{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:12:29Z","timestamp":1768705949554,"version":"3.49.0"},"reference-count":88,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2017.00516","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:15:29Z","timestamp":1506471329000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic 5-Aminoimidazole-4-Carboxamide-1-\u03b2-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6\/2 Mouse Model of Huntington\u2019s Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Marie-France","family":"Par\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Jasmin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"c3109","DOI":"10.1136\/bmj.c3109","article-title":"Huntington\u2019s disease","volume":"340","author":"Novak","year":"2010","journal-title":"BMJ"},{"key":"B2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ncl.2014.09.003","article-title":"Huntington disease","volume":"33","author":"Dayalu","year":"2015","journal-title":"Neurol Clin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. The Huntingtons Disease Collaborative Research Group","volume":"72","year":"1993","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1093\/hmg\/2.12.2069","article-title":"Characterization and localization of the Huntington disease gene product","volume":"2","author":"Hoogeveen","year":"1993","journal-title":"Hum Mol Genet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/S1474-4422(15)00177-5","article-title":"Treating the whole body in Huntington\u2019s disease","volume":"14","author":"Carroll","year":"2015","journal-title":"Lancet Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.tibs.2013.05.003","article-title":"Huntington\u2019s disease: underlying molecular mechanisms and emerging concepts","volume":"38","author":"Labbadia","year":"2013","journal-title":"Trends Biochem Sci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11910-017-0739-9","article-title":"Huntington\u2019s disease-update on treatments","volume":"17","author":"Wyant","year":"2017","journal-title":"Curr Neurol Neurosci Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000350946","article-title":"Neuroscience of exercise: from neurobiology mechanisms to mental health","volume":"68","author":"Matta Mello Portugal","year":"2013","journal-title":"Neuropsychobiology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1152\/japplphysiol.00500.2006","article-title":"Exercise, cognition, and the aging brain","volume":"101","author":"Kramer","year":"2006","journal-title":"J Appl Physiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fpsyg.2012.00086","article-title":"The effects of aerobic activity on brain structure","volume":"3","author":"Thomas","year":"2012","journal-title":"Front Psychol"},{"key":"B12","first-page":"3144","article-title":"Exercise improves cognitive function in aging patients","volume":"7","author":"Hu","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/arclin\/acv001","article-title":"The effects of a brief, water-based exercise intervention on cognitive function in older adults","volume":"30","author":"Fedor","year":"2015","journal-title":"Arch Clin Neuropsychol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1249\/MSS.0000000000000383","article-title":"Dose-response relation between exercise duration and cognition","volume":"47","author":"Chang","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"B15","doi-asserted-by":"publisher","first-page":"709","DOI":"10.3390\/brainsci2040709","article-title":"On aerobic exercise and behavioral and neural plasticity","volume":"2","author":"Swain","year":"2012","journal-title":"Brain Sci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.bbi.2011.11.008","article-title":"The association between aerobic fitness and executive function is mediated by prefrontal cortex volume","volume":"26","author":"Weinstein","year":"2012","journal-title":"Brain Behav Immun"},{"key":"B17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neuroscience.2003.09.029","article-title":"Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague\u2013Dawley rats in vivo","volume":"124","author":"Farmer","year":"2004","journal-title":"Neuroscience"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.neuroscience.2005.10.050","article-title":"Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus","volume":"137","author":"Redila","year":"2006","journal-title":"Neuroscience"},{"key":"B19","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/6368","article-title":"Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus","volume":"2","author":"van Praag","year":"1999","journal-title":"Nat Neurosci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00415-016-8310-1","article-title":"Exercise effects in Huntington disease","volume":"264","author":"Frese","year":"2017","journal-title":"J Neurol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.parkreldis.2016.06.023","article-title":"A randomized, controlled trial of a multi-modal exercise intervention in Huntington\u2019s disease","volume":"31","author":"Quinn","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"B22","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.expneurol.2013.07.014","article-title":"Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6\/1 Huntington\u2019s disease mouse model","volume":"248","author":"Harrison","year":"2013","journal-title":"Exp Neurol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.neuroscience.2015.07.025","article-title":"Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6\/1 