{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:28:35Z","timestamp":1790501315013,"version":"4.1.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00096","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:42:58Z","timestamp":1519634578000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Milk Fat Globule-Epidermal Growth Factor-8 Pretreatment Attenuates Apoptosis and Inflammation via the Integrin-\u03b23 Pathway after Surgical Brain Injury in Rats"],"prefix":"10.3389","volume":"9","author":[{"given":"Yicai","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kauthar","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/BF03012507","article-title":"Early postoperative complications following neurosurgical procedures","volume":"46","author":"Manninen","year":"1999","journal-title":"Can J Anaesth"},{"key":"B2","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jneumeth.2006.06.003","article-title":"Surgically induced brain injury in rats: the effect of erythropoietin","volume":"158","author":"Matchett","year":"2006","journal-title":"J Neurosci Methods"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.2741\/2968","article-title":"Surgical brain injury: prevention is better than cure","volume":"13","author":"Jadhav","year":"2008","journal-title":"Front Biosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nbd.2012.09.004","article-title":"PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats","volume":"50","author":"Manaenko","year":"2013","journal-title":"Neurobiol Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"10390","DOI":"10.1523\/JNEUROSCI.0546-15.2015","article-title":"Phosphoinositide 3-kinase gamma contributes to neuroinflammation in a rat model of surgical brain injury","volume":"35","author":"Huang","year":"2015","journal-title":"J Neurosci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.nbd.2015.11.003","article-title":"Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model","volume":"85","author":"Sherchan","year":"2016","journal-title":"Neurobiol Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jneuroim.2006.11.013","article-title":"The interplay between inflammation and neurodegeneration in CNS disease","volume":"184","author":"Esiri","year":"2007","journal-title":"J Neuroimmunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jneuroim.2006.11.014","article-title":"The inflammatory response in stroke","volume":"184","author":"Wang","year":"2007","journal-title":"J Neuroimmunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1742-2094-4-17","article-title":"Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat","volume":"4","author":"Williams","year":"2007","journal-title":"J Neuroinflammation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect Immun"},{"key":"B11","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1097\/TA.0b013e318249a97c","article-title":"Milk fat globule epidermal growth factor-8 mitigates inflammation and tissue injury after hemorrhagic shock in experimental animals","volume":"72","author":"Zhang","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pneurobio.2013.09.007","article-title":"Progress in translational research on intracerebral hemorrhage: is there an end in sight?","volume":"115","author":"Xi","year":"2014","journal-title":"Prog Neurobiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1006\/bbrc.1998.0107","article-title":"Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat globule glycoprotein MFG-E8","volume":"254","author":"Oshima","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"B14","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.yexcr.2003.09.011","article-title":"The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells","volume":"292","author":"Akakura","year":"2004","journal-title":"Exp Cell Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2","volume":"201","author":"Takahashi","year":"2005","journal-title":"J Exp Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1161\/STROKEAHA.114.006635","article-title":"Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin beta3\/nuclear factor erythroid 2-related factor 2\/heme oxygenase pathway in subarachnoid hemorrhage rats","volume":"45","author":"Liu","year":"2014","journal-title":"Stroke"},{"key":"B17","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.neuropharm.2011.09.018","article-title":"Recombinant human MFG-E8 attenuates cerebral ischemic injury: its role in anti-inflammation and anti-apoptosis","volume":"62","author":"Cheyuo","year":"2012","journal-title":"Neuropharmacology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1172\/JCI65167","article-title":"MFGE8 inhibits inflammasome-induced IL-1beta production and limits postischemic cerebral injury","volume":"123","author":"Deroide","year":"2013","journal-title":"J Clin Invest"},{"key":"B19","doi-asserted-by":"publisher","first-page":"921","DOI":"10.2353\/ajpath.2007.060664","article-title":"Evidence of a role for lactadherin in Alzheimer\u2019s disease","volume":"170","author":"Boddaert","year":"2007","journal-title":"Am J Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/1742-2094-9-148","article-title":"The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid beta toxicity","volume":"9","author":"Li","year":"2012","journal-title":"J Neuroinflammation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1084\/jem.20092401","article-title":"Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner","volume":"207","author":"Kranich","year":"2010","journal-title":"J Exp Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.nbd.2012.11.010","article-title":"MFGE8 does not orchestrate clearance of apoptotic neurons in a mouse model of Parkinson\u2019s disease","volume":"51","author":"Kinugawa","year":"2013","journal-title":"Neurobiol Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"E4098","DOI":"10.1073\/pnas.1308679110","article-title":"Phagocytosis executes delayed neuronal death after focal brain ischemia","volume":"110","author":"Neher","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B24","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.expneurol.2015.04.016","article-title":"MFGE8\/Integrin beta3 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats","volume":"272","author":"Liu","year":"2015","journal-title":"Exp Neurol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.brainres.2015.11.004","article-title":"Decorin alleviated chronic hydrocephalus via inhibiting TGF-beta1\/Smad\/CTGF pathway after subarachnoid hemorrhage in rats","volume":"1630","author":"Yan","year":"2016","journal-title":"Brain Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1126\/science.1092533","article-title":"Cell biology. Eat me or die","volume":"302","author":"Savill","year":"2003","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1126\/science.1094359","article-title":"Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice","volume":"304","author":"Hanayama","year":"2004","journal-title":"Science"},{"key":"B28","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1158\/0008-5472.CAN-10-1471","article-title":"The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63\/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers","volume":"71","author":"Yang","year":"2011","journal-title":"Cancer Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5000","DOI":"10.1167\/iovs.13-12084","article-title":"Activated alphavbeta3 integrin regulates alphavbeta5 integrin-mediated phagocytosis in trabecular meshwork cells","volume":"54","author":"Gagen","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/nri3607","article-title":"Apoptotic cell clearance: basic biology and therapeutic potential","volume":"14","author":"Poon","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s12975-014-0349-7","article-title":"Molecular and cellular immune responses to ischemic brain injury","volume":"5","author":"Seifert","year":"2014","journal-title":"Transl Stroke Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3892\/ijmm.2015.2196","article-title":"MFG-E8 inhibits neutrophil migration through alphavbeta(3)-integrin-dependent MAP kinase activation","volume":"36","author":"Aziz","year":"2015","journal-title":"Int J Mol Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.lpm.2013.01.012","article-title":"L13. Apoptosis, apoptotic cell clearance and resolution of inflammation","volume":"42","author":"Rossi","year":"2013","journal-title":"Presse Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/imr.12453","article-title":"Clearance of apoptotic neutrophils and resolution of inflammation","volume":"273","author":"Greenlee-Wacker","year":"2016","journal-title":"Immunol Rev"},{"key":"B35","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/imr.12462","article-title":"Complement in removal of the dead \u2013 balancing inflammation","volume":"274","author":"Martin","year":"2016","journal-title":"Immunol Rev"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00096\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:43:00Z","timestamp":1519634580000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00096\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":35,"alternative-id":["10.3389\/fneur.2018.00096"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00096","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,26]]},"article-number":"96"}}