{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:02:04Z","timestamp":1787108524162,"version":"build-2736575974"},"reference-count":121,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371289"],"award-info":[{"award-number":["81371289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>This study reported two cases of intracranial thrombotic events of aplastic anemia (AA) under therapy with cyclosporine-A (CsA) and reviewed both drug-induced cerebral venous thrombosis (CVT) and CsA-related thrombotic events systematically. We searched PubMed Central (PMC) and EMBASE up to Sep 2019 for publications on drug-induced CVT and Cs-A-induced thrombotic events. Medical subject headings and Emtree headings were used with the following keywords: \u201ccyclosporine-A\u201d and \u201ccerebral venous thrombosis OR cerebral vein thrombosis\u201d and \u201cstroke OR Brain Ischemia OR Brain Infarction OR cerebral infarction OR intracerebral hemorrhage OR intracranial hemorrhage.\u201d We found that CsA might be a significant risk factor in inducing not only CVT but also cerebral arterial thrombosis in patients with AA.<\/jats:p>","DOI":"10.3389\/fneur.2020.563037","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T17:48:06Z","timestamp":1613238486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cyclosporine-A-Induced Intracranial Thrombotic Complications: Systematic Review and Cases Report"],"prefix":"10.3389","volume":"11","author":[{"given":"Si-ying","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-ao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-chuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun-ming","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9139","DOI":"10.1186\/1757-1626-2-9139","article-title":"A kidney transplant patient on cyclosporine therapy presenting with dural venous sinus thrombosis: a case report","volume":"2","author":"Rajapakse","year":"2009","journal-title":"Cases J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/01.tp.0000232286.22319.e0","article-title":"Subclinical inflammation and prothrombotic state in heart transplant recipients: impact of cyclosporin microemulsion vs. tacrolimus","volume":"82","author":"White","year":"2006","journal-title":"Transplantation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"ii54","DOI":"10.1093\/ndt\/gfh1083","article-title":"Spectrum of surgical complications after simultaneous pancreas-kidney transplantation in a prospectively randomized study of two immunosuppressive protocols","volume":"20","author":"Steurer","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1111\/j.1538-7836.2005.01387.x","article-title":"A case of cyclosporine-induced dural sinus thrombosis","volume":"3","author":"Al-Shekhlee","year":"2005","journal-title":"J Thromb Haemost"},{"key":"B5","doi-asserted-by":"publisher","first-page":"400","DOI":"10.2169\/internalmedicine.43.400","article-title":"Cerebral sinus thrombosis associated with severe active ulcerative colitis","volume":"43","author":"Murata","year":"2004","journal-title":"Intern Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"A535","DOI":"10.1177\/2050640614548980","article-title":"Cyclosporin A in acute steroid-refractory or dependent ulcerative colitis: a prospective study on long term outcome","volume":"2","author":"Nieminen","year":"2014","journal-title":"U Eur Gastroenterol J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e11642","DOI":"10.1097\/MD.0000000000011642","article-title":"Cyclosporin A-related cerebral venous sinus thrombosis: a case report","volume":"97","author":"Gao","year":"2018","journal-title":"Medicine"},{"key":"B8","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S0140-6736(85)91610-1","article-title":"Thromboembolic complications and haemostatic changes in cyclosporin-treated cadaveric kidney allograft recipients","volume":"1","author":"Vanrenterghem","year":"1985","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"ii3","DOI":"10.1093\/ndt\/gfh1076","article-title":"Efficacy and safety of tacrolimus compared with cyclosporin microemulsion in primary spk transplantation: 3-year results of the euro-spk 001 trial","volume":"20","author":"Saudek","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"B10","doi-asserted-by":"publisher","first-page":"5414","DOI":"10.2174\/092986711798194405","article-title":"Immunophilins and thrombotic disorders","volume":"18","author":"Lopez","year":"2011","journal-title":"Curr Med Chem"},{"key":"B11","first-page":"183","article-title":"thrombosis of the superior longitudinal sinus after sacculoradiculography with iopamidol","volume":"53","author":"Glowinski","year":"1986","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"B12","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/BF00626091","article-title":"Cerebral venous thrombosis after myelography with iopamidol","volume":"38","author":"Brugeilles","year":"1996","journal-title":"Neuroradiology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1136\/jnnp.56.9.1035","article-title":"Cerebral