{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:16:18Z","timestamp":1789402578043,"version":"build-2803163510"},"reference-count":146,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2019.00076","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T23:58:57Z","timestamp":1549929537000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":72,"title":["Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases"],"prefix":"10.3389","volume":"10","author":[{"given":"A. V.","family":"Rukmini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Milea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Gooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/sj.eye.6701560","article-title":"Pupil assessment in optic nerve disorders","volume":"18","author":"Bremner","year":"2004","journal-title":"Eye"},{"key":"B2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1113\/jphysiol.1962.sp007033","article-title":"The spectral sensitivity of the consensual light reflex","volume":"164","author":"Alpern","year":"1962","journal-title":"J Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1152\/ajplegacy.1923.64.1.97","article-title":"Studies on the relative physiologial value of spectral lights","volume":"64","author":"Laurens","year":"1923","journal-title":"Am J Physiol Legacy Content"},{"key":"B4","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1152\/ajplegacy.1942.137.4.769","article-title":"The relationship between monochromatic light and pupil diameter. The low intensity visibility curve as measured by pupillary measurements","volume":"137","author":"Wagman","year":"1942","journal-title":"Am J Physiol Legacy Content"},{"key":"B5","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1001\/archopht.1958.00940050097012","article-title":"Differential threshold measurements on the light reflex of the human pupil","volume":"59","author":"Schweitzer","year":"1958","journal-title":"AMA Arch Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1126\/science.149.3687.989","article-title":"Response of the pupil to steady-state retinal illumination: contribution by cones","volume":"149","author":"Doesschate","year":"1965","journal-title":"Science"},{"key":"B7","first-page":"278","article-title":"Pupil light reflex and Purkinje displacement","volume":"68","author":"Koeppe","year":"1968","journal-title":"Bericht uber die Zusammenkunft Deutsche Ophthalmologische Gesellschaft"},{"key":"B8","first-page":"1","article-title":"Pupillomotor spectral sensitivity in normals and colour defectives","volume":"137","author":"Hedin","year":"1978","journal-title":"Acta Ophthalmol."},{"key":"B9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0161-6420(91)32267-X","article-title":"Automated pupil perimetry. Pupil field mapping in patients and normal subjects","volume":"98","author":"Kardon","year":"1991","journal-title":"Ophthalmology"},{"key":"B10","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1073\/pnas.90.20.9616","article-title":"PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect","volume":"90","author":"Pittler","year":"1993","journal-title":"Proc Natl Acad Sci USA."},{"key":"B11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1152\/ajplegacy.1927.81.1.107","article-title":"Iris movements in blind mice","volume":"81","author":"Keeler","year":"1927","journal-title":"Am J Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/jez.1400510404","article-title":"Blind mice","volume":"51","author":"Keeler","year":"1928","journal-title":"J Exp Zool."},{"key":"B13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/bf00339260","article-title":"Vision in mice with \u201crodless\u201d retinae","volume":"6","author":"Hopkins","year":"1927","journal-title":"Zeitschrift vergleichende Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/88443","article-title":"Characterization of an ocular photopigment capable of driving pupillary constriction in mice","volume":"4","author":"Lucas","year":"2001","journal-title":"Nat Neurosci."},{"key":"B15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.284.5413.505","article-title":"Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors","volume":"284","author":"Lucas","year":"1999","journal-title":"Science"},{"key":"B16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.284.5413.502","article-title":"Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors","volume":"284","author":"Freedman","year":"1999","journal-title":"Science"},{"key":"B17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/bjo.79.5.442","article-title":"Evidence for preserved direct pupillary light response in Leber's hereditary optic neuropathy","volume":"79","author":"Wakakura","year":"1995","journal-title":"Br J Ophthalmol."