{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:55:49Z","timestamp":1790430949594,"version":"4.1.0"},"reference-count":63,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2015.00031","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T03:44:52Z","timestamp":1424403892000},"source":"Crossref","is-referenced-by-count":34,"title":["Salicylate-Induced Hearing Loss and Gap Detection Deficits in Rats"],"prefix":"10.3389","volume":"6","author":[{"given":"Kelly E.","family":"Radziwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Stolzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell E.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael A.","family":"Bowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/(SICI)1098-2302(199601)29:169::AID-DEV43.3.CO;2-R","article-title":"Salicylate-induced changes in auditory thresholds of adolescent and adult rats","volume":"29","author":"Brennan","year":"1996","journal-title":"Dev Psychobiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0301-0082(00)00027-7","article-title":"Auditory sensori-neural alterations induced by salicylate","volume":"62","author":"Cazals","year":"2000","journal-title":"Prog Neurobiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.heares.2012.11.016","article-title":"Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus","volume":"295","author":"Chen","year":"2013","journal-title":"Hear Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jneumeth.2013.07.021","article-title":"A novel behavioral assay for the assessment of acute tinnitus in rats optimized for simultaneous recording of oscillatory neural activity","volume":"219","author":"Stolzberg","year":"2013","journal-title":"J Neurosci Methods"},{"key":"B5","first-page":"79","article-title":"Review of salicylate-induced hearing loss, neurotoxicity, tinnitus and neuropathophysiology","volume":"34","author":"Sheppard","year":"2014","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"B6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.heares.2010.02.010","article-title":"Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity","volume":"265","author":"Chen","year":"2010","journal-title":"Hear Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.neuroscience.2011.02.005","article-title":"Salicylate-induced peripheral auditory changes and tonotopic reorganization of auditory cortex","volume":"180","author":"Stolzberg","year":"2011","journal-title":"Neuroscience"},{"key":"B8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.neuroscience.2008.12.024","article-title":"Salicylate increases the gain of the central auditory system","volume":"159","author":"Sun","year":"2009","journal-title":"Neuroscience"},{"key":"B9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1152\/jn.00946.2011","article-title":"Intracortical circuits amplify sound-evoked activity in primary auditory cortex following systemic injection of salicylate in the rat","volume":"108","author":"Stolzberg","year":"2012","journal-title":"J Neurophysiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0378-5955(96)00019-6","article-title":"Effects of salicylate on neural activity in cat primary auditory cortex","volume":"95","author":"Ochi","year":"1996","journal-title":"Hear Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/01050398209076194","article-title":"Evoked acoustic emissions from the human ear: I. Equipment and response parameters","volume":"11","author":"Johnson","year":"1982","journal-title":"Scand Audiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0378-5955(83)90033-3","article-title":"Aspirin can potentiate the temporary hearing loss induced by intense sounds","volume":"9","author":"McFadden","year":"1983","journal-title":"Hear Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0378-5955(84)90114-X","article-title":"Aspirin-induced hearing loss as a model of sensorineural hearing loss","volume":"16","author":"McFadden","year":"1984","journal-title":"Hear Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev.ps.34.020183.000523","article-title":"Audition: some relations between normal and pathological hearing","volume":"34","author":"McFadden","year":"1983","journal-title":"Annu Rev Psychol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1121\/1.392181","article-title":"Gap detection in chinchillas with temporary high-frequency hearing loss","volume":"77","author":"Salvi","year":"1985","journal-title":"J Acoust Soc Am"},{"key":"B16","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1037\/0735-7044.102.6.811","article-title":"Phantom auditory sensation in rats: an animal model for tinnitus","volume":"102","author":"Jastreboff","year":"1988","journal-title":"Behav Neurosci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"741452","DOI":"10.1155\/2014\/741452","article-title":"Animal models of subjective tinnitus","volume":"2014","author":"von der Behrens","year":"2014","journal-title":"Neural Plast"},{"key":"B18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3389\/fneur.2014.00179","article-title":"Behavioral models of tinnitus and hyperacusis in animals","volume":"5","author":"Hayes","year":"2014","journal-title":"Front Neurol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.heares.2006.06.013","article-title":"Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats","volume":"226","author":"Yang","year":"2007","journal-title":"Hear Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"S185","DOI":"10.1044\/1059-0889(2008\/08-0006)","article-title":"Gap detection methods for assessing salicylate-induced tinnitus and hyperacusis in rats","volume":"17","author":"Turner","year":"2008","journal-title":"Am J Audiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s10162-011-0276-1","article-title":"Development