{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:31:23Z","timestamp":1791876683517,"version":"4.3.4"},"reference-count":303,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013013","name":"Target ALS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006510","name":"Association pour la Recherche sur la Scl\u00e9rose Lat\u00e9rale Amyotrophique et autres Maladies du Motoneurone","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013360","name":"Invest Northern Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2019.00400","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T05:10:57Z","timestamp":1557810657000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":66,"title":["A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS"],"prefix":"10.3389","volume":"10","author":[{"given":"Udaya Geetha","family":"Vijayakumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Milla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Yu","family":"Cynthia Stafford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Bjourson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Duddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Marie-Rose","family":"Duguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000351153","article-title":"Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature","volume":"41","author":"Chi\u00f2","year":"2013","journal-title":"Neuroepidemiology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S1474-4422(16)30199-5","article-title":"Amyotrophic lateral sclerosis: moving towards a new classification system","volume":"15","author":"Al-Chalabi","year":"2016","journal-title":"Lancet Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1007\/s00415-018-8983-8","article-title":"Amyotrophic lateral sclerosis: the complex path to precision medicine","volume":"265","author":"Talbot","year":"2018","journal-title":"J Neurol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.chest.2018.06.035","article-title":"Respiratory failure in amyotrophic lateral sclerosis","volume":"155","author":"Niedermeyer","year":"2018","journal-title":"Chest"},{"key":"B5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3233\/NRE-141149","article-title":"Amyotrophic Lateral Sclerosis survival analysis: swallowing and non-oral feeding","volume":"35","author":"Luchesi","year":"2014","journal-title":"NeuroRehabilitation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/B978-0-12-802973-2.00013-6","article-title":"The epidemiology of amyotrophic lateral sclerosis","volume":"138","author":"Talbott","year":"","journal-title":"Handb Clin Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3109\/17482960802566824","article-title":"Prognostic factors in ALS: a critical review","volume":"10","author":"Chi\u00f2","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"B8","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1212\/01.WNL.0000049472.47709.3B","article-title":"Prognosis in amyotrophic lateral sclerosis: a population-based study","volume":"60","author":"del Aguila","year":"2003","journal-title":"Neurology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1056\/NEJMc1710379","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/ane.12869","article-title":"Late age onset of amyotrophic lateral sclerosis is often not considered in elderly people","volume":"137","author":"Broussalis","year":"2018","journal-title":"Acta Neurol Scand"},{"key":"B11","doi-asserted-by":"publisher","first-page":"12408","DOI":"10.1038\/ncomms12408","article-title":"Projected increase in amyotrophic lateral sclerosis from 2015 to 2040","volume":"7","author":"Arthur","year":"2016","journal-title":"Nat Commun"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1136\/jnnp-2017-315995","article-title":"Genetic screening in sporadic ALS and FTD","volume":"88","author":"Turner","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s11825-018-0185-3","article-title":"Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis","volume":"30","author":"Volk","year":"2018","journal-title":"Med Genet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1474-4422(17)30401-5","article-title":"Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications","volume":"17","author":"Chia","year":"2018","journal-title":"Lancet Neurol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.neuron.2018.02.027","article-title":"Genome-wide analyses identify KIF5A as a novel ALS gene","volume":"97","author":"Nicolas","year":"2018","journal-title":"Neuron"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.celrep.2014.03.019","article-title":"Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons","volume":"7","author":"Wainger","year":"2014","journal-title":"Cell Rep"},{"key":"B17","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fnins.2018.00086","article-title":"Modeling protein aggregation and the heat shock response in ALS iPSC-derived motor neurons","volume":"12","author":"Seminary","year":"2018","journal-title":"Front Neurosci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nm.4490","article-title":"Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS\/FTD human induced motor neurons","volume":"24","author":"Shi","year":"2018","journal-title":"Nat Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S1474-4422(12)70043-1","article-title":"Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study","volume":"11","author":"Majounie","year":"2012","journal-title":"Lancet Neurol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jns.2018.05.016","article-title":"From snow to hill to ALS: an epidemiological odyssey in search of ALS causation","volume":"391","author":"Armon","year":"2018","journal-title":"J Neurol Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fnmol.2018.00063","article-title":"Enteroviral infection: the forgotten link to amyotrophic lateral sclerosis?","volume":"11","author":"Xue","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.neuron.2017.07.025","article-title":"TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics","volume":"95","author":"Mackenzie","year":"2017","journal-title":"Neuron"},{"key":"B23","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nrneurol.2016.182","article-title":"Gene discovery in amyotrophic lateral sclerosis: implications for clinical management","volume":"13","author":"Al-Chalabi","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.2174\/0929867321666140916120118","article-title":"The glutamate hypothesis in ALS: pathophysiology and drug development","volume":"21","author":"Blasco","year":"2014","journal-title":"Curr Med Chem"},{"key":"B25","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.3390\/ijms18102092","article-title":"Neuromuscular junction dismantling in amyotrophic lateral sclerosis","volume":"18","author":"Cappello","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1002\/jnr.24249","article-title":"Discrete mitochondrial aberrations in the spinal cord of sporadic ALS patients","volume":"96","author":"Delic","year":"2018","journal-title":"J Neurosci Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/635831","article-title":"ALS and oxidative stress: the neurovascular scenario","volume":"2013","author":"Anand","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"B29","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s11064-015-1779-7","article-title":"Cerebrospinal fluid from sporadic amyotrophic lateral sclerosis patients induces mitochondrial and lysosomal dysfunction","volume":"41","author":"Sharma","year":"2016","journal-title":"Neurochem Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40478-016-0316-5","article-title":"Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts","volume":"4","author":"Onesto","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"B31","doi-asserted-by":"publisher","first-page":"16021","DOI":"10.1073\/pnas.0607423103","article-title":"Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis","volume":"103","author":"Beers","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B32","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons","volume":"10","author":"Nagai","year":"2007","journal-title":"Nat Neurosci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/nbt.1957","article-title":"Astrocytes from familial and sporadic ALS patients are toxic to motor neurons","volume":"29","author":"Haidet-Phillips","year":"2011","journal-title":"Nat Biotechnol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"15699","DOI":"10.1074\/jbc.M112.425066","article-title":"Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis","volume":"288","author":"Basso","year":"2013","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.stem.2008.09.017","article-title":"Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation","volume":"3","author":"Di Giorgio","year":"2008","journal-title":"Cell Stem Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.stem.2008.10.001","article-title":"Non-cell-autonomous effect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells","volume":"3","author":"Marchetto","year":"2008","journal-title":"Cell Stem Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1056\/NEJM199205283262204","article-title":"Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis","volume":"326","author":"Rothstein","year":"1992","journal-title":"N Engl J Med"},{"key":"B38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate","volume":"16","author":"Rothstein","year":"1996","journal-title":"Neuron"},{"key":"B39","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1006\/exnr.1996.0198","article-title":"Differential abundance