{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:19:44Z","timestamp":1785021584991,"version":"3.55.0"},"reference-count":31,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2016.00117","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T04:27:00Z","timestamp":1469420820000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":53,"title":["Non-Motor Symptoms in Patients Suffering from Motor Neuron Diseases"],"prefix":"10.3389","volume":"7","author":[{"given":"Ren\u00e9","family":"G\u00fcnther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sauerbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallol Ray","family":"Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Martinez-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nrm2873","article-title":"Prion-like transmission of protein aggregates in neurodegenerative diseases","volume":"11","author":"Brundin","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/mds.20844","article-title":"International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson\u2019s disease: the NMSQuest study","volume":"21","author":"Chaudhuri","year":"2006","journal-title":"Mov Disord"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1002\/mds.21596","article-title":"The metric properties of a novel non-motor symptoms scale for Parkinson\u2019s disease: results from an international pilot study","volume":"22","author":"Chaudhuri","year":"2007","journal-title":"Mov Disord"},{"key":"B4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/146608299300079484","article-title":"Gastrointestinal dysfunction in amyotrophic lateral sclerosis","volume":"1","author":"Toepfer","year":"1999","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1007\/s00415-015-7672-0","article-title":"Small-fibre neuropathy related to bulbar and spinal-onset in patients with ALS","volume":"262","author":"Truini","year":"2015","journal-title":"J Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3109\/21678421.2014.951944","article-title":"The evaluation of pain in amyotrophic lateral sclerosis: a case controlled observational study","volume":"15","author":"Wallace","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"B7","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1468-1331.2011.03540.x","article-title":"Pain in amyotrophic lateral sclerosis: a population-based controlled study","volume":"19","author":"Chio","year":"2012","journal-title":"Eur J Neurol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1468-1331.2011.03541.x","article-title":"Reassessing received wisdom in ALS \u2013 pain is common when studied systematically","volume":"19","author":"Wicks","year":"2012","journal-title":"Eur J Neurol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/brain\/awr016","article-title":"Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging study","volume":"134","author":"van der Graaff","year":"2011","journal-title":"Brain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.nmd.2008.10.002","article-title":"Upper motor neuron and extra-motor neuron involvement in amyotrophic lateral sclerosis: a clinical and brain imaging review","volume":"19","author":"van der Graaff","year":"2009","journal-title":"Neuromuscul Disord"},{"key":"B11","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nrneurol.2013.221","article-title":"Amyotrophic lateral sclerosis-a model of corticofugal axonal spread","volume":"9","author":"Braak","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann Neurol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1093\/brain\/awu090","article-title":"Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology","volume":"137","author":"Kassubek","year":"2014","journal-title":"Brain"},{"issue":"Suppl","key":"B14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0022-510X(94)90191-0","article-title":"El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases\/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial \u201cClinical limits of amyotrophic lateral sclerosis\u201d workshop contributors","volume":"124","author":"Brooks","year":"1994","journal-title":"J Neurol Sci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"B16","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s00115-010-3010-z","article-title":"Non-motor symptoms questionnaire and scale for Parkinson\u2019s disease. Cross-cultural adaptation into the German language","volume":"81","author":"Storch","year":"2010","journal-title":"Nervenarzt"},{"key":"B17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3233\/JPD-130273","article-title":"An update of the impact of deep brain stimulation on non motor symptoms in Parkinson\u2019s disease","volume":"4","author":"Klingelhoefer","year":"2014","journal-title":"J Parkinsons Dis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nrneurol.2014.184","article-title":"The phenotypic variability of amyotrophic lateral sclerosis","volume":"10","author":"Swinnen","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3109\/21678421.2013.868001","article-title":"Increased prevalence of bladder and intestinal dysfunction in amyotrophic lateral sclerosis","volume":"15","author":"Nubling","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"B20","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/01.wco.0000183114.76056.0e","article-title":"Autonomic impairment in amyotrophic lateral sclerosis","volume":"18","author":"Baltadzhieva","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3109\/17482960903390855","article-title":"Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis","volume":"11","author":"Pavlovic","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"B22","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00415-013-7171-0","article-title":"Risk factors and prodromal markers and the development of Parkinson\u2019s disease","volume":"261","author":"Lerche","year":"2014","journal-title":"J Neurol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12883-015-0280-x","article-title":"The diagnostic value of midbrain hyperechogenicity in ALS is limited for discriminating key ALS differential diagnoses","volume":"15","author":"Hermann","year":"2015","journal-title":"BMC Neurol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s00415-012-6654-8","article-title":"Parkinson\u2019s disease-like midbrain hyperechogenicity is frequent in amyotrophic lateral sclerosis","volume":"260","author":"Fathinia","year":"2013","journal-title":"J Neurol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3109\/17482968.2010.536839","article-title":"Depression in amyotrophic lateral sclerosis","volume":"12","author":"Atassi","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"B26","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3238\/arztebl.2008.0397","article-title":"Depression and quality of life in patients with amyotrophic lateral sclerosis","volume":"105","author":"Lul\u00e9","year":"2008","journal-title":"Dtsch Arztebl Int"},{"key":"B27","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2165\/00023210-200721040-00003","article-title":"Depression and anxiety in individuals with amyotrophic lateral sclerosis: epidemiology and management","volume":"21","author":"Kurt","year":"2007","journal-title":"CNS Drugs"},{"key":"B28","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1136\/jnnp.73.1.68","article-title":"Progressive sudomotor dysfunction in amyotrophic lateral sclerosis","volume":"73","author":"Beck","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1212\/WNL.0000000000002305","article-title":"Cognitive-behavioral screening reveals prevalent impairment in a large multicenter ALS cohort","volume":"86","author":"Murphy","year":"2016","journal-title":"Neurology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3109\/17482961003692604","article-title":"Meaning in life in patients with amyotrophic lateral sclerosis","volume":"11","author":"Fegg","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"B31","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/13548506.2011.651149","article-title":"Quality of life of patients with amyotrophic lateral sclerosis","volume":"17","author":"Tramonti","year":"2012","journal-title":"Psychol Health Med"}],"container-title":["Frontiers in Neurology"],"original-title":[],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T15:05:43Z","timestamp":1498316743000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fneur.2016.00117\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,25]]},"references-count":31,"URL":"https:\/\/doi.org\/10.3389\/fneur.2016.00117","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,25]]}}}