{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:21:36Z","timestamp":1790504496589,"version":"4.1.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"DOI":"10.3389\/fneur.2020.563281","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:50:14Z","timestamp":1602741014000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Hyperbaric Oxygen Treatment Improves Intestinal Barrier Function After Spinal Cord Injury in Rats"],"prefix":"10.3389","volume":"11","author":[{"given":"Xuehua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1089\/neu.2018.5771","article-title":"Dietary green tea extract prior to spinal cord injury prevents hepatic iron overload but does not improve chronic hepatic and spinal cord pathology in rats","volume":"35","author":"Goodus","year":"2018","journal-title":"J Neurotrauma."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/cphy.c130045","article-title":"Autonomic consequences of spinal cord injury","volume":"4","author":"Hou","year":"2014","journal-title":"Compr Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/sc.2009.9","article-title":"Health system factors associated with rehospitalizations after traumatic spinal cord injury: a population-based study","volume":"47","author":"Jaglal","year":"2009","journal-title":"Spinal Cord."},{"key":"B4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12967-018-1735-9","article-title":"Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury","volume":"16","author":"Zhang","year":"2018","journal-title":"J Transl Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"520","DOI":"10.2741\/1816","article-title":"Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review","volume":"11","author":"Deitch","year":"2006","journal-title":"Front Biosci."},{"key":"B6","first-page":"471","article-title":"The protective effects of sacral nerve electrostimulation on intestinal mucosal mechanical barrier in rats with spinal cord injury","volume":"30","author":"Bai","year":"2014","journal-title":"Zhong guo Ying Yong Sheng Li Xue Za Zhi."},{"key":"B7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s13311-017-0583-2","article-title":"Gut microbiota are disease-modifying factors after traumatic spinal cord injury","volume":"15","author":"Kigerl","year":"2018","journal-title":"Neurotherapeutics."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1089\/neu.2018.6012","article-title":"Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice","volume":"36","author":"Jing","year":"2019","journal-title":"J Neurotrauma"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1007\/s12035-014-8949-5","article-title":"Combination of HBO and memantine in focal cerebral ischemia: isthere a synergistic effect?","volume":"52","author":"Wang","year":"2015","journal-title":"Mol Neurobiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.biopha.2018.10.025","article-title":"Effect of hyperbaric oxygen on the permeability of the blood-brain barrier in rats with global cerebral ischemia\/reperfusion injury","volume":"108","author":"Li","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.lfs.2013.10.015","article-title":"Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury","volume":"93","author":"Yang","year":"2013","journal-title":"Life Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"11411","DOI":"10.3748\/wjg.v21.i40.11411","article-title":"Tight junction disruption: helicobacter pylori and dysregulation of the gastric mucosal barrier","volume":"21","author":"Caron","year":"2015","journal-title":"World J Gastroenterol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/j.prp.2018.08.023","article-title":"Role of metabolic changes of mucosal layer in the intestinal barrier dysfunction following trauma\/hemorrhagic shock","volume":"214","author":"Zhu","year":"2018","journal-title":"Pathol Res Pract."},{"key":"B14","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.tim.2018.12.007","article-title":"Crossing the Intestinal Barrier via Listeria Adhesion Protein and Internalin A","volume":"27","author":"Drolia","year":"2019","journal-title":"Trends Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1515\/hsz-2013-0181","article-title":"Rho-kinase: regulation, (dys)function, and inhibition","volume":"394","author":"Amin","year":"2013","journal-title":"Biol Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1053\/gast.2001.27060","article-title":"Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia","volume":"121","author":"Walsh","year":"2001","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jss.2018.07.016","article-title":"Effect of simvastatin on the intestinal Rho\/ROCK signaling pathway in rats with sepsis","volume":"232","author":"Wang","year":"2018","journal-title":"J Surg Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1006\/exnr.1996.0098","article-title":"Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transaction","volume":"139","author":"Basso","year":"1996","journal-title":"Exp Neurol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.3892\/mmr.2014.2995","article-title":"Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model","volume":"11","author":"Douhara","year":"2015","journal-title":"Mol Med Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1001\/archsurg.1970.01340280036010","article-title":"Intestinal mucosal lesion in low-flow states. II The protective effect of intraluminal glucose as energy substrate","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.nbd.2018.12.008","article-title":"Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia","volume":"124","author":"Myers","year":"2019","journal-title":"Neurobiol Dis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"7141430","DOI":"10.1155\/2016\/7141430","article-title":"Anti-inflammatory effects of hyperbaric oxygenation during DSS-induced colitis in BALB\/c mice include changes in gene expression of HIF-1\u03b1, proinflammatory cytokines, and antioxidative enzymes","volume":"2016","author":"Novak","year":"2016","journal-title":"Mediators Inflamm."