{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:02Z","timestamp":1787026922873,"version":"build-2736575974"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.549624","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T04:44:43Z","timestamp":1601441083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Serum Protein Biomarker Findings Reflective of Oxidative Stress and Vascular Abnormalities in Male, but Not Female, Collision Sport Athletes"],"prefix":"10.3389","volume":"11","author":[{"given":"Brendan P.","family":"Major","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia F.","family":"Symons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan","family":"Clough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhys D.","family":"Brady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Mccullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne","family":"Aniceto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hsuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richelle","family":"Mychasiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denes V.","family":"Agoston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy R.","family":"Shultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"935","DOI":"10.3233\/JAD-190115","article-title":"Long-term neurological consequences related to boxing and American football: a review of the literature","volume":"69","author":"Casson","year":"2019","journal-title":"J Alzheimer's Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.mcn.2015.03.012","article-title":"Neurological consequences of traumatic brain injuries in sports","volume":"66","author":"Ling","year":"2015","journal-title":"Mol Cell Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1089\/neu.2019.6884","article-title":"The neurological consequences of engaging in Australian collision sports","volume":"809","author":"Symons","year":"2020","journal-title":"J Neurotrauma."},{"key":"B4","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1136\/bjsports-2017-097569","article-title":"Consensus statement on concussion in sport\u2014the 5th international conference on concussion in sport held in Berlin, October 2016","volume":"51","author":"McCrory","year":"2017","journal-title":"Br J Sports Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ijpsycho.2018.01.007","article-title":"Subconcussive head impacts in sport: a systematic review of the evidence","volume":"132","author":"Mainwaring","year":"2018","journal-title":"Int J Psychophysiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.csm.2017.05.002","article-title":"Sport concussion and the female athlete","volume":"36","author":"Resch","year":"2017","journal-title":"Clin Sports Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.pmr.2016.01.003","article-title":"The molecular pathophysiology of concussive brain injury - an update","volume":"27","author":"Barkhoudarian","year":"2016","journal-title":"Phys Med Rehabil Clin N Am."},{"key":"B8","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.neubiorev.2016.09.014","article-title":"The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies","volume":"76","author":"Shultz","year":"2017","journal-title":"Neurosci Biobehav Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1080\/02699052.2017.1357836","article-title":"Biofluid biomarkers of traumatic brain injury","volume":"31","author":"Agoston","year":"2017","journal-title":"Brain Inj."},{"key":"B10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrneurol.2016.127","article-title":"Fluid Biomarkers for Mild Traumatic Brain Injury and Related Conditions","volume":"10","author":"Zetterberg","year":"2016","journal-title":"Nat Rev Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1227\/NEU.0000000000000505","article-title":"The new neurometabolic cascade of concussion","volume":"75","author":"Giza","year":"2015","journal-title":"Neurosurgery."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e1919771","DOI":"10.1001\/jamanetworkopen.2019.19771","article-title":"Association of blood biomarkers with acute sport-related concussion in collegiate athletes findings from the NCAA and department of defense CARE consortium","volume":"3","author":"McCrea","year":"2020","journal-title":"JAMA Netw Open."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jocn.2018.07.002","article-title":"Sport related concussion \u2013 potential for biomarkers to improve acute management","volume":"56","author":"Costello","year":"2018","journal-title":"J Clin Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"14626","DOI":"10.1038\/s41598-019-51267-w","article-title":"Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat","volume":"9","author":"Wright","year":"2019","journal-title":"Sci Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"29713","DOI":"10.1038\/srep28713","article-title":"Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury","volume":"6","author":"Wright","year":"2016","journal-title":"Sci Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0159929","DOI":"10.1371\/journal.pone.0159929","article-title":"Altered blood biomarker profiles in athletes with a history of repetitive head impacts","volume":"11","author":"Battista","year":"2016","journal-title":"PLoS One."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1242\/dev.072348","article-title":"Diverse roles for VEGF-A in the nervous system","volume":"139","author":"Mackenzie","year":"2012","journal-title":"Development."},{"key":"B18","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fneur.2015.00114","article-title":"The temporal pattern of changes in serum biomarker levels reveal complex and dynamically changing pathologies after exposure to a single low-intensity blast in mice","volume":"6","author":"Ahmed","year":"2015","journal-title":"Front Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"964","DOI":"10.3389\/fneur.2018.00964","article-title":"Early microglial activation following closed-head concussive injury is dominated by pro-inflammatory M-1 type","volume":"9","author":"Madathil","year":"2018","journal-title":"Front Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.clineuro.2016.02.032","article-title":"The role of vascular endothelial growth factor and vascular endothelial growth inhibitor in clinical outcome of traumatic brain injury","volume":"144","author":"Li","year":"2016","journal-title":"Clin Neurol Neurosurg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.nicl.2017.03.006","article-title":"The effect of repetitive subconcussive collisions on brain integrity in collegiate football players over a single football season: a multi-modal neuroimaging study","volume":"14","author":"Slobounov","year":"2017","journal-title":"NeuroImage Clin."