{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:39:02Z","timestamp":1790980742027,"version":"4.1.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2019.00174","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T09:12:36Z","timestamp":1552295556000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Dual-Site Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Christopher","family":"Fricke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Duesmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo B.","family":"Woost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"von Hofen-Hohloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost-Julian","family":"Rumpf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Weise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Classen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1056\/NEJMct1208070","article-title":"Deep-brain stimulation for Parkinson's disease","volume":"367","author":"Okun","year":"2012","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"7766","DOI":"10.1523\/JNEUROSCI.20-20-07766.2000","article-title":"High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor","volume":"20","author":"Levy","year":"2000","journal-title":"J Neurosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.expneurol.2005.02.010","article-title":"The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease","volume":"194","author":"K\u00fchn","year":"2005","journal-title":"Exp Neurol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.expneurol.2012.04.024","article-title":"\u03b2 band stability over time correlates with Parkinsonian rigidity and bradykinesia","volume":"236","author":"Little","year":"2012","journal-title":"Exp Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.clinph.2016.10.095","article-title":"Subthalamic oscillations and phase amplitude coupling are greater in the more affected hemisphere in Parkinson's disease","volume":"128","author":"Shreve","year":"2017","journal-title":"Clin Neurophysiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1016\/S1353-8020(13)70013-0","article-title":"The functional role of beta oscillations in Parkinson's disease","volume":"20","author":"Little","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1523\/JNEUROSCI.21-03-01033.2001","article-title":"Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease","volume":"21","author":"Brown","year":"2001","journal-title":"J Neurosci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.expneurol.2004.05.009","article-title":"Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease","volume":"188","author":"Brown","year":"2004","journal-title":"Exp Neurol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1093\/brain\/awh616","article-title":"Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations","volume":"128","author":"Meissner","year":"2005","journal-title":"Brain"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1152\/jn.00697.2006","article-title":"Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease","volume":"96","author":"Weinberger","year":"2006","journal-title":"J Neurophysiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.expneurol.2010.08.011","article-title":"The effects of levodopa and ongoing deep brain stimulation on subthalamic beta oscillations in Parkinson's disease","volume":"226","author":"Giannicola","year":"2010","journal-title":"Exp Neurol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00422-003-0425-7","article-title":"A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations","volume":"89","author":"Tass","year":"2003","journal-title":"Biol Cybern"},{"key":"B14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fnhum.2012.00058","article-title":"Desynchronizing electrical and sensory coordinated reset neuromodulation","volume":"6","author":"Popovych","year":"2012","journal-title":"Front Hum Neurosci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/ana.23663","article-title":"Coordinated reset has sustained aftereffects in Parkinsonian monkeys","volume":"72","author":"Tass","year":"2012","journal-title":"Ann Neurol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1002\/mds.25923","article-title":"Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study","volume":"29","author":"Adamchic","year":"2014","journal-title":"Mov Disord"},{"key":"B17","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1001\/jamaneurol.2014.4380","article-title":"Effects of repetitive transcranial magnetic stimulation on motor symptoms in Parkinson disease: a systematic review and meta-analysis","volume":"72","author":"Chou","year":"2015","journal-title":"JAMA Neurol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0168-0102(02)00027-5","article-title":"Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway","volume":"43","author":"Nambu","year":"2002","journal-title":"Neurosci Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/mds.10144","article-title":"Mechanisms of deep brain stimulation: excitation or inhibition","volume":"17","author":"Vitek","year":"2002","journal-title":"Mov Disord"},{"key":"B20","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1126\/science.1167093","article-title":"Optical deconstruction of parkinsonian neural circuitry","volume":"324","author":"Gradinaru","year":"2009","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.nbd.2016.07.021","article-title":"Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice","volume":"95","author":"Sanders","year":"2016","journal-title":"Neurobiol Dis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1111\/j.1460-9568.2004.03669.x","article-title":"Transcranial magnetic stimulation of