{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:43:01Z","timestamp":1790937781418,"version":"4.1.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS064052"],"award-info":[{"award-number":["K23NS064052"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS082285"],"award-info":[{"award-number":["R01NS082285"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS086905"],"award-info":[{"award-number":["R01NS086905"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2019.00208","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:43:08Z","timestamp":1552956188000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":58,"title":["Spatial Signature of White Matter Hyperintensities in Stroke Patients"],"prefix":"10.3389","volume":"10","author":[{"given":"Markus D.","family":"Schirmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Katrin","family":"Giese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Fotiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Etherton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cloonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ona","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia S.","family":"Rost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"c3666","DOI":"10.1136\/bmj.c3666","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis","volume":"341","author":"Debette","year":"2010","journal-title":"BMJ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1161\/01.STR.0000132193.35955.69","article-title":"White matter hyperintensity on cranial magnetic resonance imaging: a predictor of stroke","volume":"35","author":"Kuller","year":"2004","journal-title":"Stroke."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e180","DOI":"10.1212\/NXG.0000000000000180","article-title":"Design and rationale for examining neuroimaging genetics in ischemic stroke The MRI-GENIE study","volume":"3","author":"Giese","year":"2017","journal-title":"Neurol Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.10.016","article-title":"Determinants of white matter hyperintensity burden differ at the extremes of ages of ischemic stroke onset","volume":"24","author":"Zhang","year":"2015","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neuroimage.2017.03.024","article-title":"Classification and characterization of periventricular and deep white matter hyperintensities on MRI: a study in older adults","volume":"170","author":"Griffanti","year":"2017","journal-title":"NeuroImage."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1161\/STROKEAHA.107.497438","article-title":"Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging","volume":"39","author":"Holland","year":"2008","journal-title":"Stroke."},{"key":"B7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.biopsych.2008.03.024","article-title":"Classification of white matter lesions on magnetic resonance imaging in elderly persons","volume":"64","author":"Kim","year":"2008","journal-title":"Biol Psychiatry."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1212\/01.wnl.0000249119.95747.1f","article-title":"Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD","volume":"67","author":"Yoshita","year":"2006","journal-title":"Neurology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1212\/WNL.0b013e3181fc279a","article-title":"White matter hyperintensity volume is increased in small vessel stroke subtypes","volume":"75","author":"Rost","year":"2010","journal-title":"Neurology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1161\/STROKEAHA.106.475483","article-title":"Comparison of clinical characteristics and functional outcomes of ischemic stroke in different vascular territories","volume":"38","author":"Ng","year":"2007","journal-title":"Stroke."},{"key":"B11","doi-asserted-by":"publisher","first-page":"S169","DOI":"10.3233\/JAD-2012-120412","article-title":"Structural brain atlases: design, rationale, and applications in normal and pathological cohorts","volume":"31","author":"Mandal","year":"2012","journal-title":"J Alzheimers Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke."},{"key":"B13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1212\/01.wnl.0000223613.57229.24","article-title":"Progression of white matter lesions and hemorrhages in cerebral amyloid angiopathy","volume":"67","author":"Chen","year":"2006","journal-title":"Neurology."},{"key":"B14","article-title":"Accuracy and execution speed of automatic voxel-based algorithms for segmenting stroke lesions in clinical DWI imaging","volume-title":"19th International Society for Magnetic Resonance in Medicine. ISMRM 2011","author":"Mocking","year":"2011"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1016\/j.neuroimage.2009.09.062","article-title":"The optimal template effect in hippocampus studies of diseased populations","volume":"49","author":"Avants","year":"2010","journal-title":"Neuroimage."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1101\/552844","article-title":"White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts-the MRI-GENIE study","author":"Schirmer","year":"2019","journal-title":"bioRxiv."},{"key":"B18","volume-title":"How to detect and handle outliers","author":"Iglewicz","year":"1993"},{"key":"B19","volume-title":"R: A Language and Environment for Statistical Computing","year":"2013"},{"key":"B20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1227\/01.NEU.0000370939.30003.D1","article-title":"Brain ventricular size in healthy elderly: comparison between Evans index and volume measurement","volume":"67","author":"Ambarki","year":"2010","journal-title":"Neurosurgery."},{"key":"B21","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/ana.1009","article-title":"Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy","volume":"49","author":"Grabowski","year":"2001","journal-title":"Ann Neurol Off J Am Neurol Assoc Child Neurol Soc."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1212\/01.wnl.0000327887.64299.a4","article-title":"Impaired visual evoked flow velocity response in cerebral amyloid angiopathy","volume":"71","author":"Smith","year":"2008","journal-title":"Neurology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s002130050554","article-title":"Cerebral effects of nicotine during cognition in smokers and non-smokers","volume":"136","author":"Ghatan","year":"1998","journal-title":"Psychopharmacology."},{"key":"B24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1212\/WNL.59.3.321","article-title":"Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis","volume":"59","author":"O'sullivan","year":"2002","journal-title":"Neurology."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00208\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:43:10Z","timestamp":1552956190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00208\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":24,"alternative-id":["10.3389\/fneur.2019.00208"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2019.00208","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/457374","asserted-by":"object"}]},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"article-number":"208"}}