in Inhibitory Interneuron Networks.","volume":"26","author":"Garrido","year":"2016","journal-title":"Int. J. Neural Syst."},{"key":"B100","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1080\/14734220310011948","article-title":"Unraveling the cerebellar cortex: Cytology and cellular physiology of large-sized interneurons in the granular layer.","volume":"2","author":"Geurts","year":"2003","journal-title":"Cerebellum"},{"key":"B101","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.1523\/JNEUROSCI.5663-11.2012","article-title":"Benzodiazepines modulate GABA A receptors by regulating the preactivation step after GABA binding.","volume":"32","author":"Gielen","year":"2012","journal-title":"J. Neurosci."},{"key":"B102","first-page":"A261","article-title":"The allen brain atlas as a resource for teaching undergraduate neuroscience.","volume":"16","author":"Gilbert","year":"2018","journal-title":"J. Undergrad. Neurosci. Educ."},{"key":"B103","doi-asserted-by":"publisher","first-page":"12153","DOI":"10.1523\/JNEUROSCI.0588-17.2017","article-title":"Morphological constraints on cerebellar granule cell combinatorial diversity.","volume":"37","author":"Gilmer","year":"2017","journal-title":"J. Neurosci."},{"key":"B104","first-page":"99","article-title":"Sulla fina anatomia del cervelletto umano.","volume":"1","author":"Golgi","year":"1874","journal-title":"Arch. Ital. Mal. Nerv."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002576","article-title":"Gap junctions.","volume":"1","author":"Goodenough","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.tins.2007.06.005","article-title":"Molecular determinants of AMPA receptor subunit assembly.","volume":"30","author":"Greger","year":"2007","journal-title":"Trends Neurosci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41467-021-22893-8","article-title":"Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.","volume":"12","author":"Guo","year":"2021","journal-title":"Nat. Commun."},{"key":"B108","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1093\/bioinformatics\/btab638","article-title":"Image enhancement to leverage the 3D morphological reconstruction of single-cell neurons.","volume":"38","author":"Guo","year":"2022","journal-title":"Bioinformatics"},{"key":"B109","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.brainres.2012.05.061","article-title":"Bursts modify electrical synaptic strength.","volume":"1487","author":"Haas","year":"2012","journal-title":"Brain Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.tins.2012.10.001","article-title":"Sustaining rapid vesicular release at active zones: Potential roles for vesicle tethering.","volume":"36","author":"Hallermann","year":"2013","journal-title":"Trends Neurosci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.neuron.2018.09.018","article-title":"Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells.","volume":"100","author":"Han","year":"2018","journal-title":"Neuron"},{"key":"B112","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/87419","article-title":"Beyond parallel fiber LTD: The diversity of synaptic and non-synaptic plasticity in the cerebellum.","volume":"4","author":"Hansel","year":"2001","journal-title":"Nat. Neurosci."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-36","article-title":"STEPS: Efficient simulation of stochastic reaction\u2013diffusion models in realistic morphologies.","volume":"6","author":"Hepburn","year":"2012","journal-title":"BMC Syst. Biol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/B978-0-12-802151-4.00007-4","article-title":"Commonly used animal models","author":"Hickman","year":"2017","journal-title":"Principles of Animal Research"},{"key":"B115","author":"Hille","year":"2001","journal-title":"Ionic Channels of Excitable Membranes."},{"key":"B116","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/107385840100700207","article-title":"Neuron: A tool for neuroscientists.","volume":"7","author":"Hines","year":"2001","journal-title":"Neuroscientist"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1162\/neco.1997.9.6.1179","article-title":"The NEURON simulation environment.","volume":"9","author":"Hines","year":"1997","journal-title":"Neural Comput."},{"key":"B118","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jneumeth.2007.09.010","article-title":"Tranlating network models to parallel hardware in Neuron.","volume":"169","author":"Hines","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.11.001.2009","article-title":"NEURON and python.","volume":"3","author":"Hines","year":"2009","journal-title":"Front. Neuroinform."},{"key":"B120","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.1952.sp004717","article-title":"Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo.","volume":"116","author":"Hodgkin","year":"","journal-title":"J. Physiol."},{"key":"B121","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8240(05)80004-7","article-title":"A quantitative description of membrane current and its application to conduction and excitation in nerve. 1952.","volume":"52","author":"Hodgkin","year":"","journal-title":"Bull. Math. Biol."