},{"key":"B18","first-page":"675","article-title":"The pupil in dominant optic atrophy","volume":"42","author":"Bremner","year":"2001","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1056\/nejm199501053320102","article-title":"Suppression of melatonin secretion in some blind patients by exposure to bright light","volume":"332","author":"Czeisler","year":"1995","journal-title":"N Engl J Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1126\/science.1067262","article-title":"Phototransduction by retinal ganglion cells that set the circadian clock","volume":"295","author":"Berson","year":"2002","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1113\/jphysiol.2007.133751","article-title":"Synaptic influences on rat ganglion-cell photoreceptors","volume":"582","author":"Wong","year":"2007","journal-title":"J Physiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nature03387","article-title":"Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN","volume":"433","author":"Dacey","year":"2005","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1523\/JNEUROSCI.23-18-07093.2003","article-title":"A broad role for melanopsin in nonvisual photoreception","volume":"23","author":"Gooley","year":"2003","journal-title":"J Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature10206","article-title":"Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs","volume":"476","author":"Chen","year":"2011","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1038\/nn768","article-title":"Melanopsin in cells of origin of the retinohypothalamic tract","volume":"4","author":"Gooley","year":"2001","journal-title":"Nat Neurosci."},{"key":"B27","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/cne.20970","article-title":"Central projections of melanopsin-expressing retinal ganglion cells in the mouse","volume":"497","author":"Hattar","year":"2006","journal-title":"J Compar Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1002\/cne.24469","article-title":"Divergent projection patterns of M1 ipRGC subtypes","volume":"526","author":"Li","year":"2018","journal-title":"J Compar Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/cne.24556","article-title":"The M6 cell: a small-field bistratified photosensitive retinal ganglion cell","volume":"527","author":"Quattrochi","year":"2019","journal-title":"J Compar Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1002\/cne.24181","article-title":"Melanopsin expressing human retinal ganglion cells: subtypes, distribution, and intraretinal connectivity","volume":"525","author":"Hannibal","year":"2017","journal-title":"J Compar Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1002\/cne.23995","article-title":"Melanopsin-expressing ganglion cells on macaque and human retinas form two morphologically distinct populations","volume":"524","author":"Liao","year":"2016","journal-title":"J Compar Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/nature01761","article-title":"Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice","volume":"424","author":"Hattar","year":"2003","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1126\/science.1086179","article-title":"Melanopsin is required for non-image-forming photic responses in blind mice","volume":"301","author":"Panda","year":"2003","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1126\/science.1077293","article-title":"Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice","volume":"299","author":"Lucas","year":"2003","journal-title":"Science"},{"key":"B35","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nature06829","article-title":"Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision","volume":"453","author":"Guler","year":"2008","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/S0166-2236(03)00130-9","article-title":"Strange vision: ganglion cells as circadian photoreceptors","volume":"26","author":"Berson","year":"2013","journal-title":"Trends Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1016\/j.cub.2007.11.034","article-title":"Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina","volume":"17","author":"Zaidi","year":"2007","journal-title":"Curr Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"14242","DOI":"10.1523\/JNEUROSCI.1321-12.2012","article-title":"Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans","volume":"32","author":"Gooley","year":"2012","journal-title":"J Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.visres.2009.10.012","article-title":"The influence of intrinsically-photosensitive retinal ganglion cells on the spectral sensitivity and response dynamics of the human pupillary light reflex","volume":"50","author":"McDougal","year":"2010","journal-title":"Vis Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1126\/science.101.2635.653","article-title":"Human Vision and the spectrum","volume":"101","author":"Wald","year":"1945","journal-title":"Science"},{"key":"B41","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.127.3292.222","article-title":"Human Rhodopsin","volume":"127","author":"Wald","year":"1958","journal-title":"Science"},{"key":"B42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1085\/jgp.25.4.553","article-title":"Visual acuity and illumination in different spectral regions","volume":"25","author":"Shlaer","year":"1942","journal-title":"J Gen Physiol."},{"key":"B43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.144.3614.45","article-title":"Visual pigments in single rods and cones of the human retina","volume":"144","author":"Brown","year":"1964","journal-title":"Science"},{"key":"B44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1364\/JOSA.67.000195","article-title":"Color vision in the peripheral retina. I. Spectral sensitivity","volume":"67","author":"Abramov","year":"1977","journal-title":"J Optical Soc Am."