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1097\/01.ccm.0000132898.27101.6c","article-title":"A potential role of hyperbaric oxygen exposure through intestinal nuclear factor-kappa B","volume":"32","author":"Sakoda","year":"2004","journal-title":"Crit Care Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5847\/wjem.j.1920-8642.2012.02.010","article-title":"Effects of hyperbaric oxygen on intestinal mucosa apoptosis caused by ischemia-reperfusion injury in rats","volume":"3","author":"Zhou","year":"2012","journal-title":"World J Emerg Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.pan.2014.06.007","article-title":"The loss of alpha SNAP downregulates the expression of occludin in the intestinal epithelial cell of acute pancreatitis model","volume":"14","author":"Chen","year":"2014","journal-title":"Pancreatology."},{"key":"B26","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/09168451.2014.951027","article-title":"Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1","volume":"79","author":"Park","year":"2015","journal-title":"Biosci Biotechnol Biochem."},{"key":"B27","first-page":"827","article-title":"Qihuang decoction promotes the recovery of intestinal immune barrier dysfunction after gastrectomy in rats","volume":"10","author":"Peng","year":"2018","journal-title":"Am J Transl Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"R146","DOI":"10.1152\/ajpregu.00347.2016","article-title":"Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury","volume":"312","author":"Besecker","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000327951","article-title":"Involvement of HIF-1a in MLCK-dependent endothelial barrier dysfunction in hypoxia","volume":"27","author":"Qi","year":"2011","journal-title":"Cell Physiol Biochem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.matbio.2017.09.003","article-title":"Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo","volume":"66","author":"Kim","year":"2018","journal-title":"Matrix Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s10571-016-0398-4","article-title":"Tetramethylpyrazine protects against oxygen-glucose deprivation-induced brain microvascular endothelial cells injury via rho\/rho-kinase signaling pathway","volume":"37","author":"Yang","year":"2017","journal-title":"Cell Mol Neurobiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"G983","DOI":"10.1152\/ajpgi.00087.2014","article-title":"Aging-associated oxidative stress leads to decrease in IAS tone via RhoA\/ROCK downregulation","volume":"306","author":"Singh","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3389\/fneur.2017.00581","article-title":"Systemic and local cytokine profile following spinal cord injury in rats: a multiplex analysis","volume":"8","author":"Mukhamedshina","year":"2017","journal-title":"Front Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/jnr.22820","article-title":"Expression of inflammatory cytokines following acute spinal cord injury in a rodent model","volume":"90","author":"Stammers","year":"2012","journal-title":"J Neurosci Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1084\/jem.20151345","article-title":"Gut dysbiosis impairs recovery after spinal cord injury","volume":"213","author":"Kigerl","year":"2016","journal-title":"J Exp Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.brainres.2015.01.029","article-title":"The effects of hyperbaric oxygen on macrophage polarization after rat spinal cord injury","volume":"1606","author":"Geng","year":"2015","journal-title":"Brain Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.3892\/mmr.2015.3314","article-title":"Effects of hyperbaric oxygen therapy on NALP3 inflammasome expression in rats after spinal cord injury","volume":"11","author":"Liang","year":"2015","journal-title":"Mol Med Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neulet.2018.10.059","article-title":"Effect of hyperbaric oxygen therapy on HMGB1\/NF-\u03baB expression and prognosis of acute spinal cord injury: a randomized clinical trial","volume":"692","author":"Sun","year":"2019","journal-title":"Neurosci Lett."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.563281\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:50:17Z","timestamp":1602741017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.563281\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":38,"alternative-id":["10.3389\/fneur.2020.563281"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2020.563281","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,15]]},"article-number":"563281"}}