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.57344","article-title":"Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex.","volume":"9","author":"Hoehne","year":"2020","journal-title":"eLife"},{"key":"B123","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neuron.2011.10.030","article-title":"Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity.","volume":"73","author":"Hull","year":"2012","journal-title":"Neuron"},{"key":"B124","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.cophys.2018.02.002","article-title":"Kinetic models for activation and modulation of NMDA receptor subtypes.","volume":"2","author":"Iacobucci","year":"2018","journal-title":"Curr. Opin. Physiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/s0168-0102(00)00173-5","article-title":"Roles of GABAergic inhibition and NMDA receptor subunits in the spatio-temporal integration in the cerebellar cortex of mice.","volume":"38","author":"Imamura","year":"2000","journal-title":"Neurosci. Res."},{"key":"B126","author":"Ito","year":"1984","journal-title":"The Cerebellum and Neural Control."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1109\/TNN.2003.820440","article-title":"Simple model of spiking neurons.","volume":"14","author":"Izhikevich","year":"2003","journal-title":"IEEE Trans. Neural Netw."},{"key":"B128","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/BF00199471","article-title":"Electroencephalogram and visual evoked potential generation in a mathematical model of coupled cortical columns.","volume":"73","author":"Jansen","year":"1995","journal-title":"Biol. Cybern."},{"key":"B129","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0896-6273(95)90075-6","article-title":"Desensitized states prolong GABAA channel responses to brief agonist pulses.","volume":"15","author":"Jones","year":"1995","journal-title":"Neuron"},{"key":"B130","doi-asserted-by":"publisher","first-page":"11786","DOI":"10.1523\/JNEUROSCI.2939-06.2006","article-title":"Properties of somatosensory synaptic integration in cerebellar granule cells in vivo.","volume":"26","author":"J\u00f6rntell","year":"2006","journal-title":"J. Neurosci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1523\/JNEUROSCI.4212-10.2011","article-title":"A subtraction mechanism of temporal coding in cerebellar cortex.","volume":"31","author":"Kalmbach","year":"2011","journal-title":"J. Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"8955","DOI":"10.1523\/JNEUROSCI.5469-07.2008","article-title":"Synaptic and cellular properties of the feedforward inhibitory circuit within the input layer of the cerebellar cortex.","volume":"28","author":"Kanichay","year":"2008","journal-title":"J. Neurosci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1113\/jphysiol.1980.sp013178","article-title":"Discharges of Purkinje cells and mossy fibres in the cerebellar vermis of the monkey during saccadic eye movements and fixation.","volume":"300","author":"Kase","year":"1980","journal-title":"J. Physiol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.celrep.2014.04.047","article-title":"Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses.","volume":"7","author":"Kim","year":"2014","journal-title":"Cell Rep."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1152\/jn.01168.2011","article-title":"Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.","volume":"109","author":"Kim","year":"2013","journal-title":"J. Neurophysiol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"8530","DOI":"10.1523\/JNEUROSCI.0468-09.2009","article-title":"Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.","volume":"29","author":"Kim","year":"2009","journal-title":"J. Neurosci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.neuropharm.2017.11.030","article-title":"Spontaneous activity, singly bound states and the impact of alpha1Phe64 mutation on GABAAR gating in the novel kinetic model based on the single-channel recordings.","volume":"131","author":"Kisiel","year":"2018","journal-title":"Neuropharmacology"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65152","article-title":"Glua4 facilitates cerebellar expansion coding and enables associative memory formation.","volume":"10","author":"Kita","year":"2021","journal-title":"eLife"},{"key":"B139","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1016\/S0006-3495(96)79435-3","article-title":"Transmitter concentration profiles in the synaptic cleft: An analytical model of release and diffusion.","volume":"71","author":"Kleinle","year":"1996","journal-title":"Biophys. J."},{"key":"B140","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/147342202753203050","article-title":"Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells.","volume":"1","author":"Kn\u00f6pfel","year":"2002","journal-title":"Cerebellum"},{"key":"B141","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/BF00317936","article-title":"Cable theory in neurons with active, linearized membranes.","volume":"50","author":"Koch","year":"1984","journal-title":"Biol. Cybern."},{"key":"B142","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195104912.001.0001","author":"Koch","year":"1998","journal-title":"Biophysics of Computation: Information Processing in Single Neurons."