venous sinus thrombosis induced by 'ecstasy'","volume":"56","author":"Rothwell","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B14","first-page":"404","article-title":"Intracranial sinus thrombosis secondary to the consumption of inhaled speed","volume":"39","author":"M\u00e9ndez-S\u00e1nchez","year":"2011","journal-title":"Actas Esp Psiquiatr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"A1","DOI":"10.1136\/jnnp-2012-304200a.3","article-title":"An unpleasant hit from cocaine: a case of cocaine-induced cerebral venous sinus thrombosis","volume":"83","author":"Burns","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.2169\/internalmedicine.56.7864","article-title":"The development of cerebral venous thrombosis after tadalafil ingestion in a patient with antiphospholipid syndrome","volume":"56","author":"Numata","year":"2017","journal-title":"Intern Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jns.2007.05.011","article-title":"Recurrent venous thrombosis including cerebral venous sinus thrombosis in a patient taking sildenafil for erectile dysfunction","volume":"260","author":"Rufa","year":"2007","journal-title":"J Neurol Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/trf.12897","article-title":"Intravenous immunoglobulin-associated thrombosis: is it such a rare event? Report of a pediatric case and of the quebec hemovigilance system","volume":"55","author":"Benadiba","year":"2015","journal-title":"Transfusion"},{"key":"B19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/pbc.22968","article-title":"Cerebral sinus thrombosis following iv immunoglobulin therapy of immune thrombocytopenia purpura","volume":"57","author":"Al-Riyami","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1055\/s-2008-1077088","article-title":"Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report","volume":"39","author":"Barada","year":"2008","journal-title":"Neuropediatrics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/ajh.21107","article-title":"Fatal case of bilateral internal jugular vein thrombosis following ivig infusion in an adolescent girl treated for itp","volume":"83","author":"Iroh Tam","year":"2008","journal-title":"Am J Hematol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"bcr2018226346","DOI":"10.1136\/bcr-2018-226346","article-title":"Dulaglutide-induced cerebral venous thrombosis in a patient with type 2 diabetes mellitus","volume":"2018","author":"Rajput","year":"2018","journal-title":"BMJ Case Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/imj.12765","article-title":"Extensive cerebral venous sinus thrombosis after romiplostim treatment for immune thrombocytopenia (itp) despite severe thrombocytopenia","volume":"45","author":"Ho","year":"2015","journal-title":"Intern Med J"},{"key":"B24","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1001\/archneur.57.2.260","article-title":"Cerebral venous thrombosis associated with epoetin alfa therapy","volume":"57","author":"Finelli","year":"2000","journal-title":"Arch Neurol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1515\/jcim-2012-0003","article-title":"Iatrogenic venous thrombosis secondary to supplemental medicine toxicity","volume":"10","author":"Newey","year":"2013","journal-title":"J complement integrat Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1212\/WNL.54.2.532","article-title":"Superior sagittal sinus thrombosis due to lithium: local urokinase thrombolysis treatment","volume":"54","author":"Wasay","year":"2000","journal-title":"Neurology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"423","DOI":"10.5692\/clinicalneurol.54.423","article-title":"Two cases of stroke associated with the use of finasteride, an approved drug for male-pattern hair loss in japan","volume":"54","author":"Tsuji","year":"2014","journal-title":"Clin Neurol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/nep.12121","article-title":"Cerebral sinus venous thrombosis temporally associated with combination tacrolimus\/sirolimus immunosuppression","volume":"18","author":"Graves","year":"2013","journal-title":"Nephrology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/JCP.0b013e3181deb88a","article-title":"Clozapine-associated cerebral venous thrombosis","volume":"30","author":"Srinivasaraju","year":"2010","journal-title":"J Clin Psychopharmacol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1055\/s-0030-1247524","article-title":"Thrombocytopenia as an adverse effect of levetiracetam therapy in a child","volume":"40","author":"Mohamed","year":"2009","journal-title":"Neuropediatrics"},{"key":"B31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000086805","article-title":"Phytoestrogens as a risk factor for cerebral sinus thrombosis","volume":"20","author":"Guimaraes","year":"2005","journal-title":"Cerebrovasc Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.3171\/2018.4.FOCUS1891","article-title":"Cerebral