{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:51:09Z","timestamp":1790844669773,"version":"4.1.0"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008164","name":"Muscular Dystrophy UK","doi-asserted-by":"publisher","award":["MC3\/1073"],"award-info":[{"award-number":["MC3\/1073"]}],"id":[{"id":"10.13039\/501100008164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","award":["CAF\/MD\/15\/01"],"award-info":[{"award-number":["CAF\/MD\/15\/01"]}],"id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00780","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T08:36:06Z","timestamp":1538469366000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcome Measures for Central Nervous System Evaluation in Myotonic Dystrophy Type 1 May Be Confounded by Deficits in Motor Function or Insight"],"prefix":"10.3389","volume":"9","author":[{"given":"Mark J.","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cumming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"McGhie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Jampana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Longman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren G.","family":"Monckton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Farrugia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/WCO.0000000000000128","article-title":"Myotonic dystrophy: diagnosis, management and new therapies","volume":"27","author":"Turner","year":"2014","journal-title":"Curr Opin Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/0092-867490154-5","article-title":"Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member","volume":"68","author":"Brook","year":"1992","journal-title":"Cell"},{"key":"B3","first-page":"1164","article-title":"Size of the unstable CTG repeat sequence in relation to phenotype and parental transmission in myotonic dystrophy","volume":"52","author":"Harley","year":"1993","journal-title":"Am J Hum Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.neurol.2016.08.003","article-title":"Unravelling the myotonic dystrophy type 1 clinical spectrum: a systematic registry-based study with implications for disease classification","volume":"172","author":"De Antonio","year":"2016","journal-title":"Rev Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1212\/WNL.0b013e318260cbe6","article-title":"Patient-reported impact of symptoms in myotonic dystrophy type 1 (PRISM-1)","volume":"79","author":"Heatwole","year":"2012","journal-title":"Neurology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1001\/archneur.61.12.1943","article-title":"Characterization of the pattern of cognitive impairment in myotonic dystrophy type 1","volume":"61","author":"Modoni","year":"2004","journal-title":"Arch Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1399-0004.1997.tb02533.x","article-title":"A study of the cognitive and psychological profile in 16 children with congenital or juvenile myotonic dystrophy","volume":"52","author":"Steyaert","year":"1997","journal-title":"Clin Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1002\/ajmg.b.30698","article-title":"Autism spectrum conditions in myotonic dystrophy type 1: a study on 57 individuals with congenital and childhood forms","author":"Ekstrom","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-314837","article-title":"Myotonic dystrophy type 1: clinical manifestations in children and adolescents","author":"Ho","year":"2018","journal-title":"Arch Dis Child."},{"key":"B10","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00787-009-0037-4","article-title":"Psychiatric and cognitive phenotype in children and adolescents with myotonic dystrophy","volume":"18","author":"Douniol","year":"2009","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1111\/j.1469-8749.2012.04379.x","article-title":"Psychiatric and cognitive phenotype of childhood myotonic dystrophy type 1","volume":"54","author":"Douniol","year":"2012","journal-title":"Dev Med Child Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1744-9081-2-16","article-title":"Cognitive deficits and CTG repeat expansion size in classical myotonic dystrophy type 1 (DM1)","volume":"2","author":"Winblad","year":"2006","journal-title":"Behav Brain Funct."