{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:20:21Z","timestamp":1787026821000,"version":"build-2736575974"},"reference-count":52,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81171181"],"award-info":[{"award-number":["No. 81171181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2017.00132","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T23:33:45Z","timestamp":1491953625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Toll-Like Receptor 4\u2013Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Inflammatory Development of Polymyositis by Mediating Interferon-\u03b3 and Interleukin-17A in Humans and Experimental Autoimmune Myositis Mouse Model"],"prefix":"10.3389","volume":"8","author":[{"given":"Hongya","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongge","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"issue":"3","key":"B1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.coph.2010.03.001","article-title":"Inflammatory muscle diseases: a critical review on pathogenesis and therapies","volume":"10","author":"Dalakas","year":"2010","journal-title":"Curr Opin Pharmacol"},{"issue":"5","key":"B2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.nmd.2004.02.006","article-title":"119th ENMC International Workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands","volume":"14","author":"Hoogendijk","year":"2004","journal-title":"Neuromuscul Disord"},{"issue":"3","key":"B3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.nmd.2014.12.001","article-title":"205th ENMC International Workshop: pathology diagnosis of idiopathic inflammatory myopathies part II 28-30 March 2014, Naarden, The Netherlands","volume":"25","author":"De Bleecker","year":"2015","journal-title":"Neuromuscul Disord"},{"issue":"8","key":"B4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.nmd.2016.05.014","article-title":"213th ENMC International Workshop: outcome measures and clinical trial readiness in idiopathic inflammatory myopathies, Heemskerk, The Netherlands, 18-20 September 2015","volume":"26","author":"Benveniste","year":"2016","journal-title":"Neuromuscul Disord"},{"issue":"8","key":"B5","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1136\/annrheumdis-2013-205127","article-title":"Prevalence and clinical characteristics of adult polymyositis and dermatomyositis; data from a large and unselected Norwegian cohort","volume":"74","author":"Dobloug","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"B6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/joim.12524","article-title":"Diagnosis and classification of idiopathic inflammatory myopathies","volume":"280","author":"Lundberg","year":"2016","journal-title":"J Intern Med"},{"issue":"9388","key":"B7","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/S0140-6736(03)14368-1","article-title":"Polymyositis and dermatomyositis","volume":"362","author":"Dalakas","year":"2003","journal-title":"Lancet"},{"issue":"5","key":"B8","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.4049\/jimmunol.173.5.2913","article-title":"Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll\/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling","volume":"173","author":"Gohda","year":"2004","journal-title":"J Immunol"},{"key":"B9","first-page":"1","article-title":"TLR signaling","volume":"311","author":"Akira","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1146\/annurev.biochem.76.060305.151318","article-title":"Structure and function of toll receptors and their ligands","volume":"76","author":"Gay","year":"2007","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"B11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.immuni.2010.07.005","article-title":"Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation","volume":"33","author":"Garin","year":"2010","journal-title":"Immunity"},{"issue":"6","key":"B12","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1097\/BOR.0b013e3283317b31","article-title":"Role of cytokines and chemokines in idiopathic inflammatory myopathies","volume":"21","author":"De Paepe","year":"2009","journal-title":"Curr Opin Rheumatol"},{"issue":"13","key":"B13","doi-asserted-by":"publisher","first-page":"7749","DOI":"10.1073\/pnas.1332767100","article-title":"T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells","volume":"100","author":"Lugo-Villarino","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"B14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/ni.1969","article-title":"T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat","volume":"12","author":"Lazarevic","year":"2011","journal-title":"Nat Immunol"},{"issue":"12","key":"B15","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/nri3095","article-title":"TLR-dependent T cell activation in autoimmunity","volume":"11","author":"Mills","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"925135","DOI":"10.1155\/2012\/925135","article-title":"CD4(+)T cells: differentiation and functions","volume":"2012","author":"Luckheeram","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"3","key":"B17","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1365-2249.2006.03311.x","article-title":"Expression of functional toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjogren\u2019s syndrome","volume":"147","author":"Spachidou","year":"2007","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"B18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.tvjl.2015.07.003","article-title":"Expression of T helper type 17 (Th17)-associated cytokines and toll-like receptor 4 and their correlation with Foxp3 positive cells in rectal biopsies of horses with clinical signs of inflammatory bowel disease","volume":"206","author":"Olofsson","year":"2015","journal-title":"Vet J"},{"issue":"7","key":"B19","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3899\/jrheum.151386","article-title":"Cell membrane-bound TLR2 and TLR4: potential predictors of active systemic lupus erythematosus and lupus nephritis","volume":"43","author":"Perez-Ferro","year":"2016","journal-title":"J Rheumatol"},{"issue":"6","key":"B20","doi-asserted-by":"publisher","first-page":"e99053","DOI":"10.1371\/journal.pone.0099053","article-title":"Toll-like receptor 4 mediates endothelial cell activation through NF-kappaB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis","volume":"9","author":"Menghini","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"B21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1093\/intimm\/dxv025","article-title":"Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4","volume":"27","author":"Duperray","year":"2015","journal-title":"Int Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jaut.2013.12.013","article-title":"Innate immunity in myasthenia gravis thymus: pathogenic effects of toll-like receptor 4 signaling on autoimmunity","volume":"52","author":"Cordiglieri","year":"2014","journal-title":"J Autoimmun"},{"issue":"3","key":"B23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10067-009-1316-7","article-title":"Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis","volume":"29","author":"Kim","year":"2010","journal-title":"Clin Rheumatol"},{"issue":"3","key":"B24","first-page":"272","article-title":"[The expression and significance of TLR4, MyD88 and NF-kappaB mRNA in mouse lymph node of experimental