venous thrombosis requiring invasive treatment for elevated intracranial pressure in women with combined hormonal contraceptive intake: risk factors, anatomical distribution, and clinical presentation","volume":"45","author":"Roethlisberger","year":"2018","journal-title":"Neurosurg focus"},{"key":"B33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/TME.0b013e318243552c","article-title":"A 21-year-old white woman diagnosed with cerebral venous sinus thrombosis related to oral contraceptive and factor v leiden","volume":"34","author":"Wharton","year":"2012","journal-title":"Adv Emerg Nurs J"},{"key":"B34","first-page":"S162","article-title":"Oc pills induced cerebral venous sinus thrombosis: a case series","volume":"45","author":"Wankhade","year":"2013","journal-title":"Indian J Pharmacol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1177\/0009922814533405","article-title":"Cerebral venous sinus thrombosis with ophthalmic manifestations in 18-year-olds on oral contraceptives","volume":"53","author":"Tan","year":"2014","journal-title":"Clin Pediatr"},{"key":"B36","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3109\/tcic.6.1.36.39","article-title":"Aggressive treatment of severe acute cerebral venous thrombosis associated with oral contraceptives in young women","volume":"6","author":"Rosi","year":"1995","journal-title":"Clin Intensive Care"},{"key":"B37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1177\/159101990401000406","article-title":"Oral contraceptive induced cerebral venous thrombosis treated by local catheter directed thrombolysis","volume":"10","author":"Prochazka","year":"2004","journal-title":"Interv Neuroradiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/path.1711060402","article-title":"The pathology of intracranial venous thrombosis in oral contraception","volume":"106","author":"Poltera","year":"1972","journal-title":"J pathol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/S0140-6736(70)91046-9","article-title":"Intracranial venous thrombosis as complication of oral contraception","volume":"1","author":"Atkinson","year":"1970","journal-title":"Lancet"},{"key":"B40","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1001\/archneur.1970.00480230058006","article-title":"Dural sinus and cerebral venous thrombosis. incidence in young women receiving oral contraceptives","volume":"22","author":"Buchanan","year":"1970","journal-title":"Arch neurol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1001\/archopht.1965.00970040630009","article-title":"Oral contraceptives and neuro-ophthalmologic interest","volume":"74","author":"Walsh","year":"1965","journal-title":"Arch Ophthalmol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/fcp.12066","article-title":"Hormonal contraception or cyproterone acetate and thromboembolic events: a study in 30 french public hospitals","volume":"28","author":"Petitpain","year":"2014","journal-title":"Fundam Clin Pharmacol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.optm.2010.01.010","article-title":"\u201cIdiopathic\u201d intracranial hypertension caused by venous sinus thrombosis associated with contraceptive usage","volume":"81","author":"Perez","year":"2010","journal-title":"Optometry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e16440","DOI":"10.1097\/MD.0000000000016440","article-title":"A case report of oral contraceptive misuse induced cerebral venous sinus thrombosis and dural arteriovenous fistula","volume":"98","author":"Huang","year":"2019","journal-title":"Medicine"},{"key":"B45","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1177\/107602960401000308","article-title":"Effect of age on oral contraceptive-induced venous thrombosis","volume":"10","author":"Girolami","year":"2004","journal-title":"Clin Appl Thromb\/Hemost"},{"key":"B46","doi-asserted-by":"publisher","first-page":"E5","DOI":"10.3171\/2009.8.FOCUS09158","article-title":"Cerebral venous sinus thrombosis associated with oral contraceptives: the case for neurosurgery","volume":"27","author":"Galarza","year":"2009","journal-title":"Neurosurg Focus"},{"key":"B47","doi-asserted-by":"publisher","first-page":"bcr2017222418","DOI":"10.1136\/bcr-2017-222418","article-title":"Norethisterone enanthate-induced cerebral venous sinus thrombosis (cvst)","volume":"2017","author":"Bahall","year":"2017","journal-title":"BMJ Case Rep"},{"key":"B48","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.jemermed.2011.06.011","article-title":"The combined vaginal contraceptive ring, nuvaring, and cerebral venous sinus thrombosis: a case report and review of the literature","volume":"42","author":"Kolacki","year":"2012","journal-title":"J Emerg Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S1701-2163(16)34454-1","article-title":"Cerebral venous sinus thrombosis in a woman using the etonogestrel-ethinyl estradiol vaginal contraceptive ring: a case