{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:12:09Z","timestamp":1788199929737,"version":"build-2803163510"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006075","name":"Greta och Johan Kocks stiftelser","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Stiftelsen Lars Hiertas Minne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvalls Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006686","name":"Thorsten och Elsa Segerfalks Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00222","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T04:24:24Z","timestamp":1522988664000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson\u2019s Disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Michael","family":"Jewett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elna","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajsa","family":"Brolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Negrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzia","family":"Jimenez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Swanberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.mcp.2016.11.001","article-title":"Genetics of Parkinson\u2019s disease","volume":"30","author":"Lill","year":"2016","journal-title":"Mol Cell Probes"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.cell.2013.11.009","article-title":"Isogenic human iPSC Parkinson\u2019s model shows nitrosative stress-induced dysfunction in MEF2-PGC1alpha transcription","volume":"155","author":"Ryan","year":"2013","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/jnc.13691","article-title":"The clinical symptoms of Parkinson\u2019s disease","volume":"139","author":"Sveinbjornsdottir","year":"2016","journal-title":"J Neurochem"},{"key":"B5","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/ng.3043","article-title":"Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease","volume":"46","author":"Nalls","year":"2014","journal-title":"Nat Genet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/ng.3955","article-title":"A meta-analysis of genome-wide association studies identifies 17 new Parkinson\u2019s disease risk loci","volume":"49","author":"Chang","year":"2017","journal-title":"Nat Genet"},{"key":"B7","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1523\/JNEUROSCI.23-30-09817.2003","article-title":"Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS","volume":"23","author":"Lidman","year":"2003","journal-title":"J Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e5906","DOI":"10.1371\/journal.pone.0005906","article-title":"Fine mapping of gene regions regulating neurodegeneration","volume":"4","author":"Swanberg","year":"2009","journal-title":"PLoS One"},{"key":"B9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1042\/bj3300175","article-title":"Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation","volume":"330","author":"Hubatsch","year":"1998","journal-title":"Biochem J"},{"key":"B10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12017-011-8164-8","article-title":"Naturally occurring genetic variability in expression of Gsta4 is associated with differential survival of axotomized rat motoneurons","volume":"14","author":"Strom","year":"2012","journal-title":"Neuromolecular Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1089\/ars.2011.4440","article-title":"Naturally occurring variation in the glutathione-S-transferase 4 gene determines neurodegeneration after traumatic brain injury","volume":"18","author":"Al Nimer","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"B12","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0197-4580(02)00139-2","article-title":"Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum","volume":"24","author":"Martinez-Lara","year":"2003","journal-title":"Neurobiol Aging"},{"key":"B13","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0167-4838(94)90019-1","article-title":"A novel glutathione S-transferase isozyme similar to GST 8-8 of rat and mGSTA4-4 (GST 5.7) of mouse is selectively expressed in human tissues","volume":"1204","author":"Singhal","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"B14","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0021-9258(17)42210-1","article-title":"Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse glutathione S-transferase mGSTA4-4 (GST 5.7)","volume":"269","author":"Zimniak","year":"1994","journal-title":"J Biol Chem"},{"key":"B15","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/mc.20478","article-title":"Association between polymorphisms in the GSTA4 gene and risk of lung cancer: a case-control study in a Southeastern Chinese population","volume":"48","author":"Qian","year":"2009","journal-title":"Mol Carcinog"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3247","DOI":"10.7314\/APJCP.2012.13.7.3247","article-title":"Predictive role of glutathione-S-transferase gene polymorphisms in risk and prognosis of hepatocellular carcinoma","volume":"13","author":"Li","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1073\/pnas.93.7.2696","article-title":"Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease","volume":"93","author":"Yoritaka","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B18","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0891-5849(98)00021-5","article-title":"(E)-4-hydroxy-2-nonenal may be involved in the pathogenesis of Parkinson\u2019s disease","volume":"25","author":"Selley","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0304-3940(01)02514-9","article-title":"Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans","volume":"319","author":"Castellani","year":"2002","journal-title":"Neurosci Lett"},{"key":"B20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/978-3-7091-6842-4_7","article-title":"Mechanism of 6-hydroxydopamine neurotoxicity","volume":"50","author":"Glinka","year":"1997","journal-title":"J Neural Transm Suppl"},{"key":"B21","doi-asserted-by":"publisher","first-page":"E73","DOI":"10.3390\/brainsci7070073","article-title":"Astrocytic expression of GSTA4 is associated to dopaminergic neuroprotection in a rat 6-OHDA model of Parkinson\u2019s disease","volume":"7","author":"Jewett","year":"2017","journal-title":"Brain Sci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"a008888","DOI":"10.1101\/cshperspect.a008888","article-title":"Genetics of Parkinson\u2019s