{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:20:40Z","timestamp":1787026840129,"version":"build-2736575974"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011264","name":"FP7 People: Marie-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2018.00879","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:42:59Z","timestamp":1540773779000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Motor Unit-Driven Identification of Pathological Tremor in Electroencephalograms"],"prefix":"10.3389","volume":"9","author":[{"given":"Ale\u0161","family":"Holobar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Gallego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jernej","family":"Kranjec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Rocon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojko","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/S0140-6736(00)02054-7","article-title":"Origins of tremor","volume":"355","author":"Elble","year":"2000","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0140-6736(00)04044-7","article-title":"Tremor-correlated cortical activity in essential tremor","volume":"357","author":"Hellwig","year":"2001","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1212\/WNL.46.5.1359","article-title":"Central motor loop oscillations in parkinsonian resting tremor revealed by magnetoencephalography","volume":"46","author":"Volkmann","year":"1996","journal-title":"Neurology"},{"key":"B4","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1212\/WNL.54.4.14A","article-title":"The pathophysiology of essential tremor","volume":"54","author":"Deuschl","year":"2000","journal-title":"Neurology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s11910-013-0378-8","article-title":"The pathophysiology of essential tremor and Parkinson's tremor","volume":"13","author":"Helmich","year":"2013","journal-title":"Curr Neurol Neurosci Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/S1388-2457(00)00248-0","article-title":"Tremor-correlated cortical activity detected by electroencephalography","volume":"111","author":"Hellwig","year":"2000","journal-title":"Clin Neurophysiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/brain\/awg022","article-title":"The cerebral oscillatory network of parkinsonian resting tremor","volume":"126","author":"Timmermann","year":"2003","journal-title":"Brain"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1152\/jn.00477.2006","article-title":"Cortical involvement in the generation of essential tremor","volume":"97","author":"Raethjen","year":"2007","journal-title":"J Neurophysiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.clinph.2009.06.028","article-title":"Cortical cor-relates of the basic and first harmonic frequency of Parkinsonian tremor","volume":"120","author":"Raethjen","year":"2009","journal-title":"Clin. Neurophysiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1002\/mds.22633","article-title":"Synchronized brain network associated with essential tremor as revealed by magnetoencephalography","volume":"24","author":"Schnitzler","year":"2009","journal-title":"Mov Disord"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1152\/jn.00187.2012","article-title":"The strength of the corticospinal coherence depends on the predictability of modulated isometric forces","volume":"109","author":"Mendez-Balbuena","year":"2013","journal-title":"J Neurophysiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"8037","DOI":"10.1523\/JNEUROSCI.4153-10.2011","article-title":"Corticospinal beta-range coherence is highly dependent on the pre-stationary motor state","volume":"31","author":"Omlor","year":"2011","journal-title":"J Neurosci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.neuroimage.2012.01.088","article-title":"Oscillating central motor networks in pathological tremors and voluntary movements. What makes the difference?","volume":"60","author":"Muthuraman","year":"2012","journal-title":"Neuroimage"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e93159","DOI":"10.1371\/journal.pone.0093159","article-title":"Effects of alprazolam on cortical activity and tremors in patients with essential tremor","volume":"9","author":"Ib\u00e1\u00f1ez","year":"2014","journal-title":"PLoS ONE"},{"key":"B15","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1152\/jn.00531.2014","article-title":"Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor","volume":"113","author":"Gallego","year":"2015","journal-title":"J Neurophysiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1073\/pnas.98.2.694","article-title":"Dynamic imaging of coherent sources: studying neural interactions in the human brain","volume":"98","author":"Gross","year":"2001","journal-title":"Proc Natl Acad Sci USA."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0079-6107(89)90004-7","article-title":"The Fourier approach to the identification of functional coupling between neuronal spike trains","volume":"53","author":"Rosenberg","year":"1989","journal-title":"Prog Biophys Mol Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e30135","DOI":"10.1371\/journal.pone.0030135","article-title":"Independent EEG sources are dipolar","volume":"7","author":"Delorme","year":"2012","journal-title":"PLoS ONE"},{"key":"B19","first-page":"135","article-title":"Corticospinal coherence during frequency-modulated isometric ankle dorsiflexion","volume-title":"Proceedings of the 3rd International Conference on NeuroRehabilitation (ICNR2016).","author":"\u00dabeda","year":"2016"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/jphysiol.2014.273581","article-title":"The effective neural drive to muscles is the common synaptic input to motor neurons","volume":"49","author":"Farina","year":"2014","journal-title":"J.Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1113\/jphysiol.2010.202473","article-title":"Linear transmission of cortical oscillations to the neural drive to muscles is mediated by common projections to populations of motor neurons in humans","volume":"589","author":"Negro","year":"2011","journal-title":"J Physiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1113\/jphysiol.2012.246082","article-title":"Identification of common synaptic inputs to motor neurons from the rectified electromyogram","volume":"15","author":"Farina","year":"2013","journal-title":"J Physiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1152\/jn.00938.2011","article-title":"Motor unit recruitment strategies and muscle properties determine the influence of synaptic noise on force steadiness","volume":"107","author":"Dideriksen","year":"2012","journal-title":"J Neurophysiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1016\/S1388-2457(03)00116-0","article-title":"Dynamic synchronisation of central oscillators in essential tremor","volume":"114","author":"Hellwig","year":"2003","journal-title":"Clin Neurophysiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4487","DOI":"10.1109\/TSP.2007.896108","article-title":"Multichannel blind source separation using convolution kernel compensation","volume":"55","author":"Holobar","year":"2007","journal-title":"IEEE Trans Signal Process."