of glutamate transporter subtypes in amyotrophic lateral sclerosis (ALS)-vulnerable versus ALS-resistant brain stem motor cell groups","volume":"142","author":"Medina","year":"1996","journal-title":"Exp Neurol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jns.2010.12.007","article-title":"Can Awaji ALS criteria provide earlier diagnosis than the revised El Escorial criteria?","volume":"302","author":"Okita","year":"2011","journal-title":"J Neurol Sci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrneurol.2011.153","article-title":"Clinical diagnosis and management of amyotrophic lateral sclerosis","volume":"7","author":"Hardiman","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"CD001447","DOI":"10.1002\/14651858.CD001447.pub3","article-title":"Riluzole for amyotrophic lateral sclerosis (ALS)\/motor neuron disease (MND)","volume":"2012","author":"Miller","year":"2012","journal-title":"Cochrane database Syst Rev"},{"key":"B43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e182","DOI":"10.1182\/blood-2011-01-331926","article-title":"Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging","volume":"117","author":"Bocker","year":"2011","journal-title":"Blood"},{"key":"B45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.brainres.2016.05.022","article-title":"Stress granules at the intersection of autophagy and ALS","volume":"1649","author":"Monahan","year":"2016","journal-title":"Brain Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.bbadis.2014.08.010","article-title":"Sporadic and hereditary amyotrophic lateral sclerosis (ALS)","volume":"1852","author":"Ajroud-Driss","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B47","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fncel.2016.00044","article-title":"Impaired autophagy and defective mitochondrial function: converging paths on the road to motor neuron degeneration","volume":"10","author":"Edens","year":"2016","journal-title":"Front Cell Neurosci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/gtc.12125","article-title":"Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1","volume":"19","author":"Kitamura","year":"2014","journal-title":"Genes to Cells"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s12035-013-8623-3","article-title":"Oxidative stress and autophagic alteration in brainstem of SOD1-G93A mouse model of ALS","volume":"49","author":"An","year":"2014","journal-title":"Mol Neurobiol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"498428","DOI":"10.1155\/2012\/498428","article-title":"Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases","volume":"2012","author":"Otomo","year":"2012","journal-title":"Neurol Res Int"},{"key":"B51","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.gene.2015.11.049","article-title":"Mutant SOD1 mediated pathogenesis of amyotrophic lateral sclerosis","volume":"577","author":"Kaur","year":"2016","journal-title":"Gene"},{"key":"B52","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/J.MITO.2015.10.003","article-title":"Novel computer vision algorithm for the reliable analysis of organelle morphology in whole cell 3D images\u2014A pilot study for the quantitative evaluation of mitochondrial fragmentation in amyotrophic lateral sclerosis","volume":"25","author":"Lautenschl\u00e4ger","year":"2015","journal-title":"Mitochondrion"},{"key":"B53","doi-asserted-by":"publisher","first-page":"E3349","DOI":"10.1073\/pnas.1523810113","article-title":"Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy","volume":"113","author":"Moore","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B54","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1073\/pnas.1523926113","article-title":"Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria","volume":"113","author":"Richter","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/FNMOL.2017.00119","article-title":"Protein quality control and the amyotrophic lateral sclerosis\/frontotemporal dementia continuum","volume":"10","author":"Shahheydari","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN\/NDP52 recruitment and TBK1 activation to promote mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.exer.2015.06.029","article-title":"Optineurin: the autophagy connection","volume":"144","author":"Ying","year":"2016","journal-title":"Exp Eye Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13041-017-0287-x","article-title":"TBK1: a new player in ALS linking autophagy and neuroinflammation","volume":"10","author":"Oakes","year":"2017","journal-title":"Mol Brain"},{"key":"B59","doi-asserted-by":"publisher","first-page":"8558","DOI":"10.15252\/emmm.201708558","article-title":"A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS","volume":"10","author":"Lehmer","year":"2018","journal-title":"EMBO Mol Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"58","DOI":"10.15252\/emmm.201505496","article-title":"CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis","volume":"8","author":"Genin","year":"2016","journal-title":"EMBO Mol Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"15558","DOI":"10.1038\/ncomms15558","article-title":"Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity","volume":"8","author":"Woo","year":"2017","journal-title":"Nat Commun"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01989-y","article-title":"ALS\/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response","author":"Anderson","year":"2019","journal-title":"Acta Neuropathol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/hmg\/ddx397","article-title":"In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions","volume":"27","author":"Burstein","year":"2018","journal-title":"Hum Mol Genet"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1126\/science.aaa3650","article-title":"Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways","volume":"347","author":"Cirulli","year":"2015","journal-title":"Science."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1093\/brain\/awy076","article-title":"Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia","volume":"141","author":"Walker","year":"2018","journal-title":"Brain"},{"key":"B66","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.1038\/s41598-017-05325-w","article-title":"NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin","volume":"7","author":"Melo-Hanchuk","year":"2017","journal-title":"Sci Rep"},{"key":"B67","doi-asserted-by":"publisher","first-page":"655","DOI":"10.4161\/cc.10.4.14814","article-title":"Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR","volume":"10","author":"Chen","year":"2011","journal-title":"Cell Cycle"},{"key":"B68","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1080\/15384101.2017.1314421","article-title":"Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity","volume":"16","author":"Singh","year":"2017","journal-title":"Cell Cycle"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1073\/pnas.1217781110","article-title":"Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling","volume":"110","author":"Liu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B70","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.str.2016.11.014","article-title":"The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase","volume":"25","author":"Al-Jassar","year":"2017","journal-title":"Structure"},{"key":"B71","doi-asserted-by":"publisher","first-page":"257","DOI":"10.4161\/cc.8.2.7551","article-title":"Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1","volume":"8","author":"Chen","year":"2009","journal-title":"Cell Cycle"},{"key":"B72","doi-asserted-by":"publisher","first-page":"e1003066","DOI":"10.1371\/journal.pgen.1003066","article-title":"Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model","volume":"8","author":"F\u00fcger","year":"2012","journal-title":"PLoS Genet"},{"key":"B73","doi-asserted-by":"publisher","first-page":"14896","DOI":"10.1523\/JNEUROSCI.3739-10.2010","article-title":"Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching","volume":"30","author":"Liu","year":"2010","journal-title":"J Neurosci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s40478-017-0457-1","article-title":"Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death","volume":"5","author":"Jacquier","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e0164625","DOI":"10.1371\/journal.pone.0164625","article-title":"Neurofilaments as biomarkers for amyotrophic lateral sclerosis: a systematic review and meta-analysis","volume":"11","author":"Xu","year":"2016","journal-title":"PLoS ONE"},{"key":"B76","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/hmg\/3.10.1757","article-title":"Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis","volume":"3","author":"Figlewicz","year":"1994","journal-title":"Hum Mol Genet"},{"key":"B77","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.ajhg.2016.02.022","article-title":"Cryptic amyloidogenic elements in the 3\u2032 UTRs of neurofilament genes trigger axonal neuropathy","volume":"98","author":"Rebelo","year":"2016","journal-title":"Am J Hum Genet"},{"key":"B78","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/S0959-4388(99)00004-5","article-title":"Neurofilament functions in health and disease","volume":"9","author":"Julien","year":"1999","journal-title":"Curr Opin Neurobiol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1016\/j.yexcr.2007.02.014","article-title":"Post-transcriptional control of neurofilaments in development and disease","volume":"313","author":"Thyagarajan","year":"2007","journal-title":"Exp Cell