},{"key":"B45","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF00431624","article-title":"The spectral sensitivity of retinal photoreceptors conducting the pupillary light reflex in humans","volume":"177","author":"Alexandridis","year":"1969","journal-title":"Albrecht Graefes Archiv klinische experimentelle Ophthalmol."},{"key":"B46","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/193690a0","article-title":"Size of the static pupil as a function of wavelength and luminosity of the light incident on the human eye","volume":"193","author":"Bouma","year":"1962","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.visres.2006.12.015","article-title":"Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells","volume":"47","author":"Gamlin","year":"2007","journal-title":"Vis Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e5991","DOI":"10.1371\/journal.pone.0005991","article-title":"Melanopsin bistability: a fly's eye technology in the human retina","volume":"4","author":"Mure","year":"2009","journal-title":"PLoS ONE"},{"key":"B49","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1177\/0748730402238237","article-title":"Photic resetting of the human circadian pacemaker in the absence of conscious vision","volume":"17","author":"Klerman","year":"2002","journal-title":"J Biol Rhythms"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1167\/iovs.14-16233","article-title":"The Post-Illumination Pupil Response (PIPR)","volume":"56","author":"Adhikari","year":"2015","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B51","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4757-1642-9_2","article-title":"Can the response of the iris to light be used to break the code of the second cranial nerve in man?","volume-title":"Pupillary Dynamics and Behavior","author":"Alpern","year":"1974"},{"key":"B52","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nature07682","article-title":"Photon capture and signalling by melanopsin retinal ganglion cells","volume":"457","author":"Do","year":"2009","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.neuron.2010.04.037","article-title":"Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance","volume":"66","author":"Lall","year":"2010","journal-title":"Neuron"},{"key":"B54","doi-asserted-by":"publisher","first-page":"11478","DOI":"10.1523\/JNEUROSCI.1423-12.2012","article-title":"A retinal ganglion cell that can signal irradiance continuously for 10 hours","volume":"32","author":"Wong","year":"2012","journal-title":"J Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1098\/rspb.2010.0330","article-title":"Contribution of human melanopsin retinal ganglion cells to steady-state pupil responses","volume":"277","author":"Tsujimura","year":"2010","journal-title":"Proc Biol Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/j.1475-1313.2010.00754.x","article-title":"The effect of controlled photopigment excitations on pupil aperture","volume":"30","author":"Vienot","year":"2010","journal-title":"Ophthal Physiol Optics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e96532","DOI":"10.1371\/journal.pone.0096532","article-title":"Effects of exposure to intermittent versus continuous red light on human circadian rhythms, melatonin suppression, and pupillary constriction","volume":"9","author":"Ho Mien","year":"2014","journal-title":"PLoS ONE"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/j.ophtha.2015.06.002","article-title":"Pupillary responses to high-irradiance blue light correlate with glaucoma severity","volume":"122","author":"Rukmini","year":"2015","journal-title":"Ophthalmology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1167\/iovs.16-19150","article-title":"Determination of rod and cone influence to the early and late dynamic of the pupillary light response","volume":"57","author":"Kostic","year":"2016","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"6624","DOI":"10.1167\/iovs.11-7586","article-title":"Toward a clinical protocol for assessing rod, cone, and melanopsin contributions to the human pupil response","volume":"52","author":"Park","year":"2011","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1177\/0748730409343767","article-title":"Circadian modulation of the intrinsically photosensitive (melanopsin) retinal ganglion cell driven pupil light response","volume":"51","author":"Markwell","year":"2010","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ophtha.2010.06.033","article-title":"Chromatic pupillometry in patients with retinitis pigmentosa","volume":"118","author":"Kardon","year":"2011","journal-title":"Ophthalmology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1111\/j.1442-9071.2011.02665.x","article-title":"Differential effect of long versus short wavelength light exposure on pupillary re-dilation in patients with outer retinal disease","volume":"40","author":"Leon","year":"2012","journal-title":"Clin Exp Ophthalmol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1167\/iovs.13-13252","article-title":"Assessing rod, cone, and melanopsin contributions to human pupil flicker responses","volume":"55","author":"Barrionuevo","year":"2014","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B65","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1167\/iovs.03-1230","article-title":"Impairment of the transient pupillary light reflex in Rpe65(-\/-) mice and humans with leber congenital amaurosis","volume":"45","author":"Aleman","year":"2004","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1167\/iovs.10-6127","article-title":"Human