{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:16:15Z","timestamp":1790399775384,"version":"4.1.0"},"reference-count":38,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["MOST 103-2314-B-182A-010 -MY3, MOST 104-2314-B-182A-053"],"award-info":[{"award-number":["MOST 103-2314-B-182A-010 -MY3, MOST 104-2314-B-182A-053"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG891511, CMRPG8B0831"],"award-info":[{"award-number":["CMRPG891511, CMRPG8B0831"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2017.00323","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T04:04:04Z","timestamp":1500264244000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson\u2019s Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Wei-Che","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chin","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Wen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsien","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuron.2012.09.023","article-title":"Dopaminergic modulation of synaptic transmission in cortex and striatum","volume":"76","author":"Tritsch","year":"2012","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nrneurol.2014.205","article-title":"Neuroimaging in Parkinson disease: from research setting to clinical practice","volume":"10","author":"Politis","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"B3","first-page":"207","article-title":"Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson\u2019s disease","volume":"45","author":"Hwang","year":"2004","journal-title":"J Nucl Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4285","DOI":"10.1073\/pnas.1119969109","article-title":"Adaptive coding of reward prediction errors is gated by striatal coupling","volume":"109","author":"Park","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1093\/cercor\/bhj088","article-title":"Basal ganglia functional connectivity based on a meta-analysis of 126 positron emission tomography and functional magnetic resonance imaging publications","volume":"16","author":"Postuma","year":"2006","journal-title":"Cereb Cortex"},{"key":"B6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"Non-motor symptoms of Parkinson\u2019s disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"Lancet Neurol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/mds.23462","article-title":"The impact of non-motor symptoms on health-related quality of life of patients with Parkinson\u2019s disease","volume":"26","author":"Martinez-Martin","year":"2011","journal-title":"Mov Disord"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1093\/cercor\/bhp178","article-title":"Spatial remapping of cortico-striatal connectivity in Parkinson\u2019s disease","volume":"20","author":"Helmich","year":"2010","journal-title":"Cereb Cortex"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1016\/j.neuroimage.2011.12.021","article-title":"Functional brain networks and abnormal connectivity in the movement disorders","volume":"62","author":"Poston","year":"2012","journal-title":"Neuroimage"},{"key":"B10","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1093\/brain\/aws360","article-title":"The cerebellum in Parkinson\u2019s disease","volume":"136","author":"Wu","year":"2013","journal-title":"Brain"},{"key":"B11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fnsys.2010.00019","article-title":"Clinical applications of resting state functional connectivity","volume":"4","author":"Fox","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1093\/cercor\/bhn041","article-title":"Functional connectivity of human striatum: a resting state FMRI study","volume":"18","author":"Di Martino","year":"2008","journal-title":"Cereb Cortex"},{"key":"B13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/mds.10338","article-title":"State of the art review: molecular diagnosis of inherited movement disorders. Movement disorders society task force on molecular diagnosis","volume":"18","author":"Gasser","year":"2003","journal-title":"Mov Disord"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/mds.20213","article-title":"Movement disorder society task force report on the Hoehn and Yahr staging scale: status and recommendations","volume":"19","author":"Goetz","year":"2004","journal-title":"Mov Disord"},{"key":"B16","volume-title":"Projection Technique for Evaluating Surgery in Parkinson\u2019s Disease","author":"Schwab","year":"1969"},{"key":"B17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000066024","article-title":"Cutoff scores of the cognitive abilities screening instrument, Chinese version in screening of dementia","volume":"14","author":"Lin","year":"2002","journal-title":"Dement Geriatr Cogn Disord"},{"key":"B19","doi-asserted-by":"publisher","first-page":"879497","DOI":"10.1155\/2014\/879497","article-title":"The feasibility of using CT-guided ROI for semiquantifying striatal dopamine transporter availability in a hybrid SPECT\/CT