{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:54:47Z","timestamp":1791618887662,"version":"4.3.4"},"reference-count":71,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1029782, 350889"],"award-info":[{"award-number":["1029782, 350889"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2016.00109","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T23:15:23Z","timestamp":1467242123000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":73,"title":["Sympathetic Responses to Noxious Stimulation of Muscle and Skin"],"prefix":"10.3389","volume":"7","author":[{"given":"Alexander R.","family":"Burton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azharuddin","family":"Fazalbhoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaughan G.","family":"Macefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,6,30]]},"reference":[{"key":"B1","volume-title":"Textbook of Medical Physiology","author":"Guyton","year":"1956"},{"issue":"2","key":"B2","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1113\/eph8702356","article-title":"Inescapable and escapable pain is represented in distinct hypothalamic-midbrain circuits: specific roles for Adelta- and C-nociceptors","volume":"87","author":"Lumb","year":"2002","journal-title":"Exp Physiol"},{"key":"B3","first-page":"411","volume-title":"The Integrative Action of the Nervous System","author":"Sherrington","year":"1906"},{"key":"B4","volume-title":"Psychological and Neural Mechanisms of Pain","author":"Price","year":"1988"},{"key":"B5","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1016\/S0304-3959(99)00139-6","article-title":"Pain: an unpleasant topic","volume":"Suppl 6","author":"Fields","year":"1999","journal-title":"Pain"},{"issue":"8","key":"B6","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel? Interoception: the sense of the physiological condition of the body","volume":"3","author":"Craig","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"B7","volume-title":"The High Price of Pain: The Economic Impact of Persistent Pain in Australia. Report by Access Economics Pty Limited for MBF Foundation in Collaboration with University of Sydney Pain Management Research Institute","author":"Access Economics","year":"2007"},{"issue":"2","key":"B8","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1213\/01.ANE.0000133383.17666.3A","article-title":"Persistent pain as a disease entity: implications for clinical management","volume":"99","author":"Siddall","year":"2004","journal-title":"Anesth Analg"},{"issue":"2","key":"B9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/BF00234006","article-title":"Reflexes in postganglionic fibres within skin and muscle nerves after noxious stimulation of skin","volume":"20","author":"Horeyseck","year":"1974","journal-title":"Exp Brain Res"},{"issue":"2","key":"B10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/BF00234387","article-title":"Reflex activity in postganglionic fibres within skin and muscle nerves elicited by somatic stimuli in chronic spinal cats","volume":"21","author":"Horeyseck","year":"1974","journal-title":"Exp Brain Res"},{"issue":"Suppl","key":"B11","first-page":"R64","article-title":"Response patterns in vasoconstrictors to the skin and muscles upon stimulation of skin receptors in chronically spinalized cats","volume":"332","author":"Horeyseck","year":"1972","journal-title":"Pflugers Arch"},{"issue":"1\u20132","key":"B12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0304-3940(84)90350-1","article-title":"Changes in blood pressure and heart rate induced by movements of normal and inflamed knee joints","volume":"52","author":"Sato","year":"1984","journal-title":"Neurosci Lett"},{"issue":"1","key":"B13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0006-8993(82)90645-X","article-title":"Long-lasting cardiovascular depression induced by acupuncture-like stimulation of the sciatic nerve in unanaesthetized spontaneously hypertensive rats","volume":"240","author":"Yao","year":"1982","journal-title":"Brain Res"},{"key":"B14","volume-title":"Principles of Neural Science","author":"Kandel","year":"2000"},{"issue":"6 Pt 2","key":"B15","first-page":"125","article-title":"Muscle receptors with fine afferent fibers which may evoke circulatory reflexes","volume":"48","author":"Kniffeki","year":"1981","journal-title":"Circ Res"},{"issue":"1 Pt 1","key":"B16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1152\/jappl.1983.55.1.105","article-title":"Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats","volume":"55","author":"Kaufman","year":"1983","journal-title":"J Appl Physiol"},{"issue":"3","key":"B17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1152\/jappl.1984.57.3.644","article-title":"Effect of ischemia on responses of group III and IV afferents to contraction","volume":"57","author":"Kaufman","year":"1984","journal-title":"J Appl Physiol"},{"issue":"2","key":"B18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1152\/jappl.1985.59.2.459","article-title":"Pressor reflex evoked by muscular contraction: contributions by neuraxis levels","volume":"59","author":"Iwamoto","year":"1985","journal-title":"J