{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:24:29Z","timestamp":1792589069413,"version":"4.5.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2019.00426","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:30:08Z","timestamp":1556670608000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuan-Chang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Er","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Hua","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Feng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"92","author":"Stary","year":"1995","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1552-6569.2007.00158.x","article-title":"Intracranial artery calcification: a newly identified risk factor of ischemic stroke","volume":"17","author":"Chen","year":"2007","journal-title":"J Neuroimaging."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1161\/01.ATV.0000093547.63630.0F","article-title":"Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture","volume":"23","author":"Demer","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1161\/ATVBAHA.110.208181","article-title":"Risk factor differences for aortic versus coronary calcified atherosclerosis: the multiethnic study of atherosclerosis","volume":"30","author":"Criqui","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1161\/ATVBAHA.111.232728","article-title":"Calcification in major vessel beds relates to vascular brain disease","volume":"31","author":"Bos","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/CIRCULATIONAHA.104.488916","article-title":"Coronary calcification improves cardiovascular risk prediction in the elderly","volume":"112","author":"Vliegenthart","year":"2005","journal-title":"Circulation."},{"key":"B7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.2214\/AJR.04.1216","article-title":"Carotid artery calcification on CT may independently predict stroke risk","volume":"186","author":"Nandalur","year":"2006","journal-title":"Am J Roentgenol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1001\/jamaneurol.2013.6223","article-title":"Intracranial carotid artery atherosclerosis and the risk of stroke in Whites: the Rotterdam Study","volume":"71","author":"Bos","year":"2014","journal-title":"JAMA Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","article-title":"Vascular calcification: pathobiological mechanisms and clinical implications","volume":"99","author":"Johnson","year":"2006","journal-title":"Circ Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1159\/000210549","article-title":"Association between cerebral arterial calcification and brachial-ankle pulse wave velocity in patients with acute ischemic stroke","volume":"61","author":"Park","year":"2009","journal-title":"Eur Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000314622","article-title":"Intracranial internal carotid artery calcification: a representative for cerebral artery calcification and association with white matter hyperintensities","volume":"30","author":"Chung","year":"2010","journal-title":"Cerebrovasc Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"","journal-title":"Lancet Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1159\/000358513","article-title":"Carotid artery calcification is associated with deep cerebral microbleeds","volume":"72","author":"Chung","year":"2014","journal-title":"Eur Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00234-010-0798-y","article-title":"The correlation between carotid siphon calcification and lacunar infarction","volume":"53","author":"Hong","year":"2011","journal-title":"Neuroradiology."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1111\/ggi.12599","article-title":"Calcifications in the carotid siphon correlate with silent cerebral small vessel disease in community-dwelling older adults: a population-based study in rural Ecuador","volume":"16","author":"Del Brutto","year":"2016","journal-title":"Geriatr Gerontol Int."},{"key":"B17","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00234-017-1838-7","article-title":"Relationship between intracranial internal carotid artery calcification and enlarged cerebral perivascular space","volume":"59","author":"Tao","year":"2017","journal-title":"Neuroradiology."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1016\/j.jalz.2012.01.008","article-title":"Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging","volume":"8","author":"Bos","year":"2012","journal-title":"Alzheimers Dement."},{"key":"B19","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1212\/wnl.62.8_suppl_6.s20","article-title":"Reconsideration of TIA diagnostic criteria","volume":"62","author":"Sherman","year":"2004","journal-title":"Neurology."},{"key":"B20","unstructured":"MONICA Manual, Part IV: Event Registration. Section 2: Stroke Event Registration Data Component.1990"},{"key":"B21","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-t","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.4065\/74.3.243","article-title":"Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons","volume":"74","author":"Rumberger","year":"1999","journal-title":"Mayo Clin Proc."},{"key":"B23","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging","volume":"12","author":"Wardlaw","year":"","journal-title":"Lancet Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1","volume":"149","author":"Fazekas","year":"1987","journal-title":"Am J Roentgenol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1161\/STROKEAHA.109.564914","article-title":"Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease","volume":"41","author":"Doubal","year":"2010","journal-title":"Stroke."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1161\/STROKEAHA.109.558049","article-title":"Brain microbleeds relate to higher ambulatory blood pressure levels in first-ever lacunar stroke patients","volume":"40","author":"Staals","year":"2009","journal-title":"Stroke."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","article-title":"Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study","volume":"70","author":"Vernooij","year":"2008","journal-title":"Neurology."},{"key":"B28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.5853\/jos.2016.00885","article-title":"Traditional risk factors for stroke in East Asia","volume":"18","author":"Kim","year":"2016","journal-title":"J Stroke."},{"key":"B29","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1159\/000212672","article-title":"Endothelial dysfunction in lacunar stroke: a systematic review","volume":"27","author":"Knottnerus","year":"2009","journal-title":"Cerebrovasc Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1253\/circj.72.778","article-title":"Evaluation of coronary calcium score by multidetector computed tomography in relation to endothelial function and inflammatory markers in asymptomatic individuals","volume":"72","author":"Ramadan","year":"2008","journal-title":"Circ J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00234-006-0159-z","article-title":"Intracranial carotid artery calcification on head CT and its association with ischemic changes on brain MRI in patients presenting with strokelike symptoms: retrospective analysis","volume":"49","author":"Erbay","year":"2007","journal-title":"Neuroradiology."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1161\/STROKEAHA.110.593657","article-title":"Cerebral microbleeds in the elderly: a pathological analysis","volume":"41","author":"Fisher","year":"2010","journal-title":"Stroke."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1161\/01.str.30.8.1637","article-title":"Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas","volume":"30","author":"Tanaka","year":"1999","journal-title":"Stroke."},{"key":"B34","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.11.123","article-title":"Volumetric analysis of carotid plaque components and cerebral microbleeds: a correlative study","volume":"26","author":"Saba","year":"2017","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.3174\/ajnr.A3498","article-title":"Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study","volume":"34","author":"Gutierrez","year":"2013","journal-title":"Am J Neuroradiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1177\/0284185114544243","article-title":"Dilatation of the Virchow-Robin spaces as an indicator of unilateral carotid artery stenosis: correlation with white matter lesions","volume":"56","author":"Sahin","year":"2015","journal-title":"Acta Radiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"312","DOI":"10.5853\/jos.2016.00171","article-title":"Association between aortic atheroma and cerebral small vessel disease in patients with ischemic stroke","volume":"18","author":"Song","year":"2016","journal-title":"J Stroke."},{"key":"B38","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.atherosclerosis.2017.10.024","article-title":"Enlarged perivascular spaces in the basal ganglia are independently associated with intracranial atherosclerosis in the elderly","volume":"267","author":"Del Brutto","year":"2017","journal-title":"Atherosclerosis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/j.1468-1331.2011.03620.x","article-title":"Cerebral artery calcification in patients with acute cerebrovascular diseases: determinants and long-term clinical outcome","volume":"19","author":"Koton","year":"2012","journal-title":"Eur J Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000090206","article-title":"The frequency and determinants of calcification in intracranial arteries in Chinese patients who underwent computed tomography examinations","volume":"21","author":"Chen","year":"2006","journal-title":"Cerebrovasc Dis."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00426\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:30:12Z","timestamp":1556670612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2019.00426\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":40,"alternative-id":["10.3389\/fneur.2019.00426"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2019.00426","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,1]]},"article-number":"426"}}