},{"key":"B13","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1136\/jmg.34.3.229","article-title":"Mild myotonic dystrophy is associated with memory impairment in the context of normal general intelligence","volume":"34","author":"Rubinsztein","year":"1997","journal-title":"J Med Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1136\/jmg.31.4.300","article-title":"Intelligence quotient profile in myotonic dystrophy, intergenerational deficit, and correlation with CTG amplification","volume":"31","author":"Turnpenny","year":"1994","journal-title":"J Med Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cortex.2017.08.008","article-title":"The cognitive profile of myotonic dystrophy type 1: a systematic review and meta-analysis","volume":"95","author":"Okkersen","year":"2017","journal-title":"Cortex"},{"key":"B16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s10072-016-2778-4","article-title":"Clusters of cognitive impairment among different phenotypes of myotonic dystrophy type 1 and type 2","volume":"38","author":"Peric","year":"2017","journal-title":"Neurol Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s10072-007-0742-z","article-title":"Cognitive impairment in adult myotonic dystrophies: a longitudinal study","volume":"28","author":"Sansone","year":"2007","journal-title":"Neurol Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1111\/ene.13062","article-title":"Cognition in myotonic dystrophy type 1: a 5-year follow-up study","volume":"23","author":"Winblad","year":"2016","journal-title":"Eur J Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1007\/s00415-008-0017-5","article-title":"Cognitive impairment in myotonic dystrophy type 1 (DM1): a longitudinal follow-up study","volume":"255","author":"Modoni","year":"2008","journal-title":"J Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0960-8966(03)00137-8","article-title":"Executive dysfunction and avoidant personality trait in myotonic dystrophy type 1 (DM-1) and in proximal myotonic myopathy (PROMM\/DM-2)","volume":"13","author":"Meola","year":"2003","journal-title":"Neuromuscul Disord."},{"key":"B21","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.nmd.2004.12.003","article-title":"Temperament and character in patients with classical myotonic dystrophy type 1 (DM-1)","volume":"15","author":"Winblad","year":"2005","journal-title":"Neuromuscul Disord."},{"key":"B22","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1001\/archneur.55.5.635","article-title":"Personality patterns in patients with myotonic dystrophy","volume":"55","author":"Delaporte","year":"1998","journal-title":"Arch Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1136\/jnnp.57.5.626","article-title":"Daytime sleep in myotonic dystrophy is not caused by sleep apnoea","volume":"57","author":"van der Meche","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0304-3940(03)00740-7","article-title":"Quantification of brain atrophy in patients with myotonic dystrophy and proximal myotonic myopathy: a controlled 3-dimensional magnetic resonance imaging study","volume":"348","author":"Kassubek","year":"2003","journal-title":"Neurosci Lett."},{"key":"B25","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s002340050385","article-title":"Cranial MRI findings in myotonic dystrophy","volume":"39","author":"Miaux","year":"1997","journal-title":"Neuroradiology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1177\/1971400915621325","article-title":"Brain MRI abnormalities in the adult form of myotonic dystrophy type 1: a longitudinal case series study","volume":"29","author":"Conforti","year":"2016","journal-title":"Neuroradiol J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1080\/02841850510015974","article-title":"Diffusion tensor imaging of cerebral white matter in patients with myotonic dystrophy","volume":"46","author":"Fukuda","year":"2005","journal-title":"Acta Radiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0130352","DOI":"10.1371\/journal.pone.0130352","article-title":"Cortical and subcortical grey and white matter atrophy in myotonic dystrophies type 1 and 2 is associated with cognitive impairment, depression and daytime sleepiness","volume":"10","author":"Schneider-Gold","year":"2015","journal-title":"PLoS ONE"},{"key":"B29","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.nicl.2016.06.011","article-title":"Relationship between neuropsychological impairment and grey and white matter changes in adult-onset myotonic dystrophy type 1","volume":"12","author":"Baldanzi","year":"2016","journal-title":"Neuroimage Clin."