report","volume":"32","author":"Dunne","year":"2010","journal-title":"J Obstet Gynaecol Can"},{"key":"B50","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0022-510X(01)00448-8","article-title":"Cerebral venous thrombosis associated with tentorial subdural hematoma during oxymetholone therapy","volume":"185","author":"Chu","year":"2001","journal-title":"J Neurol Sci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-2377-4-22","article-title":"Androgen-induced cerebral venous sinus thrombosis in a young body builder: case report","volume":"4","author":"Sahraian","year":"2004","journal-title":"BMC Neurol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/BF00313866","article-title":"Superior sagittal sinus thrombosis associated with evans' syndrome of haemolytic anaemia","volume":"232","author":"Shiozawa","year":"1985","journal-title":"J Neurol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"762","DOI":"10.4103\/0028-3886.86557","article-title":"Danazol-induced life-threatening cerebral venous thrombosis in a patient with aplastic anemia","volume":"59","author":"Sudheer Kumar","year":"2011","journal-title":"Neurol India"},{"key":"B54","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0002-9394(89)90206-7","article-title":"Pseudotumor cerebri induced by danazol","volume":"107","author":"Hamed","year":"1989","journal-title":"Am J Ophthalmol"},{"key":"B55","first-page":"88","article-title":"Cerebral venous thrombosis after high dose steroid in multiple sclerosis: a case report","volume":"17","author":"Gazioglu","year":"2013","journal-title":"Hippokratia"},{"key":"B56","doi-asserted-by":"publisher","first-page":"669","DOI":"10.4103\/0028-3886.68688","article-title":"Heparin-induced thrombocytopenia and cerebral venous thrombosis after low-molecular weight heparin","volume":"58","author":"Shah","year":"2010","journal-title":"Neurol India"},{"key":"B57","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/NRL.0000000000000146","article-title":"Cerebral venous sinus thrombosis due to low-molecular-weight heparin-induced thrombocytopenia","volume":"22","author":"Gleichgerrcht","year":"2017","journal-title":"Neurologist"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1097\/00000539-199712000-00016","article-title":"Phlegmasia cerulea dolens, cerebral venous thrombosis, and fatal pulmonary embolism due to heparin-induced thrombocytopenic thrombosis syndrome","volume":"85","author":"Beland","year":"1997","journal-title":"Anesth Analg"},{"key":"B59","doi-asserted-by":"publisher","first-page":"121","DOI":"10.15557\/AN.2017.0013","article-title":"A rare case of heparin-induced thrombocytopenia and cerebral venous sinus thrombosis with antiphospholipid syndrome and possible systemic lupus erythematosus","volume":"17","author":"Stavropoulos","year":"2017","journal-title":"Aktualnosci Neurologiczne"},{"key":"B60","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s12028-009-9320-y","article-title":"Heparin-induced thrombocytopenia and cerebral venous sinus thrombosis: case report and literature review","volume":"15","author":"Fesler","year":"2011","journal-title":"Neurocritic Care"},{"key":"B61","first-page":"913","article-title":"Disseminated coronary thrombosis and pentosane polysulfate-induced thrombocytopenia","volume":"81","author":"Meyer","year":"1988","journal-title":"Arch Mal Coeur Vaiss"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1212\/WNL.54.6.1240","article-title":"Neurologic complications in immune-mediated heparin-induced thrombocytopenia","volume":"54","author":"Pohl","year":"2000","journal-title":"Neurology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3109\/09537104.2010.527399","article-title":"Cerebral venous thrombosis due to essential thrombocythemia and worsened by heparin-induced thrombocytopenia and thrombosis","volume":"22","author":"Richard","year":"2011","journal-title":"Platelets"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.3748\/wjg.14.4576","article-title":"Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis","volume":"14","author":"Thorsteinsson","year":"2008","journal-title":"World J Gastroenterol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1160\/TH07-06-0423","article-title":"Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: a consequence of heparin \u201cflushes\u201d","volume":"98","author":"Refaai","year":"2007","journal-title":"Thromb Haemost"},{"key":"B66","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00101-004-0687-z","article-title":"Sinus vein thrombosis. a rare complication of heparin-induced thrombocytopenia type ii","volume":"53","author":"Merz","year":"2004","journal-title":"Anaesthesist"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1161\/01.STR.21.10.1503","article-title":"Cerebral venous thrombosis due to heparin-induced thrombocytopenia","volume":"21","author":"Kyritsis","year":"1990","journal-title":"Stroke"},{"key":"B68","doi-asserted-by":"publisher","first-page":"941","DOI":"10.2169\/internalmedicine.49.3053","article-title":"Cerebral