system","volume":"2014","author":"Hsu","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"B20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnsys.2010.00013","article-title":"DPARSF: a MATLAB toolbox for \u201cPipeline\u201d data analysis of resting-state fMRI","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e0126834","DOI":"10.1371\/journal.pone.0126834","article-title":"Resting state-fMRI with ReHo analysis as a non-invasive modality for the prognosis of cirrhotic patients with overt hepatic encephalopathy","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"B22","article-title":"Simultaneous inference for fMRI data","volume-title":"AFNI 3dDeconvolve Documentation","author":"Ward","year":"2000"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1002\/hbm.22724","article-title":"Structural covariance networks of striatum subdivision in patients with Parkinson\u2019s disease","volume":"36","author":"Chou","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"B24","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024S0896-6273(09)00249-9","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"key":"B25","doi-asserted-by":"publisher","first-page":"7143","DOI":"10.1523\/JNEUROSCI.1486-08.2008","article-title":"Evidence for segregated and integrative connectivity patterns in the human basal ganglia","volume":"28","author":"Draganski","year":"2008","journal-title":"J Neurosci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.brainresrev.2008.12.023","article-title":"Activity-dependent structural plasticity","volume":"60","author":"Butz","year":"2009","journal-title":"Brain Res Rev"},{"key":"B27","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1006\/brcg.1999.1099","article-title":"Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies","volume":"42","author":"Middleton","year":"2000","journal-title":"Brain Cogn"},{"key":"B28","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/brain\/awl326","article-title":"Cortical activity in Parkinson\u2019s disease during executive processing depends on striatal involvement","volume":"130","author":"Monchi","year":"2007","journal-title":"Brain"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1002\/mds.23101","article-title":"Abnormal visual activation in Parkinson\u2019s disease patients","volume":"25","author":"Cardoso","year":"2010","journal-title":"Mov Disord"},{"key":"B30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/npp.2009.88","article-title":"The neural circuitry of executive functions in healthy subjects and Parkinson\u2019s disease","volume":"35","author":"Leh","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1177\/1073858404266776","article-title":"Cognitive dysfunction in Parkinson\u2019s disease: the role of frontostriatal circuitry","volume":"10","author":"Owen","year":"2004","journal-title":"Neuroscientist"},{"key":"B32","doi-asserted-by":"publisher","first-page":"281561","DOI":"10.1155\/2009\/281561","article-title":"Synapse plasticity in motor, sensory, and limbo-prefrontal cortex areas as measured by degrading axon terminals in an environment model of gerbils (Meriones unguiculatus)","volume":"2009","author":"Neufeld","year":"2009","journal-title":"Neural Plast"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e455","DOI":"10.1038\/cddis.2012.194","article-title":"Dopamine protects neurons against glutamate-induced excitotoxicity","volume":"4","author":"Vaarmann","year":"2013","journal-title":"Cell Death Dis"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.3174\/ajnr.A4447","article-title":"Longitudinal study of gray matter changes in Parkinson disease","volume":"36","author":"Jia","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1093\/brain\/awh445","article-title":"Depression in Parkinson\u2019s disease: loss of dopamine and noradrenaline innervation in the limbic system","volume":"128","author":"Remy","year":"2005","journal-title":"Brain"},{"key":"B36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.neuroimage.2010.11.074","article-title":"Effective connectivity of brain networks during self-initiated movement in Parkinson\u2019s disease","volume":"55","author":"Wu","year":"2011","journal-title":"Neuroimage"},{"key":"B37","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.neuroimage.2006.11.047","article-title":"Role of hyperactive cerebellum and motor cortex in Parkinson\u2019s disease","volume":"35","author":"Yu","year":"2007","journal-title":"Neuroimage"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00323\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T04:04:09Z","timestamp":1500264249000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00323\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,17]]},"references-count":38,"alternative-id":["10.3389\/fneur.2017.00323"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2017.00323","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,17]]},"article-number":"323"}}