},{"key":"B143","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1523\/JNEUROSCI.20-06-02166.2000","article-title":"Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing.","volume":"20","author":"Koike","year":"2000","journal-title":"J. Neurosci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s41586-021-03220-z","article-title":"A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types.","volume":"598","author":"Kozareva","year":"2021","journal-title":"Nature"},{"key":"B145","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s12311-013-0511-x","article-title":"Consensus paper: The cerebellum\u2019s role in movement and cognition.","volume":"13","author":"Koziol","year":"2014","journal-title":"Cerebellum"},{"key":"B146","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1046\/j.0953-816x.2001.01855.x","article-title":"Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus.","volume":"15","author":"Kulik","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/s0092-8674(00)81282-9","article-title":"The gap junction communication channel.","volume":"84","author":"Kumar","year":"1996","journal-title":"Cell"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2019.00063","article-title":"CoreNEURON: An optimized compute engine for the NEURON simulator.","volume":"13","author":"Kumbhar","year":"2019","journal-title":"Front. Neuroinform."},{"key":"B149","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1523\/JNEUROSCI.18-08-02954.1998","article-title":"Evidence for a tetrameric structure of recombinant NMDA receptors.","volume":"18","author":"Laube","year":"1998","journal-title":"J. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/s0169-328x(96)00120-9","article-title":"Ultrastructural localization of Shaker-related potassium channel subunits and synapse-associated protein 90 to septate-like junctions in rat cerebellar Pinceaux.","volume":"42","author":"Laube","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B151","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0306-4522(98)00007-4","article-title":"Single-unit activity of cerebellar nuclear cells in the awake genetically dystonic rat.","volume":"86","author":"LeDoux","year":"1998","journal-title":"Neuroscience"},{"key":"B152","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1113\/jphysiol.2005.099093","article-title":"Modes and models of GABAA receptor gating.","volume":"572","author":"Lema","year":"2006","journal-title":"J. Physiol."},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2014.00157","article-title":"A spiking network model of cerebellar Purkinje cells and molecular layer interneurons exhibiting irregular firing.","volume":"8","author":"Lennon","year":"2014","journal-title":"Front. Comput. Neurosci."},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2015.00150","article-title":"A Model of In vitro Plasticity at the parallel fiber\u2014molecular layer interneuron synapses.","volume":"9","author":"Lennon","year":"2015","journal-title":"Front. Comput. Neurosci."},{"key":"B155","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1113\/jphysiol.2012.242180","article-title":"Late-onset bursts evoked by mossy fibre bundle stimulation in unipolar brush cells: Evidence for the involvement of H- and TRP-currents.","volume":"591","author":"Locatelli","year":"2013","journal-title":"J. Physiol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nn1393","article-title":"Bistability of cerebellar Purkinje cells modulated by sensory stimulation.","volume":"8","author":"Loewenstein","year":"2005","journal-title":"Nat. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuron.2017.08.043","article-title":"Slow AMPAR synaptic transmission is determined by stargazin and glutamate transporters.","volume":"96","author":"Lu","year":"2017","journal-title":"Neuron"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1007\/s00429-017-1568-y","article-title":"Differential association of GABAB receptors with their effector ion channels in Purkinje cells.","volume":"223","author":"Luj\u00e1n","year":"2018","journal-title":"Brain Struct. Funct."},{"key":"B159","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0896-6273(94)90152-X","article-title":"How quickly can GABAA receptors open?","volume":"12","author":"Maconochie","year":"1994","journal-title":"Neuron"},{"key":"B160","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1152\/jn.1998.80.5.2521","article-title":"Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer.","volume":"80","author":"Maex","year":"1998","journal-title":"J. Neurophysiol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1523\/JNEUROSCI.4873-06.2007","article-title":"The spatial organization of long-term synaptic plasticity at the input stage of cerebellum.","volume":"27","author":"Mapelli","year":"2007","journal-title":"J. Neurosci."},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00055","article-title":"Integration and regulation of glomerular inhibition in the cerebellar granular layer circuit.","volume":"8","author":"Mapelli","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B163","doi-asserted-by":"publisher","first-page":"11388","DOI":"10.1073\/pnas.0901290106","article-title":"Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization.","volume":"106","author":"Marcaggi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B164","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.cell.2015.09.029","article-title":"Reconstruction and simulation of neocortical microcircuitry.","volume":"163","author":"Markram","year":"2015","journal-title":"Cell"},{"key":"B165","doi-asserted-by":"publisher","first-page":"437","DOI":"10.2307\/1776957","article-title":"A theory of cerebellar cortex.","volume":"202","author":"Marr","year":"1969","journal-title":"J. Physiol."