{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:29:11Z","timestamp":1793190551401,"version":"4.5.0"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.01010","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T02:59:26Z","timestamp":1603421966000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["DNA Methylation Patterns of Chronic Explosive Breaching in U.S. Military Warfighters"],"prefix":"10.3389","volume":"11","author":[{"given":"Zhaoyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Nemes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"LaValle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Boutt\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Kamimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Haghighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1212\/CPJ.0b013e318283ffa,2","article-title":"Neurology and the military: five new things","volume":"3","author":"Tsao","year":"2013","journal-title":"Neurol Clin Pract."},{"key":"B2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jemermed.2015.03.013","article-title":"Blast injuries","volume":"49","author":"Mathews","year":"2015","journal-title":"J Emerg Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/MCC.0b013e3280895d5c","article-title":"Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature","volume":"13","author":"Schouten","year":"2007","journal-title":"Curr Opin Crit Care."},{"key":"B4","doi-asserted-by":"publisher","first-page":"8681","DOI":"10.1038\/s41598-018-26813-7","article-title":"Temporal and spatial effects of blast overpressure on blood-brain barrier permeability in traumatic brain injury","volume":"8","author":"Kuriakose","year":"2018","journal-title":"Sci Rep."},{"key":"B5","volume-title":"Public Law No: 115-232: John S. McCain National Defense Authorization Act for Fiscal Year 2019","year":"2019"},{"key":"B6","volume-title":"Public Law No: 116-92: National Defense Authorization Act for Fiscal Year 2020","year":"2020"},{"key":"B7","volume-title":"Gulf War and Health: Long-term Effects of Blast Exposures","year":"2014"},{"key":"B8","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1089\/neu.2008.0748","article-title":"Blast overpressure in rats: recreating a battlefield injury in the laboratory","volume":"26","author":"Long","year":"2009","journal-title":"J Neurotrauma."},{"key":"B9","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1682\/JRRD.2008.09.0129","article-title":"Auditory and visual impairments in patients with blast-related traumatic brain injury: effect of dual sensory impairment on Functional","volume":"46","author":"Measure","year":"2009","journal-title":"J Rehabil Res Dev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3109\/02699052.2010.536195","article-title":"Visual dysfunction following blast-related traumatic brain injury from the battlefield","volume":"25","author":"Dougherty","year":"2011","journal-title":"Brain Injury."},{"key":"B11","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1089\/neu.2010.1540","article-title":"Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury","volume":"28","author":"Garman","year":"2011","journal-title":"J Neurotrauma."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1682\/JRRD.2011.09.0182","article-title":"Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures","volume":"49","author":"Valiyaveettil","year":"2012","journal-title":"J Rehabil Res Dev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3171\/jns.1979.50.2.0260","article-title":"Subdural hematoma in an adult following a blast injury","volume":"50","author":"Murthy","year":"1979","journal-title":"J Neurosurg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0300-483X(97)03652-4","article-title":"The pathology of primary blast overpressure injury","volume":"121","author":"Mayorga","year":"1997","journal-title":"Toxicology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1080\/02699050010009559","article-title":"Cognitive deficits following blast injury-induced neurotrauma: possible involvement of nitric oxide","volume":"15","author":"Cernak","year":"2001","journal-title":"Brain Inj."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1056\/NEJMp058102","article-title":"Traumatic brain injury in the war zone","volume":"352","author":"Okie","year":"2005","journal-title":"N Engl J Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.ncl.2008.02.001","article-title":"Management of traumatic brain injury in the intensive care unit","volume":"26","author":"Ling","year":"2008","journal-title":"Neurol Clin."},{"key":"B18","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1682\/JRRD.2008.02.0028","article-title":"Headaches among Operation Iraqi Freedom\/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions","volume":"45","author":"Ruff","year":"2008","journal-title":"J Rehabil Res Dev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3233\/JAD-130182","article-title":"Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury","volume":"37","author":"Huber","year":"2013","journal-title":"J Alzheimers Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.cbi.2012.10.022","article-title":"Modulation of cholinergic pathways and inflammatory mediators in blast-induced traumatic brain injury","volume":"203","author":"Valiyaveettil","year":"2013","journal-title":"Chem Biol Interact."