{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:26:21Z","timestamp":1790774781467,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.00394","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T04:48:26Z","timestamp":1591937306000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["High Prevalence and Gender-Related Differences of Gastrointestinal Manifestations in a Cohort of DM1 Patients: A Perspective, Cross-Sectional Study"],"prefix":"10.3389","volume":"11","author":[{"given":"Alessia","family":"Perna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Maccora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso Filippo","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Assunta","family":"Zocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Riso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Modoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Petrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venanzio","family":"Valenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000444018","article-title":"An age-Standardized prevalence estimate and a sex and age distribution of myotonic dystrophy types 1 and 2 in the rome province, italy","volume":"46","author":"Vanacore","year":"2016","journal-title":"Neuroepidemiology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1212\/WNL.0000000000008056","article-title":"Genetic determinants of disease severity in the myotonic dystrophy type 1 OPTIMISTIC cohort","volume":"93","author":"Cumming","year":"2019","journal-title":"Neurology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3389\/fneur.2018.00368","article-title":"Abnormalities in skeletal muscle myogenesis, growth, and regeneration in myotonic dystrophy","volume":"9","author":"Andr\u00e9","year":"2018","journal-title":"Front Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1002\/acn3.496","article-title":"Relationships between grip strength, myotonia, and cTG expansion in myotonic dystrophy type 1","volume":"4","author":"Hogrel","year":"2017","journal-title":"Ann Clin Transl Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1212\/WNL.0000000000004420","article-title":"High frequency of gastrointestinal manifestations in myotonic distrophy type 1 and type 2 3rd; National Registry Scientific Advisory Committee\/Investigators","volume":"89","author":"Hilbert","year":"2017","journal-title":"Neurology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/archdischild-2018-314837","article-title":"Myotonic dystrophy type 1: clinical manifestations in children and adolescents","volume":"104","author":"Ho","year":"2019","journal-title":"Arch Dis Child."},{"key":"B7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/mus.21484","article-title":"Frequency and predictors of nonalcoholic fatty liver disease in myotonic dystrophy","volume":"41","author":"Shieh","year":"2010","journal-title":"Muscle Nerve."},{"key":"B8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.nmd.2008.06.366","article-title":"A putative role of ribonuclear inclusions and mBNL1 in the impairment of gallbladder smooth muscle contractility with cholelithiasis in myotonic dystrophy type 1","volume":"18","author":"Cardani","year":"2008","journal-title":"Neuromuscul Disord."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0148264","DOI":"10.1371\/journal.pone.0148264","article-title":"Gender as a modifying factor influencing myotonic dystrophy type 1 phenotype severity and mortality: a Nationwide multiple databases cross-Sectional observational study","volume":"11","author":"Dogan","year":"2016","journal-title":"PLoS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s40618-019-01156-w","article-title":"Hormonal and metabolic gender differences in a cohort of myotonic dystrophy type 1 subjects: a retrospective, case-control study","volume":"43","author":"Spaziani","year":"2020","journal-title":"J Endocrinol Invest."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.3748\/wjg.v12.i12.1821","article-title":"Gastrointestinal manifestations in myotonic muscular dystrophy","volume":"12","author":"Bellini","year":"2006","journal-title":"World J Gastroenterol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1212\/WNL.56.3.336","article-title":"Assessment of a disease-specific muscular impairment rating scale in myotonic dystrophy","volume":"56","author":"Mathieu","year":"2001","journal-title":"Neurology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF01535722","article-title":"GSRS-a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease","volume":"33","author":"Svedlund","year":"1988","journal-title":"Dig Dis Sci."},{"key":"B14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2165\/00044011-200424040-00002","article-title":"Psychometric validation of the italian translation of the gastrointestinal symptom-rating scale and quality of life in reflux and dyspepsia questionnaire in patients with gastro-oesophageal reflux disease","volume":"24","author":"Kulich","year":"2004","journal-title":"Clin Drug Investig."