{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:43:51Z","timestamp":1791935031663,"version":"4.3.4"},"reference-count":171,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020160100150BA"],"award-info":[{"award-number":["20020160100150BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.00483","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T05:59:25Z","timestamp":1591682365000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage"],"prefix":"10.3389","volume":"11","author":[{"given":"Mart\u00edn","family":"Bustelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Barkhuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L. A.","family":"van den Hove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry Wilhelm. M.","family":"Steinbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn A.","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Fabi\u00e1n","family":"Loidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio W. Danilo","family":"Gavilanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3109\/15376516.2011.559695","article-title":"From Waddington's epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research","volume":"21","author":"Choudhuri","year":"2011","journal-title":"Toxicol Mech Methods"},{"key":"B2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.cobeha.2016.12.012","article-title":"New insights into early-life stress and behavioral outcomes","volume":"14","author":"Bolton","year":"2017","journal-title":"Curr Opin Behav Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/mp.2009.82","article-title":"The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases","volume":"14","author":"Lahiri","year":"2009","journal-title":"Mol Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1001\/archpedi.1991.02160110117034","article-title":"How much of neonatal encephalopathy is due to birth asphyxia?","volume":"145","author":"Nelson","year":"1991","journal-title":"Am J Dis Child."},{"key":"B5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum Dev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/j.0001-6349.2004.00602.x","article-title":"Restricted fetal growth in sudden intrauterine unexplained death","volume":"83","author":"Fr\u00f8en","year":"2004","journal-title":"Acta Obstet Gynecol Scand."},{"key":"B7","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.bpobgyn.2009.08.011","article-title":"Obstetric management of intrauterine growth restriction","volume":"23","author":"Mar\u0161\u00e1l","year":"2009","journal-title":"Best Pract Res Clin Obstetr Gynaecol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.ajog.2008.06.094","article-title":"A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy","volume":"199","author":"Graham","year":"2008","journal-title":"Am J Obstet Gynecol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1016\/S0140-6736(10)60549-1","article-title":"Global, regional, and national causes of child mortality in 2008: a systematic analysis","volume":"375","author":"Black","year":"2010","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.cppeds.2010.12.002","article-title":"Current management of the infant who presents with neonatal encephalopathy","volume":"41","author":"Wachtel","year":"2011","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"B11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/pch\/pxy028","article-title":"Hypothermia for newborns with hypoxic-ischemic encephalopathy","volume":"23","author":"Lemyre","year":"2018","journal-title":"Paediatr Child Health."},{"key":"B12","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1053\/j.semperi.2016.09.007","article-title":"Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE)","volume":"40","author":"Natarajan","year":"2016","journal-title":"Semin Perinatol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"F285","DOI":"10.1136\/archdischild-2017-314685","article-title":"Hypothermia for perinatal asphyxia: trial-based resource use and costs at 6\u20137 years","volume":"104","author":"Rivero-Arias","year":"2019","journal-title":"Arch Dis Childh Fetal Neonatal Ed"},{"key":"B14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.siny.2010.02.001","article-title":"Systemic complications and hypothermia","volume":"15","author":"Sarkar","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ana.22419","article-title":"Neuronal cell death in neonatal hypoxia-ischemia","volume":"69","author":"Northington","year":"2011","journal-title":"Ann Neurol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1002\/ana.10365","article-title":"Brain alkaline intracellular pH after neonatal encephalopathy","volume":"52","author":"Robertson","year":"2002","journal-title":"Ann Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species","volume":"106","author":"Semple","year":"2013","journal-title":"Prog Neurobiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.neubiorev.2017.01.042","article-title":"25 years of research on global asphyxia in the immature rat brain","volume":"75","author":"Barkhuizen","year":"2017","journal-title":"Neurosci Biobehav Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/cne.24539","article-title":"Deep hypothermia reverses behavioral and histological alterations in a rat model of perinatal asphyxia","volume":"527","author":"Vazquez-Borsetti","year":"2019","journal-title":"J Comp Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jneumeth.2011.03.009","article-title":"A modified rat model of neonatal anoxia: development and evaluation by pulseoximetry, arterial gasometry and Fos immunoreactivity","volume":"198","author":"Takada","year":"2011","journal-title":"J