Appl Physiol"},{"issue":"1","key":"B19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0361-9230(00)00309-9","article-title":"Somatosympathetic reflex in a working heart-brainstem preparation of the rat","volume":"53","author":"Potts","year":"2000","journal-title":"Brain Res Bull"},{"issue":"2","key":"B20","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0306-4522(89)90254-6","article-title":"Somatic and vagal afferent convergence on solitary tract neurons in cat: electrophysiological characteristics","volume":"30","author":"Person","year":"1989","journal-title":"Neuroscience"},{"issue":"3","key":"B21","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1161\/01.RES.51.3.400","article-title":"Effects of lateral reticular nucleus lesions on the exercise pressor reflex in cats","volume":"51","author":"Iwamoto","year":"1982","journal-title":"Circ Res"},{"issue":"4","key":"B22","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/0306-4522(94)90395-6","article-title":"Convergence of deep somatic and visceral nociceptive information onto a discrete ventrolateral midbrain periaqueductal gray region","volume":"61","author":"Keay","year":"1994","journal-title":"Neuroscience"},{"issue":"2","key":"B23","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/BF00227243","article-title":"Longitudinal neuronal organization of defensive reactions in the midbrain periaqueductal gray region of the rat","volume":"90","author":"Depaulis","year":"1992","journal-title":"Exp Brain Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1088\/0967-3334\/22\/1\/322","article-title":"Observation of skin thermal inertia distribution during reactive hyperaemia using a single-hood measurement system","volume":"22","author":"Hassan","year":"2001","journal-title":"Physiol Meas"},{"issue":"1\u20132","key":"B25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0304-3940(93)90162-E","article-title":"Deep and superficial noxious stimulation increases Fos-like immunoreactivity in different regions of the midbrain periaqueductal grey of the rat","volume":"154","author":"Keay","year":"1993","journal-title":"Neurosci Lett"},{"key":"B26","volume-title":"Pain","author":"Lewis","year":"1942"},{"issue":"5","key":"B27","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2106\/00004623-195436050-00007","article-title":"Experiments on pain referred from deep somatic tissues","volume":"36-A","author":"Feinstein","year":"1954","journal-title":"J Bone Joint Surg"},{"issue":"Pt 1","key":"B28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1113\/jphysiol.2008.162230","article-title":"Effects of deep and superficial experimentally-induced acute pain on muscle sympathetic nerve activity in human subjects","volume":"587","author":"Burton","year":"2009","journal-title":"J Physiol"},{"issue":"2","key":"B29","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00221-009-1790-9","article-title":"Effects of experimentally-induced acute muscle and cutaneous pain on skin sympathetic nerve activity in human subjects","volume":"195","author":"Burton","year":"2009","journal-title":"Exp Brain Res"},{"issue":"2","key":"B30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/sj.sc.3101404","article-title":"Complex regional pain syndrome \u2013 diagnostic, mechanisms, CNS involvement and therapy","volume":"41","author":"Wasner","year":"2003","journal-title":"Spinal Cord"},{"issue":"3","key":"B31","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1017\/S0140525X97301496","article-title":"Is reflex sympathetic dystrophy a valid concept?","volume":"20","author":"Elam","year":"1997","journal-title":"Behav Brain Sci"},{"key":"B32","first-page":"669","article-title":"Does regional pain in humans alter regional sympathetic discharge?","author":"Nordin","year":"2000"},{"issue":"7","key":"B33","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1212\/WNL.57.7.1296","article-title":"Pain increases during sympathetic arousal in patients with complex regional pain syndrome","volume":"57","author":"Drummond","year":"2001","journal-title":"Neurology"},{"issue":"9318","key":"B34","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/S0140-6736(02)08589-6","article-title":"Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study","volume":"359","author":"Baron","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"B35","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0165-1838(92)90061-K","article-title":"Normal sympathetic nerve activity in a reflex sympathetic dystrophy with marked skin vasoconstriction","volume":"41","author":"Casale","year":"1992","journal-title":"J Auton Nerv Syst"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1113\/expphysiol.2012.066191","article-title":"Individual differences in the cardiovascular responses to tonic muscle pain: parallel increases or decreases in muscle sympathetic nerve activity, blood pressure and heart rate","volume":"97","author":"Fazalbhoy","year":"2012","journal-title":"Exp Physiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00221-012-3156-y","article-title":"Biphasic effects of tonic stimulation of muscle