disease","volume":"2","author":"Klein","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/s0140-6736(04)17103-1","article-title":"Alpha-synuclein locus duplication as a cause of familial Parkinson\u2019s disease","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/s0140-6736(04)17104-3","article-title":"Causal relation between alpha-synuclein gene duplication and familial Parkinson\u2019s disease","volume":"364","author":"Ibanez","year":"2004","journal-title":"Lancet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/ana.20753","article-title":"Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson\u2019s disease","volume":"59","author":"Nishioka","year":"2006","journal-title":"Ann Neurol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1212\/01.wnl.0000254458.17630.c5","article-title":"Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication","volume":"68","author":"Fuchs","year":"2007","journal-title":"Neurology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1212\/01.wnl.0000271080.53272.c7","article-title":"Alpha-synuclein gene duplication is present in sporadic Parkinson disease","volume":"70","author":"Ahn","year":"2008","journal-title":"Neurology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1294; author reply 1294","DOI":"10.1212\/01.wnl.0000338439.00992.c7","article-title":"Re: alpha-synuclein gene duplication is present in sporadic Parkinson disease","volume":"71","author":"Brueggemann","year":"2008","journal-title":"Neurology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1001\/archneur.65.4.514","article-title":"Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia","volume":"65","author":"Ikeuchi","year":"2008","journal-title":"Arch Neurol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1295; author reply 1295","DOI":"10.1212\/01.wnl.0000338435.78120.0f","article-title":"Re: alpha-synuclein gene duplication is present in sporadic Parkinson disease","volume":"71","author":"Troiano","year":"2008","journal-title":"Neurology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1212\/01.wnl.0000327607.28928.e6","article-title":"Prominent psychiatric symptoms and glucose hypometabolism in a family with a SNCA duplication","volume":"71","author":"Uchiyama","year":"2008","journal-title":"Neurology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1001\/archneurol.2008.555","article-title":"Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms","volume":"66","author":"Ibanez","year":"2009","journal-title":"Arch Neurol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"Alpha-synuclein locus triplication causes Parkinson\u2019s disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/ana.10846","article-title":"Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications","volume":"55","author":"Farrer","year":"2004","journal-title":"Ann Neurol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1038\/ng.487","article-title":"Genome-wide association study reveals genetic risk underlying Parkinson\u2019s disease","volume":"41","author":"Simon-Sanchez","year":"2009","journal-title":"Nat Genet"},{"key":"B36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-3-211-78205-7_15","article-title":"Transgenic rodent models of Parkinson\u2019s disease","volume":"101","author":"Harvey","year":"2008","journal-title":"Acta Neurochir Suppl"},{"key":"B37","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3389\/fnana.2014.00155","article-title":"Parkinson\u2019s disease: animal models and dopaminergic cell vulnerability","volume":"8","author":"Blesa","year":"2014","journal-title":"Front Neuroanat"},{"key":"B38","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.tins.2016.09.003","article-title":"Alpha-synuclein-based animal models of Parkinson\u2019s disease: challenges and opportunities in a new era","volume":"39","author":"Visanji","year":"2016","journal-title":"Trends Neurosci"},{"key":"B39","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1523\/JNEUROSCI.22-07-02780.2002","article-title":"Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system","volume":"22","author":"Kirik","year":"2002","journal-title":"J Neurosci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1073\/pnas.0536383100","article-title":"Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson\u2019s disease","volume":"100","author":"Kirik","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B41","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1093\/hmg\/ddn417","article-title":"Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson\u2019s disease","volume":"18","author":"Azeredo da Silveira","year":"2009","journal-title":"Hum Mol Genet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.nbd.2011.12.013","article-title":"Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons","volume":"45","author":"Decressac","year":"2012","journal-title":"Neurobiol Dis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.nbd.2013.03.014","article-title":"Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson\u2019s disease","volume":"56","author":"Febbraro","year":"2013","journal-title":"Neurobiol Dis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0002-9440(10)64553-1","article-title":"\u03b1-Synuclein promotes mitochondrial deficit and oxidative stress","volume":"157","author":"Hsu","year":"2000","journal-title":"Am J Pathol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1089\/ars.2008.2247","article-title":"Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson\u2019s disease cybrids","volume":"11","author":"Esteves","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"B46","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.nbd.2017.04.004","article-title":"Alpha-synuclein: pathology, mitochondrial dysfunction and neuroinflammation in Parkinson\u2019s disease","volume":"109","author":"Rocha","year":"2017","journal-title":"Neurobiol Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1007\/s00018-017-2541-x","article-title":"Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production","volume":"74","author":"Tapias","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"B48","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"George Paxinos","year":"2007"},{"key":"B49","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology \u2013 reconsidered","volume":"193","author":"Gundersen","year":"1999","journal-title":"J Microsc"},{"key":"B50","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B51","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.tins.2004.06.006","article-title":"Putting