Neurosci Methods"},{"key":"B21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann Neurol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1749-6632.1997.tb48634.x","article-title":"A model of perinatal hypoxic-ischemic brain damage A","volume":"835","author":"Vannucci","year":"1997","journal-title":"Ann N Y Acad Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jneumeth.2017.06.016","article-title":"Modification to the Rice-Vannucci perinatal hypoxic-ischaemic encephalopathy model in the P7 rat improves the reliability of cerebral infarct development after 48 hours","volume":"288","author":"Edwards","year":"2017","journal-title":"J Neurosci Methods"},{"key":"B24","doi-asserted-by":"publisher","first-page":"R206","DOI":"10.1186\/cc8214","article-title":"Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury","volume":"13","author":"Loetscher","year":"2009","journal-title":"Crit Care"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nbt.1678","article-title":"Epigenetic modifications as therapeutic targets","volume":"28","author":"Kelly","year":"2010","journal-title":"Nat Biotechnol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ejphar.2018.08.021","article-title":"Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy","volume":"837","author":"Biswas","year":"2018","journal-title":"Eur J Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4161\/epi.5.4.11684","article-title":"Epigenetics: the epicenter of the hypoxic response","volume":"5","author":"Watson","year":"2010","journal-title":"Epigenetics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/ijc.28190","article-title":"Epigenetic regulation of hypoxia-responsive gene expression: focusing on chromatin and DNA modifications","volume":"134","author":"Tsai","year":"2014","journal-title":"Int J Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1124\/mol.106.027029","article-title":"Hypoxia-inducible factor-1","volume":"70","author":"Ke","year":"2006","journal-title":"Mol Pharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12272-013-0058-x","article-title":"Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics","volume":"36","author":"Nguyen","year":"2013","journal-title":"Arch Pharm Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.drudis.2014.09.010","article-title":"Gestational hypoxia and epigenetic programming of brain development disorders","volume":"19","author":"Ma","year":"2014","journal-title":"Drug Discov Today"},{"key":"B32","doi-asserted-by":"publisher","first-page":"791","DOI":"10.2217\/epi.15.24","article-title":"Epigenetic regulation by histone demethylases in hypoxia","volume":"7","author":"Hancock","year":"2015","journal-title":"Epigenomics."},{"key":"B33","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/onc.2010.481","article-title":"Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1\u03b1","volume":"30","author":"Koslowski","year":"2011","journal-title":"Oncogene"},{"key":"B34","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1126\/science.6254144","article-title":"DNA methylation and gene function","volume":"210","author":"Razin","year":"1980","journal-title":"Science"},{"key":"B35","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1080\/15592294.2015.1062204","article-title":"Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase","volume":"10","author":"van der Wijst","year":"2015","journal-title":"Epigenetics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.biopsych.2008.10.036","article-title":"Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission","volume":"65","author":"Monteggia","year":"2009","journal-title":"Biol Psychiatry."},{"key":"B37","doi-asserted-by":"publisher","first-page":"6800","DOI":"10.1073\/pnas.1411269112","article-title":"Reading the unique DNA methylation landscape of the brain: non-CpG methylation, hydroxymethylation, and MeCP2","volume":"112","author":"Kinde","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B38","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nature19426","article-title":"Cancer: suffocation of gene expression","volume":"537","author":"Ye","year":"2016","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1093\/nsr\/nwu008","article-title":"Non-coding RNA: a new frontier in regulatory biology","volume":"1","author":"Fu","year":"2014","journal-title":"Nat Sci Rev"},{"key":"B40","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3389\/fgene.2012.00205","article-title":"Evolutionary conservation and functional roles of ncRNA","volume":"3","author":"Qu","year":"2012","journal-title":"Front Genet."},{"key":"B41","first-page":"447","article-title":"Chapter 18 - MicroRNAs in brain development","volume-title":"MicroRNA in Regenerative Medicine.","author":"Coolen","year":"2015"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1097\/SCS.0b013e3182a243f3","article-title":"Analysis of microRNA expression detected by microarray of the cerebral cortex after hypoxic-ischemic brain injury","volume":"24","author":"Cui","year":"2013","journal-title":"J Craniofac Surg."