{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:10:47Z","timestamp":1790187047184,"version":"4.1.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00264","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T06:38:09Z","timestamp":1524551889000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Central Lesions With Selective Semicircular Canal Involvement Mimicking Bilateral Vestibulopathy"],"prefix":"10.3389","volume":"9","author":[{"given":"Luke","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Michael","family":"Halmagyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3233\/VES-170619","article-title":"Bilateral vestibulopathy: diagnostic criteria consensus document of the classification committee of the B\u00e1r\u00e1ny society","volume":"27","author":"Strupp","year":"2017","journal-title":"J Vestib Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1001\/archneur.1988.00520310043015","article-title":"A clinical sign of canal paresis","volume":"45","author":"Halmagyi","year":"1988","journal-title":"Arch Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1093\/brain\/121.4.699","article-title":"Semicircular canal plane head impulses detect absent function of individual semicircular canals","volume":"121","author":"Cremer","year":"1998","journal-title":"Brain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.clinph.2009.10.016","article-title":"Vestibular evoked myogenic potentials: past, present and future","volume":"121","author":"Rosengren","year":"2010","journal-title":"Clin Neurophysiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/ana.21105","article-title":"Causative factors and epidemiology of bilateral vestibulopathy in 255 patients","volume":"61","author":"Zingler","year":"2007","journal-title":"Ann Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1007\/s00415-015-7918-x","article-title":"Glucocorticoids improve acute dizziness symptoms following acute unilateral vestibulopathy","volume":"262","author":"Batuecas-Caletrio","year":"2015","journal-title":"J Neurol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1212\/WNL.0000000000000906","article-title":"Head impulse gain and saccade analysis in pontine-cerebellar stroke and vestibular neuritis","volume":"83","author":"Chen","year":"2014","journal-title":"Neurology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/8904_2013_264","article-title":"Vestibular and saccadic abnormalities in Gaucher\u2019s disease","volume":"13","author":"Chen","year":"2014","journal-title":"JIMD Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1093\/brain\/awm323","article-title":"Vestibular, saccadic and fixation abnormalities in genetically confirmed Friedreich ataxia","volume":"131","author":"Fahey","year":"2008","journal-title":"Brain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jns.2016.04.013","article-title":"Selective impairment of horizontal vestibulo-ocular reflexes in acute Wernicke\u2019s encephalopathy","volume":"365","author":"Akdal","year":"2016","journal-title":"J Neurol Sci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3389\/fneur.2017.00258","article-title":"The video head impulse test","volume":"8","author":"Halmagyi","year":"2017","journal-title":"Front Neurol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1212\/WNL.0b013e3181bacf85","article-title":"The video head impulse test: diagnostic accuracy in peripheral vestibulo-pathy","volume":"73","author":"MacDougall","year":"2009","journal-title":"Neurology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e61488","DOI":"10.1371\/journal.pone.0061488","article-title":"The video head impulse test (vHIT) detects vertical semicircular canal dysfunction","volume":"8","author":"Macdougall","year":"2013","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1212\/01.wnl.0000335971.43443.d9","article-title":"Gentamicin vestibulotoxicity impairs human electrically evoked vestibulo-ocular reflex","volume":"71","author":"Aw","year":"2008","journal-title":"Neurology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1007\/s00415-012-6724-y","article-title":"Semicircular canal, saccular and utricular function in patients with bilateral vestibulopathy: analysis based on etiology","volume":"260","author":"Agrawal","year":"2013","journal-title":"J Neurol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1016\/j.clinph.2016.05.005","article-title":"Disease-specific sparing of the anterior semicircular canals in bilateral vestibulopathy","volume":"127","author":"Tarnutzer","year":"2016","journal-title":"Clin Neurophysiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.clinph.2017.04.029","article-title":"Association of posterior semicircular canal hypofunction on video-head-impulse testing with other vestibulo-cochlear deficits","volume":"128","author":"Tarnutzer","year":"2017","journal-title":"Clin Neurophysiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1161\/STROKEAHA.110.582783","article-title":"Isolated vestibular nucleus infarction mimicking acute peripheral vestibulopathy","volume":"41","author":"Kim","year":"2010","journal-title":"Stroke"},{"key":"B19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00415-013-7139-0","article-title":"Isolated vestibular nuclear infarction: report of two cases and review of the literature","volume":"261","author":"Kim","year":"2014","journal-title":"J