the human motor cortex influences the neuronal activity of subthalamic nucleus","volume":"20","author":"Strafella","year":"2004","journal-title":"Eur J Neurosci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1111\/j.1460-9568.2008.06363.x","article-title":"Suppression of beta oscillations in the subthalamic nucleus following cortical stimulation in humans","volume":"28","author":"Doyle Gaynor","year":"2008","journal-title":"Eur J Neurosci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1016\/j.clinph.2017.08.003","article-title":"The associative brain at work: evidence from paired associative stimulation studies in humans","volume":"128","author":"Suppa","year":"2017","journal-title":"Clin Neurophysiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1093\/brain\/awl221","article-title":"The two sides of associative plasticity in writer's cramp","volume":"129","author":"Weise","year":"2006","journal-title":"Brain"},{"key":"B26","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.bbr.2010.08.037","article-title":"Associative cortico-cortical plasticity may affect ipsilateral finger opposition movements","volume":"216","author":"Rizzo","year":"2011","journal-title":"Behav Brain Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1093\/cercor\/bhn144","article-title":"Paired associative stimulation of left and right human motor cortex shapes interhemispheric motor inhibition based on a Hebbian mechanism","volume":"19","author":"Rizzo","year":"2009","journal-title":"Cereb Cortex"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1113\/jphysiol.2009.174342","article-title":"Human motor associative plasticity induced by paired bihemispheric stimulation","volume":"587","author":"Koganemaru","year":"2009","journal-title":"J Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1016\/j.cub.2012.10.046","article-title":"Motor recovery after spinal cord injury enhanced by strengthening corticospinal synaptic transmission","volume":"22","author":"Bunday","year":"2012","journal-title":"Curr Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/mds.870120118","article-title":"Short-term levodopa test assessed by movement time accurately predicts dopaminergic responsiveness in Parkinson's disease","volume":"12","author":"Zappia","year":"1997","journal-title":"Mov Disord"},{"key":"B31","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/brain\/123.3.572","article-title":"Induction of plasticity in the human motor cortex by paired associative stimulation","volume":"123","author":"Stefan","year":"2000","journal-title":"Brain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/hbm.21221","article-title":"The human dorsal premotor cortex facilitates the excitability of ipsilateral primary motor cortex via a short latency cortico-cortical route","volume":"33","author":"Groppa","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"B33","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/brain\/awf128","article-title":"Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease","volume":"125","author":"Levy","year":"2002","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.clinph.2012.09.018","article-title":"A comparison of relative-frequency and threshold-hunting methods to determine stimulus intensity in transcranial magnetic stimulation","volume":"124","author":"Silbert","year":"2013","journal-title":"Clin Neurophysiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S1388-2457(01)00696-4","article-title":"Descending volleys evoked by transcranial magnetic stimulation of the brain in conscious humans: effects of coil shape","volume":"113","author":"Di Lazzaro","year":"2002","journal-title":"Clin Neurophysiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1093\/brain\/awu027","article-title":"Resting state functional MRI in Parkinson's disease: the impact of deep brain stimulation on 'effective' connectivity","volume":"137","author":"Kahan","year":"2014","journal-title":"Brain"},{"key":"B37","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.neuroimage.2017.07.012","article-title":"Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease","volume":"158","author":"Akram","year":"2017","journal-title":"Neuroimage"},{"key":"B38","doi-asserted-by":"publisher","first-page":"9129","DOI":"10.1523\/JNEUROSCI.1327-18.2018","article-title":"Cortical potentials evoked by subthalamic stimulation demonstrate a short latency hyperdirect pathway in humans","volume":"38","author":"Miocinovic","year":"2018","journal-title":"J Neurosci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.neuron.2017.08.038","article-title":"Loss of hyperdirect pathway cortico-subthalamic inputs following degeneration of midbrain dopamine neurons","volume":"95","author":"Chu","year":"2017","journal-title":"Neuron"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1152\/jn.1992.67.6.1615","article-title":"Visual and oculomotor functions of monkey subthalamic nucleus","volume":"67","author":"Matsumura","year":"1992","journal-title":"J Neurophysiol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/brain\/awh029","article-title":"The subthalamic nucleus in the context of movement disorders","volume":"127","author":"Hamani","year":"2004","journal-title":"Brain"},{"key":"B42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/mds.22364","article-title":"Effect of transcranial magnetic stimulation on Parkinson motor function\u2013systematic review of controlled clinical trials","volume":"24","author":"Elahi","year":"2009","journal-title":"Mov Disord"},{"key":"B43","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0022-510X(00)00370-1","article-title":"Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease","volume":"178","author":"Siebner","year":"2000","journal-title":"J