},{"key":"B43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuropharm.2018.11.041","article-title":"The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy","volume":"148","author":"Ponnusamy","year":"2019","journal-title":"Neuropharmacology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"5540","DOI":"10.1158\/0008-5472.CAN-07-6460","article-title":"Identification of hypoxia-inducible factor-1\u03b1 as a novel target for miR-17-92 microRNA cluster","volume":"68","author":"Taguchi","year":"2008","journal-title":"Cancer Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1161\/CIRCRESAHA.108.193102","article-title":"Downregulation of miR-199a derepresses hypoxia-inducible factor-1\u03b1 and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes","volume":"104","author":"Rane","year":"2009","journal-title":"Cicul Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1172\/JCI42980","article-title":"Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-\u03b1 isoforms and promotes angiogenesis","volume":"120","author":"Ghosh","year":"2010","journal-title":"J Clin Invest"},{"key":"B47","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.freeradbiomed.2013.05.022","article-title":"Hypoxia: a master regulator of microRNA biogenesis and activity","volume":"64","author":"Nallamshetty","year":"2013","journal-title":"Free Radic Biol Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1096\/fj.14-267054","article-title":"The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1 \u03b1 expression in human endothelial cells through a negative feedback loop","volume":"29","author":"Bartoszewska","year":"2014","journal-title":"FASEB J."},{"key":"B49","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1152\/physiolgenomics.00020.2014","article-title":"miR-21 in ischemia\/reperfusion injury: a double-edged sword?","volume":"46","author":"Xu","year":"2014","journal-title":"Physiol Genomics."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e21905","DOI":"10.1002\/jbt.21905","article-title":"Inhibition of microRNA-153 protects neurons against ischemia\/reperfusion injury in an oxygen\u2013glucose deprivation and reoxygenation cellular model by regulating Nrf2\/HO-1 signaling","volume":"31","author":"Ji","year":"2017","journal-title":"J Biochem Mol Toxicol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1158\/0008-5472.CAN-08-2516","article-title":"MicroRNA regulation of DNA repair gene expression in hypoxic stress","volume":"69","author":"Crosby","year":"2009","journal-title":"Cancer Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.molcel.2009.09.006","article-title":"Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation","volume":"35","author":"Huang","year":"2009","journal-title":"Mol Cell."},{"key":"B53","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1186\/1471-2164-15-686","article-title":"Hypoxic signature of microRNAs in glioblastoma: insights from small RNA deep sequencing","volume":"15","author":"Agrawal","year":"2014","journal-title":"BMC Genomics"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e00835","DOI":"10.1002\/brb3.835","article-title":"Combined prediction of miR-210 and miR-374a for severity and prognosis of hypoxic\u2013ischemic encephalopathy","volume":"8","author":"Wang","year":"2018","journal-title":"Brain Behav."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e78487","DOI":"10.1371\/journal.pone.0078487","article-title":"Circulating microRNAs in maternal blood as potential biomarkers for fetal hypoxia in-utero","volume":"8","author":"Whitehead","year":"2013","journal-title":"PLoS ONE."},{"key":"B56","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12920-019-0548-x","article-title":"Placental microRNAs in pregnancies with early onset intrauterine growth restriction and preeclampsia: potential impact on gene expression and pathophysiology","volume":"12","author":"Awamleh","year":"2019","journal-title":"BMC Med Genomics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1161\/HYPERTENSIONAHA.111.180232","article-title":"Hydroxysteroid. (17-\u03b2) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia","volume":"59","author":"Ishibashi","year":"2012","journal-title":"Hypertension"},{"key":"B58","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000449032","article-title":"Temporal profile of circulating microRNAs after global hypoxia-ischemia in newborn piglets","volume":"111","author":"Garberg","year":"2017","journal-title":"Neonatology."},{"key":"B59","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jpeds.2015.04.060","article-title":"Downregulation of umbilical cord blood levels of miR-374a in neonatal hypoxic ischemic encephalopathy","volume":"167","author":"Looney","year":"2015","journal-title":"J Pediatr."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1007\/s12035-018-1321-4","article-title":"Altered expression of umbilical cord blood levels of miR-181b and its downstream target mUCH-L1 in infants with moderate and severe neonatal hypoxic-ischaemic encephalopathy","volume":"56","author":"Looney","year":"","journal-title":"Mol Neurobiol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1001\/jamaneurol.2018.4182","article-title":"Validation of altered umbilical cord blood microRNA expression in neonatal hypoxic-ischemic encephalopathy","volume":"76","author":"O'Sullivan","year":"2018","journal-title":"JAMA Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.nbd.2016.02.011","article-title":"Inhibition of microRNA-210 provides neuroprotection in hypoxic\u2013ischemic brain injury in neonatal rats","volume":"89","author":"Ma","year":"2016","journal-title":"Neurobiol Dis."