{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:09:45Z","timestamp":1790683785463,"version":"4.1.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51571114"],"award-info":[{"award-number":["51571114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771267"],"award-info":[{"award-number":["81771267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.00521","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T06:17:32Z","timestamp":1593497852000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Structural and Microvascular Changes in the Macular Are Associated With Severity of White Matter Lesions"],"prefix":"10.3389","volume":"11","author":[{"given":"Chenlei","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Robert","family":"Kwapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah Mohamed","family":"Muse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jueyan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yungang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanpei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxiang","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"H1","DOI":"10.1152\/ajpheart.00581.2016","article-title":"Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging","volume":"312","author":"Toth","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz135","article-title":"Anti-aging therapies, cognitive impairment and dementia","author":"Wahl","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3389\/fpsyg.2018.00828","article-title":"Promoting well-being in old age: the psychological benefits of two training programs of adapted physical activity","volume":"9","author":"Delle Fave","year":"2018","journal-title":"Front Psychol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jns.2009.02.314","article-title":"Cerebral white matter lesions in patients with dementia - from MCI to severe Alzheimer's disease","volume":"283","author":"Targosz-Gajniak","year":"2009","journal-title":"J Neurol Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1161\/01.STR.0000126041.99024.86","article-title":"White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients","volume":"35","author":"Burton","year":"2004","journal-title":"Stroke."},{"key":"B6","doi-asserted-by":"publisher","first-page":"c3666","DOI":"10.1136\/bmj.c3666","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis","volume":"341","author":"Debette","year":"2010","journal-title":"BMJ."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1161\/STROKEAHA.107.513176","article-title":"Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study","volume":"39","author":"van Dijk","year":"2008","journal-title":"Stroke."},{"key":"B8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","article-title":"Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures","volume":"206","author":"Patton","year":"2005","journal-title":"J Anat."},{"key":"B9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.4172\/2167-7182.1000447","article-title":"Cerebral and retinal neurovascular changes: a biomarker for Alzheimer's disease","volume":"6","author":"Ravi Teja","year":"2017","journal-title":"J Gerontol Geriatr Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"H201","DOI":"10.1152\/ajpheart.00201.2016","article-title":"Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases","volume":"312","author":"Cabrera DeBuc","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.3233\/JAD-180738","article-title":"Evaluation of ocular perfusion in alzheimer's disease using optical coherence tomography angiography","volume":"66","author":"Lahme","year":"2018","journal-title":"J Alzheimers Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s11910-018-0911-x","article-title":"Principles of OCTA and applications in clinical neurology","volume":"18","author":"Wylegala","year":"2018","journal-title":"Curr Neurol Neurosci Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1161\/01.STR.0000202585.26325.74","article-title":"Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study","volume":"37","author":"van Straaten","year":"2006","journal-title":"Stroke."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e34823","DOI":"10.1371\/journal.pone.0034823","article-title":"The OSCAR-IB consensus criteria for retinal OCT quality assessment","volume":"7","author":"Tewarie","year":"2012","journal-title":"PLoS ONE."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1212\/WNL.0000000000002774","article-title":"The APOSTEL recommendations for reporting quantitative optical coherence tomography studies","volume":"86","author":"Cruz-Herranz","year":"2016","journal-title":"Neurology."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1167\/iovs.18-24710","article-title":"Human parafoveal capillary vascular anatomy and connectivity revealed by optical coherence tomography angiography","volume":"59","author":"Nesper","year":"2018","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1167\/iovs.06-1197","article-title":"Intraretinal oxygen distribution and consumption during retinal artery occlusion and graded hyperoxic ventilation in the rat","volume":"48","author":"Yu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3389\/fneur.2018.00581","article-title":"Ultrastructural characteristics of neuronal death and white matter injury in mouse brain tissues after intracerebral hemorrhage: coexistence of ferroptosis, autophagy, and necrosis","volume":"9","author":"Li","year":"2018","journal-title":"Front Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41531-018-0044-6","article-title":"Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson's disease","volume":"4","author":"Reeve","year":"2018","journal-title":"NPJ Parkinson's Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1097\/IAE.0000000000000839","article-title":"New insight into the macular deep vascular plexus imaged by optical coherence tomography angiography","volume":"35","author":"Bonnin","year":"2015","journal-title":"Retina-J Ret Vit Dis."},{"key":"B21","first-page":"1698","article-title":"Relation between superficial capillaries and foveal structures in the human retina","volume":"27","author":"Iwasaki","year":"1986","journal-title":"Invest Ophth Vis Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.3174\/ajnr.A5327","article-title":"In vivo imaging of venous side cerebral small-vessel disease in older adults: an MRI method at 7T","volume":"38","author":"Shaaban","year":"2017","journal-title":"Am J Neuroradiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neulet.2014.06.024","article-title":"Microvascular network alterations in retina of subjects with cerebral small vessel disease","volume":"577","author":"Hilal","year":"2014","journal-title":"Neurosci Lett."},{"key":"B24","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1747-4949.2012.00865.x","article-title":"Differing associations of white matter lesions and lacunar infarction with retinal microvascular signs","volume":"9","author":"Liew","year":"2014","journal-title":"Int J Stroke."},{"key":"B25","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/brain\/awh688","article-title":"Retinal vessel diameters and cerebral small vessel disease: the rotterdam scan study","volume":"129","author":"Ikram","year":"2006","journal-title":"Brain."