Res"},{"key":"B80","doi-asserted-by":"publisher","first-page":"10351","DOI":"10.1073\/pnas.0503862102","article-title":"Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS","volume":"102","author":"Lobsiger","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"B81","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1091\/mbc.E13-07-0387","article-title":"Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure","volume":"25","author":"Howes","year":"2014","journal-title":"Mol Biol Cell"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1523\/JNEUROSCI.4231-07.2008","article-title":"Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking","volume":"28","author":"Laird","year":"2008","journal-title":"J Neurosci"},{"key":"B83","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.neuron.2014.09.027","article-title":"Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS","volume":"84","author":"Smith","year":"2014","journal-title":"Neuron"},{"key":"B84","doi-asserted-by":"publisher","first-page":"4301","DOI":"10.1007\/s00018-018-2873-1","article-title":"Dysregulation of a novel miR-1825\/TBCB\/TUBA4A pathway in sporadic and familial ALS","volume":"75","author":"Helferich","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"B85","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/bpa.12422","article-title":"Sensory neuropathy in progressive motor neuronopathy (pmn) mice is associated with defects in microtubule polymerization and axonal transport","volume":"27","author":"Sch\u00e4fer","year":"2017","journal-title":"Brain Pathol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fncel.2016.00204","article-title":"A case for microtubule vulnerability in amyotrophic lateral sclerosis: altered dynamics during disease","volume":"10","author":"Clark","year":"2016","journal-title":"Front Cell Neurosci"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e0182572","DOI":"10.1371\/journal.pone.0182572","article-title":"DCTN1 gene analysis in Chinese patients with sporadic amyotrophic lateral sclerosis","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS ONE"},{"key":"B88","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/14660820310016084","article-title":"Paradigms for the identification of new genes in motor neuron degeneration","volume":"4","author":"Hafezparast","year":"2003","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"B89","doi-asserted-by":"publisher","first-page":"13729","DOI":"10.1523\/JNEUROSCI.2939-10.2010","article-title":"Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway","volume":"30","author":"Vohra","year":"2010","journal-title":"J Neurosci"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.3390\/ijms13011225","article-title":"Disruption of axonal transport in motor neuron diseases","volume":"13","author":"Ikenaka","year":"2012","journal-title":"Int J Mol Sci"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1016\/j.cub.2017.10.002","article-title":"Profilin directly promotes microtubule growth through residues mutated in amyotrophic lateral sclerosis","volume":"27","author":"Henty-Ridilla","year":"2017","journal-title":"Curr Biol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature11280","article-title":"Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis","volume":"488","author":"Wu","year":"2012","journal-title":"Nature"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1007\/s11011-018-0305-4","article-title":"Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis","volume":"33","author":"Nekouei","year":"2018","journal-title":"Metab Brain Dis"},{"key":"B94","doi-asserted-by":"publisher","first-page":"13102","DOI":"10.1038\/s41598-018-31199-7","article-title":"ALS-causing mutations in profilin-1 alter its conformational dynamics: a computational approach to explain propensity for aggregation","volume":"8","author":"Kiaei","year":"2018","journal-title":"Sci Rep"},{"key":"B95","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/hmg\/ddn375","article-title":"Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration","volume":"18","author":"Simpson","year":"2009","journal-title":"Hum Mol Genet"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/hmg\/ddy043","article-title":"Elongator subunit 3 (ELP3) modifies ALS through tRNA modification","volume":"27","author":"Bento-Abreu","year":"2018","journal-title":"Hum Mol Genet"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molmed.2009.11.002","article-title":"Elongator\u2013an emerging role in neurological disorders","volume":"16","author":"Nguyen","year":"2010","journal-title":"Trends Mol Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/cr.2016.112","article-title":"Elongator controls cortical interneuron migration by regulating actomyosin dynamics","volume":"26","author":"Tielens","year":"2016","journal-title":"Cell Res"},{"key":"B99","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature14973","article-title":"The C9orf72 repeat expansion disrupts nucleocytoplasmic transport","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"B100","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1093\/hmg\/ddu068","article-title":"C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking","volume":"23","author":"Farg","year":"2014","journal-title":"Hum Mol Genet"},{"key":"B101","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1177\/0141076813511451","article-title":"Advances in motor neurone disease","volume":"107","author":"B\u00e4umer","year":"2014","journal-title":"J R Soc Med"},{"key":"B102","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2909168","article-title":"Molecular mechanisms of neurodegeneration related to C9orf72 hexanucleotide repeat expansion","volume":"2019","author":"Babi\u0107 Leko","year":"2019","journal-title":"Behav Neurol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01964-7","article-title":"Disrupted neuronal trafficking in amyotrophic lateral sclerosis","author":"Burk","year":"2019","journal-title":"Acta Neuropathol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.cell.2017.12.030","article-title":"In situ structure of neuronal C9orf72 Poly-GA aggregates reveals proteasome recruitment","volume":"172","author":"Guo","year":"2018","journal-title":"Cell"},{"key":"B106","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1080\/15548627.2019.1569441","article-title":"The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy","volume":"15","author":"Ho","year":"2019","journal-title":"Autophagy"},{"key":"B107","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.bbrc.2012.04.041","article-title":"The functional analysis of the CHMP2B missense mutation associated with neurodegenerative diseases in the endo-lysosomal pathway","volume":"421","author":"Han","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"B108","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1172\/JCI66339","article-title":"Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy","volume":"124","author":"Zaglia","year":"2014","journal-title":"J Clin Invest"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1212\/01.wnl.0000231510.89311.8b","article-title":"ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)","volume":"67","author":"Parkinson","year":"2006","journal-title":"Neurology"},{"key":"B110","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1083\/jcb.200702115","article-title":"Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease","volume":"179","author":"Filimonenko","year":"2007","journal-title":"J Cell Biol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.3390\/ijms19061714","article-title":"Molecular genetics of frontotemporal dementia elucidated by drosophila models\u2014defects in endosomal\u2013lysosomal pathway","volume":"19","author":"Vandal","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B112","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.brainres.2016.02.051","article-title":"The role of CHMP2BIntron5 in autophagy and frontotemporal dementia","volume":"1649","author":"Krasniak","year":"2016","journal-title":"Brain Res"},{"key":"B113","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00401-015-1475-3","article-title":"Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology","volume":"130","author":"Clayton","year":"2015","journal-title":"Acta Neuropathol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neulet.2012.08.035","article-title":"Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in \u03b1-synucleinopathy","volume":"527","author":"Tanikawa","year":"2012","journal-title":"Neurosci Lett"},{"key":"B115","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.bbamcr.2013.03.031","article-title":"Create and preserve: proteostasis in development and aging is governed by Cdc48\/p97\/VCP","volume":"1843","author":"Franz","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B116","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.neuron.2010.11.040","article-title":"Capturing VCP: another molecular piece in the ALS jigsaw puzzle","volume":"68","author":"Shaw","year":"2010","journal-title":"Neuron"},{"key":"B117","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.neuron.2010.11.036","article-title":"Exome sequencing reveals VCP mutations as a cause of familial ALS","volume":"68","author":"Johnson","year":"2010","journal-title":"Neuron"},{"key":"B118","doi-asserted-by":"publisher","first-page":"e374","DOI":"10.1038\/cddis.2012.115","article-title":"Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice","volume":"3","author":"Yin","year":"2012","journal-title":"Cell Death Dis"},{"key":"B119","doi-asserted-by":"publisher","first-page":"14373","DOI":"10.1074\/jbc.M116.729343","article-title":"Pathogenic