{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:03Z","timestamp":1787026923985,"version":"build-2736575974"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24HD064754"],"award-info":[{"award-number":["K24HD064754"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.00651","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T02:38:08Z","timestamp":1594089488000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Sex Differences in Circulating T-Tau Trajectories After Sports-Concussion and Correlation With Outcome"],"prefix":"10.3389","volume":"11","author":[{"given":"Stefania","family":"Mondello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian A.","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jeromin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Bazarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nrneurol.2013.33","article-title":"The clinical spectrum of sport-related traumatic brain injury","volume":"9","author":"Jordan","year":"2013","journal-title":"Nat Rev Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000505424","article-title":"Incidence of sports-related traumatic brain injury of all severities: a systematic review","volume":"54","author":"Theadom","year":"2020","journal-title":"Neuroepidemiology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1177\/0363546515617746","article-title":"Sex-based differences as a predictor of recovery trajectories in young athletes after a sports-related concussion","volume":"44","author":"Ono","year":"2016","journal-title":"Am J Sports Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1919771","DOI":"10.1001\/jamanetworkopen.2019.19771","article-title":"Association of blood biomarkers with acute sport-related concussion in collegiate athletes: findings from the ncaa and Department of Defzense Care consortium","volume":"3","author":"McCrea","year":"2020","journal-title":"JAMA Netw Open."},{"key":"B5","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1212\/WNL.0000000000003587","article-title":"Acute plasma tau relates to prolonged return to play after concussion","volume":"88","author":"Gill","year":"2017","journal-title":"Neurology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e1919799","DOI":"10.1001\/jamanetworkopen.2019.19799","article-title":"Biomarkers may provide unique insights into neurological effects associated with sport-related concussions","volume":"3","author":"Bazarian","year":"2020","journal-title":"JAMA Netw Open."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e2133","DOI":"10.1212\/WNL.0000000000006617","article-title":"Concussion BASICS III: serum biomarker changes following sport-related concussion","volume":"91","author":"Asken","year":"2018","journal-title":"Neurology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e2109","DOI":"10.1212\/WNL.0000000000006613","article-title":"Concussion biomarkers assessed in collegiate student-athletes (BASICS) I: normative study","volume":"91","author":"Asken","year":"2018","journal-title":"Neurology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0159929","DOI":"10.1371\/journal.pone.0159929","article-title":"Altered blood biomarker profiles in athletes with a history of repetitive head impacts","volume":"11","author":"Di Battista","year":"2016","journal-title":"PLoS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Dementia Collaborators. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1001\/jamaneurol.2018.0821","article-title":"Alzheimer's disease genetics, and I. the Alzheimer's disease neuroimaging, sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau","volume":"75","author":"Hohman","year":"2018","journal-title":"JAMA Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/ana.24135","article-title":"Alzheimer's disease neuroimaging initiative, sex modifies the APOE-related risk of developing alzheimer disease","volume":"75","author":"Altmann","year":"2014","journal-title":"Ann Neurol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1385","DOI":"10.1212\/WNL.0000000000006321","article-title":"Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI","volume":"91","author":"Gill","year":"2018","journal-title":"Neurology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1780","DOI":"10.1212\/WNL.0000000000005518","article-title":"Neurofilament light and tau as blood biomarkers for sports-related concussion","volume":"90","author":"Shahim","year":"2018","journal-title":"Neurology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.28920\/dhm49.2.88-95","article-title":"Serum tau concentration after diving - an observational pilot study","volume":"49","author":"Rosen","year":"2019","journal-title":"Diving Hyperb Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrneurol.2013.9","article-title":"Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood","volume":"9","author":"Zetterberg","year":"2013","journal-title":"Nat Rev Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.4085\/1062-6050-44.4.434","article-title":"Consensus statement on concussion in sport 3rd) international conference on concussion in sport held in zurich, November 2008","volume":"19","author":"McCrory","year":"2009","journal-title":"Clin J Sport Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1021\/ac103161b","article-title":"Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range","volume":"83","author":"Rissin","year":"2011","journal-title":"Anal Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1177\/0049124101029003005","article-title":"A SAS procedure based on mixture models for estimating developmental trajectories","volume":"29","author":"Jones","year":"2001","journal-title":"Sociol Methods Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1146\/annurev.clinpsy.121208.131413","article-title":"Group-based trajectory modeling in clinical research","volume":"6","author":"Nagin","year":"2010","journal-title":"Annu Rev Clin Psychol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1212\/WNL.0b013e3182904d43","article-title":"\u03b1-Synuclein in CSF of patients with severe traumatic brain injury","volume":"80","author":"Mondello","year":"2013","journal-title":"Neurology."},{"key":"B22","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1089\/neu.2010.1586","article-title":"Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury","volume":"28","author":"Wagner","year":"2011","journal-title":"J Neurotrauma."},{"key":"B23","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3390\/cells9040977","article-title":"Circulating brain injury exosomal proteins following moderate-to-severe traumatic brain injury: temporal profile, outcome prediction and therapy implications","volume":"9","author":"Mondello","year":"2020","journal-title":"Cells."},{"key":"B24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/embor.2013.15","article-title":"Physiological release of endogenous tau is stimulated by neuronal activity","volume":"14","author":"Pooler","year":"2013","journal-title":"EMBO Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.neuron.2018.02.030","article-title":"Tauomics and kinetics in human neurons and biological fluids","volume":"97","author":"Zetterberg","year":"2018","journal-title":"Neuron."