retinal disease from AIPL1 gene mutations: foveal cone loss with minimal macular photoreceptors and rod function remaining","volume":"52","author":"Jacobson","year":"2011","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1167\/iovs.15-17467","article-title":"Full-field pupillary light responses, luminance thresholds, and light discomfort thresholds in CEP290 leber congenital amaurosis patients","volume":"56","author":"Collison","year":"2015","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.1167\/iovs.12-9974","article-title":"Chromatic pupillometry dissects function of the three different light-sensitive retinal cell populations in RPE65 deficiency","volume":"53","author":"Lorenz","year":"2012","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1167\/iovs.15-18181","article-title":"The pupillary light reflex in idiopathic intracranial hypertension","volume":"57","author":"Park","year":"2016","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"44987","DOI":"10.1038\/srep44987","article-title":"Pupillary responses in non-proliferative diabetic retinopathy","volume":"7","author":"Park","year":"2017","journal-title":"Sci Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1001\/archophthalmol.2011.1756","article-title":"Pupillometric quantification of residual rod and cone activity in leber congenital amaurosis","volume":"130","author":"Kawasaki","year":"2012","journal-title":"Arch Ophthal"},{"key":"B72","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.1167\/iovs.12-10230","article-title":"Characterization of pupil responses to blue and red light stimuli in autosomal dominant retinitis pigmentosa due to NR2E3 mutation","volume":"53","author":"Kawasaki","year":"2012","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10633-016-9535-0","article-title":"Two-color pupillometry in enhanced S-cone syndrome caused by NR2E3 mutations","volume":"132","author":"Collison","year":"2016","journal-title":"Documenta Ophthalmol Adv Ophthalmol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.exer.2013.11.005","article-title":"Pupil responses derived from outer and inner retinal photoreception are normal in patients with hereditary optic neuropathy","volume":"120","author":"Kawasaki","year":"2014","journal-title":"Exp Eye Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1167\/iovs.12-11137","article-title":"The pupil light reflex in Leber's hereditary optic neuropathy: evidence for preservation of melanopsin-expressing retinal ganglion cells","volume":"54","author":"Moura","year":"2013","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"15185","DOI":"10.1038\/srep15185","article-title":"Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls","volume":"5","author":"Munch","year":"2015","journal-title":"Sci Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1093\/brain\/awq155","article-title":"Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies","volume":"133","author":"La Morgia","year":"2010","journal-title":"Brain"},{"key":"B78","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.mito.2017.07.003","article-title":"Pupillometric evaluation of the melanopsin containing retinal ganglion cells in mitochondrial and non-mitochondrial optic neuropathies","volume":"36","author":"Ba-Ali","year":"2017","journal-title":"Mitochondrion"},{"key":"B79","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.mito.2017.04.003","article-title":"Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always","volume":"36","author":"Georg","year":"2017","journal-title":"Mitochondrion"},{"key":"B80","doi-asserted-by":"publisher","first-page":"10780","DOI":"10.1038\/srep10780","article-title":"Differential monocular vs. binocular pupil responses from melanopsin-based photoreception in patients with anterior ischemic optic neuropathy","volume":"5","author":"Tsika","year":"2015","journal-title":"Sci Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"7997","DOI":"10.1167\/iovs.14-15146","article-title":"A positive association between intrinsically photosensitive retinal ganglion cells and retinal nerve fiber layer thinning in glaucoma","volume":"55","author":"Gracitelli","year":"2014","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/5317371","article-title":"Relationship between daytime sleepiness and intrinsically photosensitive retinal ganglion cells in glaucomatous disease","volume":"2016","author":"Gracitelli","year":"2016","journal-title":"J Ophthalmol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s00417-016-3351-9","article-title":"Pupillary responses driven by ipRGCs and classical photoreceptors are impaired in glaucoma","volume":"254","author":"Kelbsch","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"33373","DOI":"10.1038\/srep33373","article-title":"Quadrant field pupillometry detects melanopsin dysfunction in glaucoma suspects and early glaucoma","volume":"6","author":"Adhikari","year":"2016","journal-title":"Sci Rep."