},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00278","article-title":"Synaptic activation of a detailed purkinje cell model predicts voltage-dependent control of burst-pause responses in active dendrites.","volume":"11","author":"Masoli","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0953-x","article-title":"Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage.","volume":"3","author":"Masoli","year":"","journal-title":"Commun. Biol."},{"key":"B168","article-title":"Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.","volume":"16","author":"Masoli","year":"","journal-title":"PLoS Comput. Biol."},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00047","article-title":"Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.","volume":"9","author":"Masoli","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B170","author":"Maxwell Cowan","year":"2000","journal-title":"Synapses."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/81486","article-title":"Computer simulation of cerebellar information processing.","volume":"3","author":"Medina","year":"2000","journal-title":"Nat. Neurosci."},{"key":"B172","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00424-015-1764-7","article-title":"TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons.","volume":"468","author":"Menigoz","year":"2016","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00641","article-title":"High-density electrical recording and impedance imaging with a multi-modal CMOS multi-electrode array chip.","volume":"13","author":"Miccoli","year":"2019","journal-title":"Front. Neurosci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/s0896-6273(03)00200-9","article-title":"Shunting inhibition modulates neuronal gain during synaptic excitation.","volume":"38","author":"Mitchell","year":"2003","journal-title":"Neuron"},{"key":"B175","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1113\/jphysiol.2004.075028","article-title":"Feed-forward inhibition shapes the spike output of cerebellar Purkinje cells.","volume":"563","author":"Mittmann","year":"2005","journal-title":"J. Physiol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neuroscience.2020.05.026","article-title":"Compartmentalized input\u2013output organization of lugaro cells in the cerebellar cortex.","volume":"462","author":"Miyazaki","year":"2021","journal-title":"Neuroscience"},{"key":"B177","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","article-title":"Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.","volume":"12","author":"Monyer","year":"1994","journal-title":"Neuron"},{"key":"B178","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/s0079-6123(08)63362-2","article-title":"The unipolar brush cells of the mammalian cerebellum and cochlear nucleus: Cytology and microcircuitry.","volume":"114","author":"Mugnaini","year":"1997","journal-title":"Prog. Brain Res."},{"key":"B179","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.brainresrev.2010.10.001","article-title":"The unipolar brush cell: A remarkable neuron finally receiving deserved attention.","volume":"66","author":"Mugnaini","year":"2011","journal-title":"Brain Res. Rev."},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/948587","article-title":"Comparative morphology of dendritic arbors in populations of purkinje cells in mouse sulcus and apex.","volume":"2013","author":"Nedelescu","year":"2013","journal-title":"Neural Plast."},{"key":"B181","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/jnr.24206","article-title":"Regional differences in Purkinje cell morphology in the cerebellar vermis of male mice.","volume":"96","author":"Nedelescu","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2018.00041","article-title":"Using NEURON for reaction-diffusion modeling of extracellular dynamics.","volume":"12","author":"Newton","year":"2018","journal-title":"Front. Neuroinform."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1002\/cphy.c110051","article-title":"Gap junctions.","volume":"2","author":"Nielsen","year":"2012","journal-title":"Compr. Physiol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1152\/jn.00696.2005","article-title":"LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: Experimental observations and theoretical predictions.","volume":"95","author":"Nieus","year":"2006","journal-title":"J. Neurophysiol."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00246","article-title":"Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.","volume":"8","author":"Nieus","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-94-007-6169-8_31-2","article-title":"Applications of Computational Methods to Simulations of Protein Dynamics","author":"Nowak","year":"2016","journal-title":"Handbook of Computational Chemistry"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2015.00029","article-title":"Integrating visualizations into modeling NEST simulations.","volume":"9","author":"Nowke","year":"2015","journal-title":"Front. Neuroinform."