{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:18:25Z","timestamp":1777421905751,"version":"3.51.4"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY18H070003"],"award-info":[{"award-number":["LY18H070003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY19H180003"],"award-info":[{"award-number":["LY19H180003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400863"],"award-info":[{"award-number":["81400863"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8161101010"],"award-info":[{"award-number":["8161101010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["2018KY522"],"award-info":[{"award-number":["2018KY522"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20170813"],"award-info":[{"award-number":["Y20170813"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20180761"],"award-info":[{"award-number":["Y20180761"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.00572","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T04:48:56Z","timestamp":1592542136000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Disrupted Regional Cerebral Blood Flow in Children With Newly-Diagnosed Type 1 Diabetes Mellitus: An Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Study"],"prefix":"10.3389","volume":"11","author":[{"given":"Jiawen","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaomeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoou","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e007917","DOI":"10.1136\/bmjopen-2015-007917","article-title":"Evaluation of the correlation between type 1 diabetes and cognitive function in children and adolescents, and comparison of this correlation with structural changes in the central nervous system: a study protocol","volume":"6","author":"Pourabbasi","year":"2016","journal-title":"BMJ Open."},{"key":"B2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/nrdp.2017.16","article-title":"Type 1 diabetes mellitus","volume":"3","author":"Katsarou","year":"2017","journal-title":"Nat Rev Dis Primers."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1042\/cs20160397","article-title":"Cerebrovascular complications of diabetes: focus on cognitive dysfunction","volume":"130","author":"Hardigan","year":"2016","journal-title":"Clin Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.2337\/diacare.24.9.1541","article-title":"Neuropsychological profiles of children with type 1 diabetes 6 years after disease onset","volume":"24","author":"Northam","year":"2001","journal-title":"Diabetes Care."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1210\/jc.2018-01315","article-title":"Cognitive dysfunction in type 1 diabetes mellitus","volume":"104","author":"Shalimova","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/j.1399-5448.2012.00870.x","article-title":"Clinical utility of mental state screening as a predictor of intellectual outcomes 6 months after diagnosis of type 1 diabetes","volume":"13","author":"Nadebaum","year":"2012","journal-title":"Pediatr Diab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1056\/NEJMoa066397","article-title":"Long-term effect of diabetes and its treatment on cognitive function","volume":"356","author":"Genuth","year":"2007","journal-title":"N Engl J Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1253\/circj.CJ-11-0121","article-title":"Neurovascular coupling in cognitive impairment associated with diabetes mellitus","volume":"75","author":"Mogi","year":"2011","journal-title":"Circ J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"H1","DOI":"10.1152\/ajpheart.00581.2016","article-title":"Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging","volume":"312","author":"Toth","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.2337\/db12-1159","article-title":"Cerebral blood flow and glucose metabolism measured with positron emission tomography are decreased in human type 1 diabetes","volume":"62","author":"van Golen","year":"2013","journal-title":"Diabetes."},{"key":"B11","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1073\/pnas.89.1.212","article-title":"Magnetic resonance imaging of perfusion using spin inversion of arterial water","volume":"89","author":"Williams","year":"1992","journal-title":"Proc Natl Acad Sci USA."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1007\/s11682-016-9583-9","article-title":"Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction","volume":"11","author":"Cui","year":"2017","journal-title":"Brain Imag Behav."},{"key":"B13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/s1388-2457(02)00038-x","article-title":"Technical aspects and utility of fMRI using BOLD and ASL","volume":"113","author":"Detre","year":"2002","journal-title":"Clin Neurophysiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.tem.2013.09.005","article-title":"Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives","volume":"25","author":"Simo","year":"2014","journal-title":"Trends Endocrinol Metab."},{"key":"B15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.neurobiolaging.2017.09.004","article-title":"The resting perfusion pattern associates with functional decline in type 2 diabetes","volume":"60","author":"Dai","year":"2017","journal-title":"Neurobiol Aging."