{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:48:32Z","timestamp":1782197312540,"version":"3.54.5"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nephrol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>An association between delayed graft function (DGF) and BK polyomavirus (BKPyV) DNAemia is not well defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated this with 1) a retrospective review of a single-center cohort analysis, and 2) a systematic review &amp;amp; meta-analysis of published data. Kidney transplant recipients at a single-center between 01\/01\/2007-30\/06\/2018 were analyzed. Comparative analyses were done with logistic regression models based upon clinical risk factors. Following a systematic review of published studies, meta-analysis was performed using the DerSimonian-Laird random effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our single-center analysis, we analyzed 1,770 kidney transplant recipients with median follow up 5.3 years (interquartile range 2.7-8.7 years).  BKPyVDNAemia was associated with; male sex (8.3% versus 5.3% respectively, p=0.017), ABO-incompatible transplantation (10.3% versus 4.6% respectively, p=0.004) and DGF (9.0% versus 6.3% respectively, p=0.048). In a multivariate analysis, only recipient male sex and ABO-incompatible transplantation was associated with BKPyVDNAemia. In a systematic review of published literature, we identified 11 studies and performed a meta-analysis of empirical data including our Birmingham cohort data. No significant association was observed between DGF rates and BKPyVDNAemia (OR 1.00, 95% CI 0.67-1.50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We did not identify any association between DGF rates and subsequent BKPyVDNAemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneph.2026.1790723","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:19:05Z","timestamp":1782195545000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["No association between delayed graft function and BK polyomavirus infection reactivation after kidney transplantation: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"6","author":[{"given":"Thidarat","family":"Kitrungphaiboon","sequence":"first","affiliation":[{"name":"Department of Nephrology, Bhumirajanagarindra Kidney Institute Hospital","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity","family":"Evison","sequence":"additional","affiliation":[{"name":"Statistics Team: Research, Development and Innovation, University Hospital Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzy","family":"Gallier","sequence":"additional","affiliation":[{"name":"Statistics Team: Research, Development and Innovation, University Hospital Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation, University Hospitals Birmingham","place":["Birmingham, United Kingdom"]},{"name":"Institute of Immunology and Immunotherapy, University of Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13711119","article-title":"Donor age, cold ischemia time, and delayed graft function","volume":"15","author":"Helantera","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16574","article-title":"Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: a national cohort study","volume":"21","author":"Phillips","year":"2021","journal-title":"Am J Transplant"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2009040412","article-title":"Delayed graft function and the risk for death with a functioning graft","volume":"21","author":"Tapiawala","year":"2010","journal-title":"J Am Soc 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