},{"key":"B188","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1124\/pr.108.00505","article-title":"International union of pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: Classification on the basis of subunit composition, pharmacology, and function. Update.","volume":"60","author":"Olsen","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"B189","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/s41593-022-01057-x","article-title":"Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties.","volume":"25","author":"Osorno","year":"2022","journal-title":"Nat. Neurosci."},{"key":"B190","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-65581-4","author":"Palay","year":"1974","journal-title":"Cerebellar Cortex Cytology and Organization."},{"key":"B191","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1002\/hbm.25551","article-title":"Motor and higher-order functions topography of the human dentate nuclei identified with tractography and clustering methods.","volume":"42","author":"Palesi","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006025","article-title":"Gap junction plasticity as a mechanism to regulate network-wide oscillations.","volume":"14","author":"Pernelle","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25956-x","article-title":"Electrical synapses between inhibitory neurons shape the responses of principal neurons to transient inputs in the thalamus: A modeling study.","volume":"8","author":"Pham","year":"2018","journal-title":"Sci. Rep."},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006440","article-title":"Electrical synapses regulate both subthreshold integration and population activity of principal cells in response to transient inputs within canonical feedforward circuits.","volume":"15","author":"Pham","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1186\/2053-8871-1-3","article-title":"Functional contributions of glutamate transporters at the parallel fibre to Purkinje neuron synapse-relevance for the progression of cerebellar ataxia.","volume":"1","author":"Power","year":"2014","journal-title":"Cerebellum and Ataxias"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010216","article-title":"Disrupted calcium signaling in animal models of human spinocerebellar ataxia (SCA).","volume":"21","author":"Prestori","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B197","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/nature05995","article-title":"High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons.","volume":"450","author":"Rancz","year":"2007","journal-title":"Nature"},{"key":"B198","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1113\/jphysiol.1980.sp013356","article-title":"Ephaptic transmission between single nerve fibres in the spinal nerve roots of dystrophic mice.","volume":"305","author":"Rasminsky","year":"1980","journal-title":"J. Physiol."},{"key":"B199","first-page":"135","article-title":"Ataxias and cerebellar dysfunction: Involvement of synaptic plasticity deficits?","volume":"25","author":"Rinaldo","year":"2010","journal-title":"Funct. Neurol."},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83209-w","article-title":"Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.","volume":"11","author":"Rizza","year":"2021","journal-title":"Sci. Rep."},{"key":"B201","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/978-3-030-89439-9_11","article-title":"Reconstruction of the Hippocampus","author":"Romani","year":"2022","journal-title":"Computational Modelling of the Brain. Advances in Experimental Medicine and Biology"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004515","article-title":"At the edge of chaos: How cerebellar granular layer network dynamics can provide the basis for temporal filters.","volume":"11","author":"R\u00f6ssert","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/nature07604","article-title":"Synaptic depression enables neuronal gain control.","volume":"457","author":"Rothman","year":"2009","journal-title":"Nature"},{"key":"B204","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0006-3495(01)75846-8","article-title":"The role of perisynaptic glial sheaths in glutamate spillover and extracellular Ca(2+) depletion.","volume":"81","author":"Rusakov","year":"2001","journal-title":"Biophys. J."},{"key":"B205","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1523\/jneurosci.18-09-03158.1998","article-title":"Extrasynaptic glutamate diffusion in the hippocampus: Ultrastructural constraints, uptake, and receptor activation.","volume":"18","author":"Rusakov","year":"1998","journal-title":"J. Neurosci."},{"key":"B206","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1126\/science.1221140","article-title":"Bergmann glial AMPA receptors are required for fine motor coordination.","volume":"337","author":"Saab","year":"2012","journal-title":"Science"},{"key":"B207","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jtbi.2004.11.036","article-title":"Modeling of slow glutamate diffusion and AMPA receptor activation in the cerebellar glomerulus.","volume":"234","author":"Saftenku","year":"2005","journal-title":"J. Theor. Biol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1523\/JNEUROSCI.1854-12.2013","article-title":"NMDA and GABAB (KIR) conductances: The \u201cperfect couple\u201d for bistability.","volume":"33","author":"Sanders","year":"2013","journal-title":"J. Neurosci."