},{"key":"B30","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.neulet.2006.08.077","article-title":"Relationship between diffusion tensor imaging and brain morphology in patients with myotonic dystrophy","volume":"407","author":"Ota","year":"2006","journal-title":"Neurosci Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.11138\/FNeur\/2015.30.1.021","article-title":"How genetics affects the brain to produce higher-level dysfunctions in myotonic dystrophy type 1","volume":"30","author":"Serra","year":"2015","journal-title":"Funct Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e104697","DOI":"10.1371\/journal.pone.0104697","article-title":"Cognitive impairment in myotonic dystrophy type 1 is associated with white matter damage","volume":"9","author":"Caso","year":"2014","journal-title":"PLoS ONE"},{"key":"B33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/arclin\/acx008","article-title":"Brain involvement in myotonic dystrophy type 1: a morphometric and diffusion tensor imaging study with neuropsychological correlation","volume":"32","author":"Cabada","year":"2017","journal-title":"Arch Clin Neuropsychol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.nicl.2016.04.012","article-title":"Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1","volume":"11","author":"Zanigni","year":"2016","journal-title":"Neuroimage Clin."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1093\/brain\/awr299","article-title":"The brain in myotonic dystrophy 1 and 2: evidence for a predominant white matter disease","volume":"134","author":"Minnerop","year":"2011","journal-title":"Brain"},{"key":"B36","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jns.2014.04.005","article-title":"Tractography reveals diffuse white matter abnormalities in Myotonic Dystrophy Type 1","volume":"341","author":"Wozniak","year":"2014","journal-title":"J Neurol Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1212\/WNL.0000000000004300","article-title":"Brain imaging in myotonic dystrophy type 1: a systematic review","volume":"89","author":"Okkersen","year":"2017","journal-title":"Neurology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1136\/jnnp.2006.107185","article-title":"Towards an integrative approach to the management of myotonic dystrophy type 1","volume":"78","author":"Gagnon","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fncel.2017.00101","article-title":"Myotonic Dystrophies: state of the art of new therapeutic developments for the CNS","volume":"11","author":"Gourdon","year":"2017","journal-title":"Front Cell Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.nmd.2013.07.004","article-title":"Report of the first Outcome Measures in Myotonic Dystrophy type 1 (OMMYD-1) international workshop: clearwater, florida, November 30, 2011","volume":"23","author":"Gagnon","year":"2013","journal-title":"Neuromuscul Disord."},{"key":"B41","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.nmd.2015.01.008","article-title":"Report of the second Outcome Measures in Myotonic Dystrophy type 1 (OMMYD-2) international workshop San Sebastian, Spain, October 16, 2013","volume":"25","author":"Gagnon","year":"2015","journal-title":"Neuromuscul Disord."},{"key":"B42","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.nmd.2015.07.016","article-title":"Workshop report: consensus on biomarkers of cerebral involvement in myotonic dystrophy, 2-3 December 2014, Milan, Italy","volume":"25","author":"Bosco","year":"2015","journal-title":"Neuromuscul Disord."},{"key":"B43","first-page":"198","article-title":"The OMERACT filter for Outcome Measures in Rheumatology","volume":"25","author":"Boers","year":"1998","journal-title":"J Rheumatol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/jnnp.2005.070763","article-title":"Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion","volume":"77","author":"Winblad","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/16501970500477967","article-title":"Health-related quality of life in myotonic dystrophy type 1 and its relationship with cognitive and emotional functioning","volume":"38","author":"Antonini","year":"2006","journal-title":"J Rehabil Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1017\/S0033291709990602","article-title":"Cognitive\/personality pattern and triplet expansion size in adult myotonic dystrophy type 1 (DM1): CTG repeats, cognition and personality in DM1","volume":"40","author":"Sistiaga","year":"2010","journal-title":"Psychol Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/arclin\/acq016","article-title":"Toward understanding cognitive impairment in patients with myotonic dystrophy type 1","volume":"25","author":"Zalonis","year":"2010","journal-title":"Arch Clin Neuropsychol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0139944","DOI":"10.1371\/journal.pone.0139944","article-title":"Reconstructing the rasch-built myotonic dystrophy type 1 activity and participation scale","volume":"10","author":"Hermans","year":"2015","journal-title":"PLoS ONE"},{"key":"B49","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/mus.23478","article-title":"Fatigue and daytime sleepiness scale in myotonic dystrophy type 1","volume":"47","author":"Hermans","year":"2013","journal-title":"Muscle Nerve"},{"key":"B50","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1002\/mus.24097","article-title":"Myotonic