Neurol"},{"key":"B20","doi-asserted-by":"crossref","first-page":"xiii","DOI":"10.1093\/acprof:oso\/9780195167085.001.0001","volume-title":"The Vestibular System: A Sixth Sense","author":"Goldberg","year":"2012"},{"key":"B21","first-page":"3","article-title":"Neurochemistry of the vestibular system","volume-title":"Overview of the Vestibular System: Anatomy","author":"B\u00fcttner-Ennever","year":"2000"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1007\/s00415-013-6837-y","article-title":"Isolated floccular infarction: impaired vestibular responses to horizontal head impulse","volume":"260","author":"Park","year":"2013","journal-title":"J Neurol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00415-017-8455-6","article-title":"Isolated vestibular syndromes due to brainstem and cerebellar lesions","volume":"264","author":"Kim","year":"2017","journal-title":"J Neurol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1152\/jn.1988.60.6.2091","article-title":"Spatial organization of visual messages of the rabbit\u2019s cerebellar flocculus. II. Complex and simple spike responses of Purkinje cells","volume":"60","author":"Graf","year":"1988","journal-title":"J Neurophysiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/cne.903490308","article-title":"Projections of individual Purkinje cells of identified zones in the flocculus to the vestibular and cerebellar nuclei in the rabbit","volume":"349","author":"De Zeeuw","year":"1994","journal-title":"J Comp Neurol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1113\/jphysiol.2013.259614","article-title":"Diversity of vestibular nuclei neurons targeted by cerebellar nodulus inhibition","volume":"592","author":"Meng","year":"2014","journal-title":"J Physiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"7904","DOI":"10.1523\/JNEUROSCI.23-21-07904.2003","article-title":"Cerebellar climbing fibers modulate simple spikes in Purkinje cells","volume":"23","author":"Barmack","year":"2003","journal-title":"J Neurosci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.neuroscience.2006.08.006","article-title":"Antiphasic Purkinje cell responses in mouse uvula-nodulus are sensitive to static roll-tilt and topographically organized","volume":"143","author":"Yakhnitsa","year":"2006","journal-title":"Neuroscience"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1152\/jn.1998.80.4.1911","article-title":"Effects of lesions of the oculomotor vermis on eye movements in primate: saccades","volume":"80","author":"Takagi","year":"1998","journal-title":"J Neurophysiol"},{"key":"B30","first-page":"455","article-title":"Internuclear ophthalmoplegia: pathophysiology and diagnosis","volume":"1","author":"Zee","year":"1992","journal-title":"Baillieres Clin Neurol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s00415-017-8607-8","article-title":"Vestibulo-ocular reflex deficits with medial longitudinal fasciculus lesions","volume":"264","author":"Aw","year":"2017","journal-title":"J Neurol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1212\/WNL.0000000000004745","article-title":"Impaired vestibular responses in internuclear ophthalmoplegia: association and dissociation","volume":"89","author":"Choi","year":"2017","journal-title":"Neurology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1001\/archneur.1963.00460040017001","article-title":"Disturbances of conjugate horizontal eye movements in the monkey. II. Physiological effects and anatomical degeneration resulting from lesions in the medical longitudinal fasciculus","volume":"8","author":"Carpenter","year":"1963","journal-title":"Arch Neurol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1001\/archneur.1976.00500060053011","article-title":"An explanation of eye movements seen in internuclear ophthalmoplegia","volume":"33","author":"Pola","year":"1976","journal-title":"Arch Neurol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/brain\/103.1.113","article-title":"Disordered inhibition in internuclear ophthalmoplegia: analysis of eye movement recordings with computer simulations","volume":"103","author":"Feldon","year":"1980","journal-title":"Brain"},{"key":"B36","first-page":"592","article-title":"Unilateral internuclear ophthalmoplegia. The lack of inhibitory involvement in medial rectus muscle activity","volume":"21","author":"Kommerell","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1749-6632.1981.tb30864.x","article-title":"The ascending tract of Deiters\u2019 and horizontal gaze","volume":"374","author":"Highstein","year":"1981","journal-title":"Ann N Y Acad Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0006-8993(81)91141-0","article-title":"Properties of secondary vestibular neurons fired by stimulation of ampullary nerve of the vertical, anterior or posterior, semicircular canals in the cat","volume":"223","author":"Uchino","year":"1981","journal-title":"Brain Res"},{"key":"B39","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1152\/jn.1990.63.4.918","article-title":"Vertical eye movement-related secondary vestibular neurons ascending in medial longitudinal fasciculus in cat I. Firing properties and projection pathways","volume":"63","author":"Iwamoto","year":"1990","journal-title":"J Neurophysiol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/cne.902150108","article-title":"The superior vestibular nucleus: an intracellular HRP study in the cat. I. Vestibulo-ocular neurons","volume":"215","author":"Mitsacos","year":"1983","journal-title":"J