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.3390\/ijms18071356","article-title":"MicroRNA-210 suppresses junction proteins and disrupts blood-brain barrier integrity in neonatal rat hypoxic-ischemic brain injury","volume":"18","author":"Ma","year":"2017","journal-title":"Int J Mol Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"76","DOI":"10.7150\/ijbs.17278","article-title":"Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats","volume":"13","author":"Wang","year":"2017","journal-title":"Int J Biol Sci"},{"key":"B65","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.nbd.2013.11.023","article-title":"MiR-139-5p inhibits HGTD-P and regulates neuronal apoptosis induced by hypoxia\u2013ischemia in neonatal rats","volume":"63","author":"Qu","year":"2014","journal-title":"Neurobiol Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"6908","DOI":"10.1002\/jcb.26704","article-title":"microRNA-129-5p involved in the neuroprotective effect of dexmedetomidine on hypoxic-ischemic brain injury by targeting COL3A1 through the Wnt\/\u03b2-catenin signaling pathway in neonatal rats","volume":"120","author":"Zhou","year":"2018","journal-title":"J Cell Biochem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.bbrc.2018.02.070","article-title":"GAS5 silencing protects against hypoxia\/ischemia-induced neonatal brain injury","volume":"497","author":"Zhao","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B68","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12974-018-1077-9","article-title":"IRE1alpha inhibition decreased TXNIP\/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats","volume":"15","author":"Chen","year":"2018","journal-title":"J Neuroinflamm"},{"key":"B69","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.neuropharm.2018.08.003","article-title":"Role of PPAR-beta\/delta\/miR-17\/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats","volume":"140","author":"Gamdzyk","year":"2018","journal-title":"Neuropharmacology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1159\/000493829","article-title":"Circular RNA expression in the brain of a neonatal rat model of periventricular white matter damage","volume":"49","author":"Zhu","year":"2018","journal-title":"J Cell Biochem"},{"key":"B71","doi-asserted-by":"publisher","first-page":"13850","DOI":"10.1038\/srep13850","article-title":"Microarray profiling and co-expression network analysis of LncRNAs and mRNAs in neonatal rats following hypoxic-ischemic brain damage","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci Rep."},{"key":"B72","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.neulet.2017.06.003","article-title":"Trans-resveratrol enriched maternal diet protects the immature hippocampus from perinatal asphyxia in rats","volume":"653","author":"Isac","year":"2017","journal-title":"Neurosci Lett."},{"key":"B73","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.brainres.2017.05.001","article-title":"Up-regulation of miR-325-3p suppresses pineal aralkylamine N-acetyltransferase. (Aanat) after neonatal hypoxia\u2013ischemia brain injury in rats","volume":"1668","author":"Yang","year":"2017","journal-title":"Brain Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e1132","DOI":"10.1038\/cddis.2014.92","article-title":"MicroRNA-23a\/b and microRNA-27a\/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis","volume":"5","author":"Chen","year":"2014","journal-title":"Cell Death Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1159\/000486923","article-title":"Effects of microRNA-592-5p on hippocampal neuron injury following hypoxic-ischemic brain damage in neonatal mice-involvement of PGD2\/DP and PTGDR","volume":"45","author":"Sun","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B76","doi-asserted-by":"publisher","first-page":"7978","DOI":"10.1002\/jcb.28075","article-title":"Silencing of long noncoding RNA MEG3 enhances cerebral protection of dexmedetomidine against hypoxic-ischemic brain damage in neonatal mice by binding to miR-129-5p","volume":"120","author":"Zhou","year":"2018","journal-title":"J Cell Biochem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1002\/glia.22404","article-title":"miR-21 represses FasL in microglia and protects against microglia-mediated neuronal cell death following hypoxia\/ischemia","volume":"60","author":"Zhang","year":"2012","journal-title":"Glia"},{"key":"B78","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41419-018-0282-x","article-title":"Long non-coding RNAs in ischemic stroke","volume":"9","author":"Bao","year":"2018","journal-title":"Cell Death Dis."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s00018-016-2174-5","article-title":"Mechanisms of long noncoding RNA function in development and disease","volume":"73","author":"Schmitz","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"B80","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/nan.12541","article-title":"Long non-coding RNA s: important regulators in the development, function and disorders of the central nervous system","volume":"45","author":"Cuevas-Diaz Duran","year":"2019","journal-title":"Neuropathol Appl Neurobiol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s10059-011-1004-8","article-title":"The coded functions of noncoding RNAs for gene regulation","volume":"31","author":"An","year":"2011","journal-title":"Mol Cells"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/nn.2371","article-title":"Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry","volume":"12","author":"Bond","year":"2009","journal-title":"Nat Neurosci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.neuron.2015.09.045","article-title":"Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution","volume":"88","author":"Briggs","year":"2015","journal-title":"Neuron"},{"key":"B84","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral thinking: how histone modifications regulate gene expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp Mol Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2217\/epi.13.79","article-title":"The roles of Jumonji-type oxygenases in human disease","volume":"6","author":"Johansson","year":"2014","journal-title":"Epigenomics"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.cellsig.2014.03.030","article-title":"Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process","volume":"26","author":"Salminen","year":"2014","journal-title":"Cell Signal."