{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:36:21Z","timestamp":1790040981592,"version":"4.0.1"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nephrol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute postinfectious glomerulonephritis (APIGN) is an immunological glomerular disease that is an important health issue in developing countries. The incidence remains high in developing countries with a male-to-female ratio of 2:1 and age predominantly above 50 years. In this case study, we present a patient with a history of <jats:italic>Staphylococcus epidermidis<\/jats:italic> infection, a past medical history of diabetes mellitus, and histopathological findings of APIGN with Immunoglobulin A (IgA) deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 58-year-old male presented to the emergency room with a 6-day history of severe low back pain. Three days later, the patient developed fever, chills, abdominal pain in the upper quadrant and a subsequent lower limb cellulitis. Various immunological tests, imaging studies, and kidney biopsy were performed to arrive at a diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following the diagnosis and treatment of Cholangitis and <jats:italic>Staphylococcus epidermidis<\/jats:italic>, further investigation led to a diagnosis of IgA-dominant APIGN. IgA-dominant APIGN was treated with antibiotics, renin-angiotensin-aldosterone system inhibitors and steroids, and the patient was discharged from the hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In developing countries, APIGN is a relatively common presentation of kidney damage due to acute kidney injury and nephritic syndrome. IgA-dominant APIGN is a rare but increasingly recognized morphological variant in which IgA is the sole or dominant immunoglobulin. This unique presentation and multidisciplinary approach for diagnosing and treating IgA-dominant APIGN need to be considered and understood by healthcare professionals to better help these patients. Further investigation is needed to understand the best treatment of this IgA-dominant APIGN presentation and its prognosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneph.2023.1284814","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T10:30:04Z","timestamp":1699007404000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["IgA-dominant postinfectious glomerulonephritis: a case report"],"prefix":"10.3389","volume":"3","author":[{"given":"Rodolfo","family":"Moreno-Alvarado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Navarro-Blackaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"De Leon-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Armas-Eguizabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Ch\u00e1vez-I\u00f1iguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.44","article-title":"An update on acute postinfectious glomerulonephritis worldwide","volume":"5","author":"Kanjanabuch","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13000-020-00980-6","article-title":"Clinicopathologic features of infection-related glomerulonephritis with IGA deposits: A French nationwide study","volume":"15","author":"Miquelestorena-Standley","year":"2020","journal-title":"Diagn Pathol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/md.0b013e318161b0fc","article-title":"Acute postinfectious glomerulonephritis in the modern era: experience with 86 adults and review of the literature","volume":"87","author":"Nasr","year":"2008","journal-title":"Med (Baltimore)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.132020","article-title":"IgA dominant postinfectious glomerulonephritis: report of 2 cases","volume":"24","author":"Rajakumar","year":"2014","journal-title":"Indian J Nephrol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s13730-013-0086-x","article-title":"Garland-pattern postinfectious glomerulonephritis with IgA-dominant deposition","volume":"3","author":"Kanno","year":"2014","journal-title":"CEN Case Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1159\/000324180","article-title":"IgA-dominant postinfectious glomerulonephritis: a new twist on an old disease","volume":"119","author":"Nasr","year":"2011","journal-title":"Nephron Clin Pract"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00424-6","article-title":"IgA-dominant acute post staphylococcal glomerulonephritis complicating diabetic nephropathy","volume":"34","author":"Nasr","year":"2003","journal-title":"Hum Pathol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12882-021-02462-3","article-title":"Clinicopathological and prognostic study of IgA-dominant postinfectious glomerulonephritis","volume":"22","author":"Huang","year":"2021","journal-title":"BMC Nephrol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.07.163","article-title":"Efficacy of corticosteroids in infection-related glomerulonephritis-a randomized controlled trial","volume":"7","author":"Arivazhagan","year":"2022","journal-title":"Kidney Int Rep"}],"container-title":["Frontiers in Nephrology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneph.2023.1284814\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T10:30:06Z","timestamp":1699007406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneph.2023.1284814\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,3]]},"references-count":9,"alternative-id":["10.3389\/fneph.2023.1284814"],"URL":"https:\/\/doi.org\/10.3389\/fneph.2023.1284814","relation":{},"ISSN":["2813-0626"],"issn-type":[{"value":"2813-0626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,3]]},"article-number":"1284814"}}