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1101\/738054","article-title":"Acute and chronic molecular signatures and associated symptoms of blast exposure in military breachers","volume":"37","author":"Wang","year":"2019","journal-title":"J Neurotrauma."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e186","DOI":"10.1212\/NXG.0000000000000186","article-title":"Moderate blast exposure alters gene expression and levels of amyloid precursor protein","volume":"3","author":"Gill","year":"2017","journal-title":"Neurol Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fneur.2020.00091","article-title":"A moderate blast exposure results in dysregulated gene network activity related to cell death, survival, structure, and metabolism","volume":"11","author":"Edwards","year":"2020","journal-title":"Front Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/HTR.0000000000000064","article-title":"Relation of repeated low-level blast exposure with symptomology similar to concussion","volume":"30","author":"Carr","year":"2015","journal-title":"J Head Trauma Rehabil."},{"key":"B25","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/BF00868811","article-title":"The rivermead post concussion symptoms questionnaire: a measure of symptoms commonly experienced after head injury and its reliability","volume":"242","author":"King","year":"1995","journal-title":"J Neurol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1037\/pas0000486","article-title":"The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5): development and initial psychometric evaluation in military veterans","volume":"30","author":"Weathers","year":"2018","journal-title":"Psychol Assess."},{"key":"B27","volume-title":"2012 National Strategy for Suicide Prevention: Goals and Objectives for action: a report of the US Surgeon General and of the National Action Alliance for Suicide Prevention","author":"General","year":"2012"},{"key":"B28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa040603","article-title":"Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care","volume":"351","author":"Hoge","year":"2004","journal-title":"N Engl J Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1101\/gr.4410706","article-title":"High-throughput DNA methylation profiling using universal bead arrays","volume":"16","author":"Bibikova","year":"2006","journal-title":"Genome Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bmcl.2013.11.052","article-title":"Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors","volume":"24","author":"He","year":"2014","journal-title":"Bioorg Med Chem Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1093\/bioinformatics\/bts545","article-title":"Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values","volume":"28","author":"Pedersen","year":"2012","journal-title":"Bioinformatics."},{"key":"B35","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1471-2105-13-86","article-title":"DNA methylation arrays as surrogate measures of cell mixture distribution","volume":"13","author":"Houseman","year":"2012","journal-title":"BMC Bioinformatics."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e71690","DOI":"10.1371\/journal.pone.0071690","article-title":"An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element","volume":"8","author":"Clop","year":"2013","journal-title":"PLoS ONE."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e0167212","DOI":"10.1371\/journal.pone.0167212","article-title":"Gene-based genome-wide association analysis in European and Asian Populations Identified Novel Genes for rheumatoid arthritis","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS ONE."},{"key":"B39","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s00438-018-1435-4","article-title":"HLA-C*06:02-independent, gender-related association of PSORS1C3 and PSORS1C1\/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis","volume":"293","author":"Wisniewski","year":"2018","journal-title":"Mol Genet Genomics."},{"key":"B40","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.joca.2005.04.016","article-title":"Accelerated osteoarthritis in the temporomandibular joint of biglycan\/fibromodulin double-deficient mice","volume":"13","author":"Wadhwa","year":"2005","journal-title":"Osteoarthritis Cartilage."},{"key":"B41","doi-asserted-by":"publisher","first-page":"949","DOI":"10.5665\/sleep.1958","article-title":"Altered sleep and affect in the neurotensin receptor 1 knockout mouse","volume":"35","author":"Fitzpatrick","year":"2012","journal-title":"Sleep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fncir.2018.00013","article-title":"F-spondin is essential for maintaining circadian rhythms","volume":"12","author":"Carrillo","year":"2018","journal-title":"Front Neural Circuits."},{"key":"B43","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/ng0598-87","article-title":"Follicular cells of the thyroid gland require Pax8 gene function","volume":"19","author":"Mansouri","year":"1998","journal-title":"Nat Genetics."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/mp.2014.133","article-title":"Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study","volume":"20","author":"Gottlieb","year":"2015","journal-title":"Mol Psychiatry."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e1006125","DOI":"10.1371\/journal.pgen.1006125","article-title":"Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci","volume":"12","author":"Jones","year":"2016","journal-title":"PLoS Genetics."