autoimmune myositis]","volume":"28","author":"Zhang","year":"2012","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"issue":"3","key":"B25","doi-asserted-by":"publisher","first-page":"989","DOI":"10.2353\/ajpath.2009.080422","article-title":"Role of regulatory T cells in a new mouse model of experimental autoimmune myositis","volume":"174","author":"Allenbach","year":"2009","journal-title":"Am J Pathol"},{"issue":"11","key":"B26","first-page":"14457","article-title":"Development of an improved animal model of experimental autoimmune myositis","volume":"8","author":"Kang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"B27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0166-4328(01)00231-5","article-title":"A comparison of 129S2\/SvHsd and C57BL\/6JOlaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice","volume":"124","author":"Contet","year":"2001","journal-title":"Behav Brain Res"},{"issue":"2","key":"B28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0022-510X(97)00148-2","article-title":"Myosin-induced autoimmune polymyositis in the rat","volume":"151","author":"Kojima","year":"1997","journal-title":"J Neurol Sci"},{"issue":"5","key":"B29","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s10067-015-2891-4","article-title":"Idiopathic inflammatory myopathies \u2013 a review","volume":"34","author":"Jones","year":"2015","journal-title":"Clin Rheumatol"},{"issue":"4","key":"B30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/MD.0b013e31829d08f9","article-title":"The myositis autoantibody phenotypes of the juvenile idiopathic inflammatory myopathies","volume":"92","author":"Rider","year":"2013","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"B31","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1097\/NEN.0b013e31826bf7f3","article-title":"Toll-like receptors promote inflammation in idiopathic inflammatory myopathies","volume":"71","author":"Brunn","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4137\/CMAMD.S10272","article-title":"Phenotypes of peripheral blood lymphocytes and cytokine expression in polymyositis and dermatomyositis before treatment and after clinical remission","volume":"5","author":"Shimojima","year":"2012","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"issue":"3","key":"B33","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/cei.12445","article-title":"Cytokines in immune-mediated inflammatory myopathies: cellular sources, multiple actions and therapeutic implications","volume":"178","author":"Moran","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.2741\/2866","article-title":"Chemokines in idiopathic inflammatory myopathies","volume":"13","author":"De Paepe","year":"2008","journal-title":"Front Biosci"},{"issue":"3","key":"B35","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3109\/03009742.2014.956141","article-title":"Correlation between serum levels of IL-15 and IL-17 in patients with idiopathic inflammatory myopathies","volume":"44","author":"Notarnicola","year":"2015","journal-title":"Scand J Rheumatol"},{"issue":"8","key":"B36","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1002\/art.39650","article-title":"CD4+ and CD8+ CD28(null) T cells are cytotoxic to autologous muscle cells in patients with polymyositis","volume":"68","author":"Pandya","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"B37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1365-2249.2006.03180.x","article-title":"Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies","volume":"146","author":"Tucci","year":"2006","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"B38","doi-asserted-by":"publisher","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"609593","DOI":"10.1155\/2015\/609593","article-title":"Th1, Th2, and Th17 cytokine involvement in thyroid associated ophthalmopathy","volume":"2015","author":"Shen","year":"2015","journal-title":"Dis Markers"},{"issue":"6","key":"B40","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"issue":"6","key":"B41","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/ni794","article-title":"T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells","volume":"3","author":"Afkarian","year":"2002","journal-title":"Nat Immunol"},{"issue":"7363","key":"B42","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature10339","article-title":"Different patterns of peripheral migration by memory CD4+ and CD8+ T cells","volume":"477","author":"Gebhardt","year":"2011","journal-title":"Nature"},{"issue":"6","key":"B43","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2177\/jsci.29.359","article-title":"[Lymphocyte trafficking and immunesurveillance]","volume":"29","author":"Tanaka","year":"2006","journal-title":"Nihon Rinsho Men\u2019eki Gakkai Kaishi"},{"issue":"5","key":"B44","doi-asserted-by":"publisher","first-page":"e1003586","DOI":"10.1371\/journal.pcbi.1003586","article-title":"Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism","volume":"10","author":"Ganusov","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"6978936","DOI":"10.1155\/2016\/6978936","article-title":"The role of toll-like receptor 4 in infectious and noninfectious inflammation","volume":"2016","author":"Molteni","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"3","key":"B46","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10974-015-9411-7","article-title":"HMGB1 expression and muscle regeneration in idiopathic inflammatory myopathies and degenerative joint diseases","volume":"36","author":"Cseri","year":"2015","journal-title":"J Muscle Res Cell Motil"},{"issue":"4","key":"B47","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrrheum.2011.222","article-title":"HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"7","key":"B48","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/gene.2015.28","article-title":"Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes","volume":"16","author":"Miller","year":"2015","journal-title":"Genes Immun"},{"issue":"6","key":"B49","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1097\/BOR.0000000000000328","article-title":"New developments in genetics of myositis","volume":"28","author":"Rothwell","year":"2016","journal-title":"Curr Opin Rheumatol"},{"issue":"8","key":"B50","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1136\/annrheumdis-2015-208119","article-title":"Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups","volume":"75","author":"Rothwell","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"B51","first-page":"198","article-title":"Association of HLA-DRB1 alleles with polymyositis\/dermatomyositis in northern Chinese Hans","volume":"17","author":"Zhai","year":"2002","journal-title":"Chin Med Sci J"},{"issue":"11","key":"B52","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.1002\/art.22205","article-title":"HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies","volume":"54","author":"O\u2019Hanlon","year":"2006","journal-title":"Arthritis Rheum"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00132\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T23:33:50Z","timestamp":1491953630000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00132\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":52,"URL":"https:\/\/doi.org\/10.3389\/fneur.2017.00132","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}