},{"key":"B209","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1152\/jn.01098.2005","article-title":"Feedforward inhibition controls the spread of granule cell-induced Purkinje cell activity in the cerebellar cortex.","volume":"97","author":"Santamaria","year":"2007","journal-title":"J. Neurophysiol."},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2013.00010","article-title":"The virtual brain: A simulator of primate brain network dynamics.","volume":"7","author":"Sanz Leon","year":"2013","journal-title":"Front. Neuroinform."},{"key":"B211","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1073\/pnas.0606636104","article-title":"The optimal height of the synaptic cleft.","volume":"104","author":"Savtchenko","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28927","article-title":"Inferring multi-scale neural mechanisms with brain network modelling.","volume":"7","author":"Schirner","year":"2018","journal-title":"eLife"},{"key":"B213","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s11065-010-9142-x","article-title":"The role of the cerebellum in cognition and emotion: Personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy.","volume":"20","author":"Schmahmann","year":"2010","journal-title":"Neuropsychol. Rev."},{"key":"B214","doi-asserted-by":"publisher","first-page":"6878","DOI":"10.1523\/JNEUROSCI.5736-11.2012.NMDA","article-title":"NMDA receptors with incomplete Mg 2 + block enable low- frequency transmission through the cerebellar cortex.","volume":"32","author":"Schwartz","year":"2012","journal-title":"J. Neurosci."},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1016\/s0898-1221(98)91179-8","article-title":"Methods in neuronal modeling: From ions to networks (second edition).","author":"Segev","year":"1998","journal-title":"Comput. Math. Appl."},{"key":"B216","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1152\/jn.00843.2014","article-title":"Asymmetry and modulation of spike timing in electrically coupled neurons.","volume":"113","author":"Sevetson","year":"2015","journal-title":"J. Neurophysiol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks.","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"B218","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/355163a0","article-title":"Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ.","volume":"355","author":"Silver","year":"1992","journal-title":"Nature"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1186\/2042-1001-1-7","article-title":"Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations.","volume":"1","author":"Sim\u00f5es de Souza","year":"2011","journal-title":"Neural Syst. Circuits"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005464","article-title":"Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating.","volume":"13","author":"Snipas","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1332-19.2019","article-title":"Erratum: Hyperexcitability and hyperplasticity disrupt cerebellar signal transfer in the ib2 ko mouse model of autism.","volume":"39","author":"Soda","year":"2019","journal-title":"J. Neurosci."},{"key":"B222","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1113\/jphysiol.2003.060285","article-title":"Increased neurotransmitter release during long-term potentiation at mossy fibre-granule cell synapses in rat cerebellum.","volume":"557","author":"Sola","year":"2004","journal-title":"J. Physiol."},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.03.004.2007","article-title":"Fast-reset of pacemaking and theta-frequency resonance patterns in cerebellar golgi cells: Simulations of their impact in vivo.","volume":"1","author":"Solinas","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.03.002.2007","article-title":"Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells.","volume":"1","author":"Solinas","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2010.00012","article-title":"A realistic large-scale model of the cerebellum granular layer predicts circuit spatio-temporal filtering properties.","volume":"4","author":"Solinas","year":"2010","journal-title":"Front. Cell. Neurosci."},{"key":"B226","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s12311-008-0078-0","article-title":"Viewing the cerebellum through the eyes of Ram??n Y Cajal.","volume":"7","author":"Sotelo","year":"2008","journal-title":"Cerebellum"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1063\/1.4939316","article-title":"Computational exploration of single-protein mechanics by steered molecular dynamics.","volume":"1703","author":"Sotomayor","year":"2015","journal-title":"AIP Conf. Proc."},{"key":"B228","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1523\/JNEUROSCI.20-01-00114.2000","article-title":"Electrophysiological characterization of voltage-gated K(+) currents in cerebellar basket and purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminals.","volume":"20","author":"Southan","year":"2000","journal-title":"J. Neurosci."