{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:57:12Z","timestamp":1790906232388,"version":"4.1.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> To evaluate the incidence and risk of tremor in patients treated with valproic aid (VPA) monotherapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We searched the PubMed, Embase, and Cochrane Library databases to gather relevant data on tremor in patients taking VPA and other drugs and performed a meta-analysis using Stata15.1 software.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Twenty-nine randomized controlled trials (RCTs) met the inclusion criteria and were included in the meta-analysis. The overall incidence of tremor in patients receiving VPA therapy was 14% [OR = 0.14, 95% CI (0.10\u20130.17)]. The pooled estimate risk of tremor showed a significant difference between patients treated with VPA and all other drugs [OR = 5.40, 95% CI (3.22\u20139.08)], other antiepileptic drugs (AEDs) [OR = 5.78, 95% CI (3.18\u201310.50)], and other non-AEDs [OR = 4.77, 95% CI (1.55\u201314.72)]. Both a dose of &amp;lt;1,500 mg\/d of VPA [included 500 mg\/d: OR = 3.57, 95% CI (1.24\u201310.26), 500\u2013999 mg\/d: OR = 3.99, 95% CI (1.95\u20138.20), 1,000\u20131,499 mg\/d: OR = 8.82, 95% CI (3.25\u201323.94)] and a VPA treatment duration of &amp;lt;12 m [included \u2264 3 months: OR = 3.06, 95% CI (1.16\u20138.09), 3\u20136 months: OR = 16.98, 95% CI (9.14\u201331.57), and 6\u201312 months: OR = 4.15, 95% CI (2.74\u20136.29)] led to a higher risk of tremor than did other drugs, as did higher doses and longer treatment times.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Compared with other drugs, VPA led to a higher risk of tremor, and the level of risk was associated with the dose and duration of treatment.<\/jats:p>","DOI":"10.3389\/fneur.2020.576579","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T18:06:26Z","timestamp":1610301986000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Risk of Valproic Acid-Related Tremor: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Chen qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao ming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei ling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"B1","first-page":"385","article-title":"On the propyl derivatives and decomposition products of ethylacetoacetate","volume":"3","author":"Burton","year":"1882","journal-title":"Am Chem J"},{"key":"B2","first-page":"435","article-title":"Proprietes pharmacodynamiques de l'acide n-diproplyacetique","volume":"18","author":"Meunier","year":"1963","journal-title":"Therapie."},{"key":"B3","doi-asserted-by":"publisher","first-page":"iii","DOI":"10.3310\/hta11390","article-title":"A systematic review and economic model of the clinical effectiveness and cost-effectiveness of interventions for preventing relapse in people with bipolar disorder","volume":"11","author":"Soares-Weiser","year":"2007","journal-title":"Health Technol Assess."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1185\/030079907X188116","article-title":"Valproate in the treatment of PTSD: systematic review and meta analysis","volume":"23","author":"Adamou","year":"2007","journal-title":"Curr Med Res Opin."},{"key":"B5","doi-asserted-by":"publisher","first-page":"CD004028","DOI":"10.1002\/14651858.CD004028.pub4","article-title":"Valproate for schizophrenia","volume":"1","author":"Wang","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"B6","first-page":"S41","article-title":"The evolving role of antiepileptic drugs in treating neuropathic pain","volume":"55","author":"Ross","year":"2000","journal-title":"Neurology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.nurt.2006.11.007","article-title":"Valproic acid: second generation","volume":"4","author":"Bialer","year":"2007","journal-title":"Neurotherapeutics."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1586\/14737140.2014.940329","article-title":"Could valproic acid be an effective anticancer agent? 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