{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:35:59Z","timestamp":1793957759860,"version":"4.8.0"},"reference-count":44,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00076","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T04:33:27Z","timestamp":1519187607000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Paul S.","family":"Page","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas K.","family":"Khattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Cambon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy N.","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shesh N.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ajo.2005.03.038","article-title":"Central retinal artery occlusion: visual outcome","volume":"140","author":"Hayreh","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1016\/S0161-6420(95)30758-0","article-title":"Efficacy of anterior chamber paracentesis and Carbogen in treating acute nonarteritic central retinal artery occlusion","volume":"102","author":"Atebara","year":"1995","journal-title":"Ophthalmology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1001\/archopht.121.10.1377","article-title":"Evaluation of minimally invasive therapies and rationale for a prospective randomized trial to evaluate selective intra-arterial lysis for clinically complete central retinal artery occlusion","volume":"121","author":"Mueller","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/j.1442-9071.2010.02280.x","article-title":"Clinical characteristics and outcome of current standard management of central retinal artery occlusion","volume":"38","author":"Rudkin","year":"2010","journal-title":"Clin Exp Ophthalmol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1471-2415-14-28","article-title":"Anterior chamber paracentesis after central retinal artery occlusion: a tenable therapy?","volume":"14","author":"Fiess","year":"2014","journal-title":"BMC Ophthalmol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/S0002-8703(03)00439-3","article-title":"Current perspectives on reperfusion therapy for acute ST-segment elevation myocardial infarction: integrating pharmacologic and mechanical reperfusion strategies","volume":"146","author":"Waters","year":"2003","journal-title":"Am Heart J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke","volume":"333","year":"1995","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.jvs.2014.10.036","article-title":"Catheter-directed interventions for acute pulmonary embolism","volume":"61","author":"Avgerinos","year":"2015","journal-title":"J Vasc Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1001\/jama.2016.13647","article-title":"Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis","volume":"316","author":"Saver","year":"2016","journal-title":"JAMA"},{"key":"B10","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1136\/bjo.84.8.914","article-title":"Local intra-arterial fibrinolysis for acute occlusion of the central retinal artery: a meta-analysis of the published data","volume":"84","author":"Beatty","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"W65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"151","author":"Liberati","year":"2009","journal-title":"Ann Intern Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3758\/BF03195354","article-title":"Meta-analysis using linear mixed models","volume":"33","author":"Sheu","year":"2001","journal-title":"Behav Res Methods Instrum Comput"},{"key":"B13","volume-title":"An Introduction to Categorical Data Analysis","author":"Argresti","year":"1996"},{"key":"B14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.neurad.2014.02.007","article-title":"Interest of local intra-arterial fibrinolysis in acute central retinal artery occlusion: clinical experience in 16 patients","volume":"42","author":"Mercier","year":"2015","journal-title":"J Neuroradiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7746","DOI":"10.1167\/iovs.13-12952","article-title":"Efficacy and safety of intra-arterial thrombolysis in central retinal artery occlusion","volume":"54","author":"Ahn","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.ophtha.2010.03.061","article-title":"Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial","volume":"117","author":"Schumacher","year":"2010","journal-title":"Ophthalmology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1179\/174313209X444008","article-title":"Intra-arterial thrombolysis for acute central retinal artery occlusion","volume":"31","author":"Zhang","year":"2009","journal-title":"Neurol Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1161\/STROKEAHA.107.505404","article-title":"Local intraarterial fibrinolysis administered in aliquots for the treatment of central retinal artery occlusion: the Johns Hopkins Hospital experience","volume":"39","author":"Aldrich","year":"2008","journal-title":"Stroke"},{"key":"B19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1017\/S0317167100004522","article-title":"Intra-arterial thrombolysis for retinal artery occlusion: the Calgary experience","volume":"32","author":"Pettersen","year":"2005","journal-title":"Can J Neurol Sci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/jnnp.2004.037135","article-title":"Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion","volume":"76","author":"Arnold","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1080\/02841850312331287829","article-title":"Selective intraarterial fibrinolysis of acute central retinal artery occlusion","volume":"44","author":"Butz","year":"2003","journal-title":"Acta Radiol"},{"key":"B22","first-page":"1301","article-title":"Prognosis