},{"key":"B46","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s11920-013-0401-4","article-title":"Deployment-related insomnia in military personnel and veterans","volume":"15","author":"Bramoweth","year":"2013","journal-title":"Curr Psychiatry Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.5665\/sleep.5972","article-title":"The national veteran sleep disorder study: descriptive epidemiology and secular trends, 2000\u20132010","volume":"39","author":"Alexander","year":"2016","journal-title":"Sleep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1378\/chest.11-1603","article-title":"Sleep disturbances among soldiers with combat-related traumatic brain injury","volume":"142","author":"Collen","year":"2012","journal-title":"Chest."},{"key":"B49","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ejmg.2006.10.005","article-title":"Clinical presentation of a variant of Axenfeld\u2013Rieger syndrome associated with subtelomeric 6p deletion","volume":"50","author":"Martinez-Glez","year":"2007","journal-title":"Eur J Med Genetics."},{"key":"B50","first-page":"243","article-title":"A boy with cleft palate, hearing impairment, microcephaly, micrognathia and psychomotor retardation and a microdeletion in 6p25.3 involving the DUSP22 gene","volume":"24","author":"Chen","year":"2013","journal-title":"Genet Couns"},{"key":"B51","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1749-6632.1999.tb11293.x","article-title":"Molecular diversity of K+ channels","volume":"868","author":"Coetzee","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"B52","author":"Miller","year":"2000","journal-title":"An Overview of the Potassium Channel Family"},{"key":"B53","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.heares.2007.01.024","article-title":"Potassium channel gene expression in the rat cochlear nucleus","volume":"228","author":"Friedland","year":"2007","journal-title":"Hear Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.mad.2004.08.012","article-title":"Superoxide dismutase evolution and life span regulation","volume":"126","author":"Landis","year":"2005","journal-title":"Mech Ageing Dev."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear."},{"key":"B56","first-page":"70","article-title":"Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs","volume":"29","author":"Fetoni","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"B57","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.heares.2006.04.003","article-title":"Effects of antioxidants on the aging inner ear","volume":"226","author":"Le","year":"2007","journal-title":"Hear Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1089\/neu.2011.1990","article-title":"Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice","volume":"28","author":"Wang","year":"2011","journal-title":"J Neurotrauma"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.2174\/092986710792927895","article-title":"Oxidative stress in the cochlea: an update","volume":"17","author":"Poirrier","year":"2010","journal-title":"Curr Med Chem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1002\/ar.22594","article-title":"Low dose oxidative stress induces mitochondrial damage in hair cells","volume":"295","author":"Baker","year":"2012","journal-title":"Anat Rec."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15761\/NDT.1000117","article-title":"The role of mitochondrial oxidative stress in hearing loss","volume":"1","author":"Gonzalez-Gonzalez","year":"2017","journal-title":"Neurol Disord Therap."},{"key":"B62","doi-asserted-by":"publisher","first-page":"63324","DOI":"10.18632\/oncotarget.18803","article-title":"Target sequencing of 307 deafness genes identifies candidate genes implicated in microtia","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"B63","first-page":"18","article-title":"Clinical analysis of 592 patients with microtia","volume":"525","author":"Okajima","year":"1996","journal-title":"Acta Otolaryngol Suppl"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/j.ijporl.2007.04.020","article-title":"Microtia in Finland: comparison of characteristics in different populations","volume":"71","author":"Suutarla","year":"2007","journal-title":"Int J Pediatric Otorhinolaryngol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1055\/s-0035-1568139","article-title":"Congenital auricular malformations: description of anomalies and syndromes","volume":"31","author":"Bartel-Friedrich","year":"2015","journal-title":"Facial Plast Surg"},{"key":"B66","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1097\/00129492-200604000-00022","article-title":"Identification of 2.3-Mb gene locus for congenital aural atresia in 18q22.3 deletion: a case report analyzed by comparative genomic hybridization","volume":"27","author":"Dostal","year":"2006","journal-title":"Otol Neurotol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/mds.25868","article-title":"Novel mutation of the WDR45 gene causing beta-propeller protein-associated neurodegeneration","volume":"29","author":"Rathore","year":"2014","journal-title":"Mov Disord"},{"key":"B68","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1055\/s-0035-1571189","article-title":"Beta propellar protein-associated neurodegeneration: a rare cause of infantile autistic regression and intracranial calcification","volume":"47","author":"Yoganathan","year":"2016","journal-title":"Neuropediatrics"},{"key":"B69","year":"2020","journal-title":"Wdr45 Data Chart International Mouse Phenotyping Consortium"},{"key":"B70","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1177\/00034894021110S304","article-title":"Recent advances in otitis media. 