{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:18:41Z","timestamp":1792084721557,"version":"4.4.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["17-29452A"],"award-info":[{"award-number":["17-29452A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["17-30101A"],"award-info":[{"award-number":["17-30101A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007059","name":"Univerzita Palack\u00e9ho v Olomouci","doi-asserted-by":"publisher","award":["IGA_LF_2019_010"],"award-info":[{"award-number":["IGA_LF_2019_010"]}],"id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2019.00417","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T04:42:27Z","timestamp":1556253747000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Intravenous Thrombolysis in Posterior Circulation Stroke"],"prefix":"10.3389","volume":"10","author":[{"given":"Tom\u00e1\u0161","family":"Dor\u0148\u00e1k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kr\u00e1l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"\u0160a\u0148\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Ka\u0148ovsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1212\/WNL.42.5.976","article-title":"Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke","volume":"42","author":"Mori","year":"1992","journal-title":"Neurology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000108714","article-title":"Intravenous tissue plasminogen activator ameliorates the outcome of hyperacute embolic stroke","volume":"3","author":"Yamaguchi","year":"1993","journal-title":"Cerebrovasc Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1161\/01.STR.24.7.1000","article-title":"Pilot randomized trial of tissue plasminogen activator in acute ischemic stroke. The TPA Bridging Study Group","volume":"24","author":"Haley","year":"1993","journal-title":"Stroke."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke","volume":"333","year":"1995","journal-title":"N Engl J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1161\/hs0202.102599","article-title":"ATLANTIS trial: results for patients treated within 3 hours of stroke onset","volume":"33","author":"Albers","year":"2002","journal-title":"Stroke."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4","volume":"359","author":"Hacke","year":"2008","journal-title":"N Engl J Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1001\/jama.1995.03530130023023","article-title":"Intravenous thrombolysis with recombinant tissueplasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)","volume":"274","author":"Hacke","year":"1995","journal-title":"JAMA."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0140-6736(98)08020-9","article-title":"Randomised double-blind placebo-controlled trial ofthrombolytic therapy with intravenous alteplase in acute ischemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators","volume":"352","author":"Hacke","year":"1998","journal-title":"Lancet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1001\/jama.282.21.2019","article-title":"Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke","volume":"282","author":"Clark","year":"1999","journal-title":"JAMA."},{"key":"B10","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1161\/01.STR.31.4.811","article-title":"The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators","volume":"31","author":"Clark","year":"2000","journal-title":"Stroke."},{"key":"B11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S1474-4422(08)70044-9","article-title":"Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial","volume":"7","author":"Davis","year":"2008","journal-title":"Lancet Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1016\/S0140-6736(12)60768-5","article-title":"The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial","volume":"379","author":"Sandercock","year":"2012","journal-title":"Lancet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"g3175","DOI":"10.1136\/bmj.g3175","article-title":"Posterior circulation ischemic stroke","volume":"348","author":"Merwick","year":"2014","journal-title":"BMJ."},{"key":"B14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1136\/jnnp.2010.222091","article-title":"The use of FAST and ABCD2 scores in posterior circulation, compared with anterior circulation, stroke and transient ischemic attack","volume":"83","author":"Gulli","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B15","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1161\/STROKEAHA.112.669929","article-title":"Stroke risk after posterior circulation stroke\/transient ischemic attack and its relationship to site of vertebrobasilar stenosis: pooled data analysis from prospective studies","volume":"44","author":"Gulli","year":"2013","journal-title":"Stroke."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1111\/ijs.12626","article-title":"Posterior vs. anterior circulation infarction: demography, outcomes, and frequency of hemorrhage after thrombolysis","volume":"10","author":"Dor\u0148\u00e1k","year":"2015","journal-title":"Int J Stroke."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1161\/STROKEAHA.112.652420","article-title":"Posterior versus anterior circulation infarction: how different are the neurological deficits?","volume":"43","author":"Tao","year":"2012","journal-title":"Stroke."