sinus thrombosis and heparin-induced thrombocytopenia in a patient with paroxysmal nocturnal hemoglobinuria","volume":"49","author":"Ishihara-Kawase","year":"2010","journal-title":"Intern Med"},{"key":"B69","doi-asserted-by":"publisher","first-page":"bcr2013009500","DOI":"10.1136\/bcr-2013-009500","article-title":"Cerebral venous thrombosis due to cryptogenic organising pneumopathy with antiphospholipid syndrome worsened by heparin-induced thrombocytopenia","volume":"2013","author":"Hsieh","year":"2013","journal-title":"BMJ Case Rep"},{"key":"B70","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1046\/j.1468-1331.2001.00297.x","article-title":"A case with cerebral thrombosis receiving tamoxifen treatment","volume":"8","author":"Akdal","year":"2001","journal-title":"Eur J Neurol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3340\/jkns.2015.57.3.204","article-title":"A case of dural arteriovenous fistula of superior sagittal sinus after tamoxifen treatment for breast cancer","volume":"57","author":"Hwang","year":"2015","journal-title":"J Korean Neurosurg Soc"},{"key":"B72","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.wneu.2016.01.009","article-title":"Isolated cortical venous thrombosis as a mimic for cortical subarachnoid hemorrhage","volume":"89","author":"Kim","year":"2016","journal-title":"World Neurosurg"},{"key":"B73","first-page":"487","article-title":"Superior sagittal sinus thrombosis related to the use of tamoxifen: a case report and review of literature","volume":"80","author":"Phuong","year":"2016","journal-title":"Conn med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1055\/s-2007-921455","article-title":"Cerebral sinus occlusion in a boy presenting with asparaginase-induced hypertriglyceridemia","volume":"219","author":"Dietel","year":"2007","journal-title":"Klin Padiatr"},{"key":"B75","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4103\/1817-1745.66683","article-title":"Sagittal sinus thrombosis due to l-asparaginase","volume":"5","author":"Wani","year":"2010","journal-title":"J Pediatr Neurosci"},{"key":"B76","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/MPH.0b013e31827e8dbd","article-title":"Cerebral venous sinus thrombosis in pediatric cancer patients: long-term neurological outcomes","volume":"35","author":"Ross","year":"2013","journal-title":"J Pediatr Hematol\/Oncol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3923\/jpt.2014.129.133","article-title":"Peg asparginase induced superior sagittal sinus thrombosis with status epilepticus pediatric in acute lymphoblastic leukemia (all): a report of 2 cases from India","volume":"9","author":"Siddaiahgari","year":"2014","journal-title":"J Pharmacol Toxicol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/MPH.0b013e31828dc614","article-title":"Screening for coagulopathy and identification of children with acute lymphoblastic leukemia at a higher risk of symptomatic venous thrombosis: an aieop experience","volume":"35","author":"Santoro","year":"2013","journal-title":"J Pediatr Hematol Oncol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/pbc.21222","article-title":"Comparison of low-molecular-weight heparin and antithrombin versus antithrombin alone for the prevention of symptomatic venous thromboembolism in children with acute lymphoblastic leukemia","volume":"50","author":"Meister","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"B80","doi-asserted-by":"publisher","first-page":"841057","DOI":"10.1155\/2013\/841057","article-title":"Cerebral sinus venous thrombosis due to asparaginase therapy","volume":"2013","author":"Alsaid","year":"2013","journal-title":"Case Rep Hematol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.3324\/haematol.12948","article-title":"Changes in antithrombin and fibrinogen levels during induction chemotherapy with l-asparaginase in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma. Use of supportive coagulation therapy and clinical outcome: the capelal study","volume":"93","author":"Hunault-Berger","year":"2008","journal-title":"Haematologica"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1182\/blood-2006-04-015511","article-title":"Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients","volume":"108","author":"Caruso","year":"2006","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","first-page":"194","DOI":"10.4103\/0976-500X.95531","article-title":"L-asparginase induced cortical venous thrombosis in a patient with acute leukemia","volume":"3","author":"Dubashi","year":"2012","journal-title":"J Pharmacol Pharmacotherapeut"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1212\/WNL.54.6.1222","article-title":"Cerebral sinus thrombosis diagnosed by mri and mr venography in cancer patients","volume":"54","author":"Raizer","year":"2000","journal-title":"Neurology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2174\/1574886310666150518112823","article-title":"A