},{"key":"B26","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.ophtha.2007.06.036","article-title":"Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters - the Rotterdam Study","volume":"115","author":"De Jong","year":"2008","journal-title":"Ophthalmology."},{"key":"B27","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.exger.2016.11.004","article-title":"Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline","volume":"94","author":"Tarantini","year":"2017","journal-title":"Exp Gerontol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10072-017-3234-9","article-title":"Evaluation of white matter hyperintensities and retinal fiber layer, ganglion cell layer, inner-plexiform layer, and choroidal layer in migraine patients","volume":"39","author":"Tak","year":"2018","journal-title":"Neurol Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nature17965","article-title":"Neural correlates of single-vessel haemodynamic responses in vivo","volume":"534","author":"O'Herron","year":"2016","journal-title":"Nature."},{"key":"B30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ajoc.2016.09.007","article-title":"The superficial and deep retinal capillary plexus in cases of fovea plana imaged by spectral-domain optical coherence tomography angiography","volume":"6","author":"Kaidonis","year":"2017","journal-title":"Am J Ophthalmol Case Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"42201","DOI":"10.1038\/srep42201","article-title":"Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1097\/IAE.0000000000000850","article-title":"Optical coherence tomography angiography in retinal artery occlusion","volume":"35","author":"Bonini Filho","year":"2015","journal-title":"Retina."},{"key":"B33","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.exer.2014.10.020","article-title":"Correlation between the radial peripapillary capillaries and the retinal nerve fibre layer in the normal human retina","volume":"129","author":"Yu","year":"2014","journal-title":"Exp Eye Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0135151","DOI":"10.1371\/journal.pone.0135151","article-title":"Label-free density measurements of radial peripapillary capillaries in the human retina","volume":"10","author":"Yu","year":"2015","journal-title":"PLoS ONE."},{"key":"B35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1136\/bjo.52.1.26","article-title":"Radial peripapillary capillaries of the retina. II. Possible role in Bjerrum scotoma","volume":"52","author":"Alterman","year":"1968","journal-title":"Br J Ophthalmol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archopht.1968.00980050698002","article-title":"Selective atrophy of the radial peripapillary capillaries in chronic glaucoma","volume":"80","author":"Kornzweig","year":"1968","journal-title":"Arch Ophthalmol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s13760-019-01094-7","article-title":"Retinal vascular density evaluation of migraine patients with and without aura and association with white matter hyperintensities","volume":"119","author":"Ulusoy","year":"2019","journal-title":"Acta Neurol Belg."},{"key":"B38","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1365-2990.2010.01139.x","article-title":"Cerebral microvascular pathology in ageing and neurodegeneration","volume":"37","author":"Brown","year":"2011","journal-title":"Neuropath Appl Neuro."},{"key":"B39","doi-asserted-by":"publisher","first-page":"8538573","DOI":"10.1155\/2018\/8538573","article-title":"Ocular manifestations of alzheimer's and other neurodegenerative diseases: the prospect of the eye as a tool for the early diagnosis of Alzheimer's disease","volume":"2018","author":"Colligris","year":"2018","journal-title":"J Ophthalmol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"20140195","DOI":"10.1098\/rstb.2014.0195","article-title":"Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters","volume":"370","author":"Newman","year":"2015","journal-title":"Philos T R Soc B."},{"key":"B41","doi-asserted-by":"publisher","first-page":"18291","DOI":"10.1038\/srep18291","article-title":"Relation of retinal blood flow and retinal oxygen extraction during stimulation with diffuse luminance flicker","volume":"5","author":"Palkovits","year":"2015","journal-title":"Sci Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.neurobiolaging.2017.09.003","article-title":"Retinal neurodegeneration and brain MRI markers: the Rotterdam Study","volume":"60","author":"Mutlu","year":"2017","journal-title":"Neurobiol Aging."},{"key":"B43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.radonc.2017.04.006","article-title":"Regional susceptibility to dose-dependent white matter damage after brain radiotherapy","volume":"123","author":"Connor","year":"2017","journal-title":"Radiother Oncol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9372050","DOI":"10.1155\/2017\/9372050","article-title":"Multiple factors involved in the pathogenesis of white matter lesions","volume":"2017","author":"Lin","year":"2017","journal-title":"Biomed Res Int."},{"key":"B45","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The retina as a window to the brain-from eye research to CNS disorders","volume":"9","author":"London","year":"2013","journal-title":"Nat Rev Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology."},{"key":"B47","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1080\/13854046.2015.1043349","article-title":"An abbreviated montreal cognitive assessment (MoCA) for dementia screening","volume":"29","author":"Horton","year":"2015","journal-title":"Clin Neuropsychol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1161\/STROKEAHA.114.007553","article-title":"White matter microstructural damage in small vessel disease is associated with montreal cognitive assessment but not with mini mental state examination performances: vascular mild cognitive impairment tuscany study","volume":"46","author":"Pasi","year":"2015","journal-title":"Stroke."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s10072-014-2055-3","article-title":"The relationship between the degree of cognitive impairment and retinal nerve fiber layer thickness","volume":"36","author":"Oktem","year":"2015","journal-title":"Neurol Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e0153830","DOI":"10.1371\/journal.pone.0153830","article-title":"Macular thickness measurements with frequency domain-OCT for quantification of retinal neural loss and its correlation with cognitive impairment in Alzheimer's disease","volume":"11","author":"Cunha","year":"2016","journal-title":"PLoS ONE."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00521\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T06:17:34Z","timestamp":1593497854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00521\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":50,"alternative-id":["10.3389\/fneur.2020.00521"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.00521","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"article-number":"521"}}