{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:29:35Z","timestamp":1791923375571,"version":"4.3.4"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2017.00734","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T04:11:36Z","timestamp":1516075896000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Pseudotumor Cerebri and Glymphatic Dysfunction"],"prefix":"10.3389","volume":"8","author":[{"given":"Marcio Luciano de Souza","family":"Bezerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Andorinho de Freitas","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"de Oliveira-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"16","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.anorl.2011.03.002","article-title":"Anatomy and physiology of cerebrospinal fluid","volume":"128","author":"Sakka","year":"2011","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1743-8454-7-9","article-title":"The function and structure of the cerebrospinal fluid outflow system","volume":"7","author":"Pollay","year":"2010","journal-title":"Cerebrospinal Fluid Res"},{"key":"B5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-01225-4_1","article-title":"The history of cerebrospinal fluid","volume-title":"Cerebrospinal Fluid in Clinical Neurology","author":"Deisenhammer","year":"2015"},{"key":"B6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1212\/WNL.0000000000002298","article-title":"Choroid plexus-CSF system: recent developments and clinical correlations","volume":"86","author":"Benarroch","year":"2016","journal-title":"Neurology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/scientificamerican0316-44","article-title":"Brain drain","volume":"314","author":"Nedergaard","year":"2016","journal-title":"Sci Am"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1172\/JCI67677","article-title":"Brain-wide pathway for waste clearance captured by contrast-enhanced MRI","volume":"123","author":"Iliff","year":"2013","journal-title":"J Clin Invest"},{"key":"B9","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/S1474-4422(15)00221-5","article-title":"Clearing the mind: implications of dural lymphatic vessels for brain function","volume":"14","author":"Iliff","year":"2015","journal-title":"Lancet Neurol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1172\/JCI68241","article-title":"Bathing the brain","volume":"123","author":"Strittmatter","year":"2013","journal-title":"J Clin Invest"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1167\/iovs.17-21479","article-title":"The ocular glymphatic system and idiopathic intracranial hypertension: author response to \u201cHypodense holes and the ocular glymphatic system\u201d","volume":"58","author":"Denniston","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1152\/physrev.00011.2013","article-title":"Physiological roles of aquaporin-4 in brain","volume":"93","author":"Nagelhus","year":"2013","journal-title":"Physiol Rev"},{"key":"B13","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The glymphatic system: a beginner\u2019s guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1007\/s11064-012-0818-x","article-title":"Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance","volume":"37","author":"O\u2019Donnell","year":"2012","journal-title":"Neurochem Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1177\/0271678X16661202","article-title":"Glymphatic clearance controls state-dependent changes in brain lactate concentration","volume":"37","author":"Lundgaard","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"B17","first-page":"63","article-title":"Human brain homeothermy during sleep and wakefulness: an experimental and comparative approach","volume":"45","author":"Narebski","year":"1985","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3389\/fnins.2014.00307","article-title":"Brain temperature and its fundamental properties: a review for clinical neuroscientists","volume":"8","author":"Wang","year":"2014","journal-title":"Front Neurosci"},{"key":"B19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.5505\/agri.2015.22599","article-title":"An update on the pathophysiology of idiopathic intracranial hypertension alias pseudotumor cerebri","volume":"27","author":"Baykan","year":"2015","journal-title":"Agri"},{"key":"B20","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S1474-4422(15)00298-7","article-title":"Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions","volume":"15","author":"Markey","year":"2016","journal-title":"Lancet Neurol"},{"key":"B21","first-page":"55","article-title":"Whence pseudotumor cerebri?","volume":"5","author":"Smith","year":"1985","journal-title":"J Clin Neuroophthalmol"},{"key":"B22","first-page":"155","article-title":"Idiopathic intracranial hypertension. A prospective study of 50 patients","volume":"114","author":"Wall","year":"1991","journal-title":"Brain"},{"key":"B23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1755-3768.2011.02231.x","article-title":"Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort","volume":"91","author":"Kerty","year":"2013","journal-title":"Acta Ophthalmol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1212\/WNL.6.11.791","article-title":"Brain swelling of unknown cause","volume":"6","author":"Sahs","year":"1956","journal-title":"Neurology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1136\/jnnp.74.12.1693","article-title":"Diffuse brain oedema in idiopathic intracranial hypertension: a quantitative magnetic resonance imaging study","volume":"74","author":"Bastin","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B26","first-page":"381","article-title":"Increased brain water self-diffusion in patients with idiopathic intracranial hypertension","volume":"16","author":"Gideon","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"B27","first-page":"363","article-title":"Brain water accumulation in pseudotumour cerebri demonstrated by MR-imaging of brain water","volume":"51","author":"S\u00f8rensen","year":"1990","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"B28","doi-asserted-by":"publisher","first-page":"903","DOI":"10.2214\/ajr.150.4.903","article-title":"Imaging of pseudotumor