},{"key":"B15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0140-6736(83)91628-8","article-title":"A persistent defect in intestinal permeability in coeliac disease demonstrated by a 51Cr-EDTA absorption test","volume":"1","author":"Bjarnason","year":"1983","journal-title":"Lancet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1053\/j.gastro.2003.06.008","article-title":"Prevention is the best defense: surgical prophylaxis of pouchitis","volume":"126","author":"Brisinda","year":"2004","journal-title":"Gastroenterology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ajg.2009.558","article-title":"Intestinal permeability in cirrhotic patients with and without spontaneous bacterial peritonitis: is the ring closed?","volume":"105","author":"Scarpellini","year":"2010","journal-title":"Am J Gastroenterol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12877-018-0767-6","article-title":"Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?","volume":"18","author":"Ganda Mall","year":"2018","journal-title":"BMC Geriatr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1177\/2050640619841545","article-title":"A high prevalence of chronic gastrointestinal symptoms in adults with cystic fibrosis is detected using tools already validated in other gI disorders","volume":"7","author":"Hayee","year":"2019","journal-title":"Gastroenterol J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"5366","DOI":"10.1212\/WNL.0000000000005366","article-title":"Reader response: high frequency of gastrointestinal manifestations in myotonic dystrophy type 1 and type 2","volume":"90","author":"Silvestri","year":"2018","journal-title":"Neurology Apr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1111\/eci.12459","article-title":"Gonadal failure is associated with visceral adiposity in myotonic dystrophies","volume":"45","author":"Passeri","year":"2015","journal-title":"Eur J Clin Invest."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12916-017-0806-8","article-title":"Neuschwander-Tetri BA","volume":"15","author":"Brent","year":"2017","journal-title":"Non-Alcoholic Fatty Liver Disease BMC Med"},{"key":"B24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng704","article-title":"Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy","volume":"29","author":"Savkur","year":"2001","journal-title":"Nat Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11010-013-1681-z","article-title":"Alternative splicing of human insulin receptor gene (INSR) in type I and type II skeletal muscle fibers of patients with myotonic dystrophy type 1 and type 2","volume":"380","author":"Santoro","year":"2013","journal-title":"Mol Cell Biochem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0184987","DOI":"10.1371\/journal.pone.0184987","article-title":"Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle","volume":"12","author":"Renna","year":"2017","journal-title":"PLoS One"},{"key":"B27","first-page":"1993","article-title":"Myotonic Dystrophy Type 1","volume-title":"GeneReviews\u00ae [Internet]","author":"Bird","year":"1999"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0214254","DOI":"10.1371\/journal.pone.0214254","article-title":"Aberrant insulin receptor expression is associated with insulin resistance and skeletal muscle atrophy in myotonic dystrophies","volume":"14","author":"Renna","year":"2019","journal-title":"PLoS One."},{"key":"B29","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3389\/fneur.2018.00303","article-title":"Core clinical phenotypes in myotonic dystrophies","volume":"9","author":"Wenninger","year":"2018","journal-title":"Front Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mus.21787","article-title":"Bacterial overgrowth syndrome in myotonic muscular dystrophy is potentially treatable","volume":"42","author":"Tarnopolsky","year":"2010","journal-title":"Muscle Nerve."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1001\/archneur.63.8.1149","article-title":"Laboratory abnormalities in ambulatory patients with myotonic dystrophy type 1","volume":"63","author":"Heatwole","year":"2006","journal-title":"Arch Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.clinbiochem.2010.07.018","article-title":"Serum gamma-glutamyltransferase fractions in myotonic dystrophy type i: differences with healthy subjects and patients with liver disease","volume":"43","author":"Franzini","year":"2010","journal-title":"Clin Biochem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1097\/00004836-199806000-00016","article-title":"Abnormal liver tests results in myotonic dystrophy","volume":"26","author":"Achiron","year":"1998","journal-title":"J Clin Gastroenterol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/mus.24540","article-title":"Metabolic syndrome in patients with myotonic dystrophy type 1","volume":"2","author":"Vujnic","year":"2015","journal-title":"Muscle Nerve."},{"key":"B35","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.0954-6820.1987.tb10669.x","article-title":"Increased activity of serum gamma-glutamyltransferase in myotonic dystrophy","volume":"222","author":"Ronnemaa","year":"1987","journal-title":"Acta Med Scand."},{"key":"B36","doi-asserted-by":"publisher","first-page":"100815","DOI":"10.1016\/j.yfrne.2019.100815","article-title":"You've got male: Sex and the microbiota-gut-brain axis across the lifespan","volume":"56","author":"Jaggar","year":"2020","journal-title":"Front Neuroendocrinol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1007\/s00415-013-6984-1","article-title":"Vitamin d deficiency in myotonic dystrophy type 1","volume":"260","author":"Terracciano","year":"2013","journal-title":"J Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jns.2013.06.008","article-title":"Vitamin D, parathyroid hormone and muscle impairment in myotonic dystrophies","volume":"331","author":"Passeri","year":"2013","journal-title":"J Neurol Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1007\/s00415-015-8006-y","article-title":"Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors","volume":"263","author":"Bianchi","year":"2016","journal-title":"J Neurol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00394\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T04:48:30Z","timestamp":1591937310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00394\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,12]]},"references-count":39,"alternative-id":["10.3389\/fneur.2020.00394"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.00394","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,12]]},"article-number":"394"}}