{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:53:07Z","timestamp":1790409187130,"version":"4.1.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00431","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T12:43:15Z","timestamp":1528720995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Betahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches"],"prefix":"10.3389","volume":"9","author":[{"given":"Brahim","family":"Tighilet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"L\u00e9onard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Watabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bernard-Demanze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lacour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1152\/jn.1998.80.5.2352","article-title":"Neuronal activity in the vestibular nuclei after contralateral or bilateral labyrinthectomy in the alert guinea pig","volume":"80","author":"Ris","year":"1998","journal-title":"J Neurophysiol."},{"key":"B2","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1152\/jn.1995.74.5.2087","article-title":"Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig","volume":"74","author":"Ris","year":"1995","journal-title":"J Neurophysiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/00016489309130556","article-title":"Recovery of head postural control following unilateral vestibular neurectomy in the cat: neck muscle activity and neuronal correlates in the Deiter's nuclei","volume":"509","author":"Zennou-Azogui","year":"1993","journal-title":"Acta Oto Laryngol Suppl."},{"key":"B4","volume-title":"Vestibular Compensation: Facts, Theories and Clinical Perspectives","author":"Lacour","year":"1989"},{"key":"B5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0165-0173(89)90013-1","article-title":"Mechanisms of recovery following unilateral labyrinthectomy: a review","volume":"14","author":"Smith","year":"1989","journal-title":"Brain Res Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/RNN-2010-0509","article-title":"Plastic events in the vestibular nuclei during vestibular compensation: the brain orchestration of a deafferentation code","volume":"27","author":"Lacour","year":"2010","journal-title":"Restor Neurol Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/MOO.0b013e32833de71f","article-title":"Mechanisms of vestibular compensation: recent advances","volume":"18","author":"Dutia","year":"2010","journal-title":"Curr Opin Otolaryngol Head Neck Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0165-0173(91)90001-O","article-title":"Neurochemical mechanisms of recovery from peripheral vestibular lesions (vestibular compensation)","volume":"17","author":"Smith","year":"1991","journal-title":"Brain Res Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0301-0082(95)80009-W","article-title":"Vestibular compensation: neural plasticity and its relations to functional recovery after labyrinthine lesions in frogs and other vertebrates","volume":"46","author":"Dieringer","year":"1995","journal-title":"Prog Neurobiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0194-5998(98)70171-8","article-title":"Vestibular compensation revisited","volume":"119","author":"Vidal","year":"1998","journal-title":"Otolaryngol Head Neck Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3389\/fneur.2014.00285","article-title":"Interaction between vestibular compensation mechanisms and vestibular rehabilitation therapy: 10 recommendations for optimal functional recovery","volume":"5","author":"Lacour","year":"2015","journal-title":"Front Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3233\/VES-130494","article-title":"Neuropharmacological basis of vestibular system disorder treatment","volume":"23","author":"Soto","year":"2013","journal-title":"J Vestib Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/lary.1986.96.8.878","article-title":"Effect of drug therapy on compensation from vestibular injury","volume":"96","author":"Peppard","year":"1986","journal-title":"Laryngology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/BF02935558","article-title":"Molecular mechanisms of brainstem plasticity. The vestibular compensation model","volume":"5","author":"Darlington","year":"1991","journal-title":"Mol Neurobiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"853","DOI":"10.2165\/00023210-200115110-00004","article-title":"Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action","volume":"15","author":"Lacour","year":"2001","journal-title":"CNS Drugs"},{"key":"B16","doi-asserted-by":"publisher","first-page":"777","DOI":"10.2165\/00003495-199550050-00002","article-title":"Antivertigo medications and drug-induced vertigo","volume":"50","author":"Rascol","year":"1995","journal-title":"Pharmacol Rev Drugs"},{"key":"B17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2165\/00023210-200317020-00002","article-title":"Pharmacological treatment of vertigo","volume":"17","author":"Hain","year":"2003","journal-title":"CNS Drugs"},{"key":"B18","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2174\/157015910790909511","article-title":"Neuropharmacology of vestibular system disorders","volume":"8","author":"Soto","year":"2010","journal-title":"Curr Neuropharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3233\/VES-130495","article-title":"New insights into vestibular neuropharmacology: from bench to bedside","volume":"23","author":"Chabbert","year":"2013","journal-title":"J Vestib Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3233\/NRE-130875","article-title":"Pharmacology of balance and dizziness","volume":"32","author":"Lin","year":"2013","journal-title":"Rev Neuro Rehabil."