Neurol Sci"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1016\/j.clinph.2004.05.025","article-title":"Improvement of motor performance and modulation of cortical excitability by repetitive transcranial magnetic stimulation of the motor cortex in Parkinson's disease","volume":"115","author":"Lefaucheur","year":"2004","journal-title":"Clin Neurophysiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1007\/s00415-011-5923-2","article-title":"Effects of rTMS on Parkinson's disease: a longitudinal fMRI study","volume":"258","author":"Gonz\u00e1lez-Garc\u00eda","year":"2011","journal-title":"J Neurol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1212\/WNL.0b013e31828c2f66","article-title":"Supplementary motor area stimulation for Parkinson disease: a randomized controlled study","volume":"80","author":"Shirota","year":"2013","journal-title":"Neurology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1093\/brain\/awh106","article-title":"Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance","volume":"127","author":"K\u00fchn","year":"2004","journal-title":"Brain"},{"key":"B48","doi-asserted-by":"publisher","first-page":"6667","DOI":"10.1523\/JNEUROSCI.5459-09.2010","article-title":"Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson's disease","volume":"30","author":"L\u00f3pez-Azc\u00e1rate","year":"2010","journal-title":"J Neurosci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1093\/brain\/awl031","article-title":"Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias","volume":"129","author":"Morgante","year":"2006","journal-title":"Brain"},{"key":"B50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/ana.20692","article-title":"Altered plasticity of the human motor cortex in Parkinson's disease","volume":"59","author":"Ueki","year":"2006","journal-title":"Ann Neurol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1093\/brain\/awy155","article-title":"Neurophysiological correlates of bradykinesia in Parkinson's disease","volume":"141","author":"Bologna","year":"2018","journal-title":"Brain"},{"key":"B52","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0891-0618(00)00099-5","article-title":"Dopaminergic innervation of human basal ganglia","volume":"20","author":"Prensa","year":"2000","journal-title":"J Chem Neuroanat"},{"key":"B53","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/nn1040","article-title":"Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia","volume":"6","author":"Picconi","year":"2003","journal-title":"Nat Neurosci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"RC157","DOI":"10.1523\/JNEUROSCI.21-15-j0003.2001","article-title":"Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus","volume":"21","author":"Strafella","year":"2001","journal-title":"J Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1111\/j.1460-9568.2005.04476.x","article-title":"Corticostriatal functional interactions in Parkinson's disease: a rTMS\/11Craclopride PET study","volume":"22","author":"Strafella","year":"2005","journal-title":"Eur J Neurosci"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1093\/cercor\/bhn201","article-title":"Two phases of interhemispheric inhibition between motor related cortical areas and the primary motor cortex in human","volume":"19","author":"Ni","year":"2009","journal-title":"Cereb Cortex"},{"key":"B57","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.neuroimage.2012.05.023","article-title":"A novel dual-site transcranial magnetic stimulation paradigm to probe fast facilitatory inputs from ipsilateral dorsal premotor cortex to primary motor cortex","volume":"62","author":"Groppa","year":"2012","journal-title":"Neuroimage"},{"key":"B58","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neurobiolaging.2014.08.017","article-title":"Reduced dorsal premotor cortex and primary motor cortex connectivity in older adults","volume":"36","author":"Ni","year":"2015","journal-title":"Neurobiol Aging"},{"key":"B59","doi-asserted-by":"publisher","first-page":"14936","DOI":"10.1038\/s41598-017-13708-2","article-title":"Long-latency interhemispheric interactions between motor-related areas and the primary motor cortex: a dual site TMS study","volume":"7","author":"Fiori","year":"2017","journal-title":"Sci Rep"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1093\/cercor\/bhp269","article-title":"The nature and time course of cortical activation following subthalamic stimulation in Parkinson's disease","volume":"20","author":"Kuriakose","year":"2010","journal-title":"Cereb Cortex"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1006\/nimg.2001.0918","article-title":"Transcranial magnetic stimulation can be used to test connections to primary motor areas from frontal and medial cortex in humans","volume":"14","author":"Civardi","year":"2001","journal-title":"Neuroimage"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1016\/j.clinph.2009.07.035","article-title":"Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest\u2013a bifocal TMS study","volume":"120","author":"B\u00e4umer","year":"2009","journal-title":"Clin Neurophysiol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00174\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T09:12:38Z","timestamp":1552295558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00174\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,7]]},"references-count":62,"alternative-id":["10.3389\/fneur.2019.00174"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2019.00174","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,7]]},"article-number":"174"}}