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1167\/iovs.09-4717","article-title":"Post-illumination pupil response in subjects without ocular disease","volume":"51","author":"Kankipati","year":"2010","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1167\/iovs.10-6023","article-title":"The post-illumination pupil response is reduced in glaucoma patients","volume":"52","author":"Kankipati","year":"2011","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"4362","DOI":"10.1167\/iovs.10-7069","article-title":"Intrinsically photosensitive (melanopsin) retinal ganglion cell function in glaucoma","volume":"52","author":"Feigl","year":"2011","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"e230","DOI":"10.1111\/j.1755-3768.2011.02226.x","article-title":"The post-illumination pupil response of melanopsin-expressing intrinsically photosensitive retinal ganglion cells in diabetes","volume":"90","author":"Feigl","year":"2012","journal-title":"Acta Ophthalmol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1097\/OPX.0000000000000284","article-title":"Melanopsin-expressing intrinsically photosensitive retinal ganglion cells in retinal disease","volume":"91","author":"Feigl","year":"2014","journal-title":"Optometry Vision Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1442-9071.2010.02212.x","article-title":"Selective wavelength pupillometry in Leber hereditary optic neuropathy","volume":"38","author":"Kawasaki","year":"2010","journal-title":"Clin Experiment Ophthalmol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fneur.2013.00052","article-title":"Unilateral anterior ischemic optic neuropathy: chromatic pupillometry in affected, fellow non-affected and healthy control eyes","volume":"4","author":"Herbst","year":"2013","journal-title":"Front Neurol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/aos.13394","article-title":"Choroideremia: melanopsin-mediated postillumination pupil relaxation is abnormally slow","volume":"95","author":"Ba-Ali","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.ophtha.2009.02.007","article-title":"Chromatic pupil responses: preferential activation of the melanopsin-mediated versus outer photoreceptor-mediated pupil light reflex","volume":"116","author":"Kardon","year":"2009","journal-title":"Ophthalmology"},{"key":"B94","volume-title":"Assessment of Photoreceptor Function Using the Pupillary Light Reflex","author":"Rukmini","year":"2016"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.02.024","article-title":"Pupillary responses to full-field chromatic stimuli are reduced in patients with early-stage primary open-angle glaucoma","author":"Najjar","year":"2018","journal-title":"Ophthalmology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/eye.2016.255","article-title":"Multiethnic involvement in autosomal-dominant optic atrophy in Singapore","volume":"31","author":"Loo","year":"2017","journal-title":"Eye"},{"key":"B97","doi-asserted-by":"publisher","first-page":"15568","DOI":"10.1073\/pnas.1400942111","article-title":"Opponent melanopsin and S-cone signals in the human pupillary light response","volume":"111","author":"Spitschan","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B98","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1073\/pnas.1716281115","article-title":"Melanopsin- and L-cone-induced pupil constriction is inhibited by S- and M-cones in humans","volume":"115","author":"Woelders","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.neuron.2005.11.016","article-title":"Photoreceptor adaptation in intrinsically photosensitive retinal ganglion cells","volume":"48","author":"Wong","year":"2005","journal-title":"Neuron"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1007\/s00417-015-3137-5","article-title":"Dark adaptation-induced changes in rod, cone and intrinsically photosensitive retinal ganglion cell (ipRGC) sensitivity differentially affect the pupil light response (PLR)","volume":"253","author":"Wang","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"5672","DOI":"10.1167\/iovs.16-19934","article-title":"The effects of short-term light adaptation on the human post-illumination pupil response","volume":"57","author":"Joyce","year":"2016","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/16.8.5","article-title":"Melanopsin-mediated post-illumination pupil response in the peripheral retina","volume":"16","author":"Joyce","year":"2016","journal-title":"J Vis."},{"key":"B103","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/15.3.13","article-title":"Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex","volume":"15","author":"Park","year":"2015","journal-title":"J Vis."},{"key":"B104","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.12-10241","article-title":"Comparative regional pupillography as a noninvasive biosensor screening method for diabetic retinopathy","volume":"54","author":"Ortube","year":"2013","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"4496","DOI":"10.1167\/iovs.14-14103","article-title":"Full-field chromatic pupillometry for the assessment of the postillumination pupil response driven by melanopsin-containing retinal ganglion cells","volume":"55","author":"Lei","year":"2014","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1167\/iovs.14-15945","article-title":"Test-retest reliability of hemifield, central-field, and full-field chromatic pupillometry for assessing the function of melanopsin-containing retinal ganglion cells","volume":"56","author":"Lei","year":"2015","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1177\/1352458508100503","article-title":"Retinal architecture predicts pupillary reflex metrics in MS","volume":"15","author":"Salter","year":"2009","journal-title":"Mult Scler."