},{"key":"B89","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1042\/BJ20081238","article-title":"Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor","volume":"416","author":"Pollard","year":"2008","journal-title":"Biochem J"},{"key":"B90","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00441-009-0805-y","article-title":"Identification and characterization of demethylase JMJD1A as a gene upregulated in the human cellular response to hypoxia","volume":"337","author":"Sar","year":"2009","journal-title":"Cell Tissue Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3109\/10409238.2010.504700","article-title":"Decoding the histone H4 lysine 20 methylation mark","volume":"45","author":"Balakrishnan","year":"2010","journal-title":"Crit Rev Biochem Mol Biol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1608501","DOI":"10.1080\/23723556.2019.1608501","article-title":"JmjC histone demethylases act as chromatin oxygen sensors","volume":"6","author":"Batie","year":"2019","journal-title":"Mol Cell Oncol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1042\/BC20080158","article-title":"Histone deacetylases: salesmen and customers in the post-translational modification market","volume":"101","author":"Brandl","year":"2009","journal-title":"Biol Cell"},{"key":"B94","doi-asserted-by":"publisher","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","article-title":"An essential role for p300\/CBP in the cellular response to hypoxia","volume":"93","author":"Arany","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"B95","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.conb.2014.03.008","article-title":"HDAC signaling in neuronal development and axon regeneration","volume":"27","author":"Cho","year":"2014","journal-title":"Curr Opin Neurobiol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3892\/or.17.3.647","article-title":"Regulation of the HIF-1\u03b1 stability by histone deacetylases","volume":"17","author":"Kim","year":"2007","journal-title":"Oncol Rep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/jbmr.2787","article-title":"Class I and IIa HDACs mediate HIF-1\u03b1 stability through PHD2-dependent mechanism, while HDAC6, a class IIb member, promotes HIF-1\u03b1 transcriptional activity in nucleus pulposus cells of the intervertebral disc","volume":"31","author":"Schoepflin","year":"2016","journal-title":"J Bone Miner Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1549-8719.2011.00154.x","article-title":"miR-210: The master hypoxamir","volume":"19","author":"Chan","year":"2012","journal-title":"Microcirculation"},{"key":"B99","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3109\/10641955.2013.832772","article-title":"MicroRNAs: are they the missing link between hypoxia and pre-eclampsia?","volume":"33","author":"Li","year":"2014","journal-title":"Hypertens Pregn"},{"key":"B100","doi-asserted-by":"publisher","first-page":"261.e26","DOI":"10.1016\/j.ajog.2007.01.008","article-title":"Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia","volume":"196","author":"Pineles","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ajog.2008.12.045","article-title":"Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies","volume":"200","author":"Zhu","year":"","journal-title":"Am J Obstetr Gynecol. ("},{"key":"B102","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/1933719110374115","article-title":"Expression profile of microRNAs and mRNAs in human placentas from pregnancies complicated by preeclampsia and preterm labor","volume":"18","author":"Mayor-Lynn","year":"2011","journal-title":"Reprod Sci"},{"key":"B103","doi-asserted-by":"publisher","first-page":"5519","DOI":"10.3390\/ijms14035519","article-title":"MicroRNAs in human placental development and pregnancy complications","volume":"14","author":"Fu","year":"2013","journal-title":"Int J Mol Sci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1582-4934.2011.01291.x","article-title":"Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease","volume":"16","author":"Zhang","year":"2012","journal-title":"J Cell Mol Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/jcbfm.2014.41","article-title":"Mechanisms of perinatal arterial ischemic stroke","volume":"34","author":"Fern\u00e1ndez-L\u00f3pez","year":"2014","journal-title":"J Cerebral Blood Flow Metab"},{"key":"B106","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.nbd.2009.06.005","article-title":"Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen\u2013glucose deprived cultured cortical cells","volume":"35","author":"Badiola","year":"2009","journal-title":"Neurobiol Dis."