{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:01:13Z","timestamp":1781157673027,"version":"3.54.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nephrol."],"abstract":"\n Background<\/jats:title>\n Asymmetric dimethylarginine (ADMA) levels in patients with chronic kidney disease (CKD) are associated with cardiovascular events and mortality following kidney transplantation (KT). Therefore, ADMA may serve as a risk factor for cardiovascular complications in kidney transplant recipients. This study aimed to evaluate plasma ADMA concentrations and their association with cardiovascular risk factors in Vietnamese patients with end-stage renal disease (ESRD) before and after KT.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n From January 2018 to December 2022, 75 patients with ESRD who underwent KT were clinically evaluated using Doppler ultrasound, laboratory tests, and ADMA quantification both before and 6 months after KT. Additionally, 80 healthy people were selected as a control group. ADMA levels before and after KT were statistically analyzed to identify associations with cardiovascular risk factors.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The findings indicate that 100% of patients with ESRD before KT exhibited elevated levels of urea, creatinine, proteinuria, a long with a decreased glomerular filtration rate (GFR)&lt; 60 ml\/min. After KT, these abnormalities decreased to 17.3%, 41.3%, 5.3%, and 9.3%, respectively. Clinical indices such as hypertension, elevated CRP, anemia, left ventricular hypertrophy, and EF%&lt; 50% were observed after KT at rates of 29.3%, 21.3%, 61.4%, and 34.7%, respectively. However, dyslipidemia and AIP &gt; 0.11 increased by 2.6% and 10.7%, respectively, after KT compared to before. The average ADMA concentrations of patients before KT, after KT, and in healthy controls were 0.62 \u00b5mol\/L, 0.57 \u00b5mol\/L vs 0.17 \u00b5mol\/L, respectively. Before KT, 93.3% of patients exhibited elevated ADMA levels, which decreased to 32.0% after KT. Males presented higher ADMA levels than females both before and after KT, as well as in healthy controls. ADMA levels showed minimal variation across different age groups. Before KT, dyslipidemia (cholesterol), AIP (&gt; 0.11), and LA diameter were associated with increased ADMA levels. Lower hemoglobin and lower HDL-C levels at 6 months post-transplant were independently associated with an increased risk of ADMA elevation from pre-transplant to 6 months post-transplant.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n ADMA levels in patients with end-stage renal disease were 3.65 times higher than those in healthy controls. Although ADMA levels decreased after KT, they remained elevated compared to healthy controls. Hemoglobin and LDL-C were independent factors associated with changes in ADMA concentration between the pre-transplant and six-month post-transplant periods.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fneph.2026.1773762","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:47:06Z","timestamp":1781156826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma asymmetric dimethylarginine and its association with cardiovascular risk factors in Vietnamese patients before and after kidney transplantation, 2018\u20132022"],"prefix":"10.3389","volume":"6","author":[{"given":"Nguyen Thi","family":"Thuy","sequence":"first","affiliation":[{"name":"Department of Nephrology and Dialysis, Military Central Hospital 108","place":["Ha Noi, Vietnam"]},{"name":"Department of Endocrinology, Military Central Hospital 108","place":["Ha Noi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Viet","family":"Thang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis, Military Hospital 103","place":["Ha Noi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/s41581-020-0268-7","article-title":"The impact of chronic kidney disease on global health","volume":"16","author":"Carney","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int Suppl (2011)"},{"key":"B3","volume-title":"Clinical practice guideline for the evaluation and management of chronic kidney disease","year":"2021"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/381082","article-title":"Cardiovascular risk factors and chronic kidney disease-FGF23: a key molecule in the cardiovascular disease","volume":"2014","author":"Jimbo","year":"2014","journal-title":"Int J Hypertens"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183787","article-title":"Lifestyle-related risk factors for the incidence and progression of chronic kidney disease in the healthy young and middle-aged population","volume":"14","author":"Kuma","year":"2022","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fneph.2025.1630867","article-title":"The global burden of chronic kidney disease attributable to high sodium intake: a comprehensive analysis of trends from 1990 to 2021 and burden prediction to 2040","volume":"5","author":"Lu","year":"2025","journal-title":"Front Nephrol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1078371","article-title":"Global, regional, and national burden of chronic kidney disease attributable to high sodium intake from 1990 to 2019","volume":"10","author":"Liu","year":"2023","journal-title":"Front Nutr"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v5.i4.183","article-title":"Cardiovascular risk factors following renal transplant","volume":"5","author":"Neale","year":"2016","journal-title":"World J Transplant"},{"key":"B9","article-title":"H\u01b0\u1edbng d\u1eabn gh\u00e9p th\u1eadn Vi\u1ec7t Nam","volume-title":"Nh\u00e0 xu\u1ea5t b\u1ea3n Y h\u1ecdc","author":"Nam","year":"2017"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.463","article-title":"Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms","volume":"77","author":"Caplin","year":"2010","journal-title":"Kidney Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000110092","article-title":"Asymmetrical dimethylarginine in renal disease: limits of variation or variation limits? 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