of tinnitus in CBA\/CaJ mice following sound exposure","volume":"12","author":"Longenecker","year":"2011","journal-title":"J Assoc Res Otolaryngol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s10162-013-0375-2","article-title":"Behavioral evidence for possible simultaneous induction of hyperacusis and tinnitus following intense sound exposure","volume":"14","author":"Chen","year":"2013","journal-title":"J Assoc Res Otolaryngol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e75011","DOI":"10.1371\/journal.pone.0075011","article-title":"Noise-induced tinnitus using individualized gap detection analysis and its relationship with hyperacusis, anxiety, and spatial cognition","volume":"8","author":"Pace","year":"2013","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fneur.2014.00203","article-title":"Changes in the response properties of inferior colliculus neurons relating to tinnitus","volume":"5","author":"Berger","year":"2014","journal-title":"Front Neurol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1111\/ejn.12580","article-title":"Neural changes accompanying tinnitus following unilateral acoustic trauma in the guinea pig","volume":"40","author":"Coomber","year":"2014","journal-title":"Eur J Neurosci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1037\/0735-7036.96.6.945","article-title":"Temporal acuity in auditory function in the rat: reflex inhibition by brief gaps in noise","volume":"96","author":"Ison","year":"1982","journal-title":"J Comp Physiol Psychol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1037\/0735-7044.111.6.1335","article-title":"Facilitation and inhibition of the acoustic startle reflex in the rat after a momentary increase in background noise level","volume":"111","author":"Ison","year":"1997","journal-title":"Behav Neurosci"},{"key":"B28","first-page":"37","article-title":"Health and nutrition examination survey of 1971-75: Part II. Tinnitus, subjective hearing loss, and well-being","volume":"5","author":"Cooper","year":"1994","journal-title":"J Am Acad Audiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1037\/0735-7044.120.1.188","article-title":"Gap detection deficits in rats with tinnitus: a potential novel screening tool","volume":"120","author":"Turner","year":"2006","journal-title":"Behav Neurosci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.4103\/1463-1741.121232","article-title":"Does tinnitus \u00e2\u20ac\u0153fill in\u00e2\u20ac\u009d the silent gaps?","volume":"15","author":"Campolo","year":"2013","journal-title":"Noise Health"},{"key":"B31","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fnsys.2012.00042","article-title":"Gap prepulse inhibition and auditory brainstem-evoked potentials as objective measures for tinnitus in guinea pigs","volume":"6","author":"Dehmel","year":"2012","journal-title":"Front Syst Neurosci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.heares.2012.01.005","article-title":"Hearing loss, hyperacusis, or tinnitus: what is modeled in animal research?","volume":"295","author":"Eggermont","year":"2013","journal-title":"Hear Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0378-5955(04)00019-X","article-title":"A novel behavioral paradigm for assessing tinnitus using schedule-induced polydipsia avoidance conditioning (SIP-AC)","volume":"190","author":"Lobarinas","year":"2004","journal-title":"Hear Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0166-4328(01)00305-9","article-title":"Using signal detection methods for analysis of operant performance in mice","volume":"125","author":"Steckler","year":"2001","journal-title":"Behav Brain Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0378-5955(02)00643-3","article-title":"Gap detection in Mongolian gerbils (Meriones unguiculatus)","volume":"176","author":"Wagner","year":"2003","journal-title":"Hear Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3758\/BF03192744","article-title":"Operant methods for mouse psychoacoustics","volume":"38","author":"Klink","year":"2006","journal-title":"Behav Res Methods"},{"key":"B37","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s00359-009-0472-1","article-title":"Behaviorally measured audiograms and gap detection thresholds in CBA\/CaJ mice","volume":"195","author":"Radziwon","year":"2009","journal-title":"J Comp Physiol A Neuroethol Sens Neural Behav Physiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.visres.2010.09.020","article-title":"Gap detection in the starling (Sturnus vulgaris)","volume":"164","author":"Klump","year":"1989","journal-title":"J Comp Physiol A"},{"key":"B39","first-page":"15","article-title":"Generalization of conditioned suppression during salicylate-induced phantom auditory perception in rats","volume":"51","author":"Brennan","year":"1991","journal-title":"Acta Neurobiol Exp"},{"key":"B40","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1121\/1.390529","article-title":"Temporal gap resolution in narrow-band noises with center frequencies from 6000-14000 Hz","volume":"75","author":"Fitzgibbons","year":"1984","journal-title":"J Acoust Soc Am"},{"key":"B41","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1121\/1.391881","article-title":"Detection of temporal gaps in bandlimited noise: effects of variations in bandwidth and signal-to-masker ratio","volume":"77","author":"Shailer","year":"1985","journal-title":"J Acoust Soc Am"},{"key":"B42","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0378-5955(02)00578-6","article-title":"Gap detection threshold in the rat before and after auditory cortex ablation","volume":"172","author":"Syka","year":"2002","journal-title":"Hear Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.heares.2004.08.014","article-title":"Effect