},{"key":"B26","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/bpa.12248","article-title":"The neuropathology of chronic traumatic encephalopathy","volume":"25","author":"McKee","year":"2015","journal-title":"Brain Pathol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1196\/annals.1347.016","article-title":"Estradiol prevents neural tau hyperphosphorylation characteristic of alzheimer's disease","volume":"1052","author":"Alvarez-de-la-Rosa","year":"2005","journal-title":"Ann N Y Acad Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1080\/14789450.2018.1464914","article-title":"Extracellular vesicles: pathogenetic, diagnostic and therapeutic value in traumatic brain injury","volume":"15","author":"Mondello","year":"2018","journal-title":"Expert Rev Proteomics."},{"key":"B29","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1177\/1073858410386492","article-title":"Brain connectivity: gender makes a difference","volume":"17","author":"Gong","year":"2011","journal-title":"Neuroscientist."},{"key":"B30","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neuroscience.2018.02.048","article-title":"Brain response to injuries: when microglia go sexist","volume":"405","author":"Rahimian","year":"2019","journal-title":"Neuroscience."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1089\/neu.2019.6800","article-title":"Sex differences in cerebral blood flow associated with a history of concussion","volume":"37","author":"Hamer","year":"2019","journal-title":"J Neurotrauma"},{"key":"B32","doi-asserted-by":"publisher","first-page":"CNC55","DOI":"10.2217\/cnc-2018-0004","article-title":"The synergistic effect of concussions and aging in women? Disparities and perspectives on moving forward","volume":"3","author":"Esopenko","year":"2018","journal-title":"Concussion."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1093\/brain\/awz286","article-title":"Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma","volume":"142","author":"Iverson","year":"2019","journal-title":"Brain."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e25475","DOI":"10.1371\/journal.pone.0025475","article-title":"Distinct temporal and anatomical distributions of amyloid-beta and tau abnormalities following controlled cortical impact in transgenic mice","volume":"6","author":"Tran","year":"2011","journal-title":"PLoS ONE."},{"key":"B35","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1148\/radiol.2018180217","article-title":"MRI-defined white matter microstructural alteration associated with soccer heading is more extensive in women than men","volume":"289","author":"Rubin","year":"2018","journal-title":"Radiology."},{"key":"B36","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1001\/jamaneurol.2019.4828","article-title":"Associations of apolipoprotein e epsilon4 genotype and ball heading with verbal memory in amateur soccer players","volume":"77","author":"Hunter","year":"2020","journal-title":"JAMA Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1227\/00006123-200009000-00026","article-title":"Lower cognitive performance of older football players possessing apolipoprotein E epsilon4","volume":"47","author":"Kutner","year":"2000","journal-title":"Neurosurgery."},{"key":"B38","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1002\/hbm.20431","article-title":"Developmental differences in white matter architecture between boys and girls","volume":"29","author":"Schmithorst","year":"2008","journal-title":"Hum Brain Mapp."},{"key":"B39","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1136\/jnnp.2009.193797","article-title":"Investigating baseline neurocognitive performance between male and female athletes with a history of multiple concussion","volume":"81","author":"Covassin","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B40","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1227\/01.NEU.0000279972.95060.CB","article-title":"Sex differences in neuropsychological function and post-concussion symptoms of concussed collegiate athletes","volume":"61","author":"Covassin","year":"2007","journal-title":"Neurosurgery."},{"key":"B41","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1177\/0363546516677246","article-title":"Sex-based differences in cognitive deficits and symptom reporting among acutely concussed adolescent lacrosse and soccer players","volume":"45","author":"Sandel","year":"2017","journal-title":"Am J Sports Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3171\/2013.9.PEDS13257","article-title":"Effect of sex on symptoms and return to baseline in sport-related concussion","volume":"13","author":"Zuckerman","year":"2014","journal-title":"J Neurosurg Pediatr."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1089\/neu.2017.5453","article-title":"The effects of sex differences and hormonal contraception on outcomes after collegiate sports-related concussion","volume":"35","author":"Gallagher","year":"2018","journal-title":"J Neurotrauma."},{"key":"B44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.31887\/DCNS.2016.18.4\/jclayton","article-title":"Sex influences in neurological disorders: case studies and perspectives","volume":"18","author":"Clayton","year":"2016","journal-title":"Dialogues Clin Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/jnr.23902","article-title":"Sex\/gender influences on the nervous system: basic steps toward clinical progress","volume":"95","author":"Brooks","year":"2017","journal-title":"J Neurosci Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1096\/fj.15-279554","article-title":"Studying both sexes: a guiding principle for biomedicine","volume":"30","author":"Clayton","year":"2016","journal-title":"FASEB J."},{"key":"B47","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.expneurol.2019.02.016","article-title":"Sex differences in pediatric traumatic brain injury","volume":"317","author":"Arambula","year":"2019","journal-title":"Exp Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/B978-0-444-52892-6.00016-7","article-title":"Biomarkers","volume":"127","author":"Mondello","year":"2015","journal-title":"Handb Clin Neurol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-1-4939-6952-4_3","article-title":"Biofluid proteomics and biomarkers in traumatic brain injury","volume":"1598","author":"Azar","year":"2017","journal-title":"Methods Mol Biol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00651\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T08:41:15Z","timestamp":1616488875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00651\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":49,"alternative-id":["10.3389\/fneur.2020.00651"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.00651","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"article-number":"651"}}