},{"key":"B107","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1186\/1742-2094-10-24","article-title":"Cerebral ischemia initiates an immediate innate immune response in neonates during cardiac surgery","volume":"10","author":"Algra","year":"2013","journal-title":"J Neuroinflamm"},{"key":"B108","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/wrna.1320","article-title":"Can circulating miRNAs live up to the promise of being minimal invasive biomarkers in clinical settings?","volume":"7","author":"Keller","year":"2016","journal-title":"Wiley Interdisc Rev"},{"key":"B109","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/pr.2015.276","article-title":"A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method","volume":"79","author":"Ponnusamy","year":"2015","journal-title":"Pediatr Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"e0206601","DOI":"10.1371\/journal.pone.0206601","article-title":"Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia","volume":"13","author":"Manueldas","year":"2018","journal-title":"PLoS ONE"},{"key":"B111","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.preghy.2018.03.010","article-title":"Prospective biomarkers in preterm preeclampsia: a review","volume":"14","author":"McCarthy","year":"2018","journal-title":"Pregn Hypertens."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2015.10.007","article-title":"Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic\u2013ischemic injury in neonatal rats","volume":"275","author":"Li","year":"2016","journal-title":"Exp Neurol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/978-3-211-85578-2_77","article-title":"HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury","volume":"102","author":"Chen","year":"2008","journal-title":"Acta Neurochir Suppl."},{"key":"B114","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1016-8478(23)17423-1","article-title":"Vitexin, an HIF-1\u03b1 inhibitor, has anti-metastatic potential in PC12 cells","volume":"22","author":"Choi","year":"2006","journal-title":"Mol Cells."},{"key":"B115","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neuropharm.2015.07.007","article-title":"Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model","volume":"99","author":"Min","year":"2015","journal-title":"Neuropharmacology"},{"key":"B116","doi-asserted-by":"publisher","first-page":"25513","DOI":"10.18632\/oncotarget.16065","article-title":"Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+\/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain","volume":"8","author":"Min","year":"2017","journal-title":"Oncotarget"},{"key":"B117","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12974-018-1221-6","article-title":"Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1","volume":"15","author":"Luo","year":"2018","journal-title":"J Neuroinflamm"},{"key":"B118","doi-asserted-by":"publisher","first-page":"L1096","DOI":"10.1152\/ajplung.00325.2017","article-title":"Epigenetic changes by DNA methylation in chronic and intermittent hypoxia","volume":"313","author":"Nanduri","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1523\/JNEUROSCI.20-09-03175.2000","article-title":"DNA methyltransferase contributes to delayed ischemic brain injury","volume":"20","author":"Endres","year":"2000","journal-title":"J Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"4100","DOI":"10.1093\/nar\/gkh739","article-title":"Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain","volume":"32","author":"Valinluck","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"B121","doi-asserted-by":"publisher","first-page":"295","DOI":"10.14336\/AD.2015.1009","article-title":"Epigenetic regulation of oxidative stress in ischemic stroke","volume":"7","author":"Zhao","year":"2016","journal-title":"Aging Dis."},{"key":"B122","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1093\/carcin\/bgp060","article-title":"Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns","volume":"30","author":"Lao","year":"2009","journal-title":"Carcinogenesis"},{"key":"B123","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1471-2202-14-61","article-title":"Fetal brain genomic reprogramming following asphyctic preconditioning","volume":"14","author":"Cox-Limpens","year":"2013","journal-title":"BMC Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.bbr.2009.11.040","article-title":"Fetal asphyctic preconditioning protects against perinatal asphyxia-induced behavioral consequences in adulthood","volume":"208","author":"Strackx","year":"2010","journal-title":"Behav Brain Res."},{"key":"B125","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1742-2094-10-14","article-title":"Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats","volume":"10","author":"Vlassaks","year":"2013","journal-title":"J Neuroinflamm"},{"key":"B126","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1471-2202-15-67","article-title":"Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia","volume":"15","author":"Cox-Limpens","year":"2014","journal-title":"BMC Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.nbd.2014.01.020","article-title":"Fetal hypoxia increases vulnerability of hypoxic\u2013ischemic brain injury in neonatal rats: role of glucocorticoid receptors","volume":"65","author":"Gonzalez-Rodriguez","year":"2014","journal-title":"Neurobiol Dis."},{"key":"B128","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat Neurosci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1161\/STROKEAHA.112.664698","article-title":"Perinatal nicotine exposure increases vulnerability of hypoxic\u2013ischemic brain injury in neonatal rats: role of angiotensin II receptors","volume":"43","author":"Li","year":"2012","journal-title":"Stroke."},{"key":"B130","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.nbd.2013.08.011","article-title":"Promoter methylation represses AT2R gene and increases brain hypoxic\u2013ischemic injury in neonatal rats","volume":"60","author":"Li","year":"2013","journal-title":"Neurobiol Dis."