very rare cerebral complication of chemotherapy in a young girl: a difficult diagnosis","volume":"10","author":"Kridis","year":"2015","journal-title":"Curr Drug Saf"},{"key":"B86","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1159\/000079739","article-title":"Venous sinus thrombosis in a patient taking thalidomide","volume":"18","author":"Lenz","year":"2004","journal-title":"Cerebrovasc Dis"},{"key":"B87","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3109\/08880010903341904","article-title":"Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (mthfr) c677t polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury","volume":"27","author":"Mahadeo","year":"2010","journal-title":"Pediatr Hematol Oncol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11239-013-0988-7","article-title":"Atra-induced cerebral sinus thrombosis","volume":"38","author":"Lee","year":"2014","journal-title":"J Thromb Thrombolysis"},{"key":"B89","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/ana.410120613","article-title":"Superior sagittal sinus thrombosis associated with androgen therapy for hypoplastic anemia","volume":"12","author":"Shiozawa","year":"1982","journal-title":"Ann Neurol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/S0140-6736(85)90543-4","article-title":"Venous thrombosis and cyclosporin","volume":"2","author":"Allen","year":"1985","journal-title":"Lancet"},{"key":"B91","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0140-6736(85)90205-3","article-title":"Venous thrombosis and cyclosporin","volume":"2","author":"Bergentz","year":"1985","journal-title":"Lancet"},{"key":"B92","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1136\/jcp.38.3.253","article-title":"Glomerular thrombi in renal allografts associated with cyclosporin treatment","volume":"38","author":"Neild","year":"1985","journal-title":"J Clin Pathol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/S0002-9610(85)80181-1","article-title":"Cyclosporine-associated renal arteriopathy resulting in loss of allograft function","volume":"149","author":"Sommer","year":"1985","journal-title":"Am J Surg"},{"key":"B94","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1097\/00007890-198705000-00008","article-title":"Postoperative deep venous thrombosis after renal transplantation. Effects of cyclosporine","volume":"43","author":"Brunkwall","year":"1987","journal-title":"Transplantation"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1139\/y87-177","article-title":"Hemolytic uremic syndrome in renal allografted patients treated with cyclosporin","volume":"65","author":"Giroux","year":"1987","journal-title":"Can J Physiol Pharmacol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3109\/08860228709047648","article-title":"Acute glomerular thrombosis with csa treatment","volume":"10","author":"Muirhead","year":"1987","journal-title":"Ren Fail"},{"key":"B97","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1365-2559.1990.tb01065.x","article-title":"Immunosuppression and thrombosis in renal transplantation: an immunohistological study","volume":"16","author":"Dunnill","year":"1990","journal-title":"Histopathology"},{"key":"B98","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF02549838","article-title":"Haematological changes after renal transplantation: differences between cyclosporin-A and azathioprine therapy","volume":"22","author":"Fang","year":"1990","journal-title":"Int Urol Nephrol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/bjs.1800770530","article-title":"Spontaneous rupture of renal allografts: the importance of renal vein thromobosis in the cyclosporin era","volume":"77","author":"Richardson","year":"1990","journal-title":"Br J Surg"},{"key":"B100","first-page":"157","article-title":"Hemolytic uremic syndrome in patients with behcet's disease treated with cyclosporin A: report of 2 cases","volume":"34","author":"Beaufils","year":"1990","journal-title":"Clin Nephrol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1136\/adc.71.6.522","article-title":"Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome","volume":"71","author":"Neuhaus","year":"1994","journal-title":"Arch Dis Child"},{"key":"B102","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1432-2277.1995.tb01481.x","article-title":"Fk 506 versus cyclosporin in the prevention of renal allograft rejection - european pilot study: six week results","volume":"8","author":"Schleibner","year":"1995","journal-title":"Transplant Int"},{"key":"B103","first-page":"27","article-title":"Case report of a recurrent nephrotic syndrome patient with sudden onset of blindness during treatment with cyclosporin A","volume":"40","author":"Ito","year":"1998","journal-title":"Jpn J Nephrol"},{"key":"B104","first-page":"238","article-title":"Thrombosis of intracranial venous veins in a patient with kidney transplant and toxic serum levels of cyclosporin","volume":"112","author":"Guerrero","year":"1999","journal-title":"Med