model of Huntington\u2019s disease","volume":"303","author":"Herbst","year":"2015","journal-title":"Neuroscience"},{"key":"B24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.12965\/jer.150182","article-title":"Treadmill exercise improves short-term memory by enhancing hippocampal cell proliferation in quinolinic acid-induced Huntington\u2019s disease rats","volume":"11","author":"Kim","year":"2015","journal-title":"J Exerc Rehabil"},{"key":"B25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.12965\/jer.150212","article-title":"Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington\u2019s disease rats","volume":"11","author":"Ji","year":"2015","journal-title":"J Exerc Rehabil"},{"key":"B26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1471-2202-9-34","article-title":"Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington\u2019s disease","volume":"9","author":"van Dellen","year":"2008","journal-title":"BMC Neurosci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.brainres.2007.04.039","article-title":"Physical activity fails to rescue hippocampal neurogenesis deficits in the R6\/2 mouse model of Huntington\u2019s disease","volume":"1155","author":"Kohl","year":"2007","journal-title":"Brain Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"RRN1201","DOI":"10.1371\/currents.RRN1201","article-title":"Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington\u2019s disease","volume":"2","author":"Potter","year":"2010","journal-title":"PLoS Curr"},{"key":"B29","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1249\/JSR.0b013e3181e93938","article-title":"Endurance exercise mimetics in skeletal muscle","volume":"9","author":"Matsakas","year":"2010","journal-title":"Curr Sports Med Rep"},{"key":"B30","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.cell.2008.06.051","article-title":"AMPK and PPAR\u03b4 agonists are exercise mimetics","volume":"134","author":"Narkar","year":"2008","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1152\/japplphysiol.00349.2003","article-title":"Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles","volume":"95","author":"Suwa","year":"2003","journal-title":"J Appl Physiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/hmg\/ddv444","article-title":"Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles","volume":"25","author":"P\u00e9ladeau","year":"2015","journal-title":"Hum Mol Genet"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.1093\/hmg\/ddr265","article-title":"Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle","volume":"20","author":"Ljubicic","year":"2011","journal-title":"Hum Mol Genet"},{"key":"B34","doi-asserted-by":"publisher","first-page":"C110","DOI":"10.1152\/ajpcell.00183.2011","article-title":"Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle","volume":"302","author":"Ljubicic","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1093\/hmg\/ddu535","article-title":"Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation","volume":"24","author":"Al-Rewashdy","year":"2015","journal-title":"Hum Mol Genet"},{"key":"B36","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1172\/JCI89616","article-title":"Targeting deregulated AMPK\/mTORC1 pathways improves muscle function in myotonic dystrophy type I","volume":"127","author":"Brockhoff","year":"2017","journal-title":"J Clin Invest"},{"key":"B37","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1101\/lm.2283011","article-title":"Running is the neurogenic and neurotrophic stimulus in environmental enrichment","volume":"18","author":"Kobilo","year":"2011","journal-title":"Learn Mem"},{"key":"B38","doi-asserted-by":"publisher","first-page":"18293","DOI":"10.18632\/oncotarget.4715","article-title":"Exercise-mimetic AICAR transiently benefits brain function","volume":"6","author":"Guerrieri","year":"2015","journal-title":"Oncotarget"},{"key":"B39","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/PSY.0000000000000268","article-title":"The role of nitric oxide in the antidepressant actions of 5-aminoimidazole-4-carboxamide-1-\u03b2-D-ribofuranoside in insulin-resistant mice","volume":"78","author":"Liu","year":"2016","journal-title":"Psychosom Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2013.11.002","article-title":"The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro","volume":"63","author":"Dulovic","year":"2014","journal-title":"Neurobiol Dis"},{"key":"B41","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1042\/CS20110386","article-title":"Cellular and molecular mechanisms of metformin: an overview","volume":"122","author":"Viollet","year":"2012","journal-title":"Clin Sci"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1093\/hmg\/ddv513","article-title":"AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington\u2019s disease","volume":"25","author":"Vasquez-Manrique","year":"2015","journal-title":"Hum Mol Genet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s12017-016-8412-z","article-title":"Metformin protects cells from mutant huntingtin toxicity through activation of AMPK and modulation of mitochondrial dynamics","volume":"18","author":"Jin","year":"2016","journal-title":"Neuromolecular Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neulet.2006.10.039","article-title":"Metformin therapy in a transgenic mouse model of Huntington\u2019s disease","volume":"411","author":"Ma","year":"2007","journal-title":"Neurosci