1. Definitions, terminology, and classification of otitis media","volume":"188","author":"Gates","year":"2002","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"B71","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s10162-002-3023-9","article-title":"Expression of mucins in mucoid otitis media","volume":"4","author":"Lin","year":"2003","journal-title":"J Assoc Res Otolaryngol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1023\/A:1006901213526","article-title":"Heterogeneity in the protein cores of mucins isolated from human middle ear effusions: evidence for expression of different mucin gene products","volume":"15","author":"Hutton","year":"1998","journal-title":"Glycoconj J"},{"key":"B73","doi-asserted-by":"publisher","first-page":"L1157","DOI":"10.1152\/ajplung.2001.280.6.L1157","article-title":"Characterization of mucins in human middle ear and Eustachian tube","volume":"280","author":"Lin","year":"2001","journal-title":"Am J Physiol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1177\/000348940211100506","article-title":"Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: the pathological basis for mucin hyperproduction in mucoid otitis media","volume":"111","author":"Haruta","year":"2002","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.heares.2015.10.010","article-title":"Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma","volume":"333","author":"Yang","year":"2016","journal-title":"Hearing Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1682\/JRRD.2007.09.0140","article-title":"Auditory dysfunction in traumatic brain injury","volume":"44","author":"Lew","year":"2007","journal-title":"J Rehabil Res Dev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1682\/JRRD.2008.09.0118","article-title":"Auditory and vestibular dysfunction associated with blast-related traumatic brain injury","volume":"46","author":"Fausti","year":"2009","journal-title":"J Rehabil Res Dev."},{"key":"B78","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000057660","article-title":"Characteristics of tinnitus induced by acute acoustic trauma: a long-term follow-up","volume":"7","author":"Mrena","year":"2002","journal-title":"Audiol Neurotol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1089\/neu.2011.1934","article-title":"Blast-induced tinnitus and hearing loss in rats: behavioral and imaging assays","volume":"29","author":"Mao","year":"2012","journal-title":"J Neurotrauma."},{"key":"B80","first-page":"1","year":"2018","journal-title":"Annual Benefits Report: Fiscal Year"},{"key":"B81","doi-asserted-by":"publisher","first-page":"D1047","DOI":"10.1093\/nar\/gkr1182","article-title":"GWASdb: a database for human genetic variants identified by genome-wide association studies","volume":"40","author":"Li","year":"2012","journal-title":"Nucl Acids Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"baw100","DOI":"10.1093\/database\/baw100","article-title":"The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins","volume":"2016","author":"Rouillard","year":"2016","journal-title":"Database."},{"key":"B83","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41588-019-0361-7","article-title":"Biological and clinical insights from genetics of insomnia symptoms","volume":"51","author":"Lane","year":"2019","journal-title":"Nat Genet."},{"key":"B84","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.prostaglandins.2005.07.001","article-title":"Lipid signaling: sleep, synaptic plasticity, and neuroprotection","volume":"77","author":"Chen","year":"2005","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"B85","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jbior.2018.09.002","article-title":"Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism","volume":"71","author":"Bowman","year":"2019","journal-title":"Adv Biol Regul."},{"key":"B86","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11910-018-0868-9","article-title":"Cerebral metabolic changes during sleep","volume":"18","author":"Aalling","year":"2018","journal-title":"Curr Neurol Neurosci Rep."},{"key":"B87","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1086\/425589","article-title":"Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain","volume":"75","author":"Chen","year":"2004","journal-title":"Am J Human Genet."},{"key":"B88","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1601-183X.2005.00163.x","article-title":"The molecular genetics of cognition: dopamine, COMT and BDNF","volume":"5","author":"Savitz","year":"2006","journal-title":"Genes Brain Behav."},{"key":"B89","doi-asserted-by":"publisher","first-page":"zsy007","DOI":"10.1093\/sleep\/zsy007","article-title":"Fast sleep spindle density is associated with rs4680 (Val108\/158Met) genotype of catechol-O-methyltransferase (COMT)","volume":"41","author":"Schilling","year":"2018","journal-title":"Sleep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/00008571-199606000-00007","article-title":"Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders","volume":"6","author":"Lachman","year":"1996","journal-title":"Pharmacogenetics."