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Mild behavioral impairment (MBI) is a validated syndrome describing emergent and persistent NPS in older adults as a marker of potential cognitive decline and dementia. This study investigated if PD patients with the Met allele were more likely to have MBI and whether they had impairments in specific domains of MBI using the Mild Behavioral Impairment Checklist (MBI-C) as the MBI ascertainment tool. One hundred forty-six PD patients were screened for neuropsychiatric and cognitive impairments with the MBI-C and the Montreal Cognitive Assessment (MoCA). All participants were genotyped for the <jats:italic>BDNF<\/jats:italic> p.Val66Met single-nucleotide polymorphism (SNP) using TaqMan Genotyping Assay. Statistical analysis was performed using multiple linear and logistic regression models. Met carriers had a 2 times higher likelihood of being MBI positive (MBI-C total score \u22658) than Val carriers. Met carriers had significantly higher MBI-C total scores and significantly greater impairments in the mood\/anxiety and the psychotic domains of MBI-C compared to Val carriers. These findings indicate that the <jats:italic>BDNF<\/jats:italic> Met allele is associated with a higher neuropsychiatric burden in PD.<\/jats:p>","DOI":"10.3389\/fneur.2020.587992","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T17:38:29Z","timestamp":1610645909000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Mehrafarin","family":"Ramezani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer 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