},{"key":"B26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1109\/TNSRE.2010.2041593","article-title":"Experimental analysis of accuracy in the identification of motor unit spike trains from high-density surface EMG","volume":"18","author":"Holobar","year":"2010","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"B27","doi-asserted-by":"publisher","first-page":"056011","DOI":"10.1088\/1741-2560\/9\/5\/056011","article-title":"Non-invasive characterization of motor unit behaviour in pathological tremor","volume":"9","author":"Holobar","year":"2012","journal-title":"J Neural Eng"},{"key":"B28","doi-asserted-by":"crossref","DOI":"10.1002\/0471221317","volume-title":"Independent Component Analysis","author":"Hyv\u00e4rinen","year":"2001"},{"key":"B29","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.clinph.2008.10.160","article-title":"Estimating motor unit firing patterns from high-density surface EMG","volume":"120","author":"Holobar","year":"2009","journal-title":"Clin Neurophysiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1109\/TNSRE.2013.2247631","article-title":"Real-time motor unit identification from high-density surface EMG","volume":"21","author":"Glaser","year":"2013","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"B31","doi-asserted-by":"publisher","first-page":"R143","DOI":"10.1088\/0967-3334\/35\/7\/R143","article-title":"Blind source identification from the multichannel surface electromyogram","volume":"35","author":"Holobar","year":"2014","journal-title":"Physiol Meas"},{"key":"B32","doi-asserted-by":"publisher","first-page":"046019","DOI":"10.1088\/1741-2560\/12\/4\/046019","article-title":"One central oscillatory drive is compatible with experimental motor unit behaviour in essential and Parkinsonian tremor","volume":"12","author":"Dideriksen","year":"2015","journal-title":"J Neural Eng."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1152\/jn.1993.70.6.2470","article-title":"Models of recruitment and rate coding organization in motor-unit pools","volume":"70","author":"Fuglevand","year":"1993","journal-title":"J Neurophysiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1109\/TBME.2003.820998","article-title":"A surface EMG generation model with multilayer cylindrical description of the volume conductor","volume":"51","author":"Farina","year":"2004","journal-title":"IEEE Trans Biomed Eng"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/S0006-3495(69)86448-9","article-title":"Statistical analysis of motor unit firing patterns in a human skeletal muscle","volume":"9","author":"Clamann","year":"1969","journal-title":"Biophys J."},{"key":"B36","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1113\/jphysiol.1996.sp021332","article-title":"Relationship of firing intervals of human motor units to the trajectory of post-spike after-hyperpolarization and synaptic noise","volume":"492","author":"Matthews","year":"1996","journal-title":"J Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1152\/jn.01122.2004","article-title":"Firing rate variability influences the variation in force fluctuations across the working range of a hand muscle","volume":"93","author":"Moritz","year":"2005","journal-title":"J Neurophysiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1109\/TBME.2011.2118756","article-title":"A model of surface electromyogram in pathological tremor","volume":"58","author":"Dideriksen","year":"2011","journal-title":"IEEE Trans Biomed Eng"},{"key":"B39","first-page":"225","article-title":"Clinical rating scale for tremor","volume-title":"Parkinson's Disease and Movement Disorders","author":"Fahn","year":"1993"},{"key":"B40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/mds.870090112","article-title":"Unified Parkinson's disease rating scale characteristics and structure. the cooperative multicentric group","volume":"9","author":"Mart\u00ednez-Mart\u00edn","year":"1994","journal-title":"Mov Disord"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.3390\/s100302129","article-title":"Real-time estimation of pathological tremor parameters from gyroscope data","volume":"10","author":"Gallego","year":"2010","journal-title":"Sensors"},{"key":"B42","doi-asserted-by":"publisher","first-page":"016008","DOI":"10.1088\/1741-2560\/11\/1\/016008","article-title":"Accurate identification of motor unit firing patterns from high-density surface EMG and validation with a novel signal-based performance metric","volume":"11","author":"Holobar","year":"2014","journal-title":"J Neural Eng"},{"key":"B43","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0079-6107(96)00009-0","article-title":"A framework for the analysis of mixed time series\/point process data - Theory and application to the study of physiological tremor, single motor unit firings and electromyograms","volume":"64","author":"Halliday","year":"1995","journal-title":"Prog Biophys Mol Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1152\/japplphysiol.00162.2014","article-title":"The extraction of neural strategies from the surface EMG: an update","volume":"117","author":"Farina","year":"2014","journal-title":"J Appl Physiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"8925","DOI":"10.1523\/JNEUROSCI.0106-15.2015","article-title":"The phase difference between neural drives to antagonist muscles in essential tremor is associated with the relative strength of supraspinal and afferent input","volume":"10","author":"Gallego","year":"2015","journal-title":"J Neurosci"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2018.00879\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:43:03Z","timestamp":1540773783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2018.00879\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,29]]},"references-count":45,"alternative-id":["10.3389\/fneur.2018.00879"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2018.00879","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,29]]},"article-number":"879"}}