mutations in the valosin-containing Protein\/p97(VCP) N-domain Inhibit the SUMOylation of VCP and lead to impaired stress response","volume":"291","author":"Wang","year":"2016","journal-title":"J Biol Chem"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e0131995","DOI":"10.1371\/journal.pone.0131995","article-title":"A fine balance of dietary lipids improves pathology of a murine model of VCP-associated multisystem proteinopathy","volume":"10","author":"Llewellyn","year":"2015","journal-title":"PLoS ONE"},{"key":"B121","doi-asserted-by":"publisher","first-page":"135","DOI":"10.15252\/embj.201695148","article-title":"VCP\/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy","volume":"36","author":"Papadopoulos","year":"2017","journal-title":"EMBO J"},{"key":"B122","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/neup.12056","article-title":"ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases","volume":"34","author":"Kon","year":"2014","journal-title":"Neuropathology"},{"key":"B123","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ajhg.2008.12.010","article-title":"Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS","volume":"84","author":"Chow","year":"2009","journal-title":"Am J Hum Genet"},{"key":"B124","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/B978-0-12-397926-1.00014-7","article-title":"Mouse models of PI(3,5)P2 deficiency with impaired lysosome function","volume":"534","author":"Lenk","year":"2014","journal-title":"Methods Enzymol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am J Hum Genet"},{"key":"B126","doi-asserted-by":"publisher","first-page":"jcs","DOI":"10.1242\/jcs.220061","article-title":"VAPB depletion alters neuritogenesis and phosphoinositide balance in motoneuron-like cells: relevance to VAPB-linked ALS","volume":"2019","author":"Genevini","year":"2019","journal-title":"J Cell Sci"},{"key":"B127","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jtbi.2014.03.027","article-title":"Protein aggregation due to nsSNP resulting in P56S VABP protein is associated with amyotrophic lateral sclerosis","volume":"354","author":"Vinay Kumar","year":"2014","journal-title":"J Theor Biol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1093\/hmg\/ddt080","article-title":"Investigating the contribution of VAPB\/ALS8 loss of function in amyotrophic lateral sclerosis","volume":"22","author":"Kabashi","year":"2013","journal-title":"Hum Mol Genet"},{"key":"B129","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1093\/hmg\/ddt279","article-title":"Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons","volume":"22","author":"Aliaga","year":"2013","journal-title":"Hum Mol Genet"},{"key":"B130","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.cell.2016.07.001","article-title":"UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome","volume":"166","author":"Hjerpe","year":"2016","journal-title":"Cell"},{"key":"B131","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00401-013-1125-6","article-title":"Protein aggregation in amyotrophic lateral sclerosis","volume":"125","author":"Blokhuis","year":"2013","journal-title":"Acta Neuropathol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nature10353","article-title":"Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS\/dementia","volume":"477","author":"Deng","year":"2011","journal-title":"Nature"},{"key":"B133","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s40478-018-0627-9","article-title":"Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats","volume":"6","author":"Chen","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"B134","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1016\/j.bbadis.2018.06.017","article-title":"Depletion of ubiquilin induces an augmentation in soluble ubiquitinated drosophila TDP-43 to drive neurotoxicity in the fly","volume":"1864","author":"Jantrapirom","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"B135","doi-asserted-by":"publisher","first-page":"jem.20180729","DOI":"10.1084\/jem.20180729","article-title":"Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice","volume":"216","author":"Brenner","year":"2019","journal-title":"J Exp Med"},{"key":"B136","doi-asserted-by":"publisher","first-page":"11253","DOI":"10.1038\/ncomms11253","article-title":"CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"7","author":"Williams","year":"2016","journal-title":"Nat Commun"},{"key":"B137","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mcn.2016.08.004","article-title":"ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling","volume":"76","author":"Goode","year":"2016","journal-title":"Mol Cell Neurosci"},{"key":"B138","doi-asserted-by":"publisher","first-page":"818","DOI":"10.14348\/molcells.2018.0243","article-title":"RNA-binding proteins in amyotrophic lateral sclerosis","volume":"41","author":"Zhao","year":"2018","journal-title":"Mol Cells"},{"key":"B139","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/ng.132","article-title":"TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis","volume":"40","author":"Kabashi","year":"2008","journal-title":"Nat Genet"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"B141","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature11922","article-title":"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS","volume":"495","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"B142","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/jnc.12194","article-title":"TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress","volume":"126","author":"Higashi","year":"2013","journal-title":"J Neurochem"},{"key":"B143","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1038\/ncomms3980","article-title":"Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs","volume":"4","author":"Villarroya-Beltri","year":"2013","journal-title":"Nat Commun"},{"key":"B144","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2018.03.002","article-title":"Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains","volume":"173","author":"Guo","year":"2018","journal-title":"Cell"},{"key":"B145","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1756-6606-2-23","article-title":"Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2\/alsin","volume":"2","author":"Lai","year":"2009","journal-title":"Mol Brain"},{"key":"B146","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1006\/geno.2000.6392","article-title":"Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33\u2013q34: candidate genes for ALS2","volume":"71","author":"Hadano","year":"2001","journal-title":"Genomics"},{"key":"B147","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1080\/15548627.2017.1384889","article-title":"The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration","volume":"13","author":"Uversky","year":"2017","journal-title":"Autophagy"},{"key":"B148","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.neuron.2016.09.050","article-title":"Protein-RNA networks regulated by normal and ALS-associated mutant HNRNPA2B1 in the nervous system","volume":"92","author":"Martinez","year":"2016","journal-title":"Neuron"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/ng.3622","article-title":"Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis","volume":"48","author":"van Rheenen","year":"2016","journal-title":"Nat Genet"},{"key":"B150","doi-asserted-by":"publisher","first-page":"17135","DOI":"10.1074\/jbc.RA118.003849","article-title":"Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function","volume":"293","author":"Sato","year":"2018","journal-title":"J Biol Chem"},{"key":"B151","doi-asserted-by":"publisher","first-page":"e9805","DOI":"10.1371\/journal.pone.0009805","article-title":"Loss of ALS2\/Alsin exacerbates motor dysfunction in a SOD1H46R-expressing mouse ALS model by disturbing endolysosomal trafficking","volume":"5","author":"Hadano","year":"2010","journal-title":"PLoS ONE"},{"key":"B152","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.nbd.2017.02.007","article-title":"Loss of spatacsin function alters lysosomal lipid clearance leading to upper and lower motor neuron degeneration","volume":"102","author":"Branchu","year":"2017","journal-title":"Neurobiol Dis"},{"key":"B153","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/brain\/awp325","article-title":"SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis","volume":"133","author":"Orlacchio","year":"2010","journal-title":"Brain"},{"key":"B154","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/abbs\/gmv076","article-title":"The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair","volume":"47","author":"Fang","year":"2015","journal-title":"Acta Biochim Biophys Sin"},{"key":"B155","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/17482968.2010.545952","article-title":"Senataxin mutations and amyotrophic lateral sclerosis","volume":"12","author":"Hirano","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"B156","doi-asserted-by":"publisher","first-page":"e1003435","DOI":"10.1371\/journal.pgen.1003435","article-title":"Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing","volume":"9","author":"Becherel","year":"2013","journal-title":"PLoS Genet"},{"key":"B157","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/978-3-319-89689-2_10","article-title":"Senataxin, a novel helicase at the interface of RNA transcriptome regulation and neurobiology: from normal function to pathological roles in motor neuron disease and cerebellar degeneration","volume":"20","author":"Bennett","year":"","journal-title":"Adv