{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:02:55Z","timestamp":1768384975336,"version":"3.49.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nephrol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The prevalence of bone disease in peritoneal dialysis patients has been recently shown to exceed 54%, including patients with parathormone (PTH) levels within the theoretical adequate target, yet demonstrating low bone turnover on histomorphometry. Moreover, bone disease is often associated with abnormalities in calcium and phosphate metabolism, leading to tissular deposits such as extraosseous calcifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present a 22-year-old female patient managed on peritoneal dialysis with persistent swelling of all four extremities, including the fingers, hands, and feet, accompanied by a marked decrease in PTH. Many extraosseous calcifications in the hands were seen in the X-ray images, prompting a switch from peritoneal dialysis to conventional high-flow haemodialysis and intravenous sodium thiosulphate (STS) therapy. The patient showed adequate treatment tolerance, with most calcifications disappearing after 3 months of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our experience suggests that the treatment of extraosseous calcifications requires timely and multi-angle intervention. At the same time, treatment with STS has proven effective and well tolerated in this patient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneph.2025.1702475","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T05:15:36Z","timestamp":1768367736000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evanescent extraosseous calcifications in low turnover bone: management and outcomes: a case report"],"prefix":"10.3389","volume":"5","author":[{"given":"Mariel","family":"Hernandez-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Enos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020","article-title":"Mortality risk. for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the dialysis outcomes and practice patterns study (DOPPS)","volume":"52","author":"Tentori","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004040275","article-title":"Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in haemodialysis patients: the USRDS waves 1, 3, and 4 study","volume":"16","author":"Slinin","year":"2005","journal-title":"JASN"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance haemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2007.00190.x","article-title":"Association of mineral metabolism factors with all-cause and cardiovascular mortality in haemodialysis patients: the Japan dialysis outcomes and practice patterns study","volume":"11","author":"Kimata","year":"2007","journal-title":"Hemodial Int"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1523124","article-title":"Association between the achievement of target range CKD-MBD markers and mortality in prevalent haemodialysis patients in Taiwan by using the kidney disease: improving global outcomes clinical guidelines","volume":"1523124","author":"Ying","year":"2016","journal-title":"BioMed Res Int"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","article-title":"Clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease\u2013mineral and bone disorder (CKD-MBD)Kidney international supplements","volume":"7","year":"2017","journal-title":"Kidney international"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4636","article-title":"Evaluation of renal osteodystrophy and serum bone-related biomarkers in a peritoneal dialysis population","volume":"37","author":"Pereira","year":"2022","journal-title":"J Bone Miner Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000093597","article-title":"Calcium and phosphate handling in peritoneal dialysis","volume":"150","author":"Cozzolino","year":"2006","journal-title":"Contrib Nephrol. Basel Karger"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1159\/000337831","article-title":"Phosphate control in peritoneal dialysis","volume":"178","author":"Cozzolinoa","year":"2012","journal-title":"Contrib Nephrol. Basel Karger"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2023.05.003","article-title":"Vascular calcification in peritoneal dialysis patients and its association with bone-derived molecules and bone Histomorphometry","volume":"44","author":"Pereira","year":"2024","journal-title":"Nefrologia"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-2017-0012","article-title":"Bone biopsy in nephrology practice","volume":"40","author":"Barreto","year":"2018","journal-title":"J Bras Nefrol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3390\/nu14091742","article-title":"Time for revival of bone biopsy with histomorphometric analysis in chronic kidney disease (CKD):Moving from skepticism to pragmatism","volume":"14","author":"Fusaro","year":"2022","journal-title":"Nutrients"},{"key":"B13","article-title":"Phosphate control in peritoneal dialysis. Contrib nephrol","volume":"178","author":"Ronco","year":"2012","journal-title":"Basel