},{"key":"B91","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev.pharmtox.39.1.19","article-title":"Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase","volume":"39","author":"Weinshilboum","year":"1999","journal-title":"Ann Rev Pharmacol Toxicol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.cortex.2017.11.012","article-title":"Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation","volume":"99","author":"Satterfield","year":"2018","journal-title":"Cortex."},{"key":"B93","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3109\/07420528.2014.896376","article-title":"Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep\u2013wake cycles in young adults","volume":"31","author":"Valomon","year":"2014","journal-title":"Chronobiol Int."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1093\/sleep\/33.12.1615","article-title":"Sleep patterns before, during, and after deployment to Iraq and Afghanistan","volume":"33","author":"Seelig","year":"2010","journal-title":"Sleep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.5665\/SLEEP.1236","article-title":"Prevalence and impact of short sleep duration in redeployed OIF soldiers","volume":"34","author":"Luxton","year":"2011","journal-title":"Sleep."},{"key":"B96","doi-asserted-by":"publisher","first-page":"167","DOI":"10.5665\/sleep.2364","article-title":"Sleep disorders and associated medical comorbidities in active duty military personnel","volume":"36","author":"Mysliwiec","year":"2013","journal-title":"Sleep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3389\/fphar.2019.01475","article-title":"Fibromodulin\u2014a new target of osteoarthritis management?","volume":"10","author":"Li","year":"2019","journal-title":"Front Pharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1016\/j.joms.2010.03.003","article-title":"Facial skin-mucosal biodynamic blast injuries and management","volume":"68","author":"Shuker","year":"2010","journal-title":"J Oral Maxillofacial Surg."},{"key":"B99","doi-asserted-by":"publisher","first-page":"60","DOI":"10.4103\/2277-9531.134765","article-title":"Temporomandibular joint health status in war veterans with post-traumatic stress disorder","volume":"3","author":"Mottaghi","year":"2014","journal-title":"J Edu Health Promotion."},{"key":"B100","doi-asserted-by":"publisher","first-page":"363","DOI":"10.5125\/jkaoms.2017.43.6.363","article-title":"Association between headache and temporomandibular disorder","volume":"43","author":"Abouelhuda","year":"2017","journal-title":"J Korean Assoc Oral Maxillofacial Surgeons."},{"key":"B101","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/j.1526-4610.2012.02112.x","article-title":"Chronic daily headache in US soldiers after concussion","volume":"52","author":"Theeler","year":"2012","journal-title":"Headache"},{"key":"B102","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s11916-012-0294-7","article-title":"Combat-related headache and traumatic brain injury","volume":"16","author":"Waung","year":"2012","journal-title":"Curr Pain Headache Rep"},{"key":"B103","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1016\/j.apmr.2017.04.008","article-title":"Associations between traumatic brain injury history and future headache severity in veterans: a longitudinal study","volume":"98","author":"Suri","year":"2017","journal-title":"Arch Phys Med Rehabil"},{"key":"B104","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.amjmed.2017.02.013","article-title":"Joint hypermobility syndrome: recognizing a commonly overlooked cause of chronic pain","volume":"130","author":"Kumar","year":"2017","journal-title":"Am J Med."},{"key":"B105","first-page":"S116","article-title":"Hypermobility, the Ehlers-Danlos syndromes and chronic pain","volume":"35","author":"Syx","year":"2017","journal-title":"Clin Exp Rheumatol."},{"key":"B106","volume-title":"Joint Hypermobility Syndrome: A Common Clinical Disorder Associated with Migraine Headache in Women","author":"Bendik","year":"2010"},{"key":"B107","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/HTR.0b013e3181957032","article-title":"The Veterans Health Administration system of care for mild traumatic brain injury: costs, benefits, and controversies","volume":"24","author":"Belanger","year":"2009","journal-title":"J Head Trauma Rehabil."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/j.1526-4610.2011.01946.x","article-title":"Prevalence and treatment of headaches in veterans with mild traumatic brain injury","volume":"51","author":"Patil","year":"2011","journal-title":"Headache."},{"key":"B109","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1191\/0269215505cr905oa","article-title":"Construct validity and reliability of the rivermead post-concussion symptoms questionnaire","volume":"19","author":"Eyres","year":"2005","journal-title":"Clin Rehabil"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.01010\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T02:59:32Z","timestamp":1603421972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.01010\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":109,"alternative-id":["10.3389\/fneur.2020.01010"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.01010","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]},"article-number":"1010"}}