Neurobiol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.molcel.2017.12.030","article-title":"Senataxin mutation reveals how R-loops promote transcription by blocking DNA methylation at gene promoters","volume":"69","author":"Grunseich","year":"2018","journal-title":"Mol Cell"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"B160","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1038\/s41467-018-06111-6","article-title":"Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"B161","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1093\/brain\/awx248","article-title":"Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in \u201cFUSDelta14\u201d knockin mice","volume":"140","author":"Devoy","year":"2017","journal-title":"Brain"},{"key":"B162","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3389\/fgene.2018.00712","article-title":"RNA Dysregulation in amyotrophic lateral sclerosis","volume":"9","author":"Butti","year":"2019","journal-title":"Front Genet"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature09320","article-title":"Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS","volume":"466","author":"Elden","year":"2010","journal-title":"Nature"},{"key":"B164","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3390\/genes8060157","article-title":"Ataxin-2: from RNA control to human health and disease","volume":"8","author":"Ostrowski","year":"2017","journal-title":"Genes (Basel)"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/ncomms2126","article-title":"Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons","volume":"3","author":"Thiyagarajan","year":"2012","journal-title":"Nat Commun"},{"key":"B166","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ng1742","article-title":"ANG mutations segregate with familial and \u201csporadic\u201d amyotrophic lateral sclerosis","volume":"38","author":"Greenway","year":"2006","journal-title":"Nat Genet"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1212\/01.wnl.0000244466.46020.47","article-title":"Elevated serum angiogenin levels in ALS","volume":"67","author":"Cronin","year":"2006","journal-title":"Neurology"},{"key":"B168","first-page":"26","article-title":"Angiogenin-mediated rRNA transcription in cancer and neurodegeneration","volume":"1","author":"Li","year":"2010","journal-title":"Int J Biochem Mol Biol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nn.3688","article-title":"Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis","volume":"17","author":"Johnson","year":"2014","journal-title":"Nat Neurosci"},{"key":"B170","doi-asserted-by":"publisher","first-page":"eLife","DOI":"10.7554\/eLife.35977","article-title":"Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization","volume":"7","author":"Malik","year":"2018","journal-title":"Elife"},{"key":"B171","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1515\/bmc-2013-0038","article-title":"Transthyretin: a multifaceted protein","volume":"5","author":"Vieira","year":"2014","journal-title":"Biomol Concepts"},{"key":"B172","doi-asserted-by":"publisher","first-page":"e1497","DOI":"10.1038\/cddis.2014.459","article-title":"Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity","volume":"5","author":"Watanabe","year":"2014","journal-title":"Cell Death Dis"},{"key":"B173","doi-asserted-by":"publisher","first-page":"e15133","DOI":"10.1371\/journal.pone.0015133","article-title":"Cystatin C: a candidate biomarker for amyotrophic lateral sclerosis","volume":"5","author":"Wilson","year":"2010","journal-title":"PLoS ONE"},{"key":"B174","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s00415-017-8730-6","article-title":"CSF neurofilament proteins as diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis","volume":"265","author":"Rossi","year":"2018","journal-title":"J Neurol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s12883-016-0689-x","article-title":"Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis","volume":"16","author":"Chen","year":"2016","journal-title":"BMC Neurol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1080\/21678421.2016.1212894","article-title":"Phosphoneurofilament heavy chain and vascular endothelial growth factor as cerebrospinal fluid biomarkers for ALS","volume":"18","author":"Gon\u00e7alves","year":"2017","journal-title":"Amyotroph Lateral Scler Front Degener"},{"key":"B177","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/ana.24980","article-title":"Phosphorylated neurofilament heavy chain: a biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis","volume":"82","author":"Gendron","year":"2017","journal-title":"Ann Neurol"},{"key":"B178","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1136\/jnnp-2012-303768","article-title":"Phosphorylated neurofilament heavy subunit (pNF-H) in peripheral blood and CSF as a potential prognostic biomarker in amyotrophic lateral sclerosis","volume":"84","author":"Boylan","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B179","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/ana.25143","article-title":"Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis","volume":"83","author":"Thompson","year":"2018","journal-title":"Ann Neurol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12014-016-9109-x","article-title":"Clinical utility of serum biomarkers in Duchenne muscular dystrophy","volume":"13","author":"Hathout","year":"2016","journal-title":"Clin Proteomics"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2898-7","article-title":"miR-451 elevation relieves inflammatory pain by suppressing microglial activation-evoked inflammatory response via targeting TLR4","author":"Sun","year":"2018","journal-title":"Cell Tissue Res"},{"key":"B182","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00018-013-1459-1","article-title":"Monocyte chemoattractant protein-1 and the blood-brain barrier","volume":"71","author":"Yao","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"B183","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13395-014-0023-5","article-title":"The miR-206\/133b cluster is dispensable for development, survival and regeneration of skeletal muscle","volume":"4","author":"Boettger","year":"2014","journal-title":"Skelet Muscle"},{"key":"B184","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.gene.2012.07.058","article-title":"A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis","volume":"508","author":"De Felice","year":"2012","journal-title":"Gene"},{"key":"B185","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.YDBIO.2015.12.013","article-title":"Muscle-specific microRNAs in skeletal muscle development","volume":"410","author":"Horak","year":"2016","journal-title":"Dev Biol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S1474-4422(13)70036-X","article-title":"Controversies and priorities in amyotrophic lateral sclerosis","volume":"12","author":"Turner","year":"2013","journal-title":"Lancet Neurol"},{"key":"B187","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1007\/s12035-015-9165-7","article-title":"Metabolomic analysis reveals increased aerobic glycolysis and amino acid deficit in a cellular model of amyotrophic lateral sclerosis","volume":"53","author":"Valbuena","year":"2016","journal-title":"Mol Neurobiol"},{"key":"B188","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/17482960802295192","article-title":"High metabolic level in patients with familial amyotrophic lateral sclerosis","volume":"10","author":"Funalot","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"B189","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1136\/jnnp-2017-317887","article-title":"Hypermetabolism in ALS is associated with greater functional decline and shorter survival","volume":"89","author":"Steyn","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B190","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1194\/jlr.P071639","article-title":"Defective cholesterol metabolism in amyotrophic lateral sclerosis","volume":"58","author":"Abdel-Khalik","year":"2017","journal-title":"J Lipid Res"},{"key":"B191","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1038\/ejcn.2017.54","article-title":"A decrease in blood cholesterol after gastrostomy could impact survival in ALS","volume":"71","author":"Blasco","year":"2017","journal-title":"Eur J Clin Nutr"},{"key":"B192","doi-asserted-by":"publisher","first-page":"e7566","DOI":"10.1590\/1414-431X20187566","article-title":"Role of non-coding RNAs in non-aging-related neurological disorders","volume":"51","author":"Vieira","year":"2018","journal-title":"Braz J Med Biol Res."