Lett"},{"key":"B45","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S1734-1140(10)70357-1","article-title":"Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide","volume":"62","author":"\u0141abuzek","year":"2010","journal-title":"Pharmacol Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1528-1157.1990.tb05371.x","article-title":"Adenosinergic modulation of homocysteine-induced seizures in mice","volume":"31","author":"Marangos","year":"1990","journal-title":"Epilepsia"},{"key":"B47","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1101\/lm.033332.113","article-title":"AMPK agonist AICAR improves cognition and motor coordination in young and aged mice","volume":"21","author":"Kobilo","year":"2014","journal-title":"Learn Mem"},{"key":"B48","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1101\/lm.2001611","article-title":"Endurance factors improve hippocampal neurogenesis and spatial memory in mice","volume":"18","author":"Kobilo","year":"2011","journal-title":"Learn Mem"},{"key":"B49","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.nbd.2009.05.007","article-title":"Systematic behavioral evaluation of Huntington\u2019s disease transgenic and knock-in mouse models","volume":"35","author":"Menalled","year":"2009","journal-title":"Neurobiol Dis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/hmg\/ddp467","article-title":"Identical oligomeric and fibrillar structures captured from the brains of R6\/2 and knock-in mouse models of Huntington\u2019s disease","volume":"19","author":"Sathasivam","year":"2010","journal-title":"Hum Mol Genet"},{"key":"B52","doi-asserted-by":"crossref","DOI":"10.1002\/0470119055","volume-title":"What\u2019s Wrong with My Mouse?","author":"Crawley","year":"2007"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000432","article-title":"Succinate dehydrogenase B (SDHB) immunohistochemistry for the evaluation of muscle biopsies","author":"Punsoni","year":"2016","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1083\/jcb.201108113","article-title":"The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing","volume":"196","author":"Ravel-Chapuis","year":"2012","journal-title":"J Cell Biol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e12625","DOI":"10.14814\/phy2.12625","article-title":"Combined pharmacological activation of AMPK and PPAR\u03b4 potentiates the effects of exercise in trained mice","volume":"4","author":"Manio","year":"2016","journal-title":"Physiol Rep"},{"key":"B56","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s13311-015-0399-x","article-title":"Chronic treatment with the AMPK agonist AICAR prevents skeletal muscle pathology but fails to improve clinical outcome in a mouse model of severe spinal muscular atrophy","volume":"13","author":"Cerver\u00f3","year":"2016","journal-title":"Neurotherapeutics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/MOL.0b013e328328d0a4","article-title":"PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure","volume":"20","author":"Cant\u00f3","year":"2009","journal-title":"Curr Opin Lipidol"},{"key":"B58","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1152\/jappl.2000.88.6.2219","article-title":"Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle","volume":"88","author":"Winder","year":"2000","journal-title":"J Appl Physiol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1113\/jphysiol.2003.040691","article-title":"AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions","volume":"551","author":"Putman","year":"2003","journal-title":"J Physiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"E49","DOI":"10.1152\/ajpendo.00630.2010","article-title":"Molecular characterization of skeletal muscle atrophy in the R6\/2 mouse model of Huntington\u2019s disease","volume":"301","author":"She","year":"2011","journal-title":"Am J Physiol Endrocrinol Metab"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e1005021","DOI":"10.1371\/journal.pgen.1005021","article-title":"HDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophy","volume":"11","author":"Mielcarek","year":"2015","journal-title":"PLoS Genet"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1111\/j.1460-9568.2004.03783.x","article-title":"Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington\u2019s disease mutation","volume":"20","author":"Ribchester","year":"2004","journal-title":"Eur J Neurosci"},{"key":"B63","doi-asserted-by":"publisher","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Bodine","year":"2014","journal-title":"Am J Physiol Endrocrinol Metab"},{"key":"B64","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/jcb.23399","article-title":"AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1","volume":"113","author":"Sanchez","year":"2012","journal-title":"J Cell Biochem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/jcb.22272","article-title":"AMP-activated protein kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1\/Akt signaling in C2C12 myotubes","volume":"108","author":"Tong","year":"2009","journal-title":"J Cell Biochem"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1271\/bbb.70057","article-title":"AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes","volume":"71","author":"Nakashima","year":"2007","journal-title":"Biosci Biotechnol Biochem"},{"key":"B67","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1093\/hmg\/ddp243","article-title":"Impaired PGC-1 function in muscle in Huntington\u2019s