cerebri","volume":"150","author":"Moser","year":"1988","journal-title":"AJR Am J Roentgenol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s00234-013-1207-0","article-title":"Magnetic resonance imaging finding of empty sella in obesity related idiopathic intracranial hypertension is associated with enlarged sella turcica","volume":"55","author":"Ranganathan","year":"2013","journal-title":"Neuroradiology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2147\/JPR.S60633","article-title":"Idiopathic intracranial hypertension: ongoing clinical challenges and future prospects","volume":"9","author":"Julayanont","year":"2016","journal-title":"J Pain Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"94131J","DOI":"10.1117\/12.2076289","article-title":"Optimal-mass-transfer-based estimation of glymphatic transport in living brain","volume":"9413","author":"Ratner","year":"2015","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"B32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2463\/mrms.mp.2016-0039","article-title":"Gd-based contrast enhancement of the perivascular spaces in the basal ganglia","volume":"16","author":"Naganawa","year":"2017","journal-title":"Magn Reson Med Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1093\/brain\/awx191","article-title":"Glymphatic MRI in idiopathic normal pressure hydrocephalus","volume":"140","author":"Ringstad","year":"2017","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/ana.24271","article-title":"Impairment of paravascular clearance pathways in the aging brain","volume":"76","author":"Kress","year":"2014","journal-title":"Ann Neurol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e0139574","DOI":"10.1371\/journal.pone.0139574","article-title":"Modeling the role of the glymphatic pathway and cerebral blood vessel properties in Alzheimer\u2019s disease pathogenesis","volume":"10","author":"Kyrtsos","year":"2015","journal-title":"PLoS One"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1091\/mbc.E06-10-0975","article-title":"Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils","volume":"18","author":"Majumdar","year":"2007","journal-title":"Mol Biol Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1001\/jamaneurol.2015.4791","article-title":"Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis","volume":"73","author":"Gomm","year":"2016","journal-title":"JAMA Neurol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1001\/jamaneurol.2016.4370","article-title":"Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains","volume":"74","author":"Zeppenfeld","year":"2017","journal-title":"JAMA Neurol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn J Radiol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1038\/ijo.2016.96","article-title":"Obesity but not high-fat diet impairs lymphatic function","volume":"40","author":"Garc\u00eda Nores","year":"2016","journal-title":"Int J Obes"},{"key":"B41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nrn3898","article-title":"Astrocyte barriers to neurotoxic inflammation","volume":"16","author":"Sofroniew","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"B42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1742-2094-5-22","article-title":"Neuromyelitis optica pathogenesis and aquaporin 4","volume":"5","author":"Graber","year":"2008","journal-title":"J Neuroinflammation"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1523\/JNEUROSCI.3390-16.2017","article-title":"Cortical spreading depression closes paravascular space and impairs glymphatic flow: implications for migraine headache","volume":"37","author":"Schain","year":"2017","journal-title":"J Neurosci"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2333721416643702","article-title":"Idiopathic normal pressure hydrocephalus: a review for general practitioners","volume":"2","author":"Nassar","year":"2016","journal-title":"Gerontol Geriatr Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJM196507152730301","article-title":"Symptomatic occult hydrocephalus with \u201cnormal\u201d cerebrospinal pressures: a treatable syndrome","volume":"273","author":"Adams","year":"1965","journal-title":"N Engl J Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3174\/ajnr.A4124","article-title":"CSF flow in the brain in the context of normal pressure hydrocephalus","volume":"36","author":"Bradley","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1212\/WNL.0b013e31828c2fda","article-title":"Idiopathic normal-pressure hydrocephalus: pathophysiology and diagnosis by CSF biomarkers","volume":"80","author":"Jeppsson","year":"2013","journal-title":"Neurology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1212\/WNL.0000000000000916","article-title":"Alzheimer CSF biomarkers may be misleading in normal-pressure hydrocephalus","volume":"83","author":"Graff-Radford","year":"2014","journal-title":"Neurology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12987-015-0012-z","article-title":"A new glaucoma hypothesis: a role of glymphatic system dysfunction","volume":"12","author":"Wostyn","year":"2015","journal-title":"Fluids Barriers CNS"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1002\/jmri.24923","article-title":"MR-derived cerebral spinal fluid hydrodynamics as a marker and a risk factor for intracranial hypertension in astronauts exposed to microgravity","volume":"42","author":"Kramer","year":"2015","journal-title":"J Magn Reson Imaging"},{"key":"B51","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jaapos.2015.01.006","article-title":"Low cerebrospinal fluid protein in prepubertal children with idiopathic intracranial hypertension","volume":"19","author":"Margeta","year":"2015","journal-title":"J AAPOS"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00734\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:34:35Z","timestamp":1693474475000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2017.00734\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":51,"alternative-id":["10.3389\/fneur.2017.00734"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2017.00734","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]},"article-number":"734"}}