dystrophy health index: initial evaluation of a disease-specific outcome measure","volume":"49","author":"Heatwole","year":"2014","journal-title":"Muscle Nerve"},{"key":"B51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13023-016-0417-z","article-title":"Disease awareness in myotonic dystrophy type 1: an observational cross-sectional study","volume":"11","author":"Baldanzi","year":"2016","journal-title":"Orphanet J Rare Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/4.1.1","article-title":"Somatic mosaicism, germline expansions, germline reversions and intergenerational reductions in myotonic dystrophy males: small pool PCR analyses","volume":"4","author":"Monckton","year":"1995","journal-title":"Hum Mol Genet."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3558","DOI":"10.1093\/hmg\/dds185","article-title":"Somatic instability of the expanded CTG triplet repeat in myotonic dystrophy type 1 is a heritable quantitative trait and modifier of disease severity","volume":"21","author":"Morales","year":"2012","journal-title":"Hum Mol Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/cge.12954","article-title":"Myotonic dystrophy type 1: role of CCG, CTC and CGG interruptions within DMPK alleles in the pathogenesis and molecular diagnosis","volume":"92","author":"Santoro","year":"2016","journal-title":"Clin Genet"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e013351","DOI":"10.1136\/bmjopen-2016-013351","article-title":"Cohort profile: the Scottish Research register SHARE. A register of people interested in research participation linked to NHS data sets","volume":"7","author":"McKinstry","year":"2017","journal-title":"BMJ Open"},{"key":"B56","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3109\/21678421.2013.805784","article-title":"Screening for cognition and behaviour changes in ALS","volume":"15","author":"Abrahams","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener."},{"key":"B57","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3109\/21678421.2014.959451","article-title":"The edinburgh cognitive and behavioural amyotrophic lateral sclerosis screen: a cross-sectional comparison of established screening tools in a German-Swiss population","volume":"16","author":"Lule","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener."},{"key":"B58","volume-title":"The Stroop Color and Word Test Adult Version: A Manual for Clinical and Experimental Uses","author":"Golden","year":"2002"},{"key":"B59","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3109\/17482968.2011.639376","article-title":"Amyotrophic lateral sclerosis and frontotemporal dementia: a behavioural and cognitive continuum","volume":"13","author":"Lillo","year":"2012","journal-title":"Amyotroph Lateral Scler."},{"key":"B60","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of beck depression inventories -IA and -II in psychiatric outpatients","volume":"67","author":"Beck","year":"1996","journal-title":"J Pers Assess"},{"key":"B61","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0304-3959(87)91074-8","article-title":"The short-form McGill Pain Questionnaire","volume":"30","author":"Melzack","year":"1987","journal-title":"Pain"},{"key":"B62","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"B63","first-page":"239","article-title":"Behavioural assessment of the dysexecutive syndrome","volume-title":"Methodology of Frontal and Executive Function.","author":"Wilson","year":"1997"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1093\/hmg\/ddq015","article-title":"Variant CCG and GGC repeats within the CTG expansion dramatically modify mutational dynamics and likely contribute toward unusual symptoms in some myotonic dystrophy type 1 patients","volume":"19","author":"Braida","year":"2010","journal-title":"Hum Mol Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"Neuroimage"},{"key":"B66","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.nicl.2015.10.012","article-title":"Quantifying brain tissue volume in multiple sclerosis with automated lesion segmentation and filling","volume":"9","author":"Valverde","year":"2015","journal-title":"Neuroimage Clin."},{"key":"B67","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods"},{"key":"B69","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1136\/practneurol-2017-001743","article-title":"Neuropsychological testing","volume":"18","author":"Zucchella","year":"2018","journal-title":"Pract Neurol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1038\/nprot.2006.390","article-title":"Administration and interpretation of the Trail Making Test","volume":"1","author":"Bowie","year":"2006","journal-title":"Nat Protoc."