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There have been many efforts to build mathematical and computational embodiments in the form of discrete cell-group activities\u2014termed neural masses\u2014to understand in particular the origins of evoked potentials, intrinsic patterns of activities such as theta, regulation of sleep, Parkinson\u2019s disease related dynamics, and mimic seizure dynamics. As originally utilized, standard neural masses convert input through a sigmoidal function to a firing rate, and firing rate through a synaptic alpha function to other masses. Here we define a process to build mechanistic neural masses (mNMs) as mean-field models of microscopic membrane-type (Hodgkin Huxley type) models of different neuron types that duplicate the stability, firing rate, and associated bifurcations as function of relevant slow variables - such as extracellular potassium - and synaptic current; and whose output is both firing rate and impact on the slow variables - such as transmembrane potassium flux. Small networks composed of just excitatory and inhibitory mNMs demonstrate expected dynamical states including firing, runaway excitation and depolarization block, and these transitions change in biologically observed ways with changes in extracellular potassium and excitatory-inhibitory balance.<\/jats:p>","DOI":"10.3389\/fnetp.2022.911090","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T06:24:01Z","timestamp":1664346241000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics"],"prefix":"10.3389","volume":"2","author":[{"given":"Richa","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Gluckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.clinph.2013.10.051","article-title":"Seizure Prediction in Hippocampal and Neocortical Epilepsy Using a Model-Based Approach","volume":"125","author":"Aarabi","year":"2014","journal-title":"Clin. 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