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3705","DOI":"10.1002\/elps.201200299","article-title":"Time-dependent changes of protein biomarker levels in the cerebrospinal fluid after blast traumatic brain injury","volume":"33","author":"Ahmed","year":"2012","journal-title":"Electrophoresis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"881","DOI":"10.3892\/etm.2014.1818","article-title":"Overexpression of netrin-1 increases the expression of tight junction-associated proteins, claudin-5, occludin, and ZO-1, following traumatic brain injury in rats","volume":"8","author":"Wen","year":"2014","journal-title":"Exp Ther Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.brainres.2018.12.030","article-title":"Contributions of sex to cerebrovascular function and pathology","volume":"1710","author":"Robison","year":"2019","journal-title":"Brain Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fncel.2014.00328","article-title":"A perspective on the role of class iii semaphorin signaling in central nervous system trauma","volume":"8","author":"Mecollari","year":"2014","journal-title":"Front Cell Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s00421-014-2861-6","article-title":"Circulating angiogenic and inflammatory cytokine responses to acute aerobic exercise in trained and sedentary young men","volume":"114","author":"Landers-Ramos","year":"2014","journal-title":"Eur J Appl Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"C537","DOI":"10.1152\/ajpcell.00101.2016","article-title":"4-Hydroxy-2-nonenal: a critical target in oxidative stress?","volume":"311","author":"Breitzig","year":"2016","journal-title":"Am J Physiol Cell Physiol."},{"key":"B28","first-page":"267","article-title":"GSH transporters: molecular characterization role in GSH homeostasis","volume":"377","author":"Kaplowitz","year":"1996","journal-title":"Biol Chem Hoppe Seyler."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1164\/rccm.200311-1516OC","article-title":"Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis","volume":"170","author":"Kettle","year":"2004","journal-title":"Am J Respir Crit Care Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1067\/mlc.2000.105976","article-title":"Blood glutathione and cysteine changes in cardiovascular disease","volume":"135","author":"Mills","year":"2000","journal-title":"J Lab Clin Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1177\/0963689717714092","article-title":"Repeated mild traumatic brain injury: potential mechanisms of damage","volume":"26","author":"Fehily","year":"2017","journal-title":"Cell Transplant."},{"key":"B32","doi-asserted-by":"publisher","first-page":"E2123","DOI":"10.1212\/WNL.0000000000006616","article-title":"Concussion BASICS II: baseline serum biomarkers, head impact exposure, and clinical measures","volume":"91","author":"Asken","year":"2018","journal-title":"Neurology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e0206466","DOI":"10.1371\/journal.pone.0206466","article-title":"No change in plasma tau and serum neurofilament light concentrations in adolescent athletes following sport-related concussion","volume":"13","author":"Wallace","year":"2018","journal-title":"PLoS One."},{"key":"B34","doi-asserted-by":"publisher","first-page":"E2133","DOI":"10.1212\/WNL.0000000000006617","article-title":"Concussion BASICS III: serum biomarker changes following sport-related concussion","volume":"91","author":"Asken","year":"2018","journal-title":"Neurology."},{"key":"B35","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1089\/neu.2016.4413","article-title":"Cumulative head impact exposure predicts later-life depression, apathy, executive dysfunction, and cognitive impairment in former high school and college football players","volume":"34","author":"Montenigro","year":"2017","journal-title":"J Neurotrauma."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1249\/MSS.0000000000000591","article-title":"Head impact exposure and neurologic function of youth football players","volume":"47","author":"Munce","year":"2015","journal-title":"Med Sci Sports Exerc."},{"key":"B37","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cyto.2015.08.007","article-title":"Peripheral blood proinflammatory response in women during menstrual cycle and endometriosis","volume":"76","author":"Sikora","year":"2015","journal-title":"Cytokine."},{"key":"B38","doi-asserted-by":"publisher","first-page":"A486","DOI":"10.1016\/j.autrev.2011.11.023","article-title":"Immunology and the menstrual cycle","volume":"11","author":"Oertelt-Prigione","year":"2012","journal-title":"Autoimmun Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/acn3.441","article-title":"Sex matters: repetitive mild traumatic brain injury in adolescent rats","volume":"4","author":"Wright","year":"2017","journal-title":"Ann Clin Transl Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1080\/02699052.2020.1725129","article-title":"Neurofilament light and tau in serum after head-impact exposure in soccer","volume":"34","author":"Sandmo","year":"2020","journal-title":"Brain Inj."},{"key":"B41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12865-020-0339-3","article-title":"The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion","volume":"21","author":"Di Battista","year":"2020","journal-title":"BMC Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fneur.2018.00239","article-title":"A preliminary report on brain-derived extracellular vesicle as novel blood biomarkers for sport-related concussions","volume":"9","author":"Kawata","year":"2018","journal-title":"Front Neurol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"115263","DOI":"10.1016\/j.bone.2020.115263","article-title":"A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury","volume":"133","author":"Brady","year":"2020","journal-title":"Bone."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.549624\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T04:44:45Z","timestamp":1601441085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.549624\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":43,"alternative-id":["10.3389\/fneur.2020.549624"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.549624","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"article-number":"549624"}}