{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:50:19Z","timestamp":1787500219793,"version":"build-2736575974"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31611130035, U1604165"],"award-info":[{"award-number":["31611130035, U1604165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["VINNOVA, 2015-04780"],"award-info":[{"award-number":["VINNOVA, 2015-04780"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR 2015-06276"],"award-info":[{"award-number":["VR 2015-06276"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00182","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:14:12Z","timestamp":1521677652000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Combined Analysis of Interleukin-10 Gene Polymorphisms and Protein Expression in Children With Cerebral Palsy"],"prefix":"10.3389","volume":"9","author":[{"given":"Lei","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengna","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghe","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ejpn.2011.10.004","article-title":"The effects of multiple pre- and perinatal risk factors on the occurrence of cerebral palsy. A Norwegian register based study","volume":"16","author":"Stoknes","year":"2012","journal-title":"Eur J Paediatr Neurol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1067\/mob.2000.104207","article-title":"Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years","volume":"182","author":"Yoon","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cyto.2011.12.018","article-title":"The association between proinflammatory cytokine polymorphisms and cerebral palsy in very preterm infants","volume":"58","author":"Kapitanovic Vidak","year":"2012","journal-title":"Cytokine"},{"key":"B4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1046\/j.1440-1789.2002.00438.x","article-title":"Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system","volume":"22","author":"Rezaie","year":"2002","journal-title":"Neuropathology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1515\/JPM.2006.001","article-title":"Cerebral palsy and fetal inflammatory response syndrome: a review","volume":"34","author":"Bashiri","year":"2006","journal-title":"J Perinat Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1161\/01.STR.0000254729.27386.05","article-title":"Maturation-dependent vulnerability of perinatal white matter in premature birth","volume":"38","author":"Back","year":"2007","journal-title":"Stroke"},{"key":"B7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0002-9378(97)70432-0","article-title":"Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy","volume":"177","author":"Yoon","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1365-3083.2012.02710.x","article-title":"Serial examination of serum IL-8, IL-10 and IL-1Ra levels is significant in neonatal seizures induced by hypoxic-ischaemic encephalopathy","volume":"76","author":"Youn","year":"2012","journal-title":"Scand J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/S0140-6736(01)06723-X","article-title":"Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions","volume":"358","author":"Duggan","year":"2001","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1212\/WNL.56.10.1278","article-title":"Inflammatory cytokines in the pathogenesis of periventricular leukomalacia","volume":"56","author":"Kadhim","year":"2001","journal-title":"Neurology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/jid.2010.340","article-title":"Integrative responses to IL-17 and TNF-alpha in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis","volume":"131","author":"Chiricozzi","year":"2011","journal-title":"J Invest Dermatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1056\/NEJMra0707449","article-title":"Interleukin-17 and type 17 helper T cells","volume":"361","author":"Miossec","year":"2009","journal-title":"N Engl J Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/ni0407-345","article-title":"T(H)-17 cells in the circle of immunity and autoimmunity","volume":"8","author":"Bettelli","year":"2007","journal-title":"Nat Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"490804","DOI":"10.1155\/2012\/490804","article-title":"Anti-inflammatory cytokines: important immunoregulatory factors contributing to chemotherapy-induced gastrointestinal mucositis","volume":"2012","author":"Sultani","year":"2012","journal-title":"Chemother Res Pract"},{"key":"B15","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.clp.2008.07.011","article-title":"Cytokines and perinatal brain damage","volume":"35","author":"Dammann","year":"2008","journal-title":"Clin Perinatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1615\/CritRevImmunol.v21.i5.20","article-title":"Interleukin-10 in the brain","volume":"21","author":"Strle","year":"2001","journal-title":"Crit Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jneuroim.2005.01.010","article-title":"Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures","volume":"162","author":"Kremlev","year":"2005","journal-title":"J Neuroimmunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.ajog.2004.06.093","article-title":"Maternal infection-induced white matter injury is reduced by treatment with interleukin-10","volume":"191","author":"Rodts-Palenik","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1046\/j.1365-2567.1999.00828.x","article-title":"Interleukin-10-induced CD8 cell proliferation","volume":"98","author":"Rowbottom","year":"1999","journal-title":"Immunology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1073\/pnas.89.5.1890","article-title":"Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes","volume":"89","author":"Rousset","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1172\/JCI200523139","article-title":"Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells","volume":"115","author":"Ma","year":"2005","journal-title":"J Clin Invest"},{"key":"B22","doi-asserted-by":"publisher","first-page":"F209","DOI":"10.1136\/fn.88.3.F209","article-title":"Proinflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infections","volume":"88","author":"Ng","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B23","doi-asserted-by":"publisher","first-page":"561494","DOI":"10.1155\/2012\/561494","article-title":"The role of cytokines and inflammatory cells in perinatal brain injury","volume":"2012","author":"McAdams","year":"2012","journal-title":"Neurol Res Int"},{"key":"B24","doi-asserted-by":"publisher","first-page":".e1","DOI":"10.1016\/j.ajog.2006.01.093","article-title":"The association between inherited cytokine polymorphisms