{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:03:08Z","timestamp":1781071388545,"version":"3.54.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nephrol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To check if there is a link between good vitamin D levels in the blood and subclinical atherosclerosis in people on hemodialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety end-stage renal disease patients undergoing regular hemodialysis were included in a cross-sectional study. Based on carotid intima-media thickness (CIMT), patients were grouped into Group A (n = 44) with normal CIMT and Group B (n = 46) with increased CIMT. Clinical assessments, laboratory parameters (serum vitamin D, lipid profiles, and inflammatory markers), and CIMT were measured using carotid ultrasound. The researcher compared students\u2019 t-tests with quantitative variables, while employing the Chi-square or Fisher\u2019s exact test with qualitative variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A positive correlation was observed between serum vitamin D and calcium (p = 0.010) and triglycerides (p = 0.025). Serum vitamin D showed a negative correlation with weight, serum alkaline phosphatase, and urea. No significant differences were found between the two groups in terms of demographic factors, BMI, hemodialysis duration, diabetes prevalence, or vitamin D supplementation. Group B exhibited elevated serum calcium levels (p\u00a0= 0.008). Multivariate analysis found weight as an independent predictor of low vitamin D levels (p = 0.016).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum calcium levels were significantly associated with CIMT; however, no correlation was seen between vitamin D levels and CIMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>registered at clinicaltrials.gov (ID: NCT07200804).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneph.2026.1738155","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:42:04Z","timestamp":1781070124000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the relationship between serum vitamin D and 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