of noise exposure on gap detection in rats","volume":"200","author":"Rybalko","year":"2005","journal-title":"Hear Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s003590050103","article-title":"Neural correlates of behavioral gap detection in the inferior colliculus of the young CBA mouse","volume":"181","author":"Walton","year":"1997","journal-title":"J Comp Physiol A"},{"key":"B45","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1121\/1.384818","article-title":"Gap detection by the chinchilla","volume":"68","author":"Giraudi","year":"1980","journal-title":"J Acoust Soc Am"},{"key":"B46","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1121\/1.1918946","article-title":"Rate of decay of auditory sensation","volume":"36","author":"Plomp","year":"1964","journal-title":"J Acoust Soc Am"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3944","DOI":"10.1121\/1.1904387","article-title":"The behavioral response of mice to gaps in noise depends on its spectral components and its bandwidth","volume":"117","author":"Ison","year":"2005","journal-title":"J Acoust Soc Am"},{"key":"B48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-642-70622-6_10","article-title":"Gap detection in normal and impaired listeners: the effect of level and frequency","volume-title":"Time Resolution in Auditory Systems","author":"Buus","year":"1985"},{"key":"B49","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1121\/1.396831","article-title":"Modulation and gap detection for broadband and filtered noise signals","volume":"84","author":"Formby","year":"1988","journal-title":"J Acoust Soc Am"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1121\/1.398606","article-title":"Gap detection as a function of stimulus bandwidth with fixed high-frequency cutoff in normal-hearing and hearing-impaired listeners","volume":"86","author":"Grose","year":"1989","journal-title":"J Acoust Soc Am"},{"key":"B51","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1121\/1.401780","article-title":"Gap detection in multiple narrow bands of noise as a function of spectral configuration","volume":"90","author":"Grose","year":"1991","journal-title":"J Acoust Soc Am"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1121\/1.402633","article-title":"The detection of temporal gaps as a function of frequency region and absolute noise bandwidth","volume":"91","author":"Eddins","year":"1992","journal-title":"J Acoust Soc Am"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1121\/1.410288","article-title":"The effects of signal frequency and absolute bandwidth on gap detection in noise","volume":"96","author":"Snell","year":"1994","journal-title":"J Acoust Soc Am"},{"key":"B54","article-title":"Gap detection thresholds in tinnitus subjects: does tinnitus fill in the silent gaps?","author":"Boyen","year":"2014"},{"key":"B55","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.heares.2012.05.011","article-title":"Gap detection deficits in humans with tinnitus as assessed with the acoustic startle paradigm: does tinnitus fill in the gap?","volume":"295","author":"Fournier","year":"2013","journal-title":"Hear Res"},{"key":"B56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-4614-3728-4_2","article-title":"Behavioral tests for tinnitus in animals","volume-title":"Tinnitus","author":"Heffner","year":"2012"},{"key":"B57","doi-asserted-by":"publisher","first-page":"658741","DOI":"10.1155\/2014\/658741","article-title":"Salicylate-induced auditory perceptual disorders and plastic changes in nonclassical auditory centers in rats","volume":"2014","author":"Chen","year":"2014","journal-title":"Neural Plast"},{"key":"B58","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3109\/14992027.2012.664290","article-title":"Self-reported and behavioral sound level avoidance in tinnitus and hyperacusis subjects, and association with anxiety ratings","volume":"51","author":"Blaesing","year":"2012","journal-title":"Int J Audiol"},{"issue":"4","key":"B59","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1044\/2014_AJA-14-0010","article-title":"A review of hyperacusis and future directions: part I. Definitions and manifestations","volume":"23","author":"Tyler","year":"2014","journal-title":"Am J Audiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1152\/jn.00184.2013","article-title":"Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?","volume":"111","author":"Hickox","year":"2014","journal-title":"J Neurophysiol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1037\/0735-7044.122.4.885","article-title":"On the influence of baseline startle reactivity on the indexation of prepulse inhibition","volume":"122","author":"Csomor","year":"2008","journal-title":"Behav Neurosci"},{"key":"B62","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.heares.2012.06.001","article-title":"The gap-startle paradigm for tinnitus screening in animal models: limitations and optimization","volume":"295","author":"Lobarinas","year":"2013","journal-title":"Hear Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.bbr.2013.10.024","article-title":"High doses of salicylate causes prepulse facilitation of onset-gap induced acoustic startle response","volume":"258","author":"Sun","year":"2014","journal-title":"Behav Brain Res"}],"container-title":["Frontiers in Neurology"],"original-title":[],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T01:56:50Z","timestamp":1498183010000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fneur.2015.00031\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":63,"URL":"https:\/\/doi.org\/10.3389\/fneur.2015.00031","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,20]]}}}