},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002298","article-title":"Modeling brain resonance phenomena using a neural mass model.","volume":"7","author":"Spiegler","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"B230","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0006-3495(67)86574-3","article-title":"Some models of neuronal variability.","volume":"7","author":"Stein","year":"1967","journal-title":"Biophys. J."},{"key":"B231","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neuron.2007.03.015","article-title":"Cerebellar LTD and pattern recognition by Purkinje cells.","volume":"54","author":"Steuber","year":"2007","journal-title":"Neuron"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47314","article-title":"Brian 2, an intuitive and efficient neural simulator.","volume":"8","author":"Stimberg","year":"2019","journal-title":"eLife"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51771","article-title":"Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity.","volume":"9","author":"Straub","year":"2020","journal-title":"eLife"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00237","article-title":"Computational modeling predicts the ionic mechanism of late-onset responses in unipolar brush cells.","volume":"8","author":"Subramaniyam","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005754","article-title":"Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer.","volume":"13","author":"Sudhakar","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"B236","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.neuron.2008.10.011","article-title":"Understanding synapses: Past, present, and future.","volume":"60","author":"S\u00fcdhof","year":"2008","journal-title":"Neuron"},{"key":"B237","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/(SICI)1096-9861(19980413)393:3<353::AID-CNE7>3.0.CO;2-0","article-title":"Quantitative Golgi study of the rat cerebellar molecular layer interneurons using principal component analysis.","volume":"393","author":"Sultan","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1523\/JNEUROSCI.2533-13.2014","article-title":"\u03b11F64 residue at GABAA receptor binding site is involved in gating by influencing the receptor flipping transitions.","volume":"34","author":"Szczot","year":"2014","journal-title":"J. Neurosci."},{"key":"B239","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.1113\/JP274252","article-title":"Heterogeneity of Purkinje cell simple spike\u2013complex spike interactions: Zebrin- and non-zebrin-related variations.","volume":"595","author":"Tang","year":"2017","journal-title":"J. Physiol."},{"key":"B240","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jtbi.2004.03.003","article-title":"Maximum geometrical hindrance to diffusion in brain extracellular space surrounding uniformly spaced convex cells.","volume":"229","author":"Tao","year":"2004","journal-title":"J. Theor. Biol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1126\/science.7134978","article-title":"Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses.","volume":"218","author":"Taylor","year":"1982","journal-title":"Science"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.805670","article-title":"Discovering microcircuit secrets with multi-spot imaging and electrophysiological recordings: The example of cerebellar network dynamics.","volume":"16","author":"Tognolina","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002580","article-title":"The generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillations.","volume":"8","author":"Torben-Nielsen","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1109\/EMPDP.2019.8671581","article-title":"GPU Parallelization of Realistic Purkinje Cells with Complex Morphology","author":"Torti","year":"2019","journal-title":"Proceedings - 27th Euromicro International Conference on Parallel, Distributed and Network-Based Processing, PDP 2019"},{"key":"B245","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1162\/089976698300017502","article-title":"Neural networks with dynamic synapses.","volume":"10","author":"Tsodyks","year":"1998","journal-title":"Neural Comput."},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511623202","author":"Tuckwell","year":"1988","journal-title":"Introduction to Theoretical Neurobiology."},{"key":"B247","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s12311-010-0240-3","article-title":"Functional classification of neurons in the mouse lateral cerebellar nuclei.","volume":"10","author":"Uusisaari","year":"2011","journal-title":"Cerebellum"},{"key":"B248","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1152\/jn.00974.2006","article-title":"Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei.","volume":"97","author":"Uusisaari","year":"2007","journal-title":"J. Neurophysiol."},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00095","article-title":"High frequency burst firing of granule cells ensures transmission at the parallel fiber to purkinje cell synapse at the cost of temporal coding.","volume":"7","author":"van Beugen","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2016.00017","article-title":"BluePyOpt: Leveraging open source software and cloud infrastructure to optimise model parameters in neuroscience.","volume":"10","author":"Van Geit","year":"2016","journal-title":"Front. Neuroinform."