nociceptors on skin sympathetic nerve activity in human subjects","volume":"221","author":"Hall","year":"2012","journal-title":"Exp Brain Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s00221-014-3847-7","article-title":"Consistent interindividual differences increases or decreases in muscle sympathetic nerve activity during experimental muscle pain","volume":"232","author":"Fazalbhoy","year":"2014","journal-title":"Exp Brain Res"},{"issue":"Pt 3","key":"B39","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1113\/jphysiol.1995.sp021101","article-title":"Effect of noxious stimulation on sympathetic vasoconstrictor outflow to human muscles","volume":"489","author":"Nordin","year":"1995","journal-title":"J Physiol"},{"issue":"3","key":"B40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1748-1716.1989.tb08760.x","article-title":"The cold pressor test: effects on sympathetic nerve activity in human muscle and skin nerve fascicles","volume":"137","author":"Fagius","year":"1989","journal-title":"Acta Physiol Scand"},{"issue":"2\u20133","key":"B41","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0304-3959(96)03079-5","article-title":"Hemodynamic and sympathetic nerve responses to painful stimuli in normotensive and borderline hypertensive subjects","volume":"66","author":"Schobel","year":"1996","journal-title":"Pain"},{"issue":"6","key":"B42","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1046\/j.1526-4610.1997.3706358.x","article-title":"Sympathetic vasoconstrictor outflow to extremity muscles in cluster headache. Recordings during spontaneous and nitroglycerin-induced attacks","volume":"37","author":"Nordin","year":"1997","journal-title":"Headache"},{"issue":"3\u20134","key":"B43","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0165-1838(83)90077-2","article-title":"Discharge patterns of sympathetic neurons supplying skeletal muscle and skin in man and cat","volume":"7","author":"J\u00e4nig","year":"1983","journal-title":"J Auton Nerv Syst"},{"issue":"1","key":"B44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1748-1716.1972.tb05157.x","article-title":"General characteristics of sympathetic activity in human muscle nerves","volume":"84","author":"Delius","year":"1972","journal-title":"Acta Physiol Scand"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/00002508-200103000-00002","article-title":"The peripheral apparatus of muscle pain: evidence from animal and human studies","volume":"17","author":"Graven-Nielsen","year":"2001","journal-title":"Clin J Pain"},{"key":"B46","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/sc.2008.33","article-title":"Selective activation of muscle and skin nociceptors does not trigger exaggerated sympathetic responses in spinal injured subjects","volume":"46","author":"Burton","year":"2008","journal-title":"Spinal Cord"},{"issue":"1\u20132","key":"B47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pain.2004.04.033","article-title":"Human and animal experimental models of acute and chronic muscle pain: intramuscular algesic injection","volume":"110","author":"Capra","year":"2004","journal-title":"Pain"},{"issue":"6 Pt 2","key":"B48","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1161\/01.HYP.13.6.870","article-title":"Age-related changes in muscle sympathetic nerve activity in essential hypertension","volume":"13","author":"Yamada","year":"1989","journal-title":"Hypertension"},{"issue":"2","key":"B49","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1161\/01.HYP.27.2.276","article-title":"Sympathetic nerve activity and insulin in obese normotensive and hypertensive men","volume":"27","author":"Gudbj\u00f6rnsd\u00f3ttir","year":"1996","journal-title":"Hypertension"},{"issue":"4","key":"B50","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1161\/01.HYP.0000160318.46725.46","article-title":"Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity","volume":"45","author":"Narkiewicz","year":"2005","journal-title":"Hypertension"},{"key":"B51","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jpsychores.2010.09.012","article-title":"Autonomic cardiovascular control and responses to experimental pain stimulation in fibromyalgia syndrome","volume":"70","author":"Reyes del Paso","year":"2011","journal-title":"J Psychosom Res"},{"issue":"6","key":"B52","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1469-8986.1997.tb02140.x","article-title":"Heart rate variability: origins, methods, and interpretive caveats","volume":"34","author":"Berntson","year":"1997","journal-title":"Psychophysiology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/01.CIR.84.2.482","article-title":"Cardiovascular neural regulation explored in the frequency domain","volume":"84","author":"Malliani","year":"1991","journal-title":"Circulation"},{"issue":"12","key":"B54","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1113\/expphysiol.2010.056259","article-title":"Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes","volume":"96","author":"Goldstein","year":"2011","journal-title":"Exp Physiol"},{"issue":"9","key":"B55","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3389\/fnins.2015.00471","article-title":"Inter-individual