},{"key":"B71","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3389\/fpsyg.2017.00557","article-title":"The stroop color and word test","volume":"8","author":"Scarpina","year":"2017","journal-title":"Front Psychol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.nmd.2016.10.003","article-title":"Cognitive decline over time in adults with myotonic dystrophy type 1: a 9-year longitudinal study","volume":"27","author":"Gallais","year":"2017","journal-title":"Neuromuscul Disord."},{"key":"B73","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1037\/0882-7974.18.1.91","article-title":"What needs to be explained to account for age-related effects on multiple cognitive variables?","volume":"18","author":"Salthouse","year":"2003","journal-title":"Psychol Aging"},{"key":"B74","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1515\/REVNEURO.2010.21.3.187","article-title":"Structural brain changes in aging: courses, causes and cognitive consequences","volume":"21","author":"Fjell","year":"2010","journal-title":"Rev Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuroimage.2009.01.036","article-title":"Cognitive function and brain structure correlations in healthy elderly East Asians","volume":"46","author":"Chee","year":"2009","journal-title":"Neuroimage"},{"key":"B76","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuroimage.2015.08.034","article-title":"Differential age-dependent associations of gray matter volume and white matter integrity with processing speed in healthy older adults","volume":"123","author":"Hong","year":"2015","journal-title":"Neuroimage"},{"key":"B77","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12883-015-0401-6","article-title":"Prevalence and correlates of apathy in myotonic dystrophy type 1","volume":"15","author":"Gallais","year":"2015","journal-title":"BMC Neurol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/j.1600-0404.1995.tb00446.x","article-title":"Cognitive function in early adult and adult onset myotonic dystrophy","volume":"91","author":"Van Spaendonck","year":"1995","journal-title":"Acta Neurol Scand."},{"key":"B79","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fnagi.2017.00062","article-title":"Cognitive processing speed across the lifespan: beyond the influence of motor speed","volume":"9","author":"Ebaid","year":"2017","journal-title":"Front Aging Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"522","DOI":"10.2466\/pms.2000.90.2.522","article-title":"Block design as a measure of everyday spatial ability: a study of ecological validity","volume":"90","author":"Groth-Marnat","year":"2000","journal-title":"Percept Mot Skills"},{"key":"B81","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s13063-015-0737-7","article-title":"Cognitive behaviour therapy plus aerobic exercise training to increase activity in patients with myotonic dystrophy type 1 (DM1) compared to usual care (OPTIMISTIC): study protocol for randomised controlled trial","volume":"16","author":"van Engelen","year":"2015","journal-title":"Trials"},{"key":"B82","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1744-9081-6-25","article-title":"Depression in Myotonic Dystrophy type 1: clinical and neuronal correlates","volume":"6","author":"Winblad","year":"2010","journal-title":"Behav Brain Funct."},{"key":"B83","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/mus.24725","article-title":"Myotonic dystrophy health index: correlations with clinical tests and patient function","volume":"53","author":"Heatwole","year":"2016","journal-title":"Muscle Nerve"},{"key":"B84","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"B85","doi-asserted-by":"publisher","first-page":"e0148264","DOI":"10.1371\/journal.pone.0148264","article-title":"Gender as a modifying factor influencing myotonic dystrophy type 1 phenotype severity and mortality: a nationwide multiple databases cross-sectional observational study","volume":"11","author":"Dogan","year":"2016","journal-title":"PLoS ONE"},{"key":"B86","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1212\/WNL.0b013e318227b227","article-title":"Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline","volume":"77","author":"Debette","year":"2011","journal-title":"Neurology"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2018.00780\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T08:36:09Z","timestamp":1538469369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2018.00780\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":86,"alternative-id":["10.3389\/fneur.2018.00780"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00780","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"article-number":"780"}}