Comp Neurol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1152\/jn.1984.52.4.724","article-title":"Neuron activity in monkey vestibular nuclei during vertical vestibular stimulation and eye movements","volume":"52","author":"Chubb","year":"1984","journal-title":"J Neurophysiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1152\/jn.1984.51.6.1121","article-title":"Signals in vestibular nucleus mediating vertical eye movements in the monkey","volume":"51","author":"Tomlinson","year":"1984","journal-title":"J Neurophysiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/BF00227966","article-title":"Neural basis for eye velocity generation in the vestibular nuclei of alert monkeys during off-vertical axis rotation","volume":"92","author":"Reisine","year":"1992","journal-title":"Exp Brain Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1152\/jn.1965.28.6.991","article-title":"Tonic and kinetic responses of cat\u2019s vestibular neurons to horizontal angular acceleration","volume":"28","author":"Shimazu","year":"1965","journal-title":"J Neurophysiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jns.2016.09.063","article-title":"Chasing dizzy chimera: diagnosis of combined peripheral and central vestibulopathy","volume":"371","author":"Choi","year":"2016","journal-title":"J Neurol Sci"},{"key":"B46","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3389\/fneur.2017.00711","article-title":"Oculomotor and vestibular findings in Gaucher disease type 3 and their correlation with neurological findings","volume":"8","author":"Bremova-Ertl","year":"2017","journal-title":"Front Neurol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1136\/jnnp.2007.121061","article-title":"The vestibulo-ocular reflexes during head impulse in Wernicke\u2019s encephalopathy","volume":"78","author":"Choi","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1093\/brain\/awh030","article-title":"Cerebellar ataxia with bilateral vestibulopathy: description of a syndrome and its characteristic clinical sign","volume":"127","author":"Migliaccio","year":"2004","journal-title":"Brain"},{"key":"B49","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s12311-015-0650-3","article-title":"Vestibular performance during high-acceleration stimuli correlates with clinical decline in SCA6","volume":"14","author":"Huh","year":"2015","journal-title":"Cerebellum"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1212\/WNL.42.12.2274","article-title":"Vertigo and the anterior inferior cerebellar artery syndrome","volume":"42","author":"Oas","year":"1992","journal-title":"Neurology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1161\/STROKEAHA.109.564682","article-title":"Infarction in the territory of anterior inferior cerebellar artery: spectrum of audiovestibular loss","volume":"40","author":"Lee","year":"2009","journal-title":"Stroke"},{"key":"B52","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1113\/jphysiol.1979.sp012934","article-title":"The role of the flocculus of the monkey in saccadic eye movements","volume":"294","author":"Noda","year":"1979","journal-title":"J Physiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1152\/jn.1981.46.4.878","article-title":"Effects of ablation of flocculus and paraflocculus of eye movements in primate","volume":"46","author":"Zee","year":"1981","journal-title":"J Neurophysiol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e22410","DOI":"10.1371\/journal.pone.0022410","article-title":"The saccadic and neurological deficits in type 3 Gaucher disease","volume":"6","author":"Benko","year":"2011","journal-title":"PLoS One"},{"key":"B55","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1212\/WNL.33.8.994","article-title":"Non-infantile neuronopathic Gaucher\u2019s disease: a clinicopathologic study","volume":"33","author":"Winkelman","year":"1983","journal-title":"Neurology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/S1474-4422(07)70104-7","article-title":"Wernicke\u2019s encephalopathy: new clinical settings and recent advances in diagnosis and management","volume":"6","author":"Sechi","year":"2007","journal-title":"Lancet Neurol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00415-017-8670-1","article-title":"The medial vestibular nuclei, a vulnerable target in thiamine deficiency","volume":"265","author":"Kattah","year":"2018","journal-title":"J Neurol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1212\/WNL.0000000000005206","article-title":"Vestibular signs of thiamine deficiency during the early phase of suspected Wernicke encephalopathy","volume":"3","author":"Kattah","year":"2013","journal-title":"Neurol Clin Pract"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1212\/WNL.0000000000000352","article-title":"Dorsal root ganglionopathy is responsible for the sensory impairment in CANVAS","volume":"82","author":"Szmulewicz","year":"2014","journal-title":"Neurology"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00264\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T06:38:14Z","timestamp":1524551894000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fneur.2018.00264\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,24]]},"references-count":59,"alternative-id":["10.3389\/fneur.2018.00264"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00264","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,24]]},"article-number":"264"}}