and cerebral palsy","volume":"194","author":"Gibson","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1542\/peds.2007-3758","article-title":"Candidate genes and cerebral palsy: a population-based study","volume":"122","author":"Gibson","year":"2008","journal-title":"Pediatrics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/mc.21992","article-title":"IL17A gene polymorphisms, serum IL-17A and IgE levels, and hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection","volume":"53","author":"Li","year":"2014","journal-title":"Mol Carcinog"},{"key":"B27","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1055\/s-2006-924554","article-title":"Interleukin-10 high producer allele and ultrasound-defined periventricular white matter abnormalities in preterm infants: a preliminary study","volume":"37","author":"Dordelmann","year":"2006","journal-title":"Neuropediatrics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/1742-2094-11-100","article-title":"The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy","volume":"11","author":"Bi","year":"2014","journal-title":"J Neuroinflammation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.pediatrneurol.2008.09.016","article-title":"Role of perinatal inflammation in cerebral palsy","volume":"40","author":"Girard","year":"2009","journal-title":"Pediatr Neurol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/AOG.0b013e318297f37f","article-title":"Cerebral palsy and perinatal infection in children born at term","volume":"122","author":"Ahlin","year":"2013","journal-title":"Obstet Gynecol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.4049\/jimmunol.1701162","article-title":"Locus-specific reversible DNA methylation regulates transient IL-10 expression in Th1\u2009cells","volume":"200","author":"Hwang","year":"2018","journal-title":"J Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"46818","DOI":"10.1074\/jbc.M401722200","article-title":"Chromatin-level regulation of the IL10 gene in T cells","volume":"279","author":"Im","year":"2004","journal-title":"J Biol Chem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1055\/s-0032-1316443","article-title":"Cytokines and posthemorrhagic ventricular dilation in premature infants","volume":"29","author":"Ambalavanan","year":"2012","journal-title":"Am J Perinatol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1097\/NEN.0b013e31819dca30","article-title":"Interleukin-10 and interleukin-10 receptor-I are upregulated in glial cells after an excitotoxic injury to the postnatal rat brain","volume":"68","author":"Gonzalez","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/jmri.23931","article-title":"Anatomical characterization of athetotic and spastic cerebral palsy using an atlas-based analysis","volume":"38","author":"Yoshida","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"B36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.tim.2007.02.006","article-title":"IL-10, T cell exhaustion and viral persistence","volume":"15","author":"Blackburn","year":"2007","journal-title":"Trends Microbiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/S1474-4422(12)70058-3","article-title":"Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?","volume":"11","author":"Fleiss","year":"2012","journal-title":"Lancet Neurol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.imbio.2009.01.011","article-title":"Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency","volume":"215","author":"Rezaei","year":"2010","journal-title":"Immunobiology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.cyto.2013.01.011","article-title":"Association of interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study","volume":"61","author":"Chen","year":"2013","journal-title":"Cytokine"},{"key":"B41","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1479-828X.2009.00999.x","article-title":"Genetic susceptibility to viral exposure may increase the risk of cerebral palsy","volume":"49","author":"Djukic","year":"2009","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1159\/000338099","article-title":"A systematic review and meta-analysis of long-term development of early term infants","volume":"102","author":"Dong","year":"2012","journal-title":"Neonatology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e74126","DOI":"10.1371\/journal.pone.0074126","article-title":"Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population","volume":"8","author":"Xie","year":"2013","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s11033-012-2232-5","article-title":"Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population","volume":"40","author":"Park","year":"2013","journal-title":"Mol Biol Rep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/humrep\/deu043","article-title":"IL-10 gene promoter and intron polymorphisms and changes in IL-10 secretion in women with idiopathic recurrent miscarriage","volume":"29","author":"Qaddourah","year":"2014","journal-title":"Hum Reprod"},{"key":"B46","doi-asserted-by":"publisher","first-page":"6851","DOI":"10.1007\/s11033-012-1510-6","article-title":"Association of the interleukin-10 1082G\/A, 819C\/T and 3575T\/A gene polymorphisms with systemic sclerosis: a meta-analysis","volume":"39","author":"Peng","year":"2012","journal-title":"Mol Biol Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jns.2010.12.005","article-title":"The -1082G\/A polymorphism in IL-10 gene is associated with risk of Alzheimer\u2019s disease: a meta-analysis","volume":"303","author":"Zhang","year":"2011","journal-title":"J Neurol Sci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e414","DOI":"10.1542\/peds.2011-0739","article-title":"Fetal and maternal candidate single nucleotide polymorphism associations with cerebral palsy: a case-control study","volume":"129","author":"O\u2019Callaghan","year":"2012","journal-title":"Pediatrics"},{"key":"B49","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/1756-185X.12221","article-title":"Meta-analysis of association between cytokine gene polymorphisms and Behcet\u2019s disease risk","volume":"16","author":"Liang","year":"2013","journal-title":"Int J Rheum Dis"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00182\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:14:20Z","timestamp":1521677660000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00182\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":49,"alternative-id":["10.3389\/fneur.2018.00182"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00182","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,22]]},"article-number":"182"}}