disease","volume":"18","author":"Chaturvedi","year":"2009","journal-title":"Hum Mol Genet"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e0166106","DOI":"10.1371\/journal.pone.0166106","article-title":"Fast-to-slow transition of skeletal muscle contractile function and corresponding changes in myosin heavy and light chain formation in the R6\/2 mouse model of Huntington\u2019s disease","volume":"11","author":"Hering","year":"2016","journal-title":"PLoS One"},{"key":"B70","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1139\/h02-023","article-title":"The adaptive potential of skeletal muscle fibers","volume":"27","author":"Pette","year":"2002","journal-title":"Can J Appl Physiol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.ajpath.2012.04.004","article-title":"AMPK activation stimulates autophagy and ameliorates muscular dystrophy in the mdx mouse diaphragm","volume":"181","author":"Pauly","year":"2012","journal-title":"Am J Pathol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"26991","DOI":"10.1038\/srep26991","article-title":"Aerobic exercise and pharmacological treatments counteract cachexia by modulating autophagy in colon cancer","volume":"6","author":"Pigna","year":"2016","journal-title":"Sci Rep"},{"key":"B73","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.abb.2016.04.015","article-title":"AMP-activated kinase \u03b12 deficiency protects mice from denervation-induced skeletal muscle atrophy","volume":"600","author":"Guo","year":"2016","journal-title":"Arch Biochem Biophys"},{"key":"B74","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.bbadis.2008.10.011","article-title":"The involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy","volume":"1782","author":"Murton","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"B76","doi-asserted-by":"publisher","first-page":"E1555","DOI":"10.1152\/ajpendo.00622.2006","article-title":"AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells","volume":"292","author":"Krawiec","year":"2007","journal-title":"Am J Physiol Endrocrinol Metab"},{"key":"B77","doi-asserted-by":"publisher","first-page":"16260","DOI":"10.1073\/pnas.0607795103","article-title":"PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription","volume":"103","author":"Sandri","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B78","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ajpath.2010.11.030","article-title":"Regulation of AMPK by the ubiquitin proteasome system","volume":"178","author":"Zungu","year":"2011","journal-title":"Am J Pathol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.cellsig.2015.02.024","article-title":"Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase","volume":"27","author":"Jiang","year":"2015","journal-title":"Cell Signal"},{"key":"B80","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.cmet.2014.09.013","article-title":"AMPK\u2014sensing energy while talking to other signaling pathways","volume":"20","author":"Hardie","year":"2014","journal-title":"Cell Metab"},{"key":"B81","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.arr.2016.04.003","article-title":"Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways","volume":"28","author":"Salminen","year":"2016","journal-title":"Ageing Res Rev"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/j.bbadis.2014.06.012","article-title":"AMPK-\u03b11 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington\u2019s disease","volume":"1842","author":"Ju","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B83","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1083\/jcb.201105010","article-title":"Nuclear translocation of AMPK-\u03b11 potentiates striatal neurodegeneration in Huntington\u2019s disease","volume":"194","author":"Ju","year":"2011","journal-title":"J Cell Biol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3389\/fphys.2014.00380","article-title":"Skeletal muscle pathology in Huntington\u2019s disease","volume":"5","author":"Zielonka","year":"2014","journal-title":"Front Physiol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1098\/rstb.1999.0447","article-title":"Transgenic models of Huntington\u2019s disease","volume":"354","author":"Sathasivam","year":"1999","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e8025","DOI":"10.1371\/journal.pone.0008025","article-title":"Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington\u2019s disease","volume":"4","author":"Moffitt","year":"2009","journal-title":"PLoS One"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1038\/sj.cdd.4401967","article-title":"Increased apoptosis, huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington\u2019s disease subjects","volume":"13","author":"Ciammola","year":"2006","journal-title":"Cell Death Differ"},{"key":"B88","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fnmol.2016.00027","article-title":"Subcellular clearance and accumulation of Huntington disease protein: a mini-review","volume":"9","author":"Zhao","year":"2016","journal-title":"Front Mol Neurosci"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00516\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T20:30:54Z","timestamp":1570134654000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00516\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":88,"alternative-id":["10.3389\/fneur.2017.00516"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2017.00516","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]},"article-number":"516"}}