Karger"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000109","article-title":"Phosphate removal in peritoneal dialysis regimens: an underestimated adequacy parameter","volume":"33","author":"Botelho","year":"2010","journal-title":"NDT Plus"},{"key":"B15","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1681\/ASN.V9154","article-title":"1,25(OH)2- vitamin D3 reduces spontaneous and hypocalcemia- stimulated pulsatile component of parathyroid hormone secretion","volume":"9","author":"Schmitt","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.3390\/jcm11237130","article-title":"Is adynamic bone always a disease? Lessons from patients with chronic kidney disease","volume":"11","author":"Nagy","year":"2022","journal-title":"J Clin Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.06.023","article-title":"Diagnostic accuracy of bone turnover markers and bone histology in patients with CKD treated by dialysis","volume":"67","author":"Sprague","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00177","article-title":"Calcium balance and negative impact of calcium load in peritoneal dialysis patients","volume":"34","author":"Wang","year":"2014","journal-title":"Perit Dial Int"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.157","article-title":"The KDIGO guideline for dialysate calcium will result in an increased incidence of calcium accumulation in hemodialysis patients","volume":"78","author":"Gotch","year":"2010","journal-title":"Kidney Int"},{"key":"B20","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.bone.2007.06.014","article-title":"Improvement of bone and mineral parameters related to adynamic bone disease by diminishing dialysate calcium","volume":"40","author":"Spasovski","year":"2007","journal-title":"Bone"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.393995","article-title":"Study on the effect of low calcium dialysate on biochemical profile of adynamic bone disease in patients on maintenance hemodialysis","volume":"34","author":"Sethi","year":"2023","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050490","article-title":"Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy","volume":"18","author":"Mathew","year":"2007","journal-title":"J Am Soc Nephrology"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006101089","article-title":"Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients","volume":"19","author":"Ferreira","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.544","article-title":"Treatment of hyperphosphatemia with sevelamer hydrochloride in dialysis patients: effects on vascular calcification, bone and a close look into the survival data","volume":"74","author":"Frazao","year":"2008","journal-title":"Kidney Int"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09880912","article-title":"Sodium thiosulfate therapy for calcific uremic arteriolopathy","volume":"8","author":"Nigwekar","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.1093\/ndt\/gfr375","article-title":"The chemistry of thiosulfate and vascular calcification","volume":"27","author":"O\u2019Neill","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"B27","doi-asserted-by":"publisher","first-page":"6452","DOI":"10.3390\/ijms22126452","article-title":"Hydrogen sulfide metabolite, sodium thiosulfate: clinical applications and underlying molecular mechanisms","volume":"22","author":"Zhang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket388","article-title":"Sodium thiosulphate treatment of uraemic tumoral calcinosis","volume":"53","author":"Malbos","year":"2014","journal-title":"Rheumatology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1177\/089686088700700411","article-title":"Sodium thiosulfate treatment of soft-tissue calcifications in patients with end-stage renal disease","volume":"7","author":"Yatzidis","year":"1987","journal-title":"Perit Dial Bull"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.3109\/08860229009060727","article-title":"Sodium thiosulfate treatment of tumoral calcinosis in patients with end-stage renal disease","volume":"12","author":"Kyriakopoulos","year":"1990","journal-title":"Ren Fail"},{"key":"B31","doi-asserted-by":"publisher","first-page":"30812","DOI":"10.1159\/000188861","article-title":"Sodium thiosulfate in the treatment of tumoral calcifications in a hemodialysis patient without hyperparathyroidism","volume":"72","author":"Papadakis","year":"1996","journal-title":"Nephron"}],"container-title":["Frontiers in Nephrology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneph.2025.1702475\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T05:15:36Z","timestamp":1768367736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneph.2025.1702475\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":31,"alternative-id":["10.3389\/fneph.2025.1702475"],"URL":"https:\/\/doi.org\/10.3389\/fneph.2025.1702475","relation":{},"ISSN":["2813-0626"],"issn-type":[{"value":"2813-0626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"article-number":"1702475"}}