},{"key":"B18","first-page":"1434","article-title":"False-negative diffusion-weighted MR findings in acute ischemic stroke","volume":"21","author":"Oppenheim","year":"2000","journal-title":"Am J Neuroradiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1161\/STROKEAHA.107.511428","article-title":"Reliability of clinical diagnosis of the symptomatic vascular territory in patients with recent transient ischemic attack or minor stroke","volume":"39","author":"Flossmann","year":"2008","journal-title":"Stroke."},{"key":"B20","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/ene.13578","article-title":"Perfusion computed tomography in posterior circulation stroke: predictors and prognostic implications of focal hypoperfusion","volume":"25","author":"Pallesen","year":"2018","journal-title":"Eur J Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S1474-4422(11)70229-0","article-title":"Basilar artery occlusion","volume":"10","author":"Mattle","year":"2011","journal-title":"Lancet Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1227\/00006123-199307000-00012","article-title":"The surgical anatomy of the perforating branches of the basilar artery","volume":"33","author":"Marinkovi\u0107","year":"1993","journal-title":"Neurosurgery."},{"key":"B23","volume-title":"Atlas of Human Anatomy","author":"Frank","year":"2014"},{"key":"B24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/ana.20204","article-title":"New England Medical Center Posterior Circulation registry","volume":"56","author":"Caplan","year":"2004","journal-title":"Ann Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1161\/01.STR.31.8.2011","article-title":"Posterior circulation ischemia: then, now, and tomorrow","volume":"31","author":"Caplan","year":"2000","journal-title":"Stroke."},{"key":"B26","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s12028-015-0211-0","article-title":"Delay in diagnosis of basilar artery stroke","volume":"24","author":"Burns","year":"2016","journal-title":"Neurocrit Care."},{"key":"B27","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1111\/j.1468-1331.2006.01274.x","article-title":"Posterior circulation ischemic stroke in Korean population","volume":"13","author":"Lee","year":"2006","journal-title":"Eur J Neurol."},{"key":"B28","volume-title":"Dissection, Vertebral Artery","author":"Britt","year":"2018"},{"key":"B29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S1474-4422(05)70201-5","article-title":"The Recognition of Stroke in the Emergency Room (ROSIER) scale: development and validation of a stroke recognition instrument","volume":"4","author":"Nor","year":"2005","journal-title":"Lancet Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.08.011","article-title":"e-NIHSS: an expanded national institutes of health stroke scale weighted for anterior and posterior circulation strokes","volume":"25","author":"Olivato","year":"2016","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(07)60151-2","article-title":"Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison","volume":"369","author":"Chalela","year":"2007","journal-title":"Lancet."},{"key":"B32","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s10140-018-1623-x","article-title":"Imaging of acute ischemic stroke","volume":"25","author":"Rudkin","year":"2018","journal-title":"Emerg Radiol."},{"key":"B33","first-page":"1012","article-title":"Intracranial vascular stenosis and occlusive disease: evaluation with CT angiography, MR angiography, and digital subtraction angiography","volume":"26","author":"Bash","year":"2005","journal-title":"Am J Neuroradiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.3174\/ajnr.A5771","article-title":"Value of contrast-enhanced MRA versus time-of-flight MRA in acute ischemic stroke MRI","volume":"39","author":"Boujan","year":"2018","journal-title":"Am J Neuroradiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jns.2013.08.036","article-title":"Predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis: stroke territory as a potential pitfall","volume":"335","author":"Sung","year":"2013","journal-title":"J Neurol Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1161\/STROKEAHA.110.607614","article-title":"Outcomes of intravenous thrombolysis in posterior versus anterior circulation stroke","volume":"42","author":"Sarikaya","year":"2011","journal-title":"Stroke."},{"key":"B37","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1159\/000330346","article-title":"Thrombolysis in posterior circulation stroke: stroke subtypes and patterns, complications and outcome","volume":"32","author":"F\u00f6rster","year":"2011","journal-title":"Cerebrovasc Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1186\/s13104-017-2889-x","article-title":"Frequency and determinants for hemorrhagic transformation of posterior cerebral stroke : posterior ischemic stroke and hemorrhagic transformation","volume":"10","author":"Valentino","year":"2017","journal-title":"BMC Res Notes."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1001\/archneur.62.7.1126","article-title":"Initial Glasgow Coma Scale score predicts outcome following thrombolysis for posterior circulation stroke","volume":"62","author":"Tsao","year":"2005","journal-title":"Arch Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1161\/STROKEAHA.114.005135","article-title":"Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the National Institute of Neurological Disorders and Stroke tissue-type plasminogen activator trials","volume":"45","author":"Rao","year":"2014","journal-title":"Stroke."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1212\/01.wnl.0000304346.14354.0b","article-title":"Baseline NIH Stroke Scale Score predicting outcome in anterior and posterior circulation strokes","volume":"70","author":"Sato","year":"2008","journal-title":"Neurology."