},{"key":"B193","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1007\/s12035-016-9793-6","article-title":"The Role of Long Noncoding RNAs in neurodegenerative diseases","volume":"54","author":"Wan","year":"2017","journal-title":"Mol Neurobiol"},{"key":"B194","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1159\/000493043","article-title":"Diagnostic and prognostic potential of circulating long non-coding RNAs in non small cell lung cancer","volume":"49","author":"Peng","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B195","doi-asserted-by":"publisher","first-page":"epi-2018-0121","DOI":"10.2217\/epi-2018-0121","article-title":"Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer","volume":"2018","author":"Bermejo","year":"2018","journal-title":"Epigenomics"},{"key":"B196","doi-asserted-by":"publisher","first-page":"5064","DOI":"10.12659\/MSM.909348","article-title":"Circulating long noncoding RNA LIPCAR acts as a novel biomarker in patients with ST-segment elevation myocardial infarction","volume":"24","author":"Li","year":"2018","journal-title":"Med Sci Monit"},{"key":"B197","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/J.ARR.2018.10.008","article-title":"microRNA diagnostic panel for Alzheimer's disease and epigenetic trade-off between neurodegeneration and cancer","volume":"49","author":"Nagaraj","year":"2018","journal-title":"Ageing Res Rev"},{"key":"B198","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jneuroim.2016.01.003","article-title":"Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis","volume":"292","author":"Punga","year":"2016","journal-title":"J Neuroimmunol"},{"key":"B199","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jns.2016.06.046","article-title":"MicroRNAs-424 and 206 are potential prognostic markers in spinal onset amyotrophic lateral sclerosis","volume":"368","author":"de Andrade","year":"2016","journal-title":"J Neurol Sci"},{"key":"B200","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nbd.2012.08.015","article-title":"Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis","volume":"49","author":"Russell","year":"2013","journal-title":"Neurobiol Dis"},{"key":"B201","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/J.NBD.2018.02.009","article-title":"Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosis","volume":"114","author":"Si","year":"2018","journal-title":"Neurobiol Dis"},{"key":"B202","doi-asserted-by":"publisher","first-page":"e89065","DOI":"10.1371\/journal.pone.0089065","article-title":"MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis","volume":"9","author":"Toivonen","year":"2014","journal-title":"PLoS ONE"},{"key":"B203","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1111\/j.1471-4159.2005.03478.x","article-title":"Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis","volume":"95","author":"Ranganathan","year":"2005","journal-title":"J Neurochem"},{"key":"B204","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/mus.21683","article-title":"Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomics","volume":"42","author":"Ryberg","year":"2010","journal-title":"Muscle Nerve"},{"key":"B205","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1212\/01.wnl.0000203129.82104.07","article-title":"Identification of potential CSF biomarkers in ALS","volume":"66","author":"Pasinetti","year":"2006","journal-title":"Neurology"},{"key":"B206","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuroscience.2018.03.023","article-title":"TLQP Peptides in amyotrophic lateral sclerosis: possible blood biomarkers with a neuroprotective role","volume":"380","author":"Brancia","year":"2018","journal-title":"Neuroscience"},{"key":"B207","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1001\/jamaneurol.2016.6179","article-title":"Serum C-reactive protein as a prognostic biomarker in amyotrophic lateral sclerosis","volume":"74","author":"Lunetta","year":"2017","journal-title":"JAMA Neurol"},{"key":"B208","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1001\/jamaneurol.2016.5398","article-title":"Diagnostic and Prognostic Biomarkers in amyotrophic lateral sclerosis: neurofilament light chain levels in definite subtypes of disease","volume":"74","author":"Gaiani","year":"2017","journal-title":"JAMA Neurol"},{"key":"B209","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/mus.21625","article-title":"Plasma biomarkers associated with ALS and their relationship to iron homeostasis","volume":"42","author":"Mitchell","year":"2010","journal-title":"Muscle Nerve"},{"key":"B210","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1212\/WNL.62.10.1758","article-title":"Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden","volume":"62","author":"Simpson","year":"2004","journal-title":"Neurology"},{"key":"B211","doi-asserted-by":"publisher","first-page":"e25545","DOI":"10.1371\/journal.pone.0025545","article-title":"Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells","volume":"6","author":"Nardo","year":"2011","journal-title":"PLoS ONE"},{"key":"B212","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fnmol.2017.00099","article-title":"Decreased levels of foldase and chaperone proteins are associated with an early-onset amyotrophic lateral sclerosis","volume":"10","author":"Filareti","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"B213","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fnmol.2016.00069","article-title":"Aberration of miRNAs expression in leukocytes from sporadic amyotrophic lateral sclerosis","volume":"9","author":"Chen","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"B214","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10048-014-0420-2","article-title":"miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients","volume":"15","author":"De Felice","year":"2014","journal-title":"Neurogenetics"},{"key":"B215","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fnmol.2018.00106","article-title":"Differential expression of several miRNAs and the host genes AATK and DNM2 in leukocytes of sporadic ALS patients","volume":"11","author":"Vrabec","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"B216","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neurobiolaging.2017.03.027","article-title":"Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS)","volume":"55","author":"Waller","year":"2017","journal-title":"Neurobiol Aging"},{"key":"B217","doi-asserted-by":"publisher","first-page":"22","DOI":"10.5414\/NP300889","article-title":"Circulating microRNAs as biomarkers of muscle differentiation and atrophy in ALS","volume":"35","author":"Tasca","year":"2016","journal-title":"Clin Neuropathol"},{"key":"B218","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/mus.26106","article-title":"Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis","volume":"58","author":"Raheja","year":"2018","journal-title":"Muscle Nerve"},{"key":"B219","doi-asserted-by":"publisher","first-page":"e13223","DOI":"10.1371\/journal.pone.0013223","article-title":"1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis","volume":"5","author":"Blasco","year":"2010","journal-title":"PLoS ONE"},{"key":"B220","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3109\/17482968.2011.619197","article-title":"Biochemical alterations associated with ALS","volume":"13","author":"Lawton","year":"2012","journal-title":"Amyotroph Lateral Scler"},{"key":"B221","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1179\/016164105X18430","article-title":"Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation","volume":"27","author":"Ihara","year":"2005","journal-title":"Neurol Res"},{"key":"B222","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ymgme.2011.11.201","article-title":"ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations","volume":"105","author":"Wuolikainen","year":"2012","journal-title":"Mol Genet Metab"},{"key":"B223","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.cca.2010.01.016","article-title":"Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis","volume":"411","author":"Kumar","year":"2010","journal-title":"Clin Chim Acta"},{"key":"B224","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3109\/21678421.2014.908311","article-title":"Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics","volume":"15","author":"Lawton","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"B225","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/ana.410280106","article-title":"Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis","volume":"28","author":"Rothstein","year":"1990","journal-title":"Ann Neurol"},{"key":"B226","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0022-510X(92)90292-S","article-title":"Plasma amino acid levels in patients with amyotrophic lateral sclerosis","volume":"107","author":"Iwasaki","year":"1992","journal-title":"J Neurol Sci"},{"key":"B227","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3109\/21678421.2015.1053490","article-title":"The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis","volume":"16","author":"Gray","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"B228","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1039\/c5mb00711a","article-title":"Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects","volume":"12","author":"Wuolikainen","year":"2016","journal-title":"Mol Biosyst"},{"key":"B229","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1212\/01.wnl.0000285080.70324.27","article-title":"Dyslipidemia is a protective factor in amyotrophic lateral sclerosis","volume":"70","author":"Dupuis","year":"2008","journal-title":"Neurology"},{"key":"B230","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1468-1331.2009.02752.x","article-title":"Elevated cerebrospinal fluid and plasma homocysteine levels in ALS","volume":"17","author":"Valentino","year":"2010","journal-title":"Eur J Neurol"},{"key":"B231","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1159\/000314841","article-title":"Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis","volume":"29","author":"Levin","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"key":"B232","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1212\/01.wnl.0000297193.53986.6f","article-title":"Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis","volume":"70","author":"Zoccolella","year":"2008","journal-title":"Neurology"},{"key":"B233","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/J.TALANTA.2017.03.103","article-title":"Capillary electrophoresis tandem mass spectrometry determination of glutamic acid and