},{"key":"B21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0957-4271(94)00023-U","article-title":"Betahistine dihydrochloride treatment facilitates vestibular compensation in the cat","volume":"5","author":"Tighilet","year":"1995","journal-title":"J Vestib Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/00001756-19960322000008","article-title":"Distribution of histaminergic axonal fibers in the vestibular nuclei of the cat","volume":"7","author":"Tighilet","year":"1996","journal-title":"Neuroreport"},{"key":"B23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0014-2999(97)10124-8","article-title":"Histamine immunoreactivity changes in vestibular lesioned and histaminergic treated cats","volume":"330","author":"Tighilet","year":"1997","journal-title":"Eur J Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ejphar.2005.09.017","article-title":"Dose and duration-dependant effects of betahistine dihydrochloride treatment on histamine turnover in the cat","volume":"523","author":"Tighilet","year":"2005","journal-title":"Eur J Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ejphar.2007.04.052","article-title":"Histaminergic ligands improve vestibular compensation in the cat: behavioural, neurochemical and molecular correlates","volume":"446","author":"Tighilet","year":"","journal-title":"Eur J Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1177\/0091270010369241","article-title":"Betahistine treatment improves the recovery of static symptoms in patients with unilateral vestibular loss","volume":"51","author":"Redon","year":"2011","journal-title":"J Clin Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"CD010696","DOI":"10.1002\/14651858.CD010696","article-title":"Betahistine for symptoms of vertigo","volume":"21","author":"Murdin","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e39086","DOI":"10.1371\/journal.pone.0039086","article-title":"Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo","volume":"7","author":"Ihler","year":"2012","journal-title":"PLoS ONE"},{"key":"B29","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3109\/14992027.2014.917208","article-title":"Betahistine metabolites, aminoethylpyridine, and hydroxyethylpyridine increase cochlear blood flow in guinea pigs in vivo","volume":"53","author":"Bertlich","year":"2014","journal-title":"Int J Audiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1159\/000368293","article-title":"Histaminergic H3-heteroreceptors as a potential mediator of betahistine-induced increase in cochlear blood flow","volume":"20","author":"Bertlich","year":"2015","journal-title":"Audiol Neuro Otol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.lfs.2017.08.015","article-title":"Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear model","volume":"187","author":"Bertlich","year":"2017","journal-title":"Life Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"h6816","DOI":"10.1136\/bmj.h6816","article-title":"Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial","volume":"352","author":"Adrion","year":"2016","journal-title":"BMJ"},{"key":"B33","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1080\/00016480701724912","article-title":"Long-term prophylactic treatment of attacks of vertigo in Meni\u00e8re's disease\u2013comparison of a high with a low dosage of betahistine in an open trial","volume":"128","author":"Strupp","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"B34","article-title":"Differences of betahistine pharmacokinetics and metabolism in dog, cat and man","volume-title":"Abstracts from the 13th European ISSX Meeting","author":"Matthias","year":"2015"},{"key":"B35","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3109\/00016488009131743","article-title":"Compensation deficits in posture and kinetics following unilateral vestibular neurectomy in cats. The role of sensorimotor activity","volume":"90","author":"Xerri","year":"1980","journal-title":"Acta Otolaryngol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0006-8993(76)90940-9","article-title":"Modifications and development of spinal reflexes in the alert baboon (Papio papio) following an unilateral vestibular neurotomy","volume":"113","author":"Lacour","year":"1976","journal-title":"Brain Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.neuroscience.2009.02.070","article-title":"Stress axis plasticity during vestibular compensation in the adult cat","volume":"160","author":"Tighilet","year":"2009","journal-title":"Neuroscience"},{"key":"B38","first-page":"239","article-title":"The thalamus and basal telencephalon of the cat. A Cytoarchitectonic Atlas with Stereotaxic Coordinates","volume":"144","author":"Berman","year":"1982","journal-title":"J Anat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00429-014-0899-1","article-title":"Sequential [(18)F]FDG \u03bcPET whole-brain imaging of central vestibular compensation: a model of deafferentation-induced brain plasticity","volume":"221","author":"Zwergal","year":"2016","journal-title":"Brain Struct Funct."