},{"key":"B42","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/01.STR.25.7.1371","article-title":"Comparison of clinical and neuroradiological findings in first-ever stroke. A population-based study","volume":"25","author":"Lindgren","year":"1994","journal-title":"Stroke."},{"key":"B43","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/jcbfm.2012.171","article-title":"Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke","volume":"33","author":"Menon","year":"2013","journal-title":"J Cereb Blood Flow Metab."},{"key":"B44","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jns.2011.08.048","article-title":"Blood-brain barrier permeability derangements in posterior circulation ischemic stroke: frequency and relation to hemorrhagic transformation","volume":"313","author":"Lee","year":"2012","journal-title":"J Neurol Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1161\/STR.0000000000000158","article-title":"2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"49","author":"Powers","year":"2018","journal-title":"Stroke."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1161\/STROKEAHA.111.000651","article-title":"Comparison of risk-scoring systems in predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis","volume":"44","author":"Sung","year":"2013","journal-title":"Stroke."},{"key":"B47","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s12028-014-0060-2","article-title":"Comparison of 8 scores for predicting symptomatic intracerebral hemorrhage after IV thrombolysis","volume":"22","author":"Asuzu","year":"2015","journal-title":"Neurocrit Care."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e3848","DOI":"10.1097\/MD.0000000000003848","article-title":"Intravenous thrombolysis is more safe and effective for posterior circulation stroke: data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China)","volume":"95","author":"Tong","year":"2016","journal-title":"Medicine."},{"key":"B49","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s12975-018-0608-0","article-title":"Predictors for intracranial hemorrhage following intravenous thrombolysis in posterior circulation stroke","volume":"9","author":"Dor\u0148\u00e1k","year":"2018","journal-title":"Transl Stroke Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"528","DOI":"10.5507\/bp.2013.075","article-title":"Management of acute basilar artery occlusion: should any treatment strategy prevail?","volume":"58","author":"Dor\u0148\u00e1k","year":"2014","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1212\/01.WNL.0000125330.06520.0D","article-title":"Intravenous r-TPA in vertebrobasilar acute infarcts","volume":"62","author":"Montavont","year":"2004","journal-title":"Neurology."},{"key":"B52","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/ijs.12209","article-title":"Reperfusion after 4","volume":"9","author":"Pican\u00e7o","year":"2014","journal-title":"Int J Stroke."},{"key":"B53","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S1474-4422(09)70173-5","article-title":"Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study","volume":"8","author":"Schonewille","year":"2009","journal-title":"Lancet Neurol."},{"key":"B54","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/01.STR.27.5.875","article-title":"Thrombolytic therapy of acute basilar artery occlusion. Variables affecting recanalization and outcome","volume":"27","author":"Brandt","year":"1996","journal-title":"Stroke."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1161\/STROKEAHA.110.606038","article-title":"Three-month and long-term outcomes and their predictors in acute basilar artery occlusion treated with intra-arterial thrombolysis","volume":"42","author":"Jung","year":"2011","journal-title":"Stroke."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1161\/STROKEAHA.110.605584","article-title":"Intravenous thrombolysis of basilar artery occlusion: predictors of recanalization and outcome","volume":"42","author":"Sairanen","year":"2011","journal-title":"Stroke."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1016\/j.crad.2015.01.008","article-title":"Endovascular treatment of acute basilar artery occlusion: time to treatment is crucial","volume":"70","author":"Dor\u0148\u00e1k","year":"2015","journal-title":"Clin Radiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1161\/STROKEAHA.111.635029","article-title":"Bridging therapy in acute ischemic stroke: a systematic review and meta-analysis","volume":"43","author":"Mazighi","year":"2012","journal-title":"Stroke."},{"key":"B59","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1017\/S0317167100017327","article-title":"Outcome predictors in acute basilar artery occlusion","volume":"41","author":"Dor\u0148\u00e1k","year":"2014","journal-title":"Can J Neurol Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1161\/STROKEAHA.109.567552","article-title":"Drip, ship, and retrieve: cooperative recanalization therapy in acute basilar artery occlusion","volume":"41","author":"Pfefferkorn","year":"2010","journal-title":"Stroke."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00417\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T04:42:30Z","timestamp":1556253750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00417\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,26]]},"references-count":60,"alternative-id":["10.3389\/fneur.2019.00417"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2019.00417","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,26]]},"article-number":"417"}}