},{"key":"B131","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1161\/STROKEAHA.109.553644","article-title":"Proapoptotic role of human growth and transformation-dependent protein in the developing rat brain after hypoxia-ischemia","volume":"40","author":"Qu","year":"2009","journal-title":"Stroke"},{"key":"B132","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s11481-016-9658-9","article-title":"Dexmedetomidine postconditioning reduces brain injury after brain hypoxia-ischemia in neonatal rats","volume":"11","author":"Ren","year":"2016","journal-title":"J Neuroimmune Pharmacol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12871-017-0413-4","article-title":"Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia","volume":"17","author":"Liu","year":"2017","journal-title":"BMC Anesthesiol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00401-013-1142-5","article-title":"MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation","volume":"126","author":"Doeppner","year":"2013","journal-title":"Acta Neuropathol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3389\/fncel.2015.00193","article-title":"An updated role of microRNA-124 in central nervous system disorders: a review","volume":"9","author":"Sun","year":"2015","journal-title":"Front Cell Neurosci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.biomaterials.2016.03.025","article-title":"MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia","volume":"91","author":"Taj","year":"2016","journal-title":"Biomaterials."},{"key":"B137","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1177\/0271678X16647738","article-title":"Lithium-induced neuroprotection in stroke involves increased miR-124 expression, reduced RE1-silencing transcription factor abundance and decreased protein deubiquitination by GSK3\u03b2 inhibition-independent pathways","volume":"37","author":"Doeppner","year":"2017","journal-title":"J Cereb Blood Flow Metab."},{"key":"B138","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1523\/JNEUROSCI.1777-16.2017","article-title":"Distinct effects of miR-210 reduction on neurogenesis: increased neuronal survival of inflammation but reduced proliferation associated with mitochondrial enhancement","volume":"37","author":"Voloboueva","year":"2017","journal-title":"J Neurosci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12974-016-0753-x","article-title":"In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response","volume":"13","author":"Pena-Philippides","year":"2016","journal-title":"J Neuroinflammation."},{"key":"B140","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1159\/000105477","article-title":"Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury","volume":"29","author":"West","year":"2007","journal-title":"Dev Neurosci"},{"key":"B141","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.brainres.2011.09.044","article-title":"Resveratrol ameliorates hypoxia\/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain","volume":"1425","author":"Karalis","year":"2011","journal-title":"Brain Res."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.3892\/etm.2017.4683","article-title":"Curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through induction of nuclear factor erythroid-2-related factor 2 and heme oxygenase-1","volume":"14","author":"Cui","year":"2017","journal-title":"Exp Ther Med."},{"key":"B143","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s12263-011-0222-1","article-title":"Epigenetic changes induced by curcumin and other natural compounds","volume":"6","author":"Reuter","year":"2011","journal-title":"Genes Nutr."},{"key":"B144","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gene.2015.02.045","article-title":"The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review","volume":"562","author":"Vahid","year":"2015","journal-title":"Gene."},{"key":"B145","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neulet.2015.12.061","article-title":"Distinctive sleep problems in children with perinatal moderate or mild hypoxic-ischemia","volume":"614","author":"Ding","year":"2016","journal-title":"Neurosci Lett"},{"key":"B146","doi-asserted-by":"publisher","first-page":"8499","DOI":"10.1002\/jcb.28138","article-title":"Analysis of long noncoding RNA expression profiles in the whole blood of neonates with hypoxic-ischemic encephalopathy","volume":"120","author":"Dong","year":"2018","journal-title":"J Cell Biochem"},{"key":"B147","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/jnc.14689","article-title":"Analysis of long non-coding RNA expression profiles in neonatal rats with hypoxic-ischemic brain damage","volume":"149","author":"Zhou","year":"2019","journal-title":"J Neurochem"},{"key":"B148","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroscience.2016.09.017","article-title":"Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke","volume":"337","author":"Yan","year":"2016","journal-title":"Neuroscience"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.3892\/ijmm.2019.4111","article-title":"Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage","volume":"43","author":"Jiang","year":"2019","journal-title":"Int J Mol Med."},{"key":"B150","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.mcn.2013.07.012","article-title":"Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons","volume":"57","author":"Henriquez","year":"2013","journal-title":"Mol Cell Neurosci"},{"key":"B151","doi-asserted-by":"publisher","first-page":"5184","DOI":"10.1523\/JNEUROSCI.4129-13.2014","article-title":"Ezh2 regulates adult hippocampal neurogenesis and memory","volume":"34","author":"Zhang","year":"2014","journal-title":"J Neurosci"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s10072-014-1726-4","article-title":"Sevoflurane postconditioning provides neuroprotection against brain hypoxia\u2013ischemia in neonatal rats","volume":"35","author":"Ren","year":"2014","journal-title":"Neurol Sci"},{"key":"B153","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00540-015-2132-7","article-title":"Isoflurane postconditioning induces concentration-and timing-dependent neuroprotection partly mediated by the GluR2 AMPA receptor in neonatal rats after brain hypoxia\u2013ischemia","volume":"30","author":"Xu","year":"2016","journal-title":"J Anesth."