{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:52:32Z","timestamp":1768791152214,"version":"3.49.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["10051152"],"award-info":[{"award-number":["10051152"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2019.00357","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T04:26:38Z","timestamp":1554870398000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis\/Neurogenesis and Behavioral Recovery After Stroke"],"prefix":"10.3389","volume":"10","author":[{"given":"Sunyoung","family":"Hwang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JeeIn","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MinYoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.brainres.2013.06.014","article-title":"Cerebroprotective effects of TAK-937, a novel cannabinoid receptor agonist, in permanent and thrombotic focal cerebral ischemia in rats: therapeutic time window, combination with t-PA and efficacy in aged rats","volume":"1526","author":"Murakami","year":"2013","journal-title":"Brain Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.12659\/MSMBR.883750","article-title":"The failure of animal models of neuroprotection in acute ischemic stroke to translate to clinical efficacy","volume":"19","author":"Xu","year":"2013","journal-title":"Med Sci Monit Basic Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"9831210","DOI":"10.1155\/2018\/9831210","article-title":"An overview of meta-analyses of endovascular bridging therapies for acute ischemic stroke","volume":"2018","author":"Chen","year":"2018","journal-title":"Biomed Res Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1136\/jnnp.46.1.5","article-title":"Recovery after stroke","volume":"46","author":"Skilbeck","year":"1983","journal-title":"J Neurol Neurosurg Psychiatr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.apsb.2016.06.013","article-title":"The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995-2015","volume":"6","author":"Chen","year":"2016","journal-title":"Acta Pharm Sin B."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0144218","DOI":"10.1371\/journal.pone.0144218","article-title":"Effects of mesenchymal stem cell treatment on the expression of matrix metalloproteinases and angiogenesis during ischemic stroke recovery","volume":"10","author":"Nam","year":"2015","journal-title":"PLoS ONE."},{"key":"B9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pneurobio.2013.11.007","article-title":"Cell based therapies for ischemic stroke: from basic science to bedside","volume":"115","author":"Liu","year":"2014","journal-title":"Prog Neurobiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fneur.2018.00034","article-title":"Potential of stem cell-based therapy for ischemic stroke","volume":"9","author":"Marei","year":"2018","journal-title":"Front Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/bmt.2009.280","article-title":"History of cord blood transplantation","volume":"44","author":"Gluckman","year":"2009","journal-title":"Bone Marrow Transplant."},{"key":"B12","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3727\/096368911X627417","article-title":"Therapeutic benefit of treatment of stroke with simvastatin and human umbilical cord blood cells: neurogenesis, synaptic plasticity, and axon growth","volume":"21","author":"Cui","year":"2012","journal-title":"Cell Transplant."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1089\/scd.2015.0074","article-title":"Involvement of immune responses in the efficacy of cord blood cell therapy for cerebral palsy","volume":"24","author":"Kang","year":"2015","journal-title":"Stem Cells Dev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12264-013-1397-9","article-title":"Time-dependent effect of combination therapy with erythropoietin and granulocyte colony-stimulating factor in a mouse model of hypoxic-ischemic brain injury","volume":"30","author":"Yu","year":"2014","journal-title":"Neurosci Bull."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/sj.jcbfm.9600417","article-title":"Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice","volume":"27","author":"Li","year":"2007","journal-title":"J Cereb Blood Flow Metab."},{"key":"B16","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.bbrc.2015.02.020","article-title":"Protection of erythropoietin against ischemic neurovascular unit injuries through the effects of connexin43","volume":"458","author":"Zhou","year":"2015","journal-title":"Biochem Biophys Res Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2202-14-27","article-title":"Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat","volume":"14","author":"Unden","year":"2013","journal-title":"BMC Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"410","DOI":"10.14336\/AD.2016.1209","article-title":"Effects of erythropoietin on gliogenesis during cerebral ischemic\/reperfusion recovery in adult mice","volume":"8","author":"Wang","year":"2017","journal-title":"Aging Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.1073\/pnas.95.8.4635","article-title":"In vivo evidence that erythropoietin protects neurons from ischemic damage","volume":"95","author":"Sakanaka","year":"1998","journal-title":"Proc Natl Acad Sci USA."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1161\/01.STR.0000132196.49028.a4","article-title":"Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats","volume":"35","author":"Wang","year":"2004","journal-title":"Stroke."},{"key":"B21","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000444810","article-title":"MLC901 Favors angiogenesis and associated recovery after ischemic stroke in mice","volume":"42","author":"Gandin","year":"2016","journal-title":"Cerebrovasc Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.brainres.2015.02.042","article-title":"Coupling of neurogenesis and angiogenesis after ischemic stroke","volume":"1623","author":"Ruan","year":"2015","journal-title":"Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1161\/01.RES.0000063425.51108.8D","article-title":"Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats","volume":"92","author":"Chen","year":"2003","journal-title":"Circ Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.nbd.2009.06.012","article-title":"Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke","volume":"36","author":"Cui","year":"2009","journal-title":"Neurobiol Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12967-016-0979-5","article-title":"Sodium ferulate and n-butylidenephthalate combined with bone marrow stromal cells (BMSCs) improve the therapeutic effects of angiogenesis and neurogenesis after rat focal cerebral ischemia","volume":"14","author":"Zhang","year":"2016","journal-title":"J Transl Med."