of central retinal artery occlusion: local intraarterial fibrinolysis versus conservative treatment","volume":"23","author":"Schmidt","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/S0161-6420(99)90165-3","article-title":"Treatment of retinal arterial occlusion with local fibrinolysis using recombinant tissue plasminogen activator","volume":"106","author":"Richard","year":"1999","journal-title":"Ophthalmology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1161\/01.STR.29.10.2076","article-title":"Selective intra-arterial fibrinolysis of acute central retinal artery occlusion","volume":"29","author":"Weber","year":"1998","journal-title":"Stroke"},{"key":"B25","first-page":"458","article-title":"Local fibrinolysis in central retinal artery occlusion: follow-up in 36 cases","author":"Schumacher","year":"1995"},{"key":"B26","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9394(14)76167-7","article-title":"Microcatheter urokinase infusion in central retinal artery occlusion","volume":"113","author":"Schmidt","year":"1992","journal-title":"Am J Ophthalmol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/BF00588405","article-title":"Intra-arterial fibrinolytic therapy in central retinal artery occlusion","volume":"35","author":"Schumacher","year":"1993","journal-title":"Neuroradiology"},{"key":"B28","first-page":"240","article-title":"[Intra-arterial fibrinolysis in central artery occlusion]","volume":"31","author":"Schumacher","year":"1991","journal-title":"Radiologe"},{"key":"B29","first-page":"81","article-title":"[Selective ophthalmic artery fibrinolysis in acute central retinal artery occlusion]","volume":"77","author":"Fernandez","year":"2002","journal-title":"Arch Soc Esp Oftalmol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s003470170079","article-title":"[Central retinal artery occlusion. Importance of selective intra-arterial fibrinolysis]","volume":"98","author":"Framme","year":"2001","journal-title":"Ophthalmologe"},{"key":"B31","first-page":"466","article-title":"[Persistent value of intra-arterial fibrinolysis 8 hours or more following central retinal artery occlusion or of its branches]","volume":"21","author":"Weill","year":"1998","journal-title":"J Fr Ophtalmol"},{"key":"B32","first-page":"149","article-title":"[Selective percutaneous transluminal thrombolytic therapy with rt-PA in central retinal artery occlusion]","volume":"93","author":"Vulpius","year":"1996","journal-title":"Ophthalmologe"},{"key":"B33","first-page":"711","article-title":"[Local fibrinolytic treatment in occlusions of the central retinal artery]","volume":"7","author":"Annonier","year":"1984","journal-title":"J Fr Ophtalmol"},{"key":"B34","first-page":"1167","article-title":"[Role of fibrinolysis in the treatment of retinal arterial occlusion. Discussion of 5 cases]","volume":"88","author":"Annonier","year":"1988","journal-title":"Bull Soc Ophtalmol Fr"},{"key":"B35","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1136\/bmj.323.7303.42","article-title":"Systematic reviews in health care: assessing the quality of controlled clinical trials","volume":"323","author":"Juni","year":"2001","journal-title":"BMJ"},{"key":"B36","doi-asserted-by":"publisher","first-page":"536","DOI":"10.2307\/2532893","article-title":"Meta-analysis of published data using a linear mixed-effects model","volume":"52","author":"Stram","year":"1996","journal-title":"Biometrics"},{"key":"B37","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s00417-006-0473-5","article-title":"Comment re: multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications","volume":"245","author":"Hayreh","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/2013.11.FOCUS13331","article-title":"Current endovascular treatment options for central retinal arterial occlusion: a review","volume":"36","author":"Agarwal","year":"2014","journal-title":"Neurosurg Focus"},{"key":"B39","doi-asserted-by":"publisher","first-page":"604; author reply 604","DOI":"10.1016\/j.ophtha.2010.10.042","article-title":"Thrombolysis for artery occlusion","volume":"118","author":"Arthur","year":"2011","journal-title":"Ophthalmology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ajo.2008.07.025","article-title":"Thrombolysis for acute central retinal artery occlusion: is it time?","volume":"146","author":"Biousse","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000446853","article-title":"Visual improvement after intra-arterial thrombolysis for central retinal artery occlusion does not correlate with time to treatment","volume":"5","author":"Page","year":"2016","journal-title":"Interv Neurol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/1745-6215-15-343","article-title":"MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial","volume":"15","author":"Fransen","year":"2014","journal-title":"Trials"},{"key":"B43","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"N Engl J Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/WNO.0b013e31814b1f66","article-title":"Thrombolysis for central retinal artery occlusion","volume":"27","author":"Biousse","year":"2007","journal-title":"J Neuroophthalmol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00076\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T04:33:27Z","timestamp":1519187607000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00076\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":44,"alternative-id":["10.3389\/fneur.2018.00076"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00076","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]},"article-number":"76"}}