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.2147\/DDDT.S197325","article-title":"Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy","volume":"13","author":"Xue","year":"2019","journal-title":"Drug Des DevTher."},{"key":"B155","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/jpi.12156","article-title":"Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia\u2013ischemia","volume":"57","author":"Carloni","year":"2014","journal-title":"J Pineal Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3233\/RNN-150549","article-title":"Uridine protects against hypoxic-ischemic brain injury by reducing histone deacetylase activity in neonatal rats","volume":"33","author":"Koyuncuoglu","year":"2015","journal-title":"Restor Neurol Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/jnc.12744","article-title":"Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult. (HI) in neonates","volume":"130","author":"Lange","year":"2014","journal-title":"J Neurochem."},{"key":"B158","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fneur.2016.00022","article-title":"Peptidylarginine deiminases as drug targets in neonatal hypoxic-ischemic encephalopathy","volume":"7","author":"Lange","year":"2016","journal-title":"Front Neurol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1523\/JNEUROSCI.23-06-02112.2003","article-title":"Ischemic insults derepress the gene silencer REST in neurons destined to die","volume":"23","author":"Calderone","year":"2003","journal-title":"J Neurosci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1007\/s12035-018-1254-y","article-title":"Inhibition of the epigenetic regulator REST ameliorates ischemic brain injury","volume":"56","author":"Morris-Blanco","year":"2019","journal-title":"Mol Neurobiol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"13866","DOI":"10.1038\/ncomms13866","article-title":"Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury","volume":"7","author":"Jablonska","year":"2016","journal-title":"Nat Commun."},{"key":"B162","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1177\/08830738050200070801","article-title":"Protective effects of valproic acid against hypoxic-ischemic brain injury in neonatal rats","volume":"20","author":"Kabakus","year":"2005","journal-title":"J Child Neurol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1742-2094-9-70","article-title":"Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury","volume":"9","author":"Fleiss","year":"2012","journal-title":"J Neuroinflamm"},{"key":"B164","doi-asserted-by":"publisher","first-page":"6341","DOI":"10.1007\/s12035-019-1518-1","article-title":"Effect of the HDAC inhibitor, sodium butyrate, on neurogenesis in a rat model of neonatal hypoxia\u2013ischemia: potential mechanism of action","volume":"56","author":"Jaworska","year":"2019","journal-title":"Mol Neurobiol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.brainres.2014.01.035","article-title":"Quercetin improves hypoxia-ischemia induced cognitive deficits via promoting remyelination in neonatal rat","volume":"1553","author":"Qu","year":"2014","journal-title":"Brain Res."},{"key":"B166","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1101\/gad.927301","article-title":"Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails","volume":"15","author":"Zhang","year":"2001","journal-title":"Genes Dev"},{"key":"B167","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.4161\/cc.9.22.13973","article-title":"REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions","volume":"9","author":"Qureshi","year":"2010","journal-title":"Cell Cycle"},{"key":"B168","doi-asserted-by":"publisher","first-page":"E962","DOI":"10.1073\/pnas.1121568109","article-title":"Repressor element-1 silencing transcription factor. (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death","volume":"109","author":"Noh","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B169","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1016\/j.jmb.2014.07.032","article-title":"The gene silencing transcription factor REST represses miR-132 expression in hippocampal neurons destined to die","volume":"426","author":"Hwang","year":"2014","journal-title":"J Mol Biol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"17851","DOI":"10.1038\/srep17851","article-title":"REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia","volume":"5","author":"Cavadas","year":"2015","journal-title":"Sci Rep"},{"key":"B171","doi-asserted-by":"publisher","first-page":"31355","DOI":"10.1038\/srep31355","article-title":"REST is a hypoxia-responsive transcriptional repressor","volume":"6","author":"Cavadas","year":"2016","journal-title":"Sci Rep."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00483\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:24:38Z","timestamp":1723011878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00483\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":171,"alternative-id":["10.3389\/fneur.2020.00483"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.00483","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"article-number":"483"}}