},{"key":"B108","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1001\/jamaneurol.2016.5131","article-title":"Retinal architecture and melanopsin-mediated pupillary response characteristics: a putative pathophysiologic signature for the retino-hypothalamic tract in multiple sclerosis","volume":"74","author":"Meltzer","year":"2017","journal-title":"JAMA Neurol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"7796","DOI":"10.1038\/s41598-018-26078-0","article-title":"Melanopsin-mediated pupil function is impaired in Parkinson's disease","volume":"8","author":"Joyce","year":"2018","journal-title":"Sci Rep."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1212\/01.CON.0000453306.42981.94","article-title":"Diagnostic approach to pupillary abnormalities","volume":"20","author":"Kawasaki","year":"2014","journal-title":"CONTINUUM Lifelong Learn Neurol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/b978-0-444-52903-9.00022-4","article-title":"Disorders of the pupil","volume":"102","author":"Wilhelm","year":"2011","journal-title":"Handbook Clin Neurol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.psychres.2013.05.023","article-title":"The post illumination pupil response is reduced in seasonal affective disorder","volume":"210","author":"Roecklein","year":"2013","journal-title":"Psychiat Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/acps.12851","article-title":"Decreased retinal sensitivity in depressive disorder: a controlled study","volume":"137","author":"Berman","year":"2018","journal-title":"Acta Psychiatr Scand."},{"key":"B114","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3389\/fneur.2017.00464","article-title":"Melanopsin-mediated acute light responses measured in winter and in summer: seasonal variations in adults with and without cataracts","volume":"8","author":"Munch","year":"2017","journal-title":"Front Neurol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jad.2008.08.005","article-title":"A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder","volume":"114","author":"Roecklein","year":"2009","journal-title":"J Affect Disord."},{"key":"B116","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1880-6805-32-16","article-title":"Association between melanopsin gene polymorphism (I394T) and pupillary light reflex is dependent on light wavelength","volume":"32","author":"Lee","year":"2013","journal-title":"J Physiol Anthropol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"e60310","DOI":"10.1371\/journal.pone.0060310","article-title":"Melanopsin gene polymorphism I394T is associated with pupillary light responses in a dose-dependent manner","volume":"8","author":"Higuchi","year":"2013","journal-title":"PLoS ONE"},{"key":"B118","doi-asserted-by":"publisher","first-page":"e17860","DOI":"10.1371\/journal.pone.0017860","article-title":"The circadian response of intrinsically photosensitive retinal ganglion cells","volume":"6","author":"Zele","year":"2011","journal-title":"PLoS ONE"},{"key":"B119","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1167\/iovs.12-9494","article-title":"Circadian and wake-dependent effects on the pupil light reflex in response to narrow-bandwidth light pulses","volume":"53","author":"Munch","year":"2012","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fneur.2015.00093","article-title":"Effect of topical anti-glaucoma medications on late pupillary light reflex, as evaluated by pupillometry","volume":"6","author":"Ba-Ali","year":"2015","journal-title":"Front Neurol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"18333","DOI":"10.1073\/pnas.1318395110","article-title":"Pupil response as a predictor of blindsight in hemianopia","volume":"110","author":"Sahraie","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1007\/s00417-017-3721-y","article-title":"Chromatic pupillography in hemianopia patients with homonymous visual field defects","volume":"255","author":"Maeda","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol."},{"key":"B123","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/ageing\/25.6.432","article-title":"Changes in autonomic function with age: a study of pupillary kinetics in healthy young and old people","volume":"25","author":"Bitsios","year":"1996","journal-title":"Age Ageing"},{"key":"B124","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1177\/0748730412441172","article-title":"Does pupil constriction under blue and green monochromatic light exposure change with age?","volume":"27","author":"Daneault","year":"2012","journal-title":"J Biol Rhythms"},{"key":"B125","doi-asserted-by":"publisher","first-page":"43832","DOI":"10.1038\/srep43832","article-title":"Pupillary responses to short-wavelength light are preserved in aging","volume":"7","author":"Rukmini","year":"2017","journal-title":"Sci Rep."},{"key":"B126","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2415-12-4","article-title":"Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens","volume":"12","author":"Herbst","year":"2012","journal-title":"BMC Ophthalmol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"17610","DOI":"10.1038\/srep17610","article-title":"Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR)","volume":"5","author":"Adhikari","year":"2015","journal-title":"Sci Rep."