},{"key":"B16","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3389\/fneur.2017.00717","article-title":"Cerebral hemodynamic and white matter changes of type 2 diabetes revealed by multi-ti arterial spin labeling and double inversion recovery sequence","volume":"8","author":"Shen","year":"2017","journal-title":"Front Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1097\/ijg.0000000000001017","article-title":"Reduced cerebral blood flow in the visual cortex and its correlation with glaucomatous structural damage to the retina in patients with mild to moderate primary open-angle glaucoma","volume":"27","author":"Wang","year":"2018","journal-title":"J Glauc."},{"key":"B18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fnagi.2017.00014","article-title":"Resting-State brain anomalies in type 2 diabetes: a meta-analysis","volume":"9","author":"Xia","year":"2017","journal-title":"Front Aging Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1177\/1073858416645088","article-title":"Sensorimotor convergence in circuitry of the motor cortex","volume":"23","author":"Hooks","year":"2017","journal-title":"Neuroscientist."},{"key":"B20","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1055\/s-0033-1345120","article-title":"Macrostructural brain changes in patients with longstanding type 1 diabetes mellitus - a cortical thickness analysis study","volume":"121","author":"Frokjaer","year":"2013","journal-title":"Exp Clin Endocrinol Diabetes."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1002\/hbm.24204","article-title":"Deficient supplementary motor area at rest: Neural basis of limb kinetic deficits in Parkinson's disease","volume":"39","author":"Kubel","year":"2018","journal-title":"Hum Brain Mapp."},{"key":"B22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pneurobio.2014.09.001","article-title":"Motor system evolution and the emergence of high cognitive functions","volume":"122","author":"Mendoza","year":"2014","journal-title":"Prog Neurobiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s11357-017-0003-x","article-title":"Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice","volume":"39","author":"Tarantini","year":"2017","journal-title":"Geroscience."},{"key":"B24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/ana.22433","article-title":"Neurovascular coupling is impaired in slow walkers: the MOBILIZE boston study","volume":"70","author":"Sorond","year":"2011","journal-title":"Ann Neurol."},{"key":"B25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00231073","article-title":"The role of the left somatosensory cortex in human hand movement","volume":"106","author":"Okuda","year":"1995","journal-title":"Exp Brain Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/nn.2905","article-title":"A lateralized brain network for visuospatial attention","volume":"14","author":"Thiebaut de Schotten","year":"2011","journal-title":"Nat Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fnagi.2018.00055","article-title":"Altered brain functional hubs and connectivity in type 2 diabetes mellitus patients: a resting-state fMRI study","volume":"10","author":"Liu","year":"2018","journal-title":"Front Aging Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuroimage.2013.01.032","article-title":"Neuroanatomic overlap between intelligence and cognitive factors: morphometry methods provide support for the key role of the frontal lobes","volume":"72","author":"Colom","year":"2013","journal-title":"Neuroimage."},{"key":"B29","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.intell.2008.09.006","article-title":"Positive association between cognitive ability and cortical thickness in a representative US sample of healthy 6 to 18 year-olds","volume":"37","author":"Karamaa","year":"2009","journal-title":"Intelligence."},{"key":"B30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fnagi.2020.00048","article-title":"Resting state glucose utilization and adult reading test performance","volume":"12","author":"Lee","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.2337\/dc06-2052","article-title":"Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity","volume":"30","author":"Last","year":"2007","journal-title":"Diabetes Care."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.2337\/db11-1286","article-title":"Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism","volume":"61","author":"Glaser","year":"2012","journal-title":"Diabetes."},{"key":"B33","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.smrv.2005.05.002","article-title":"Steep function and synaptic homeostasis","volume":"10","author":"Tononi","year":"2006","journal-title":"Sleep Med Rev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuron.2013.12.025","article-title":"Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration","volume":"81","author":"Tononi","year":"2014","journal-title":"Neuron."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.5665\/sleep.1994","article-title":"Cerebral perfusion differences between drowsy and nondrowsy individuals after acute sleep restriction","volume":"35","author":"Poudel","year":"2012","journal-title":"Sleep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.neuroimage.2018.11.032","article-title":"Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation","volume":"186","author":"Elvsashagen","year":"2019","journal-title":"Neuroimage."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00572\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T04:48:59Z","timestamp":1592542139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00572\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":36,"alternative-id":["10.3389\/fneur.2020.00572"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.00572","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]},"article-number":"572"}}