homocysteine's metabolites: potential biomarkers of amyotrophic lateral sclerosis","volume":"170","author":"Cieslarova","year":"2017","journal-title":"Talanta"},{"key":"B234","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neulet.2009.10.053","article-title":"Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS)","volume":"468","author":"Brettschneider","year":"2010","journal-title":"Neurosci Lett"},{"key":"B235","doi-asserted-by":"publisher","first-page":"5133","DOI":"10.1021\/pr100409r","article-title":"Galectin-3 is a candidate biomarker for amyotrophic lateral sclerosis: discovery by a proteomics approach","volume":"9","author":"Zhou","year":"2010","journal-title":"J Proteome Res"},{"key":"B236","doi-asserted-by":"publisher","first-page":"e0136937","DOI":"10.1371\/journal.pone.0136937","article-title":"Elevated levels of IFN-\u03b3 in CSF and serum of patients with amyotrophic lateral sclerosis","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS ONE"},{"key":"B237","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jns.2014.08.031","article-title":"VEGF levels in CSF and serum in mild ALS patients","volume":"346","author":"Gao","year":"2014","journal-title":"J Neurol Sci"},{"key":"B238","doi-asserted-by":"publisher","first-page":"e0149821","DOI":"10.1371\/journal.pone.0149821","article-title":"A multiplex protein panel applied to cerebrospinal fluid reveals three new biomarker candidates in ALS but none in neuropathic pain patients","volume":"11","author":"Lind","year":"2016","journal-title":"PLoS ONE"},{"key":"B239","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41598-017-18627-w","article-title":"Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms","volume":"8","author":"Kano","year":"2018","journal-title":"Sci Rep"},{"key":"B240","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3233\/CH-162066","article-title":"Identification of erythrocyte biomarkers in amyotrophic lateral sclerosis","volume":"63","author":"Lima","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"key":"B241","doi-asserted-by":"publisher","first-page":"e35772","DOI":"10.1371\/journal.pone.0035772","article-title":"Glycans in sera of amyotrophic lateral sclerosis patients and their role in killing neuronal cells","volume":"7","author":"Edri-Brami","year":"2012","journal-title":"PLoS ONE"},{"key":"B242","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3940(97)00947-6","article-title":"Decrease of S100 beta protein in serum of patients with amyotrophic lateral sclerosis","volume":"240","author":"Otto","year":"1998","journal-title":"Neurosci Lett"},{"key":"B243","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/acn3.83","article-title":"Plasma profiling reveals three proteins associated to amyotrophic lateral sclerosis","volume":"1","author":"H\u00e4ggmark","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"B244","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12868-017-0334-7","article-title":"TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis","volume":"18","author":"Williams","year":"2017","journal-title":"BMC Neurosci"},{"key":"B245","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/2051-5960-1-42","article-title":"Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis","volume":"1","author":"Freischmidt","year":"2013","journal-title":"Acta Neuropathol Commun"},{"key":"B246","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s12017-016-8396-8","article-title":"Identification of miRNAs as potential biomarkers in cerebrospinal fluid from amyotrophic lateral sclerosis patients","volume":"18","author":"Benigni","year":"2016","journal-title":"Neuromolecular Med"},{"key":"B247","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3389\/fnins.2017.00731","article-title":"Small RNA sequencing of sporadic amyotrophic lateral sclerosis cerebrospinal fluid reveals differentially expressed miRNAs related to neural and glial activity","volume":"11","author":"Waller","year":"2017","journal-title":"Front Neurosci"},{"key":"B248","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1172\/JCI62636","article-title":"Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS","volume":"122","author":"Butovsky","year":"2012","journal-title":"J Clin Invest"},{"key":"B249","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/brain\/awu249","article-title":"Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers","volume":"137","author":"Freischmidt","year":"2014","journal-title":"Brain"},{"key":"B250","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1016\/j.neurobiolaging.2015.06.003","article-title":"Serum microRNAs in sporadic amyotrophic lateral sclerosis","volume":"36","author":"Freischmidt","year":"2015","journal-title":"Neurobiol Aging"},{"key":"B251","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neurobiolaging.2017.12.020","article-title":"Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis","volume":"64","author":"Matamala","year":"2018","journal-title":"Neurobiol Aging"},{"key":"B252","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13041-015-0161-7","article-title":"Identification of plasma microRNAs as a biomarker of sporadic amyotrophic lateral sclerosis","volume":"8","author":"Takahashi","year":"2015","journal-title":"Mol Brain"},{"key":"B253","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/1471-2164-10-405","article-title":"Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients","volume":"10","author":"Saris","year":"2009","journal-title":"BMC Genomics"},{"key":"B254","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1755-8794-4-74","article-title":"Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway","volume":"4","author":"Mougeot","year":"2011","journal-title":"BMC Med Genomics"},{"key":"B255","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1001\/jamaneurol.2017.0357","article-title":"Characterization of gene expression phenotype in amyotrophic lateral sclerosis monocytes","volume":"74","author":"Zhao","year":"2017","journal-title":"JAMA Neurol"},{"key":"B256","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3233\/DMA-2011-0885","article-title":"Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis","volume":"32","author":"Nachmany","year":"2012","journal-title":"Dis Markers"},{"key":"B257","doi-asserted-by":"publisher","first-page":"4720","DOI":"10.1093\/hmg\/ddt325","article-title":"Characterization of human sporadic ALS biomarkers in the familial ALS transgenic mSOD1(G93A) mouse model","volume":"22","author":"Lilo","year":"2013","journal-title":"Hum Mol Genet"},{"key":"B258","doi-asserted-by":"publisher","first-page":"e17947","DOI":"10.1371\/journal.pone.0017947","article-title":"Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC\/TOFMS","volume":"6","author":"Wuolikainen","year":"2011","journal-title":"PLoS ONE"},{"key":"B259","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0022-510X(01)00661-X","article-title":"Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients","volume":"193","author":"Spreux-Varoquaux","year":"2002","journal-title":"J Neurol Sci"},{"key":"B260","doi-asserted-by":"publisher","first-page":"e13346","DOI":"10.1371\/journal.pone.0013346","article-title":"Platelet serotonin level predicts survival in amyotrophic lateral sclerosis","volume":"5","author":"Dupuis","year":"2010","journal-title":"PLoS ONE"},{"key":"B261","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1001\/archneurol.2011.217","article-title":"Serum N-acetylaspartate level in amyotrophic lateral sclerosis","volume":"68","author":"Simone","year":"2011","journal-title":"Arch Neurol"},{"key":"B262","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jns.2009.06.002","volume":"285","author":"Keizman","year":"2009","journal-title":"J Neurol Sci"},{"key":"B263","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00415-010-5805-z","article-title":"Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis","volume":"258","author":"Dorst","year":"2011","journal-title":"J Neurol"},{"key":"B264","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1179\/1743132812Y.0000000049","article-title":"Is hyperlipidemia correlated with longer survival in patients with amyotrophic lateral sclerosis?","volume":"34","author":"Dedic","year":"2012","journal-title":"Neurol Res"},{"key":"B265","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11306-005-4810-1","article-title":"Metabolomic analysis and signatures in motor neuron disease","volume":"1","author":"Rozen","year":"2005","journal-title":"Metabolomics"},{"key":"B266","doi-asserted-by":"publisher","first-page":"5361","DOI":"10.1007\/s12035-016-0078-x","article-title":"Omics to explore amyotrophic lateral sclerosis evolution: the central role of arginine and proline metabolism","volume":"54","author":"Patin","year":"2017","journal-title":"Mol Neurobiol"},{"key":"B267","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/J.BBADIS.2013.10.013","article-title":"Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients","volume":"1842","author":"Conti","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B268","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1002\/mus.23411","article-title":"Alterations of signaling pathways in muscle tissues of patients with amyotrophic lateral sclerosis","volume":"46","author":"Yin","year":"2012","journal-title":"Muscle Nerve"},{"key":"B269","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jprot.2014.05.004","article-title":"Alterations in muscle proteome of patients diagnosed with amyotrophic lateral sclerosis","volume":"108","author":"Elf","year":"2014","journal-title":"J