responses to experimental muscle pain: baseline physiological parameters do not determine whether muscle sympathetic nerve activity increases or decreases during pain","volume":"17","author":"Kobuch","year":"2015","journal-title":"Front Neurosci"},{"key":"B56","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1113\/jphysiol.1977.sp012050","article-title":"The variability of muscle nerve sympathetic activity in resting recumbent man","volume":"272","author":"Sundlof","year":"1977","journal-title":"J Physiol"},{"issue":"6","key":"B57","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/01.HYP.0000165695.98915.9a","article-title":"Baroreflex regulation of heart rate and sympathetic vasomotor tone in women and men","volume":"45","author":"Tank","year":"2005","journal-title":"Hypertension"},{"issue":"Pt 9","key":"B58","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1113\/jphysiol.2009.170134","article-title":"Age- and fitness-related alterations in vascular sympathetic control","volume":"587","author":"Studinger","year":"2009","journal-title":"J Physiol"},{"issue":"3","key":"B59","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s11906-011-0191-1","article-title":"Sympathetic neural mechanisms in human blood pressure regulation","volume":"13","author":"Hart","year":"2011","journal-title":"Curr Hypertens Rep"},{"issue":"5","key":"B60","doi-asserted-by":"crossref","first-page":"H2028","DOI":"10.1152\/ajpheart.2001.281.5.H2028","article-title":"Gender affects sympathetic and hemodynamic response to postural stress","volume":"281","author":"Shoemaker","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijpsycho.2016.04.003","article-title":"Inter-individual responses to experimental muscle pain: baseline anxiety ratings and attitudes to pain do not determine the direction of the sympathetic response to tonic muscle pain in humans","volume":"104","author":"Kobuch","year":"2016","journal-title":"Int J Psychophysiol"},{"issue":"5","key":"B62","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/mus.20831","article-title":"Sympathetic neural control of integrated cardiovascular function: insights from measurement of human sympathetic nerve activity","volume":"36","author":"Wallin","year":"2007","journal-title":"Muscle Nerve"},{"issue":"3","key":"B63","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0165-1838(96)00043-4","article-title":"Skin sympathetic nerve activity and event-related potentials during auditory oddball paradigms","volume":"60","author":"Ito","year":"1996","journal-title":"J Auton Nerv Syst"},{"issue":"2\u20133","key":"B64","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0165-1838(97)00014-3","article-title":"Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis","volume":"64","author":"Iwase","year":"1997","journal-title":"J Auton Nerv Syst"},{"issue":"11","key":"B65","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1016\/j.clinph.2006.06.002","article-title":"Microneurography as a tool in clinical neurophysiology to investigate peripheral neural traffic in humans","volume":"117","author":"Mano","year":"2006","journal-title":"Clin Neurophysiol"},{"key":"B66","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511541667","volume-title":"The Integrative Action of the Autonomic Nervous System \u2013 Neurobiology of Homeostasis","author":"J\u00e4nig","year":"2006"},{"issue":"5","key":"B67","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1161\/01.CIR.82.5.1607","article-title":"Sex differences in control of cutaneous blood flow","volume":"82","author":"Cooke","year":"1990","journal-title":"Circulation"},{"issue":"3","key":"B68","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/S0008-6363(01)00508-9","article-title":"Gender, sex hormones and autonomic nervous control of the cardiovascular system","volume":"53","author":"Dart","year":"2002","journal-title":"Cardiovasc Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/00002508-200503000-00006","article-title":"Prevalence of clinical hypertension in patients with chronic pain compared to nonpain general medical patients","volume":"21","author":"Bruehl","year":"2005","journal-title":"Clin J Pain"},{"key":"B70","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1113\/eph8702355","article-title":"Distinct central representations of inescapable and escapable pain: observations and speculation","volume":"87","author":"Keay","year":"2002","journal-title":"Exp Physiol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0304-3959(79)90047-2","article-title":"On the relation of injury to pain","volume":"6","author":"Wall","year":"1979","journal-title":"Pain"}],"container-title":["Frontiers in Neurology"],"original-title":[],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T08:14:35Z","timestamp":1568103275000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fneur.2016.00109\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,30]]},"references-count":71,"URL":"https:\/\/doi.org\/10.3389\/fneur.2016.00109","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,30]]}}}