},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.910015","article-title":"On the diverse functions of electrical synapses.","volume":"16","author":"Vaughn","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"B252","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.neuron.2010.06.028","article-title":"Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input.","volume":"67","author":"Vervaeke","year":"2010","journal-title":"Neuron"},{"key":"B253","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/s0166-2236(98)01318-6","article-title":"The anatomy of the cerebellum.","volume":"21","author":"Voogd","year":"1998","journal-title":"Trends Neurosci."},{"key":"B254","doi-asserted-by":"crossref","first-page":"S567","DOI":"10.33549\/physiolres.933231","article-title":"Jan evangelista purkyn\u011b and the cerebellum then and now.","volume":"64","author":"Vo\u017deh","year":"2015","journal-title":"Physiol. Res."},{"key":"B255","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1113\/jphysiol.1993.sp019876","article-title":"Calcium-mediated modulation of N-methyl-D-aspartate (n.d.) responses in cultured rat hippocampal neurones.","volume":"470","author":"Vyklick\u00fd","year":"1993","journal-title":"J. Physiol."},{"key":"B256","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0896-6273(01)00488-3","article-title":"Multivesicular release at climbing fiber-purkinje cell synapses evidence for the one-site, one-vesicle hypothesis comes from combined morphological and electrophysi-ological studies suggesting that the number of morpho.","volume":"32","author":"Wadiche","year":"2001","journal-title":"Neuron"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14912","article-title":"Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice.","volume":"8","author":"White","year":"2017","journal-title":"Nat. Commun."},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2013.00019","article-title":"Autism spectrum disorder causes, mechanisms, and treatments: Focus on neuronal synapses.","volume":"6","author":"Won","year":"2013","journal-title":"Front. Mol. Neurosci."},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169169","article-title":"The emerging key role of the mGluR1-PKC \u03b3 signaling pathway in the pathogenesis of spinocerebellar ataxias: A neurodevelopmental viewpoint.","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B260","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0006-3495(92)81872-6","article-title":"Time course of transmitter release calculated from simulations of a calcium diffusion model.","volume":"61","author":"Yamada","year":"1992","journal-title":"Biophys. J."},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108629","article-title":"mGluR1 signaling in cerebellar Purkinje cells: Subcellular organization and involvement in cerebellar function and disease.","volume":"194","author":"Yamasaki","year":"2021","journal-title":"Neuropharmacology"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32671","article-title":"Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions.","volume":"7","author":"Yang","year":"2018","journal-title":"eLife"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1186\/s13408-020-0078-z","article-title":"Exact solutions to cable equations in branching neurons with tapering dendrites.","volume":"10","author":"Yihe","year":"2020","journal-title":"J. Math. Neurosci."},{"key":"B264","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.neuron.2015.07.020","article-title":"Neuroligins sculpt cerebellar purkinje-cell circuits by differential control of distinct classes of synapses.","volume":"87","author":"Zhang","year":"2015","journal-title":"Neuron"},{"key":"B265","doi-asserted-by":"publisher","first-page":"9070","DOI":"10.1523\/JNEUROSCI.1356-16.2016","article-title":"Neuroligins are selectively essential for NMDAR signaling in cerebellar stellate interneurons.","volume":"36","author":"Zhang","year":"2016","journal-title":"J. Neurosci."},{"key":"B266","doi-asserted-by":"publisher","first-page":"4584","DOI":"10.1529\/biophysj.108.129874","article-title":"Receptor actions of synaptically released glutamate: The role of transporters on the scale from nanometers to microns.","volume":"95","author":"Zheng","year":"2008","journal-title":"Biophys. J."},{"key":"B267","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1152\/jn.00925.2014","article-title":"Differential purkinje cell simple spike activity and pausing behavior related to cerebellar modules.","volume":"113","author":"Zhou","year":"2015","journal-title":"J. Neurophysiol."}],"container-title":["Frontiers in Computational Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncom.2022.1006989\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:53:28Z","timestamp":1666932808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncom.2022.1006989\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":267,"alternative-id":["10.3389\/fncom.2022.1006989"],"URL":"https:\/\/doi.org\/10.3389\/fncom.2022.1006989","relation":{},"ISSN":["1662-5188"],"issn-type":[{"value":"1662-5188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,28]]},"article-number":"1006989"}}