Clin"},{"key":"B105","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1097\/00007890-200203150-00017","article-title":"De novo hemolytic uremic syndrome after kidney transplantation in patients treated with cyclosporine-sirolimus combination","volume":"73","author":"Langer","year":"2002","journal-title":"Transplantation"},{"key":"B106","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S0399-8320(04)94941-X","article-title":"Inflammatory bowel disease and latent thrombocythemia: a novel cause of hepatic vein thrombosis","volume":"28","author":"Decaens","year":"2004","journal-title":"Gastroenterol Clin Biol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"ii33","DOI":"10.1093\/ndt\/gfh1080","article-title":"Secondary effects of immunosuppressive drugs after simultaneous pancreas-kidney transplantation","volume":"20","author":"Kuypers","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"B108","doi-asserted-by":"publisher","first-page":"361","DOI":"10.2165\/00044011-200626060-00008","article-title":"Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin","volume":"26","author":"Simic","year":"2006","journal-title":"Clin Drug Investig"},{"key":"B109","first-page":"63","article-title":"Neuro-behets disease in brazil: higher incidence in females and atypical manifestations","author":"Dutra","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1111\/j.1468-1331.2010.03011.x","article-title":"EFNS guideline on the treatment of cerebral venous and sinus thrombosis in adult patients","volume":"17","author":"Einhaupl","year":"2010","journal-title":"Eur J Neurol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"23","DOI":"10.5582\/irdr.2012.v1.1.23","article-title":"The etiologies of new cases of cerebral venous sinus thrombosis reported in the past year","volume":"1","author":"Meng","year":"2012","journal-title":"Intractable Rare Dis Res"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1111\/j.1538-7836.2009.03355.x","article-title":"Protein phosphatase 2b inhibition promotes the secretion of von willebrand factor from endothelial cells","volume":"7","author":"Nolasco","year":"2009","journal-title":"J Thromb Haemost"},{"key":"B113","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0022-4804(91)90076-X","article-title":"Cyclosporin A augments human platelet sensitivity to aggregating agents by increasing fibrinogen receptor availability","volume":"51","author":"Fishman","year":"1991","journal-title":"J Surg Res"},{"key":"B114","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000159089","article-title":"Nitric oxide in cardiovascular disorders","volume":"32","author":"Dusting","year":"1995","journal-title":"J Vasc Res"},{"key":"B115","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0049-3848(94)90211-9","article-title":"Fibrinolysis and serotonin under cyclosporine a treatment in renal transplant recipients","volume":"76","author":"Ueda","year":"1994","journal-title":"Thromb Res"},{"key":"B116","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1056\/NEJMoa071142","article-title":"Effect of cyclosporine on reperfusion injury in acute myocardial infarction","volume":"359","author":"Piot","year":"2008","journal-title":"N Engl J Med"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.bbabio.2008.12.017","article-title":"The role of the mitochondrial permeability transition pore in heart disease","volume":"1787","author":"Halestrap","year":"2009","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1161\/STROKEAHA.115.009843","article-title":"Association between anemia and cerebral venous thrombosis: case-control study","volume":"46","author":"Coutinho","year":"2015","journal-title":"Stroke"},{"key":"B119","doi-asserted-by":"publisher","first-page":"e82952","DOI":"10.1371\/journal.pone.0082952","article-title":"Association between ischemic stroke and iron-deficiency anemia: a population-based study","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS ONE"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e2870","DOI":"10.7759\/cureus.2870","article-title":"Association of anemia with stroke severity in acute ischemic stroke patients","volume":"10","author":"Khan","year":"2018","journal-title":"Cureus"},{"key":"B121","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-2377-10-22","article-title":"Anemia status, hemoglobin concentration and outcome after acute stroke: a cohort study","volume":"10","author":"Tanne","year":"2010","journal-title":"BMC Neurol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.563037\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T17:48:20Z","timestamp":1613238500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.563037\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":121,"alternative-id":["10.3389\/fneur.2020.563037"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.563037","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"article-number":"563037"}}