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1177\/0023677218815210","article-title":"Reliability of behavioral tests in the middle cerebral artery occlusion model of rat","author":"Yu","year":"2018","journal-title":"Lab Anim."},{"key":"B27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3233\/RNN-120289","article-title":"Allogenic umbilical cord blood therapy combined with erythropoietin for patients with severe traumatic brain injury: three case reports","volume":"31","author":"Min","year":"2013","journal-title":"Restor Neurol Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4103\/2542-3932.217491","article-title":"Safety and efficacy of allogeneic umbilical cord blood therapy combined with erythropoietin in children with cerebral palsy: study protocol for a double-blind, randomized, placebo-controlled trial","volume":"2","author":"Kim","year":"2017","journal-title":"Asia Pac J Clin Trials."},{"key":"B29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000488409","article-title":"Electrical stimulation enhances migratory ability of transplanted bone marrow stromal cells in a rodent ischemic stroke model","volume":"46","author":"Morimoto","year":"2018","journal-title":"Cell Physiol Biochem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.nbd.2016.04.006","article-title":"Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke","volume":"93","author":"Larpthaveesarp","year":"2016","journal-title":"Neurobiol Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/1440-1681.12587","article-title":"Characterisation of a mouse cerebral microvascular endothelial cell line (bEnd.3) after oxygen glucose deprivation and reoxygenation","volume":"43","author":"Ku","year":"2016","journal-title":"Clin Exp Pharmacol Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.3892\/etm.2018.6466","article-title":"Protective effects of primary neural stem cell treatment in ischemic stroke models","volume":"16","author":"Yu","year":"2018","journal-title":"Exp Ther Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ijdevneu.2015.04.009","article-title":"Enhanced differentiation of neural stem cells to neurons and promotion of neurite outgrowth by oxygen-glucose deprivation","volume":"43","author":"Wang","year":"2015","journal-title":"Int J Dev Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"127170","DOI":"10.1155\/2013\/127170","article-title":"Angiogenesis and its therapeutic opportunities","volume":"2013","author":"Yoo","year":"2013","journal-title":"Mediators Inflamm."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e38776","DOI":"10.1371\/journal.pone.0038776","article-title":"Combined transfer of human VEGF165 and HGF genes renders potent angiogenic effect in ischemic skeletal muscle","volume":"7","author":"Makarevich","year":"2012","journal-title":"PLoS ONE."},{"key":"B36","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/sj.jcbfm.9600034","article-title":"Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice","volume":"25","author":"Chen","year":"2005","journal-title":"J Cereb Blood Flow Metab."},{"key":"B37","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.brainres.2015.08.003","article-title":"Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke","volume":"1624","author":"Zhao","year":"2015","journal-title":"Brain Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain","volume":"106","author":"Zhang","year":"2000","journal-title":"J Clin Invest."},{"key":"B39","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/sj.jcbfm.9600573","article-title":"Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke","volume":"28","author":"Teng","year":"2008","journal-title":"J Cereb Blood Flow Metab."},{"key":"B40","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fncel.2016.00129","article-title":"Central role of maladapted astrocytic plasticity in ischemic brain edema formation","volume":"10","author":"Wang","year":"2016","journal-title":"Front Cell Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00401-015-1513-1","article-title":"Astrocytes: a central element in neurological diseases","volume":"131","author":"Pekny","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/S0028-3908(00)00006-X","article-title":"Intracerebral transplantation of bone marrow with BDNF after MCAo in rat","volume":"39","author":"Chen","year":"2000","journal-title":"Neuropharmacology."},{"key":"B43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2174\/157488811797904362","article-title":"Adult neural stem cells: response to stroke injury and potential for therapeutic applications","volume":"6","author":"Barkho","year":"2011","journal-title":"Curr Stem Cell Res Ther."},{"key":"B44","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1742-7843.2011.00848.x","article-title":"Therapeutic effects of a combinatorial treatment of simvastatin and bone marrow stromal cells on experimental embolic stroke","volume":"110","author":"Pirzad Jahromi","year":"2012","journal-title":"Basic Clin Pharmacol Toxicol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s13287-018-1011-1","article-title":"Combination therapy of human bone marrow-derived mesenchymal stem cells and minocycline improves neuronal function in a rat middle cerebral artery occlusion model","volume":"9","author":"Cho","year":"2018","journal-title":"Stem Cell Res Ther."},{"key":"B46","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1161\/STROKEAHA.115.011230","article-title":"Combining growth factor and bone marrow cell therapy induces bleeding and alters immune response after stroke in mice","volume":"47","author":"Strecker","year":"2016","journal-title":"Stroke."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00357\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T04:26:40Z","timestamp":1554870400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00357\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":46,"alternative-id":["10.3389\/fneur.2019.00357"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2019.00357","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,10]]},"article-number":"357"}}