{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:54:42Z","timestamp":1791262482550,"version":"4.1.0"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nephrol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Light chain (AL) amyloidosis is typically associated with plasma cell dyscrasias but can rarely arise from low-grade B-cell non-Hodgkin lymphoma. Renal involvement may present with nephrotic-range proteinuria, acute kidney injury, edema, anasarca, and hypoalbuminemia. Recognizing lymphoma-associated AL amyloidosis is essential because diagnosis requires tissue confirmation, and treatment must target the underlying clonal B-cell disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We report a rare case of severe renal AL amyloidosis in a patient with known low-grade B-cell non-Hodgkin lymphoma previously treated with rituximab. The patient presented with witnessed syncope, progressive peripheral edema, anasarca, and hypotension. Initial evaluation showed acute kidney injury with nephrotic-range proteinuria, including a urine protein-to-creatinine ratio greater than 10 g\/g. Workup for autoimmune, infectious, and malignant causes of proteinuric kidney disease revealed positive hepatitis C antibody, mildly elevated serum lambda free light chains, a mildly decreased kappa-to-lambda ratio, and serum immunofixation positive for an IgM monoclonal lambda gammopathy. Renal biopsy demonstrated severe AL amyloidosis with predominant renal involvement. Bone marrow biopsy showed low-grade B-cell non-Hodgkin lymphoma involving 85% of the marrow, with CD20-positive immunophenotyping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights a rare presentation of renal AL amyloidosis secondary to low-grade B-cell non-Hodgkin lymphoma. Persistent nephrotic-range proteinuria in patients with B-cell lymphoma, particularly with IgM lambda monoclonal gammopathy, should prompt evaluation for amyloidosis with renal biopsy and hematologic assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneph.2026.1959759","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:30Z","timestamp":1791260790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Light chain amyloidosis in a patient with low-grade B-cell lymphoma"],"prefix":"10.3389","volume":"6","author":[{"given":"Alex","family":"Matthaeus","sequence":"first","affiliation":[{"name":"Graduate Medical Education (GME), Hospital Corporation of America (HCA) Blake Florida Hospital","place":["Bradenton, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Thomas","sequence":"additional","affiliation":[{"name":"NEPHROCOR","place":["Bradenton, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan R.","family":"Toka","sequence":"additional","affiliation":[{"name":"Manatee Kidney Diseases Consultants","place":["Bradenton, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.915420","article-title":"Diagnosis and management of AL amyloidosis due to B-cell non-Hodgkin lymphoma","volume":"12","author":"Berkowitz","year":"2022","journal-title":"Front Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2021.09.003","article-title":"AL amyloidosis: current chemotherapy and immune therapy treatment strategies: JACC: CardioOncology state-of-the-art review","volume":"3","author":"Bianchi","year":"2021","journal-title":"JACC CardioOncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13020217","article-title":"The role of tumor microenvironment in multiple myeloma development and progression","volume":"13","author":"Garc\u00eda-Ortiz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0667-6","article-title":"IgM AL amyloidosis: delineating disease biology and outcomes with clinical, genomic and bone marrow morphological features","volume":"34","author":"Sidana","year":"2020","journal-title":"Leukemia"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2015.1092433","article-title":"Clinical presentation and treatment responses in IgM-related AL amyloidosis","volume":"22","author":"Sissoko","year":"2015","journal-title":"Amyloid"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2020.08.016","article-title":"Systemic amyloidosis due to low-grade lymphoma","volume":"34","author":"Wechalekar","year":"2020","journal-title":"Hematol Oncol Clin North Am"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2069281","article-title":"The clinical features and outcomes of systemic light chain amyloidosis with hepatic involvement","volume":"54","author":"Zhao","year":"2022","journal-title":"Ann Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.05.004","article-title":"AA-type amyloidosis associated with non-Hodgkin's lymphoma: a case report","volume":"35","author":"Zhu","year":"2004","journal-title":"Hum Pathol"}],"container-title":["Frontiers in Nephrology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneph.2026.1959759\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:31Z","timestamp":1791260791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneph.2026.1959759\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":8,"alternative-id":["10.3389\/fneph.2026.1959759"],"URL":"https:\/\/doi.org\/10.3389\/fneph.2026.1959759","relation":{},"ISSN":["2813-0626"],"issn-type":[{"value":"2813-0626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"article-number":"1959759"}}