{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:48:57Z","timestamp":1790693337414,"version":"4.1.0"},"reference-count":31,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2017.00040","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T02:36:13Z","timestamp":1489458973000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Decreased HHV-6 IgG in Alzheimer\u2019s Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Gabriel","family":"Westman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Blomberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibing","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lannfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ingelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt-Marie","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"issue":"8","key":"B1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5694\/j.1326-5377.1985.tb113444.x","article-title":"Pyloric Campylobacter infection and gastroduodenal disease","volume":"142","author":"Marshall","year":"1985","journal-title":"Med J Aust"},{"issue":"1","key":"B2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:112::AID-PATH4313.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"issue":"4","key":"B3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3109\/00365548409073957","article-title":"IgG antibodies to cytomegalovirus in a normal urban Swedish population","volume":"16","author":"Ahlfors","year":"1984","journal-title":"Scand J Infect Dis"},{"issue":"1","key":"B4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/jmv.1890430117","article-title":"Seroprevalence of antibodies to human herpesviruses in England and Hong Kong","volume":"43","author":"Kangro","year":"1994","journal-title":"J Med Virol"},{"issue":"3","key":"B5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1136\/sti.2003.005850","article-title":"The seroepidemiology of herpes simplex virus type 1 and 2 in Europe","volume":"80","author":"Pebody","year":"2004","journal-title":"Sex Transm Infect"},{"issue":"2","key":"B6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jcv.2006.07.012","article-title":"Changes in seroprevalence to four herpesviruses over 30 years in Swedish children aged 9-12 years","volume":"37","author":"Svahn","year":"2006","journal-title":"J Clin Virol"},{"issue":"6","key":"B7","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1001\/archneur.1990.00530060054017","article-title":"Long-term cognitive sequelae of acyclovir-treated herpes simplex encephalitis","volume":"47","author":"Gordon","year":"1990","journal-title":"Arch Neurol"},{"issue":"3","key":"B8","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/path.1127","article-title":"Herpesviruses in brain and Alzheimer\u2019s disease","volume":"197","author":"Lin","year":"2002","journal-title":"J Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/82_2009_3","article-title":"Neurological disease produced by varicella zoster virus reactivation without rash","volume":"342","author":"Gilden","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"issue":"3","key":"B10","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pediatrneurol.2007.05.011","article-title":"Primary human herpesvirus-6 infection in the central nervous system can cause severe disease","volume":"37","author":"Mannonen","year":"2007","journal-title":"Pediatr Neurol"},{"issue":"24","key":"B11","doi-asserted-by":"crossref","first-page":"10948","DOI":"10.1523\/JNEUROSCI.19-24-10948.1999","article-title":"Cytomegalovirus cell tropism, replication, and gene transfer in brain","volume":"19","author":"van Den Pol","year":"1999","journal-title":"J Neurosci"},{"issue":"8","key":"B12","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.arcmed.2012.11.003","article-title":"Epidemiology of dementias and Alzheimer\u2019s disease","volume":"43","author":"Sosa-Ortiz","year":"2012","journal-title":"Arch Med Res"},{"issue":"11","key":"B13","doi-asserted-by":"publisher","first-page":"e3637","DOI":"10.1371\/journal.pone.0003637","article-title":"Seropositivity to herpes simplex virus antibodies and risk of Alzheimer\u2019s disease: a population-based cohort study","volume":"3","author":"Letenneur","year":"2008","journal-title":"PLoS One"},{"issue":"6","key":"B14","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jalz.2014.04.522","article-title":"Reactivated herpes simplex infection increases the risk of Alzheimer\u2019s disease","volume":"11","author":"Lovheim","year":"2015","journal-title":"Alzheimers Dement"},{"issue":"6","key":"B15","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jalz.2014.07.157","article-title":"Herpes simplex infection and the risk of Alzheimer\u2019s disease \u2013 a nested case-control study","volume":"11","author":"Lovheim","year":"2015","journal-title":"Alzheimers Dement"},{"issue":"7","key":"B16","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.neurobiolaging.2004.09.008","article-title":"Interaction of herpesviridae, APOE gene, and education in cognitive impairment","volume":"26","author":"Strandberg","year":"2005","journal-title":"Neurobiol Aging"},{"issue":"9","key":"B17","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1161\/01.STR.0000086754.32238.DA","article-title":"Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases","volume":"34","author":"Strandberg","year":"2003","journal-title":"Stroke"},{"issue":"4","key":"B18","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/infdis\/jit210","article-title":"Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease","volume":"208","author":"Lurain","year":"2013","journal-title":"J Infect Dis"},{"issue":"7","key":"B19","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1111\/j.1532-5415.2006.00796.x","article-title":"The influence of latent viral infection on rate of cognitive decline over 4 years","volume":"54","author":"Aiello","year":"2006","journal-title":"J Am Geriatr Soc"},{"issue":"10","key":"B20","doi-asserted-by":"publisher","first-page":"e77921","DOI":"10.1371\/journal.pone.0077921","article-title":"Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer\u2019s disease","volume":"8","author":"Westman","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"B21","doi-asserted-by":"publisher","first-page":"e96779","DOI":"10.1371\/journal.pone.0096779","article-title":"Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer\u2019s disease","volume":"9","author":"Westman","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"B22","doi-asserted-by":"publisher","first-page":"e81155","DOI":"10.1371\/journal.pone.0081155","article-title":"Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis","volume":"8","author":"Elfaitouri","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"B23","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.4049\/jimmunol.135.4.2589","article-title":"Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodies","volume":"135","author":"Akerstrom","year":"1985","journal-title":"J Immunol"},{"key":"B24","volume-title":"Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment","author":"Westfall","year":"1993"},{"issue":"1","key":"B25","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neurobiolaging.2013.06.024","article-title":"Herpes virus in Alzheimer\u2019s disease: relation to progression of the disease","volume":"35","author":"Carbone","year":"2013","journal-title":"Neurobiol Aging"},{"issue":"1","key":"B26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3233\/JAD-150464","article-title":"Lack of evidence for a role of HHV-6 in the pathogenesis of Alzheimer\u2019s disease","volume":"49","author":"Agostini","year":"2015","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"B27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1096\/fasebj.13.1.63","article-title":"TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs","volume":"13","author":"Blasko","year":"1999","journal-title":"FASEB J"},{"issue":"2","key":"B28","first-page":"105","article-title":"Interferences in immunoassay","volume":"25","author":"Tate","year":"2004","journal-title":"Clin Biochem Rev"},{"issue":"8","key":"B29","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1128\/CDLI.12.8.959-969.2005","article-title":"Optimization and validation of a multiplexed Luminex assay to quantify antibodies to neutralizing epitopes on human papillomaviruses 6, 11, 16, and 18","volume":"12","author":"Dias","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"issue":"1","key":"B30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/JVI.56.1.333-336.1985","article-title":"Cross-reactivity between herpes simplex virus glycoprotein B and a 63,000-dalton varicella-zoster virus envelope glycoprotein","volume":"56","author":"Edson","year":"1985","journal-title":"J Virol"},{"issue":"4","key":"B31","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1128\/CDLI.8.4.747-756.2001","article-title":"Cross-reactivity of Epstein-Barr virus-specific immunoglobulin M antibodies with cytomegalovirus antigens containing glycine homopolymers","volume":"8","author":"Lang","year":"2001","journal-title":"Clin Diagn Lab Immunol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00040\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:26:26Z","timestamp":1692707186000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00040\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,20]]},"references-count":31,"URL":"https:\/\/doi.org\/10.3389\/fneur.2017.00040","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,20]]}}}