},{"key":"B40","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1523\/JNEUROSCI.0945-16.2016","article-title":"BDNF signaling promotes vestibular compensation by increasing neurogenesis and remodeling the expression of potassium-chloride cotransporter KCC2 and GABAA receptor in the vestibular nuclei","volume":"36","author":"Dutheil","year":"2016","journal-title":"J Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1013\/jphysiol.2006.107805","article-title":"Changes in the histaminergic system during vestibular compensation in the cat","volume":"573","author":"Tighilet","year":"2006","journal-title":"J Physiol Lond."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1016\/0921-8696(91)90671-9","article-title":"Effect of unilateral vestibular stimulation on histamine release from the hypothalamus of rats in vivo","volume":"70","author":"Horii","year":"1993","journal-title":"J Neurophysiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S0031-9384(96)00613-0","article-title":"Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness","volume":"61","author":"Uno","year":"1997","journal-title":"Physiol Behav."},{"key":"B44","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/BF02461359","article-title":"Responses of hypothalamic neurons to stimulation of the vestibular nerve and lateral vestibular nucleus in the rabbit","volume":"29","author":"Grigoryan","year":"1999","journal-title":"Neurosci Behav Physiol."},{"key":"B45","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1152\/jn.1966.29.6.996","article-title":"A mechanism of central compensation of vestibular function following hemilabyrinthectomy","volume":"29","author":"Precht","year":"1966","journal-title":"J Neurophysiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1002\/ddr.430340211","article-title":"Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor","volume":"302","author":"Arrang","year":"1983","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/0306-4522(85)90233-7","article-title":"Autoregulation of histamine release in brain by presynaptic H3-receptors","volume":"15","author":"Arrang","year":"1985","journal-title":"Neuroscience"},{"key":"B48","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0306-4522(87)90279-X","article-title":"Autoregulation of histamine synthesis in brain mediated by presynaptic H3 receptors","volume":"23","author":"Arrang","year":"1987","journal-title":"Neuroscience"},{"key":"B49","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1749-6632.1990.tb311981.x","article-title":"Modulation of histamine synthesis and release in brain via presynaptic autoreceptors and heteroreceptors","volume":"604","author":"Schwartz","year":"1990","journal-title":"Ann N Y Acad Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0014-2999(02)01795-8","article-title":"Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms","volume":"446","author":"Tighilet","year":"2002","journal-title":"Eur J Pharmacol."},{"key":"B51","first-page":"459","article-title":"Effects of histamine on rat medial vestibular nucleus neurons in vitro","author":"Inverarity","year":"1993","journal-title":"J Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0304-3940(90)90009-X","article-title":"Histamine depolarizes rat medial vestibular nucleus neurons recorded intracellularly in vitro","volume":"109","author":"Phelan","year":"1990","journal-title":"Neurosci Lett."},{"key":"B53","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/BF00228392","article-title":"Medial vestibular nucleus in the guinea-pig: histaminergic receptors. I. An in vitro study","volume":"93","author":"Serafin","year":"1993","journal-title":"Exp Brain Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/BF00242178","article-title":"Effects of histamine and betahistine on rat medial vestibular nucleus neurons: possible mechanism of action of anti-histaminergic drugs in vertigo and motion sickness","volume":"105","author":"Wang","year":"1995","journal-title":"Exp Brain Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1007\/s00405-015-3731-5","article-title":"Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease","volume":"273","author":"Moller","year":"2016","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s00405-011-1647-2","article-title":"High-dosage betahistine dihydrochloride between 288 and 480 mg\/day in patients with severe Meni\u00e8re's disease: a case series","volume":"268","author":"Lezius","year":"2011","journal-title":"Eur Arch Otorhinolaryngol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2018.00431\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T12:43:21Z","timestamp":1528721001000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2018.00431\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,11]]},"references-count":56,"alternative-id":["10.3389\/fneur.2018.00431"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00431","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,11]]},"article-number":"431"}}