},{"key":"B128","doi-asserted-by":"publisher","first-page":"10190","DOI":"10.1038\/s41598-017-10303-3","article-title":"Pupillary responses to light are not affected by narrow irido-corneal angles","volume":"7","author":"Rukmini","year":"2017","journal-title":"Sci Rep."},{"key":"B129","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fneur.2011.00010","article-title":"Test-retest repeatability of the pupil light response to blue and red light stimuli in normal human eyes using a novel pupillometer","volume":"2","author":"Herbst","year":"2011","journal-title":"Front Neurol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tins.2013.10.004","article-title":"Measuring and using light in the melanopsin age","volume":"37","author":"Lucas","year":"2014","journal-title":"Trends Neurosci."},{"key":"B131","article-title":"Optical Generation of the Visual Stimulus, Sections 5","volume-title":"Handbook of OpticsVision and Vision Optics. 3rd ed","author":"Burns","year":"2010"},{"key":"B132","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fneur.2011.00092","article-title":"The effect of pupil size on stimulation of the melanopsin containing retinal ganglion cells, as evaluated by monochromatic pupillometry","volume":"2","author":"Nissen","year":"2011","journal-title":"Front Neurol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13054-016-1239-z","article-title":"Reliability of standard pupillometry practice in neurocritical care: an observational, double-blinded study","volume":"20","author":"Couret","year":"2016","journal-title":"Critical Care"},{"key":"B134","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neulet.2008.05.037","article-title":"Inter-individual difference in pupil size correlates to suppression of melatonin by exposure to light","volume":"440","author":"Higuchi","year":"2008","journal-title":"Neurosci Lett."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.5665\/sleep.5858","article-title":"Individual differences in sleep timing relate to melanopsin-based phototransduction in healthy adolescents and young adults","volume":"39","author":"van der Meijden","year":"2016","journal-title":"Sleep"},{"key":"B136","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1167\/iovs.07-0249","article-title":"Evaluation of retinal status using chromatic pupil light reflex activity in healthy and diseased canine eyes","volume":"48","author":"Grozdanic","year":"2007","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1167\/iovs.16-19865","article-title":"Assessment of rod, cone, and intrinsically photosensitive retinal ganglion cell contributions to the canine chromatic pupillary response","volume":"58","author":"Yeh","year":"2017","journal-title":"Invest Ophthalmol Visual Sci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1292\/jvms.12-0363","article-title":"Efficacy of the use of a colorimetric pupil light reflex device in the diagnosis of fundus disease or optic pathway disease in dogs","volume":"75","author":"Terakado","year":"2013","journal-title":"J Veterinary Med Sci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"16009","DOI":"10.1073\/pnas.0806114105","article-title":"Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin","volume":"105","author":"Lin","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B140","doi-asserted-by":"publisher","first-page":"11211","DOI":"10.1073\/pnas.1701589114","article-title":"Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy","volume":"114","author":"De Silva","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/mt.2011.103","article-title":"LiGluR restores visual responses in rodent models of inherited blindness","volume":"19","author":"Caporale","year":"2011","journal-title":"Mol Ther."},{"key":"B142","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.neuron.2012.05.022","article-title":"Photochemical restoration of visual responses in blind mice","volume":"75","author":"Polosukhina","year":"2012","journal-title":"Neuron"},{"key":"B143","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/s41467-018-03212-0","article-title":"Nanowire arrays restore vision in blind mice","volume":"9","author":"Tang","year":"2018","journal-title":"Nat Commun."},{"key":"B144","doi-asserted-by":"publisher","first-page":"e333","DOI":"10.1371\/journal.pmed.0020333","article-title":"Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis","volume":"2","author":"Batten","year":"2005","journal-title":"PLoS Med."},{"key":"B145","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/s0140-6736(16)30371-3","article-title":"Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial","volume":"388","author":"Bennett","year":"2016","journal-title":"Lancet"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/s0140-6736(09)61836-5","article-title":"Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial","volume":"374","author":"Maguire","year":"2009","journal-title":"Lancet"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00076\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T12:51:19Z","timestamp":1573908679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00076\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":146,"alternative-id":["10.3389\/fneur.2019.00076"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2019.00076","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,12]]},"article-number":"76"}}