a spin on the dorsal-ventral divide of the striatum","volume":"27","author":"Voorn","year":"2004","journal-title":"Trends Neurosci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"9938","DOI":"10.1073\/pnas.94.18.9938","article-title":"VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity","volume":"94","author":"Takahashi","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B53","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1006\/exnr.1998.7008","article-title":"Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson\u2019s disease","volume":"156","author":"Miller","year":"1999","journal-title":"Exp Neurol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.neuroscience.2006.10.004","article-title":"Oxidative stress and dopamine depletion in an intrastriatal 6-hydroxydopamine model of Parkinson\u2019s disease","volume":"144","author":"Smith","year":"2007","journal-title":"Neuroscience"},{"key":"B55","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1006\/exnr.1998.6848","article-title":"Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat","volume":"152","author":"Kirik","year":"1998","journal-title":"Exp Neurol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1006\/exnr.2002.7891","article-title":"Modeling Parkinson\u2019s disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway","volume":"175","author":"Deumens","year":"2002","journal-title":"Exp Neurol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.tins.2010.09.004","article-title":"Alpha-synuclein and dopamine at the crossroads of Parkinson\u2019s disease","volume":"33","author":"Venda","year":"2010","journal-title":"Trends Neurosci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.expneurol.2012.02.012","article-title":"Comparison of the behavioural and histological characteristics of the 6-OHDA and alpha-synuclein rat models of Parkinson\u2019s disease","volume":"235","author":"Decressac","year":"2012","journal-title":"Exp Neurol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1006\/exnr.1999.7296","article-title":"Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model","volume":"161","author":"Rosenblad","year":"2000","journal-title":"Exp Neurol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0304-3940(02)00016-2","article-title":"Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine","volume":"320","author":"Junn","year":"2002","journal-title":"Neurosci Lett"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.freeradbiomed.2008.08.002","article-title":"Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson\u2019s disease: validation by cell culture data","volume":"45","author":"Vali","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"103","DOI":"10.5607\/en.2015.24.2.103","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"24","author":"Moon","year":"2015","journal-title":"Exp Neurobiol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1212\/WNL.66.10_suppl_4.S24","article-title":"The pathogenesis of cell death in Parkinson\u2019s disease","volume":"66","author":"Jenner","year":"2006","journal-title":"Neurology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3233\/jpd-130230","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"3","author":"Dias","year":"2013","journal-title":"J Parkinsons Dis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.redox.2015.11.013","article-title":"Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice","volume":"7","author":"Shearn","year":"2016","journal-title":"Redox Biol"},{"key":"B66","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1523\/JNEUROSCI.13-05-02013.1993","article-title":"Glutathione S-transferase isoenzymes in rat brain neurons and glia","volume":"13","author":"Johnson","year":"1993","journal-title":"J Neurosci"},{"key":"B67","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00401-006-0119-z","article-title":"Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration","volume":"112","author":"Croisier","year":"2006","journal-title":"Acta Neuropathol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00401-007-0244-3","article-title":"Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson\u2019s disease","volume":"114","author":"Braak","year":"2007","journal-title":"Acta Neuropathol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s12035-012-8340-3","article-title":"The role of glia in alpha-synucleinopathies","volume":"47","author":"Fellner","year":"2013","journal-title":"Mol Neurobiol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e39465","DOI":"10.1371\/journal.pone.0039465","article-title":"Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo","volume":"7","author":"Angot","year":"2012","journal-title":"PLoS One"},{"key":"B71","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.mcn.2017.04.009","article-title":"Extensive uptake of alpha-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage","volume":"82","author":"Lindstrom","year":"2017","journal-title":"Mol Cell Neurosci"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1007\/s11064-013-1123-z","article-title":"Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage","volume":"38","author":"Sheng","year":"2013","journal-title":"Neurochem Res"},{"key":"B73","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/0306-4522(89)90298-4","article-title":"Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus","volume":"32","author":"Sugiyama","year":"1989","journal-title":"Neuroscience"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1167\/iovs.05-0921","article-title":"Retinal ganglion cell axotomy induces an increase in intracellular superoxide anion","volume":"47","author":"Lieven","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B75","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1023\/B:NERE.0000014822.69384.0f","article-title":"Neurodegeneration or neuroprotection: the pivotal role of astrocytes","volume":"29","author":"Heales","year":"2004","journal-title":"Neurochem Res"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00222\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T06:10:09Z","timestamp":1660803009000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00222\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":75,"alternative-id":["10.3389\/fneur.2018.00222"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00222","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]},"article-number":"222"}}