Proteomics"},{"key":"B270","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2217\/bmm-2016-0025","article-title":"Identification of Apo B48 and other novel biomarkers in amyotrophic lateral sclerosis patient fibroblasts","volume":"10","author":"Narayan","year":"2016","journal-title":"Biomark Med"},{"key":"B271","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40478-014-0181-z","article-title":"Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients","volume":"3","author":"Par\u00e9","year":"2015","journal-title":"Acta Neuropathol Commun"},{"key":"B272","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1590\/S0100-879X2005000600015","article-title":"Quantitative evidence for neurofilament heavy subunit aggregation in motor neurons of spinal cords of patients with amyotrophic lateral sclerosis","volume":"38","author":"Mendon\u00e7a","year":"2005","journal-title":"Brazilian J Med Biol Res"},{"key":"B273","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.1038\/s41598-018-23139-2","article-title":"Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls","volume":"8","author":"Kovanda","year":"2018","journal-title":"Sci Rep"},{"key":"B274","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1756-6606-6-26","article-title":"Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels","volume":"6","author":"Campos-Melo","year":"2013","journal-title":"Mol Brain"},{"key":"B275","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1093\/hmg\/ddt261","article-title":"Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice","volume":"22","author":"Koval","year":"2013","journal-title":"Hum Mol Genet"},{"key":"B276","doi-asserted-by":"publisher","first-page":"e85653","DOI":"10.1371\/journal.pone.0085653","article-title":"Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis","volume":"9","author":"Ishtiaq","year":"2014","journal-title":"PLoS ONE"},{"key":"B277","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.15252\/embj.201490493","article-title":"Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS","volume":"34","author":"Emde","year":"2015","journal-title":"EMBO J"},{"key":"B278","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/acn3.117","article-title":"Smads as muscle biomarkers in amyotrophic lateral sclerosis","volume":"1","author":"Si","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"B279","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3109\/17482968.2011.560946","article-title":"Differential gene expression in patients with amyotrophic lateral sclerosis","volume":"12","author":"Shtilbans","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"B280","doi-asserted-by":"publisher","first-page":"e57739","DOI":"10.1371\/journal.pone.0057739","article-title":"Mitochondrial network genes in the skeletal muscle of amyotrophic lateral sclerosis patients","volume":"8","author":"Bernardini","year":"2013","journal-title":"PLoS ONE"},{"key":"B281","doi-asserted-by":"publisher","first-page":"e0138425","DOI":"10.1371\/journal.pone.0138425","article-title":"Transforming growth factor beta (TGF-\u03b2) Is a muscle biomarker of disease progression in ALS and correlates with smad expression","volume":"10","author":"Si","year":"2015","journal-title":"PLoS ONE"},{"key":"B282","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1006\/NBDI.2002.0522","article-title":"Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis","volume":"10","author":"Dupuis","year":"2002","journal-title":"Neurobiol Dis"},{"key":"B283","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1046\/j.1471-4159.2001.00231.x","article-title":"Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays","volume":"77","author":"Malaspina","year":"2008","journal-title":"J Neurochem"},{"key":"B284","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/ana.20379","article-title":"Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis","volume":"57","author":"Jiang","year":"2005","journal-title":"Ann Neurol"},{"key":"B285","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S0014-5793(02)03546-9","article-title":"Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords-screening by molecular indexing and subsequent cDNA microarray analysis","volume":"531","author":"Ishigaki","year":"2002","journal-title":"FEBS Lett"},{"key":"B286","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1152\/physiolgenomics.00087.2001","article-title":"Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter","volume":"16","author":"Dangond","year":"2004","journal-title":"Physiol Genomics"},{"key":"B287","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/17482960600947689","article-title":"Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex","volume":"7","author":"Wang","year":"2006","journal-title":"Amyotroph Lateral Scler"},{"key":"B288","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2164-8-26","article-title":"Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis","volume":"8","author":"Lederer","year":"2007","journal-title":"BMC Genomics"},{"key":"B289","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s12031-007-9004-z","article-title":"Spinal cord mRNA profile in patients with ALS: comparison with transgenic mice expressing the human SOD-1 mutant","volume":"38","author":"Offen","year":"2009","journal-title":"J Mol Neurosci"},{"key":"B290","doi-asserted-by":"publisher","first-page":"e9872","DOI":"10.1371\/journal.pone.0009872","article-title":"Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)","volume":"5","author":"Cox","year":"2010","journal-title":"PLoS ONE"},{"key":"B291","doi-asserted-by":"publisher","first-page":"39297","DOI":"10.1038\/srep39297","article-title":"Unraveling gene expression profiles in peripheral motor nerve from amyotrophic lateral sclerosis patients: insights into pathogenesis","volume":"6","author":"Riva","year":"2016","journal-title":"Sci Rep"},{"key":"B292","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1046\/j.0022-3042.2001.00731.x","article-title":"Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients","volume":"80","author":"Wiedemann","year":"2002","journal-title":"J Neurochem"},{"key":"B293","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0022-510X(95)00072-A","article-title":"Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amytrophic lateral sclerosis)","volume":"129","author":"Jones","year":"1995","journal-title":"J Neurol Sci"},{"key":"B294","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1212\/WNL.48.4.878","article-title":"Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy","volume":"48","author":"Gredal","year":"1997","journal-title":"Neurology"},{"key":"B295","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1212\/WNL.50.1.72","article-title":"Estimation of brainstem neuronal loss in amyotrophic lateral sclerosis with in vivo proton magnetic resonance spectroscopy","volume":"50","author":"Cwik","year":"1998","journal-title":"Neurology"},{"key":"B296","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1212\/WNL.50.2.576-b","article-title":"Quantification of brain metabolites in ALS by localized proton magnetic spectroscopy","volume":"50","author":"Ikeda","year":"1998","journal-title":"Neurology"},{"key":"B297","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3109\/17482968.2010.515223","article-title":"Magnetic resonance spectroscopy of the cervical cord in amyotrophic lateral sclerosis","volume":"12","author":"Carew","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"B298","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/mus.23467","article-title":"Relationship between cervical cord 1 H-magnetic resonance spectroscopy and clinoco-electromyographic profile in amyotrophic lateral sclerosis","volume":"47","author":"Ikeda","year":"2013","journal-title":"Muscle Nerve"},{"key":"B299","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1007\/s00259-013-2667-5","article-title":"The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients","volume":"41","author":"Cistaro","year":"2014","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"B300","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1007\/s11064-017-2248-2","article-title":"Ultra-high field proton MR spectroscopy in early-stage amyotrophic lateral sclerosis","volume":"42","author":"Cheong","year":"2017","journal-title":"Neurochem Res"},{"key":"B301","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1001\/jamaneurol.2013.234","article-title":"An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy","volume":"70","author":"Foerster","year":"2013","journal-title":"JAMA Neurol"},{"key":"B302","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s00415-006-0495-2","article-title":"Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study","volume":"254","author":"Unrath","year":"2007","journal-title":"J Neurol"},{"key":"B303","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1001\/archneur.63.8.1144","article-title":"Detection of cerebral degeneration in amyotrophic lateral sclerosis using high-field magnetic resonance spectroscopy","volume":"63","author":"Kalra","year":"2006","journal-title":"Arch Neurol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00400\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T05:11:05Z","timestamp":1557810665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00400\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":303,"alternative-id":["10.3389\/fneur.2019.00400"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2019.00400","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"article-number":"400"}}